TCF7L2 and PRKAB2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		TCF7L2	PRKAB2
Description		transcription factor 7 like 2	protein kinase AMP-activated non-catalytic subunit beta 2
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GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm PML Body Protein-DNA Complex Beta-catenin-TCF7L2 Complex Catenin-TCF7L2 Complex Beta-catenin-TCF Complex	Nucleus Nucleoplasm Cytoplasm Cytosol Nucleotide-activated Protein Kinase Complex
	Molecular Function	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Transcription Corepressor Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Beta-catenin Binding Nuclear Receptor Binding Protein Kinase Binding Sequence-specific DNA Binding Gamma-catenin Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding Armadillo Repeat Domain Binding Promoter-specific Chromatin Binding	AMP-activated Protein Kinase Activity Protein Binding Protein Kinase Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Blood Vessel Development Regulation Of Transcription By RNA Polymerase II Response To Glucose Positive Regulation Of Epithelial To Mesenchymal Transition Positive Regulation Of Heparan Sulfate Proteoglycan Biosynthetic Process Wnt Signaling Pathway Pancreas Development Positive Regulation Of Insulin Secretion Regulation Of Hormone Metabolic Process Glucose Homeostasis Maintenance Of DNA Repeat Elements Fat Cell Differentiation Negative Regulation Of Gluconeogenesis Negative Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Myoblast Fate Commitment Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Epithelial Cell Proliferation Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Canonical Wnt Signaling Pathway Negative Regulation Of Androgen Receptor Signaling Pathway Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Protein Localization To Nucleus Negative Regulation Of Type B Pancreatic Cell Apoptotic Process Negative Regulation Of Extrinsic Apoptotic Signaling Pathway	Lipid Metabolic Process Fatty Acid Metabolic Process Fatty Acid Biosynthetic Process Signal Transduction Cellular Response To Nutrient Levels Positive Regulation Of Cold-induced Thermogenesis
Pathways		Formation of the beta-catenin:TCF transactivating complex Formation of the beta-catenin:TCF transactivating complex Deactivation of the beta-catenin transactivating complex Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) Ca2+ pathway Binding of TCF/LEF:CTNNB1 to target gene promoters Repression of WNT target genes Repression of WNT target genes Signaling by TCF7L2 mutants Transcriptional Regulation by VENTX RUNX3 regulates WNT signaling Formation of definitive endoderm Regulation of MITF-M-dependent genes involved in cell cycle and proliferation Regulation of PD-L1(CD274) transcription	Translocation of SLC2A4 (GLUT4) to the plasma membrane Macroautophagy AMPK inhibits chREBP transcriptional activation activity AMPK inhibits chREBP transcriptional activation activity Carnitine shuttle Activation of PPARGC1A (PGC-1alpha) by phosphorylation Energy dependent regulation of mTOR by LKB1-AMPK TP53 Regulates Metabolic Genes Regulation of TP53 Activity through Phosphorylation Lipophagy Activation of AMPK downstream of NMDARs AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)
Drugs			Adenosine phosphate Acetylsalicylic acid Fostamatinib
Diseases		Type II diabetes mellitus
