Wiki-Pi
About
Search
People
Updates
Search
PTPN21 and BAG3
Number of citations of the paper that reports this interaction (PubMedID
32296183
)
50
Data Source:
BioGRID
(two hybrid)
PTPN21
BAG3
Description
protein tyrosine phosphatase non-receptor type 21
BAG cochaperone 3
Image
No pdb structure
GO Annotations
Cellular Component
Cytoplasm
Cytoskeleton
Stress Fiber
Nucleus
Nucleoplasm
Cytoplasm
Mitochondrion
Cytosol
Membrane
Aggresome
Z Disc
Ciliary Basal Body
Protein Folding Chaperone Complex
Molecular Function
Phosphoprotein Phosphatase Activity
Protein Tyrosine Phosphatase Activity
Protein Binding
Hydrolase Activity
Adenyl-nucleotide Exchange Factor Activity
Protein Binding
Protein-macromolecule Adaptor Activity
Protein-containing Complex Binding
Cadherin Binding
Dynein Intermediate Chain Binding
Protein-folding Chaperone Binding
Protein Carrier Chaperone
Biological Process
Protein Dephosphorylation
Autophagosome Assembly
Protein Folding
Apoptotic Process
Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
Striated Muscle Cell Apoptotic Process
Negative Regulation Of Striated Muscle Cell Apoptotic Process
Spinal Cord Development
Cellular Response To Heat
Cellular Response To Unfolded Protein
Positive Regulation Of Protein Import Into Nucleus
Negative Regulation Of Apoptotic Process
Muscle Cell Cellular Homeostasis
Positive Regulation Of Protein Export From Nucleus
Protein Stabilization
Chaperone-mediated Autophagy
Aggresome Assembly
Cellular Response To Mechanical Stimulus
Extrinsic Apoptotic Signaling Pathway
Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Protein Transport Along Microtubule
Negative Regulation Of Protein Targeting To Mitochondrion
Positive Regulation Of Aggrephagy
Pathways
Regulation of HSF1-mediated heat shock response
Drugs
Diseases
GWAS
Prudent dietary pattern (
28644415
)
Suicidality in mood disorders (
33783297
)
Suicide attempt severity in mood disorders (
33783297
)
Aspartate aminotransferase levels (
33547301
)
Diastolic blood pressure (
27841878
)
Dilated cardiomyopathy (
33495596
)
Dilated cardiomyopathy (MTAG) (
33495596
)
Electrocardiogram morphology (amplitude at temporal datapoints) (
32916098
)
Heart failure (
31919418
)
Hypertrophic cardiomyopathy (
33495597
33495596
)
Hypertrophic cardiomyopathy (MTAG) (
33495596
)
Hypertrophic cardiomyopathy (sarcomere negative) (
33495597
)
Idiopathic dilated cardiomyopathy (
21459883
)
Left ventricular ejection fraction (
32605384
32382064
33495596
)
Left ventricular end-diastolic volume (
33495596
)
Left ventricular end-systolic volume (
32382064
33495596
)
Left ventricular global circumferential strain (
33495596
)
Left ventricular global radial strain (
33495596
)
Parkinson's disease (
28892059
27182965
32201043
)
Parkinson's disease or first degree relation to individual with Parkinson's disease (
31701892
)
Interacting Genes
27 interacting genes:
AKAP1
ATOSB
BAG3
BMX
CATSPER1
CWC22
ERBB4
FBXO17
GOLGA2
KIF1C
MAGOHB
MOB3C
NEK6
NSMF
PAK5
PARD6A
PIBF1
QARS1
RASD1
SNX18
SRC
TEC
TRIM14
UBASH3B
VPS26C
YAP1
ZNF497
76 interacting genes:
ACD
ARRDC3
ATN1
ATXN7L2
BAIAP2L1
BCL2
CRYAB
CTDSP1
CYSRT1
CYSTM1
DAZAP2
DNM2
DTX3
DVL1
DVL2
DYNLT1
EGR4
ENTREP1
EYA2
FAM168B
FBXO7
FOXD4L1
GGN
GLIS3
HELT
HSPA1A
HSPA5
HSPA8
HSPB2
HSPB2-C11orf52
HSPB7
HSPB8
INCA1
LENG8
LITAF
LRRK1
LRRK2
MAGED1
MDFI
MRPL38
NEDD8
NIBAN3
NOTO
NR1H3
PDE9A
PDLIM7
PIH1D2
PLA2G10
PLCG1
PLEKHB1
POT1
PRDM6
PRKAR1B
PRR34
PTPN21
RUNX1
SF3B4
SHISA6
SIAH1
SPRY2
SRPK2
TBC1D3B
TBC1D3G
TINF2
TMEM174
TNK2
TP53BP2
TRIB3
TRIM27
TRIP6
TSC1
UBC
UNKL
VPS37B
WBP2
WNK1
Entrez ID
11099
9531
HPRD ID
04468
04860
Ensembl ID
ENSG00000070778
ENSG00000151929
Uniprot IDs
Q16825
O95817
PDB IDs
8GVL
8GVV
8GWH
8GXE
8Y8Y
Enriched GO Terms of Interacting Partners
?
