TERF1 and APEX1

Number of citations of the paper that reports this interaction (PubMedID 21044950)
82

Data Source:
BioGRID (two hybrid)

		TERF1	APEX1
Description		telomeric repeat binding factor 1	apurinic/apyrimidinic endodeoxyribonuclease 1
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GO Annotations	Cellular Component	Chromosome, Telomeric Region Nuclear Telomere Cap Complex Fibrillar Center Nucleus Nucleoplasm Chromosome Nucleolus Cytoplasm Spindle Cytoskeleton Nuclear Body Shelterin Complex	Chromosome, Telomeric Region Nucleus Nucleoplasm Nucleolus Cytoplasm Mitochondrion Endoplasmic Reticulum Centrosome Ribosome Nuclear Speck Perinuclear Region Of Cytoplasm
	Molecular Function	DNA Binding Double-stranded Telomeric DNA Binding Telomerase Activity Protein Binding Microtubule Binding DNA Binding, Bending Telomeric DNA Binding Identical Protein Binding Protein Homodimerization Activity Ankyrin Repeat Binding G-rich Strand Telomeric DNA Binding	DNA Binding Damaged DNA Binding Double-stranded Telomeric DNA Binding Transcription Coactivator Activity Transcription Corepressor Activity RNA Binding Catalytic Activity DNA-(apurinic Or Apyrimidinic Site) Endonuclease Activity Nuclease Activity Endonuclease Activity DNA Endonuclease Activity RNA-DNA Hybrid Ribonuclease Activity Exonuclease Activity Phosphodiesterase I Activity Uracil DNA N-glycosylase Activity Protein Binding Phosphoric Diester Hydrolase Activity 3'-5'-DNA Exonuclease Activity Double-stranded DNA Exodeoxyribonuclease Activity Double-stranded DNA 3'-5' DNA Exonuclease Activity 3'-5' Exonuclease Activity Oxidoreductase Activity Hydrolase Activity Chromatin DNA Binding Deoxyribonuclease (pyrimidine Dimer) Activity Metal Ion Binding Class II DNA-(apurinic Or Apyrimidinic Site) Endonuclease Activity Phosphodiesterase Activity, Acting On 3'-phosphoglycolate-terminated DNA Strands DNA-(abasic Site) Binding
	Biological Process	Telomere Maintenance Telomere Maintenance Via Telomerase Negative Regulation Of DNA Replication Response To Xenobiotic Stimulus Telomere Capping Positive Regulation Of Telomere Maintenance Negative Regulation Of Telomere Maintenance Via Telomerase Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication Meiotic Telomere Clustering Cell Division Telomeric D-loop Disassembly T-circle Formation Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Positive Regulation Of Shelterin Complex Assembly Negative Regulation Of Establishment Of Protein Localization To Telomere Negative Regulation Of Establishment Of RNA Localization To Telomere Negative Regulation Of Establishment Of Protein-containing Complex Localization To Telomere Negative Regulation Of Telomeric D-loop Disassembly	Telomere Maintenance DNA Repair Base-excision Repair Base-excision Repair, Gap-filling DNA Catabolic Process DNA Recombination DNA Damage Response Regulation Of Apoptotic Process Regulation Of MRNA Stability Positive Regulation Of Gene Expression Via Chromosomal CpG Island Demethylation Cell Redox Homeostasis Negative Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Telomere Maintenance Via Base-excision Repair