GWAS		Adult body size ( 32376654) Aging traits (healthspan, parental lifespan or longevity) (multivariate analysis) ( 32678081) Alzheimer's disease or fasting glucose levels (pleiotropy) ( 30805717) Bipolar disorder (body mass index interaction) ( 24322204) Blood glucose levels ( 29615537 31928498) BMI (adjusted for smoking behaviour) ( 28443625) BMI in non-smokers ( 28443625) Body fat percentage and fasting glucose (pairwise) ( 33619380) Body fat percentage and type 2 diabetes (pairwise) ( 33619380) Body mass index ( 25673413 26426971 28448500 28892062 29381148 31453325) Body mass index (age>50) ( 26426971) Body mass index (joint analysis main effects and physical activity interaction) ( 28448500) Body mass index (joint analysis main effects and smoking interaction) ( 28443625) Body mass index and fasting glucose (pairwise) ( 33619380) Body mass index and systole blood pressure (pairwise) ( 33619380) Body mass index and type 2 diabetes (pairwise) ( 33619380) Body mass index in physically active individuals ( 28448500) Body mass index variance ( 31453325) Body mass index x sex x age interaction (4df test) ( 26426971) Brain morphology (MOSTest) ( 32665545) Breast cancer ( 23535729 27117709) Breast Cancer in BRCA1 mutation carriers ( 23544013) Childhood onset type 2 diabetes ( 33479058) Circulating leptin levels or type 2 diabetes ( 32341051) Clinical laboratory measurements ( 27897004) Cognitive decline (age-related) ( 28078323) Colorectal cancer ( 24836286 29471430 30529582) Colorectal cancer or advanced adenoma ( 30510241) Coronary artery disease ( 29212778) Fasting blood glucose ( 20081858 22581228 25631608) Fasting blood glucose (BMI interaction) ( 22581228) Fasting blood insulin ( 22581228) Fasting blood insulin (BMI interaction) ( 22581228) Fasting glucose ( 34059833) Fasting insulin ( 34059833) Femur bone mineral density x serum urate levels interaction ( 34046847) Glucosuria ( 30476138) Glucosuria (mild) ( 30476138) Glucosuria (moderate to severe) ( 30476138) Glycated hemoglobin levels ( 20849430 28898252 34059833) Glycemic traits (pleiotropy) ( 31021400) Granulocyte percentage of myeloid white cells ( 27863252) Gut microbiota relative abundance (Ruminococcus belonging to family Lachnospiraceae) ( 33208821) Heel bone mineral density ( 28869591 30598549) Hemoglobin ( 32888494) Hemoglobin A1c levels ( 29403010) High light scatter reticulocyte count ( 32888494) High myopia ( 31816047 33830181) Hip circumference ( 25673412) Hip circumference adjusted for BMI ( 34021172) Hip index ( 34021172) Hypertrophic cardiomyopathy ( 33495597) Insulin-related traits (multivariate analysis) ( 32002517) Intraocular pressure ( 29617998 29785010) Ischemic stroke ( 26732560) Medication use (drugs used in diabetes) ( 31015401) Medication use (HMG CoA reductase inhibitors) ( 31015401) Metabolic syndrome ( 20694148) Metabolite levels ( 23823483) Mild age-related type 2 diabetes ( 34737425) Mild obesity-related type 2 diabetes ( 34737425) Monocyte count ( 32888494) Monocyte percentage of white cells ( 27863252 32888494) Myopia ( 27182965) Offspring birth weight ( 31043758) Peak insulin response ( 28490609) Peripheral artery disease ( 31285632) Proinsulin levels ( 21873549) Prostate cancer ( 29892016) Pulse pressure ( 27841878 30578418) Refractive error ( 32231278) Retinopathy x type 2 diabetes interaction ( 32541925) Schizophrenia vs type 2 diabetes ( 30470734) Severe insulin-deficient type 2 diabetes ( 34737425) Spherical equivalent or myopia (age of diagnosis) ( 29808027) Systolic blood pressure ( 27841878 30578418) Two-hour glucose ( 34059833) Two-hour glucose challenge ( 20081857) Type 2 diabetes ( 17293876 17460697 17463246 17463248 17463249 17554300 17668382 18372903 19056611 19401414 19734900 20581827 21347282 22101970 22693455 22885922 23209189 23300278 23945395 24390345 24509480 25102180 25483131 26818947 26961502 27189021 28254843 28869590 29358691 30054458 30297969 30470734 30718926 31049640 31118516 31324766 32499647 34737425) Urate levels ( 31578528) Waist circumference ( 25673412) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172) Waist-to-hip ratio adjusted for body mass index ( 28430825)
