PTPN21 and BMX

Number of citations of the paper that reports this interaction (PMID 11013262)
8

Data Source:
HPRD (in vitro, in vivo, two hybrid)

		PTPN21	BMX
Gene Name		protein tyrosine phosphatase, non-receptor type 21	BMX non-receptor tyrosine kinase
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Cytoskeleton	Cytosol Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Ruffle Membrane
	Molecular Function	Protein Tyrosine Phosphatase Activity Protein Binding	Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Signal Transducer Activity Receptor Binding Protein Binding ATP Binding Metal Ion Binding
	Biological Process	Protein Dephosphorylation Peptidyl-tyrosine Dephosphorylation	Adaptive Immune Response Protein Phosphorylation Apoptotic Process Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Cell Adhesion Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Mesoderm Development Cell Differentiation Intracellular Signal Transduction Peptidyl-tyrosine Autophosphorylation Regulation Of Cell Proliferation Innate Immune Response Protein Autophosphorylation T Cell Receptor Signaling Pathway B Cell Receptor Signaling Pathway
Pathways			Apoptotic cleavage of cellular proteins Programmed Cell Death Apoptotic execution phase
Drugs
Diseases
GWAS
Protein-Protein Interactions		5 interactors: AKAP1 BMX KIF1C SRC TEC	23 interactors: APP BCAR1 BTK C12orf45 CASP3 CAV1 EGFR ERBB2 FBXO25 ITK KDR PAK1 PTK2 PTPN21 RAP1A RUFY1 RUFY2 SRC STAT1 STAT3 STAT5A TEC TNFRSF1B
Entrez ID		11099	660
HPRD ID		04468	02111
Ensembl ID		ENSG00000070778	ENSG00000102010
Uniprot IDs		Q16825	P51813
PDB IDs			2EKX 2YS2 3SXR 3SXS
Enriched GO Terms of Interacting Partners?		Peptidyl-tyrosine Autophosphorylation Protein Autophosphorylation Peptidyl-tyrosine Phosphorylation Wound Healing Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Response To Wounding Integrin-mediated Signaling Pathway Response To Hydrogen Peroxide Mesoderm Development Innate Immune Response Cellular Response To Progesterone Stimulus Enzyme Linked Receptor Protein Signaling Pathway Cellular Response To Steroid Hormone Stimulus Positive Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Peptidyl-amino Acid Modification Response To Reactive Oxygen Species Intracellular Receptor Signaling Pathway Vestibular Reflex Positive Regulation Of Integrin Activation Negative Regulation Of Mitochondrial Depolarization Positive Regulation Of Podosome Assembly Negative Regulation Of Protein Homooligomerization Progesterone Receptor Signaling Pathway Fc Receptor Signaling Pathway Adaptive Immune Response Regulation Of Podosome Assembly Immune Response-activating Cell Surface Receptor Signaling Pathway Positive Regulation Of Cell Cycle Immune Response Regulation Of Caveolin-mediated Endocytosis Protein Phosphorylation Defense Response Osteoclast Development Negative Regulation Of Protein Oligomerization Response To Stress Regulation Of Cell Proliferation Movement Of Cell Or Subcellular Component Semicircular Canal Morphogenesis Regulation Of Integrin Activation Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Early Endosome To Late Endosome Transport Axon Guidance Transcytosis Cellular Response To Organic Cyclic Compound Signal Complex Assembly Semicircular Canal Development Stress Fiber Assembly Cellular Response To Lipid Blood Coagulation Response To Oxidative Stress	Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Protein Autophosphorylation Cell Surface Receptor Signaling Pathway Immune System Process Peptidyl-tyrosine Phosphorylation Peptidyl-tyrosine Autophosphorylation Regulation Of Cell Proliferation Intracellular Signal Transduction Response To Organic Substance Regulation Of Immune System Process Immune Response-regulating Cell Surface Receptor Signaling Pathway Cellular Response To Growth Factor Stimulus Cellular Response To Organic Substance Response To Growth Factor Regulation Of Immune Response Fc Receptor Signaling Pathway Positive Regulation Of Protein Metabolic Process Cellular Response To Organonitrogen Compound Positive Regulation Of Cellular Metabolic Process Immune Response-regulating Signaling Pathway Response To Wounding Defense Response Vascular Endothelial Growth Factor Receptor Signaling Pathway Cell Differentiation Positive Regulation Of Metabolic Process Response To Stress Phosphorylation Neurotrophin TRK Receptor Signaling Pathway Positive Regulation Of Cellular Protein Metabolic Process Innate Immune Response Response To Organonitrogen Compound Cellular Response To Hormone Stimulus Neurotrophin Signaling Pathway Wound Healing Regulation Of Cell Death Signal Transduction Peptidyl-amino Acid Modification Response To Hormone Response To Peptide Hormone Immune Response Protein Phosphorylation Cell Activation Immune Response-activating Cell Surface Receptor Signaling Pathway Regulation Of Cell Activation Signaling Response To Peptide Cell Communication Growth Hormone Receptor Signaling Pathway Regulation Of Protein Kinase Activity
Tagcloud ?		16p 17p 17q 20q 6q16 8q amplifications amplifier bbs12 bbs9 ciliogenesis dnah9 exome firestorm fmn2 foxo3 hsp90b1 idcs impc impcs micropapillary pangenomic polarity q22 sawtooth sec63 sptlc3 ubr4 unsupervised	additive androgen attenuation btk chemo confer correlates ctn06 docetaxel dtx dual etk grades healing herein immortalized impeded independence killing never pc3 perception prostate raf sensitizer tec vegfr wound xenograft
Tagcloud (Difference) ?		16p 17p 17q 20q 6q16 8q amplifications amplifier bbs12 bbs9 ciliogenesis dnah9 exome firestorm fmn2 foxo3 hsp90b1 idcs impc impcs micropapillary pangenomic polarity q22 sawtooth sec63 sptlc3 ubr4 unsupervised	additive androgen attenuation btk chemo confer correlates ctn06 docetaxel dtx dual etk grades healing herein immortalized impeded independence killing never pc3 perception prostate raf sensitizer tec vegfr wound xenograft
Tagcloud (Intersection) ?