Pathways		Recognition and association of DNA glycosylase with site containing an affected pyrimidine Cleavage of the damaged pyrimidine Recognition and association of DNA glycosylase with site containing an affected purine Recognition and association of DNA glycosylase with site containing an affected purine Cleavage of the damaged purine Cleavage of the damaged purine Meiotic synapsis Packaging Of Telomere Ends Telomere Extension By Telomerase Polymerase switching on the C-strand of the telomere Processive synthesis on the C-strand of the telomere Telomere C-strand (Lagging Strand) Synthesis Telomere C-strand synthesis initiation Removal of the Flap Intermediate from the C-strand DNA Damage/Telomere Stress Induced Senescence Inhibition of DNA recombination at telomere	Displacement of DNA glycosylase by APEX1 POLB-Dependent Long Patch Base Excision Repair Resolution of AP sites via the multiple-nucleotide patch replacement pathway PCNA-Dependent Long Patch Base Excision Repair Abasic sugar-phosphate removal via the single-nucleotide replacement pathway Resolution of Abasic Sites (AP sites)
Drugs			Lucanthone
Diseases
GWAS		Age at first sexual intercourse ( 34211149) Crohn's disease ( 22412388) Leukocyte telomere length ( 31171785) Telomere length ( 33941849)	Menopause (age at onset) ( 26414677)
Interacting Genes		212 interacting genes: ACAT2 ACOT7 ACY1 AFAP1L2 AHCY AK1 AKR1A1 ALDOA AMPD2 AMPH ANXA2 ANXA5 ANXA8L1 APEX1 ARHGDIA ARHGEF3 ARPP21 ASS1 ATM BCL7B BIN2 BLM BRAF C12orf43 C1orf35 CALD1 CAPNS1 CASP7 CCDC9 CDC6 CDK1 CEP85 CFL1 CKB CORO1B CPNE3 CRYBB1 CRYM DBN1 DBNL DCX DDX19B DDX21 DDX23 DDX24 DDX39A DLG5 DNAAF11 DNAJB1 DNPH1 DPP3 DPYSL3 EEF1D EIF4B ENO2 EPB41L1 EPHX2 EVL FANCD2 FBP1 FBXO4 FEN1 FES FKBP8 GAMT GAPDH GIT1 GNL3L GNMT GSS H1-1 HCLS1 HDGFL2 HEXIM1 HEXIM2 HGD HMGN3 HMGN4 HMOX1 HNMT HOXA3 HSP90AB1 HSPA6 IPO5 JSRP1 KCTD7 KDM1A KEAP1 KIFBP KLHDC4 KPNB1 LASP1 LDHA LDHB LRSAM1 LYAR MAP4 MAP7 MAPK12 MAPRE1 MCM2 MDH1 MISP MSN MT1X MVK NAP1L1 NBN NEFL NEK7 NME1 NME2 NOL12 NOL3 NRIP1 NUDCD2 NUDT14 NUMA1 NXNL1 OCM2 OGFR OGT PA2G4 PACSIN2 PAFAH1B3 PAGE2 PAICS PAK4 PCLAF PCP4 PEPD PFKP PFN2 PGD PGLS PGM1 PGM2 PINX1 PKM PNMT POT1 PPM1G PRDX1 PRDX6 PRKCB PTMA PTPN5 RBMY1A1 RECQL4 RIC8A RLIM RNF10 RPAP3 RPL19 RTN3 RTN4 SALL1 SARS1 SBDS SENP8 SET SH3BP1 SH3GL2 SH3GL3 SHFL SIRPD SKP1 SMAD9 SMARCC2 SNCG SOAT1 SP100 SRM SRSF6 STUB1 SULT1C2 SUPT5H SYK TALDO1 TBC1D10A TBCD TBL1X TCIRG1 TERT THG1L TINAG TINF2 TKT TMSB10 TMSB4Y TNKS TNKS2 TNPO2 TOMM34 TPI1 TRIM16 TRIP10 TRMT1 TUBB2A TUBB3 TUBB4B UBE2M UTP14A WARS1 WDR4 WFS1 YWHAG ZBTB16 ZC3H18 ZFP36L1 ZHX1 ZNF790	46 interacting genes: ANP32A ANP32CP APP CDC42 CEBPA CSNK2A1 DCTN1 EP300 FBXO7 FEN1 GZMA GZMK HDAC1 HIF1A HMGA1 HMGA2 HMGB2 HNRNPL HOXC13 HSPA1A LINC01554 MCL1 MDM2 MUTYH NFE2L2 NME1 NUDT3 NXF2 PCNA POLB POLR3D SET SLC25A21-AS1 SRPK1 SRPK2 TCF21 TERF1 TERF2 TERF2IP TP53 TXN UBE2I UBR3 XRCC1 XRCC5 XRCC6
Entrez ID		7013	328
HPRD ID		02975	00136
Ensembl ID		ENSG00000147601	ENSG00000100823
Uniprot IDs		A0A7I2V5T5 A0A7I2YQE7 P54274	P27695 Q5TZP7
PDB IDs		1BA5 1H6O 1ITY 1IV6 1W0T 3BQO 3L82 5HKP 5WIR 5XUP 8F0A 8F0U 8F1T 8F1U 8F21 8F26 8OX1 8W8G	1BIX 1CQG 1CQH 1DE8 1DE9 1DEW 1E9N 1HD7 2ISI 2O3H 3U8U 4IEM 4LND 4QH9 4QHD 4QHE 5CFG 5DFF 5DFH 5DFI 5DFJ 5DG0 5WN0 5WN1 5WN2 5WN3 5WN4 5WN5 6BOQ 6BOR 6BOS 6BOT 6BOU 6BOV 6BOW 6MK3 6MKK 6MKM 6MKO 6P93 6P94 6W0Q 6W2P 6W3L 6W3N 6W3Q 6W3U 6W43 6W4I 6W4T 7LPG 7LPH 7LPI 7LPJ 7MCR 7MEV 7SUV 7SVB 7TC2 7TC3 7TR7 7U50 9DP1 9DP2 9DP3 9DP4