Interacting Genes		46 interacting genes: ACTMAP AR BPIFA1 CCNG2 CNFN CRX CSNK2A1 CSNK2A2 CTNNB1 CTNNBIP1 CYSRT1 DAXX DAZAP2 EP300 FAM168B FBLN1 HIC1 INTS11 JUP KCNE4 KMT5A KRTAP19-5 KRTAP19-7 KRTAP21-2 KRTAP6-1 KRTAP6-2 KRTAP6-3 KRTAP7-1 MEN1 MSX2 PRKAB2 PRR20A PRR20B PRR20C PRR20D PRR20E PSEN1 PSMA3 RBPMS RNF138 SMUG1 TLE5 TRAF1 TSC1 UFSP1 ZNF34	172 interacting genes: ABHD11 ACTMAP ADAMTSL4 ANAPC11 ARID5A AUNIP AVP BANP BEND5 BLZF1 C2orf42 C3orf36 CALCOCO2 CASP2 CASP6 CCDC28B CCDC33 CDC14B CDSN CDX4 CFAP68 CFP CREB3L1 CRX CSNK2B CYSRT1 DAO DDAH2 DDIT4L DICER1 DOK3 DST ELL2 EPM2A ESM1 FDX1 FLNC GATA1 GATAD2B GCSAML GET4 GOLGA2 GOLGA6L9 GORASP2 GPRASP3 GRAPL GRN GSC2 IHO1 IKZF1 IKZF3 IL37 IRAK1BP1 KATNBL1 KCTD5 KHDC4 KLF15 KRABD4 KRT31 KRT40 KRTAP1-1 KRTAP1-3 KRTAP10-11 KRTAP10-3 KRTAP10-5 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP17-1 KRTAP2-3 KRTAP2-4 KRTAP3-3 KRTAP4-12 KRTAP4-2 KRTAP4-5 KRTAP5-9 KRTAP9-2 KRTAP9-3 KRTAP9-4 KRTAP9-8 LHX3 LRIF1 LZTS1 LZTS2 MAGED1 MAJIN MDFI MEOX2 METTL27 MORN3 NAB2 NEBL NHLRC4 NUTM1 OXER1 PDE6G PDE6H PFDN5 PIAS2 PNMA1 PPP1R13B PPP1R16A PPP1R3B PPP1R3C PRDM14 PRKAA1 PRKAG1 PRKAG2 PSMD11 PSME3 PYGM QKI RAB3IP RACK1 RBM48 RBPMS REL RHEBL1 RIMBP3 RNF144B ROR2 RPH3AL SAMD4A SERTAD2 SMARCB1 SMUG1 SPRY1 SPRY2 SSC4D SSX2IP STX11 STX19 TADA2A TASOR2 TCF12 TCF19 TCF4 TCF7L2 TGM7 TLE5 TNNI1 TP53 TP53BP2 TRAF1 TRAF2 TRIB3 TRIM10 TRIM14 TRIM35 TRIM42 TRIM54 TRIM55 TRIM63 TSR2 TTC23 UBXN11 USP54 VBP1 VPS28 WDR83 YPEL3 YY1AP1 ZBTB32 ZC2HC1C ZFP90 ZMYND19 ZNF177 ZNF236 ZNF474 ZNF526 ZNF559-ZNF177 ZNF581
Entrez ID		6934	5565
HPRD ID		03751	04117
Ensembl ID		ENSG00000148737	ENSG00000131791
Uniprot IDs		A0A0A0MTL7 A0A994J711 B4DJZ2 C6ZRJ7 C6ZRK1 C6ZRK2 C6ZRK5 Q5JRY4 Q5VVR7 Q6FHW4 Q9NQB0	O43741 X5D2Z8
PDB IDs		1JDH 1JPW 2GL7	2F15 2V8Q 2V92 2V9J 2Y8L 2Y8Q 2YA3 4CFH 4EAI 4EAJ 4RER 4REW 6B2E 7JHG 7JHH 7JIJ 7M74
Enriched GO Terms of Interacting Partners?		Intermediate Filament Wnt Signaling Pathway Nuclear Receptor Binding Beta-catenin-ICAT Complex Regulation Of Wnt Signaling Pathway Positive Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development Protein Kinase CK2 Complex Catenin-TCF7L2 Complex Keratinization Cellular Response To Indole-3-methanol Response To Indole-3-methanol Transcription Coactivator Activity Cell Surface Receptor Signaling Pathway Beta-catenin Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding Canonical Wnt Signaling Pathway Positive Regulation Of Protein Import Into Nucleus Regulation Of DNA-templated Transcription Negative Regulation Of Transcription By RNA Polymerase II Regulation Of RNA Biosynthetic Process Epithelial Cell Differentiation Involved In Prostate Gland Development DNA Damage Response Protein-DNA Complex Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development Regulation Of Signal Transduction By P53 Class Mediator Alpha-catenin Binding Transcription Coactivator Binding Cytosol Negative Regulation Of Apoptotic Signaling Pathway Genitalia Morphogenesis Beta-catenin Destruction Complex Pre-mRNA Intronic Binding Cornified Envelope Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Canonical Wnt Signaling Pathway Regulation Of Protein Import Into Nucleus Regulation Of Apoptotic Signaling Pathway Positive Regulation Of Nucleocytoplasmic Transport Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Osteoblast Differentiation Regulation Of RNA Metabolic Process Regionalization Osteoblast Development Protein-containing Complex Negative Regulation Of Signal Transduction Negative Regulation Of RNA Metabolic Process Positive Regulation Of Osteoblast Differentiation P53 Binding	Keratin Filament Intermediate Filament Protein Binding Identical Protein Binding AMP-activated Protein Kinase Activity Regulation Of Carbohydrate Catabolic Process Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway P53 Binding Glycogen Binding Nucleotide-activated Protein Kinase Complex
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