Protein Phosphorylation
Cardiac Muscle Tissue Regeneration
Non-membrane Spanning Protein Tyrosine Kinase Activity
Protein Tyrosine Kinase Activity
Phosphorylation
Protein Autophosphorylation
Peptidyl-tyrosine Phosphorylation
Centriolar Satellite
Tissue Regeneration
Intestinal Epithelial Cell Development
Protein Kinase Activity
U2-type Catalytic Step 1 Spliceosome
Microtubule-based Process
Columnar/cuboidal Epithelial Cell Development
Interleukin-6-mediated Signaling Pathway
Cytoskeleton
Kinase Activity
Establishment Of Planar Polarity
Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein
ERBB2 Signaling Pathway
Mitotic Spindle Organization
Spindle Assembly
Negative Regulation Of Apoptotic Signaling Pathway
Positive Regulation Of Protein Localization To Nucleus
Negative Regulation Of Extrinsic Apoptotic Signaling Pathway
Polarized Epithelial Cell Differentiation
Positive Regulation Of Protein Localization
Regulation Of Tyrosine Phosphorylation Of STAT Protein
Positive Regulation Of Cardiac Muscle Cell Proliferation
Ubiquitin Protein Ligase Binding
Protein Refolding
Telomere Assembly
Regulation Of Protein Stability
Shelterin Complex
Nuclear Telomere Cap Complex
Negative Regulation Of Signal Transduction
Protein Folding Chaperone Complex
Negative Regulation Of Signaling
Negative Regulation Of Cell Communication
Identical Protein Binding
Telomere Capping
Regulation Of Protein Ubiquitination
Response To Unfolded Protein
Regulation Of Signal Transduction
Regulation Of Nucleobase-containing Compound Metabolic Process
Convergent Extension Involved In Neural Plate Elongation
Regulation Of Primary Metabolic Process
Cytoplasm
Nucleus
Negative Regulation Of Response To Endoplasmic Reticulum Stress
Positive Regulation Of Metabolic Process
Protein Binding
Positive Regulation Of Macromolecule Metabolic Process
Regulation Of Post-translational Protein Modification
Negative Regulation Of Telomere Maintenance Via Telomerase
Negative Regulation Of Autophagy
Regulation Of Mitochondrial Membrane Permeability
Negative Regulation Of Intracellular Signal Transduction
Protein Folding Chaperone
Unfolded Protein Binding
WW Domain Binding
Convergent Extension Involved In Organogenesis
C3HC4-type RING Finger Domain Binding
Protein Serine/threonine Kinase Inhibitor Activity
Negative Regulation Of Pancreatic Juice Secretion
Intracellular Signal Transduction
Regulation Of Membrane Permeability
Regulation Of Autophagy
Regulation Of DNA-templated Transcription
Regulation Of RNA Biosynthetic Process
Negative Regulation Of Cellular Component Organization
Convergent Extension Involved In Gastrulation
ATP-dependent Protein Disaggregase Activity
Telomeric DNA Binding
Negative Regulation Of Telomere Maintenance Via Telomere Lengthening
Regulation Of Cellular Component Organization
Protein Folding
Negative Regulation Of DNA Biosynthetic Process
Regulation Of Apoptotic Signaling Pathway
Tagcloud
?
Tagcloud (Difference)
?
Tagcloud (Intersection)
?