PTPN21 and FBXO17

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		PTPN21	FBXO17
Description		protein tyrosine phosphatase non-receptor type 21	F-box protein 17
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytoskeleton	Cytoplasm Cytosol SCF Ubiquitin Ligase Complex
	Molecular Function	Phosphoprotein Phosphatase Activity Protein Tyrosine Phosphatase Activity Protein Binding Hydrolase Activity	Protein Binding Ubiquitin Protein Ligase Activity
	Biological Process	Protein Dephosphorylation	Glycoprotein Catabolic Process SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process ERAD Pathway
Pathways			Neddylation Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Prudent dietary pattern ( 28644415) Suicidality in mood disorders ( 33783297) Suicide attempt severity in mood disorders ( 33783297)	SAPHO syndrome ( 33816493)
Interacting Genes		27 interacting genes: AKAP1 ATOSB BAG3 BMX CATSPER1 CWC22 ERBB4 FBXO17 GOLGA2 KIF1C MAGOHB MOB3C NEK6 NSMF PAK5 PARD6A PIBF1 QARS1 RASD1 SNX18 SRC TEC TRIM14 UBASH3B VPS26C YAP1 ZNF497	22 interacting genes: ADAMTSL4 ADRB2 CBY2 CDCA8 DZIP3 EIF4H JRK KPRP KRT75 KRTAP13-2 LASP1 OAS2 PTPN21 RAB11FIP2 RUNX1 SAXO1 SAXO2 SKP1 USP54 ZNF213 ZNF829 ZSCAN9
Entrez ID		11099	115290
HPRD ID		04468	16436
Ensembl ID		ENSG00000070778	ENSG00000269190
Uniprot IDs		Q16825	Q96EF6
PDB IDs		8GVL 8GVV 8GWH 8GXE 8Y8Y
Enriched GO Terms of Interacting Partners?		Protein Phosphorylation Cardiac Muscle Tissue Regeneration Non-membrane Spanning Protein Tyrosine Kinase Activity Protein Tyrosine Kinase Activity Phosphorylation Protein Autophosphorylation Peptidyl-tyrosine Phosphorylation Centriolar Satellite Tissue Regeneration Intestinal Epithelial Cell Development Protein Kinase Activity U2-type Catalytic Step 1 Spliceosome Microtubule-based Process Columnar/cuboidal Epithelial Cell Development Interleukin-6-mediated Signaling Pathway Cytoskeleton Kinase Activity Establishment Of Planar Polarity Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein ERBB2 Signaling Pathway Mitotic Spindle Organization Spindle Assembly Negative Regulation Of Apoptotic Signaling Pathway Positive Regulation Of Protein Localization To Nucleus Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Polarized Epithelial Cell Differentiation Positive Regulation Of Protein Localization Regulation Of Tyrosine Phosphorylation Of STAT Protein Positive Regulation Of Cardiac Muscle Cell Proliferation
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