PTPN21 and TEC

Number of citations of the paper that reports this interaction (PubMedID 11013262)
0

Data Source:
HPRD (in vivo)

		PTPN21	TEC
Description		protein tyrosine phosphatase non-receptor type 21	tec protein tyrosine kinase
Image
GO Annotations	Cellular Component	Cytoplasm Cytoskeleton	Cytoplasm Cytosol Cytoskeleton Plasma Membrane Membrane
	Molecular Function	Phosphoprotein Phosphatase Activity Protein Tyrosine Phosphatase Activity Protein Binding Hydrolase Activity	Nucleotide Binding Protein Kinase Activity Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Protein Binding ATP Binding Phospholipid Binding Zinc Ion Binding Lipid Binding Kinase Activity Transferase Activity Metal Ion Binding
	Biological Process	Protein Dephosphorylation	Adaptive Immune Response Immune System Process Protein Phosphorylation Integrin-mediated Signaling Pathway Regulation Of Platelet Activation Intracellular Signal Transduction Tissue Regeneration T Cell Receptor Signaling Pathway B Cell Receptor Signaling Pathway
Pathways			Signaling by SCF-KIT FCERI mediated Ca+2 mobilization FCERI mediated Ca+2 mobilization Interleukin-3, Interleukin-5 and GM-CSF signaling
Drugs			Fostamatinib Zanubrutinib
Diseases
GWAS		Prudent dietary pattern ( 28644415) Suicidality in mood disorders ( 33783297) Suicide attempt severity in mood disorders ( 33783297)	Crohn's disease ( 23128233) Metabolite levels ( 23823483) Pulse pressure ( 27841878) Rheumatoid arthritis ( 24390342 30423114) Systolic blood pressure ( 27841878)
Interacting Genes		27 interacting genes: AKAP1 ATOSB BAG3 BMX CATSPER1 CWC22 ERBB4 FBXO17 GOLGA2 KIF1C MAGOHB MOB3C NEK6 NSMF PAK5 PARD6A PIBF1 QARS1 RASD1 SNX18 SRC TEC TRIM14 UBASH3B VPS26C YAP1 ZNF497	37 interacting genes: ARHGEF12 BMX BTK DOK1 EGFR ERBB2 ERBB3 ERBB4 FASLG FBXO7 GAB1 GNA12 IKBKG JAK1 JAK2 KIT LRRK1 LYN MET PIK3R1 PIK3R2 PIK3R3 PIP4K2A PIP5K1A PLCG1 PLCG2 PLK4 PRLR PRRG4 PTPN18 PTPN21 SHC1 SOCS1 STAP1 TP53 VAV1 WAS
Entrez ID		11099	7006
HPRD ID		04468	02786
Ensembl ID		ENSG00000070778	ENSG00000135605
Uniprot IDs		Q16825	P42680
PDB IDs		8GVL 8GVV 8GWH 8GXE 8Y8Y	2LUL
Enriched GO Terms of Interacting Partners?		Protein Phosphorylation Cardiac Muscle Tissue Regeneration Non-membrane Spanning Protein Tyrosine Kinase Activity Protein Tyrosine Kinase Activity Phosphorylation Protein Autophosphorylation Peptidyl-tyrosine Phosphorylation Centriolar Satellite Tissue Regeneration Intestinal Epithelial Cell Development Protein Kinase Activity U2-type Catalytic Step 1 Spliceosome Microtubule-based Process Columnar/cuboidal Epithelial Cell Development Interleukin-6-mediated Signaling Pathway Cytoskeleton Kinase Activity Establishment Of Planar Polarity Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein ERBB2 Signaling Pathway Mitotic Spindle Organization Spindle Assembly Negative Regulation Of Apoptotic Signaling Pathway Positive Regulation Of Protein Localization To Nucleus Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Polarized Epithelial Cell Differentiation Positive Regulation Of Protein Localization Regulation Of Tyrosine Phosphorylation Of STAT Protein Positive Regulation Of Cardiac Muscle Cell Proliferation	Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Protein Tyrosine Kinase Activity Enzyme-linked Receptor Protein Signaling Pathway Cell Surface Receptor Signaling Pathway Intracellular Signal Transduction Signal Transduction Regulation Of Signal Transduction Kinase Activity Regulation Of Cell Communication Regulation Of Signaling Regulation Of Intracellular Signal Transduction Intracellular Signaling Cassette Protein Kinase Activity Phosphotyrosine Residue Binding Positive Regulation Of Intracellular Signal Transduction Lymphocyte Activation Cellular Developmental Process Phosphate-containing Compound Metabolic Process Positive Regulation Of Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Mononuclear Cell Differentiation Regulation Of Programmed Cell Death Cytosol Protein Phosphorylation Leukocyte Activation ERBB Signaling Pathway Non-membrane Spanning Protein Tyrosine Kinase Activity Receptor Complex Positive Regulation Of Cell Communication Positive Regulation Of Signaling Leukocyte Differentiation Phosphorylation Negative Regulation Of Programmed Cell Death Peptidyl-tyrosine Phosphorylation Fc-epsilon Receptor Signaling Pathway Cell Activation Developmental Process Fc Receptor Signaling Pathway Lymphocyte Differentiation Regulation Of Immune System Process Regulation Of Locomotion Immune System Process B Cell Activation Immune Response-regulating Cell Surface Receptor Signaling Pathway Cell Differentiation Regulation Of Immune Response Phosphatidylinositol Metabolic Process T Cell Activation ATP Binding Positive Regulation Of Immune System Process
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