PTPN21 and TEC

Number of citations of the paper that reports this interaction (PMID 11013262)
8

Data Source:
HPRD (in vivo)

		PTPN21	TEC
Gene Name		protein tyrosine phosphatase, non-receptor type 21	tec protein tyrosine kinase
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Cytoskeleton	Cytosol Cytoskeleton Cell-cell Junction Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane
	Molecular Function	Protein Tyrosine Phosphatase Activity Protein Binding	Non-membrane Spanning Protein Tyrosine Kinase Activity Receptor Binding Protein Binding ATP Binding Lipid Binding Metal Ion Binding
	Biological Process	Protein Dephosphorylation Peptidyl-tyrosine Dephosphorylation	Adaptive Immune Response Protein Phosphorylation Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Integrin-mediated Signaling Pathway Regulation Of Platelet Activation Cell Differentiation Intracellular Signal Transduction Peptidyl-tyrosine Autophosphorylation Fc-epsilon Receptor Signaling Pathway Regulation Of Cell Proliferation Tissue Regeneration Innate Immune Response T Cell Receptor Signaling Pathway B Cell Receptor Signaling Pathway
Pathways			Signaling by SCF-KIT Signaling by Interleukins Fc epsilon receptor (FCERI) signaling Cytokine Signaling in Immune system FCERI mediated Ca+2 mobilization Interleukin-3, 5 and GM-CSF signaling Innate Immune System
Drugs
Diseases
GWAS			Crohn's disease ( 23128233)
Protein-Protein Interactions		5 interactors: AKAP1 BMX KIF1C SRC TEC	30 interactors: ARHGEF12 BMX BTK DOK1 ERBB2 FASLG GNA12 IKBKG JAK1 JAK2 KIT LYN PIK3R1 PIK3R2 PIK3R3 PIP4K2A PIP5K1A PLCG1 PLCG2 PLK4 PRLR PTPN18 PTPN21 RHOA SHC1 SOCS1 STAP1 TP53 VAV1 WAS
Entrez ID		11099	7006
HPRD ID		04468	02786
Ensembl ID		ENSG00000070778	ENSG00000135605
Uniprot IDs		Q16825	P42680
PDB IDs			2LUL
Enriched GO Terms of Interacting Partners?		Peptidyl-tyrosine Autophosphorylation Protein Autophosphorylation Peptidyl-tyrosine Phosphorylation Wound Healing Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Response To Wounding Integrin-mediated Signaling Pathway Response To Hydrogen Peroxide Mesoderm Development Innate Immune Response Cellular Response To Progesterone Stimulus Enzyme Linked Receptor Protein Signaling Pathway Cellular Response To Steroid Hormone Stimulus Positive Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Peptidyl-amino Acid Modification Response To Reactive Oxygen Species Intracellular Receptor Signaling Pathway Vestibular Reflex Positive Regulation Of Integrin Activation Negative Regulation Of Mitochondrial Depolarization Positive Regulation Of Podosome Assembly Negative Regulation Of Protein Homooligomerization Progesterone Receptor Signaling Pathway Fc Receptor Signaling Pathway Adaptive Immune Response Regulation Of Podosome Assembly Immune Response-activating Cell Surface Receptor Signaling Pathway Positive Regulation Of Cell Cycle Immune Response Regulation Of Caveolin-mediated Endocytosis Protein Phosphorylation Defense Response Osteoclast Development Negative Regulation Of Protein Oligomerization Response To Stress Regulation Of Cell Proliferation Movement Of Cell Or Subcellular Component Semicircular Canal Morphogenesis Regulation Of Integrin Activation Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Early Endosome To Late Endosome Transport Axon Guidance Transcytosis Cellular Response To Organic Cyclic Compound Signal Complex Assembly Semicircular Canal Development Stress Fiber Assembly Cellular Response To Lipid Blood Coagulation Response To Oxidative Stress	Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Cell Surface Receptor Signaling Pathway Intracellular Signal Transduction Innate Immune Response Fc Receptor Signaling Pathway Immune Response Fc-epsilon Receptor Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Immune System Process Regulation Of Immune Response Blood Coagulation Hemostasis Regulation Of Body Fluid Levels Signal Transduction Wound Healing Immune Response-regulating Signaling Pathway Response To Organic Substance Signaling Defense Response Response To Wounding Cell Communication Regulation Of Signal Transduction Regulation Of Intracellular Signal Transduction Phosphate-containing Compound Metabolic Process Neurotrophin TRK Receptor Signaling Pathway Antigen Receptor-mediated Signaling Pathway Neurotrophin Signaling Pathway Cellular Response To Organic Substance Regulation Of Immune System Process Cell Activation Regulation Of Signaling Regulation Of Catalytic Activity Cellular Response To Stimulus Peptidyl-tyrosine Phosphorylation Immune Response-activating Cell Surface Receptor Signaling Pathway Regulation Of Kinase Activity Response To Growth Factor Cell Differentiation Cellular Response To Peptide Hormone Stimulus Growth Hormone Receptor Signaling Pathway Cellular Response To Peptide Cellular Response To Growth Hormone Stimulus Movement Of Cell Or Subcellular Component Phagocytosis Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc Receptor Mediated Stimulatory Signaling Pathway Fc-gamma Receptor Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway Phosphorylation
Tagcloud ?		16p 17p 17q 20q 6q16 8q amplifications amplifier bbs12 bbs9 ciliogenesis dnah9 exome firestorm fmn2 foxo3 hsp90b1 idcs impc impcs micropapillary pangenomic polarity q22 sawtooth sec63 sptlc3 ubr4 unsupervised
Tagcloud (Difference) ?		16p 17p 17q 20q 6q16 8q amplifications amplifier bbs12 bbs9 ciliogenesis dnah9 exome firestorm fmn2 foxo3 hsp90b1 idcs impc impcs micropapillary pangenomic polarity q22 sawtooth sec63 sptlc3 ubr4 unsupervised
Tagcloud (Intersection) ?