Enriched GO Terms of Interacting Partners?		Cytosol Cytoplasm Extracellular Exosome Identical Protein Binding Protein Binding Nucleobase-containing Compound Metabolic Process Nicotinamide Nucleotide Metabolic Process Telomere Maintenance Chromosome, Telomeric Region Nucleobase-containing Small Molecule Metabolic Process Purine-containing Compound Metabolic Process Telomere Organization Cadherin Binding Nucleus Negative Regulation Of Telomere Maintenance Purine Nucleotide Metabolic Process ADP Metabolic Process Regulation Of Telomere Maintenance Via Telomerase Regulation Of Chromosome Organization Positive Regulation Of Chromosome Organization Nucleoside Diphosphate Metabolic Process Glycolytic Process Pyruvate Metabolic Process Positive Regulation Of Cellular Component Organization Regulation Of Cellular Component Organization ADP Catabolic Process Nucleotide Metabolic Process Purine Ribonucleoside Diphosphate Catabolic Process Regulation Of Telomere Maintenance Via Telomere Lengthening Ribonucleoside Diphosphate Catabolic Process Nucleoside Phosphate Metabolic Process Ficolin-1-rich Granule Lumen Nucleoside Diphosphate Catabolic Process Ribonucleoside Diphosphate Metabolic Process Nucleoside Phosphate Catabolic Process RNA Binding Phosphate-containing Compound Metabolic Process Microtubule Cytoskeleton Organization Negative Regulation Of DNA Metabolic Process Regulation Of Telomere Maintenance Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Purine Nucleotide Catabolic Process Protein Localization To Organelle Positive Regulation Of Protein-containing Complex Assembly Cytoskeleton Positive Regulation Of Organelle Organization Organelle Organization Catalytic Activity Small Molecule Metabolic Process Organophosphate Catabolic Process	Negative Regulation Of Nucleobase-containing Compound Metabolic Process Nucleus Nucleoplasm Nucleic Acid Metabolic Process DNA Metabolic Process 5'-deoxyribose-5-phosphate Lyase Activity Protein-containing Complex DNA Damage Response Damaged DNA Binding Nuclear Telomere Cap Complex Macromolecule Metabolic Process Enzyme Binding Negative Regulation Of DNA Metabolic Process Cellular Response To Stress Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of DNA-templated Transcription Telomere Maintenance Negative Regulation Of Metabolic Process DNA Binding Base-excision Repair Nucleobase-containing Compound Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Chromatin Negative Regulation Of RNA Metabolic Process Response To Stress Chromosome Organization Transcription Cis-regulatory Region Binding Regulation Of Intrinsic Apoptotic Signaling Pathway Telomere Organization Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Programmed Cell Death Regulation Of Apoptotic Signaling Pathway Double-stranded Telomeric DNA Binding DNA Repair Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Signaling Pathway Telomeric DNA Binding Regulation Of Cellular Response To Stress Double-strand Break Repair Via Nonhomologous End Joining Negative Regulation Of Biosynthetic Process Response To Radiation Chromosome, Telomeric Region Regulation Of Primary Metabolic Process Negative Regulation Of Telomere Maintenance Regulation Of Metabolic Process DNA Binding, Bending Protein-DNA Complex Double-strand Break Repair DNA Biosynthetic Process
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