TCF7L2 and TSC1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		TCF7L2	TSC1
Description		transcription factor 7 like 2	TSC complex subunit 1
Image
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm PML Body Protein-DNA Complex Beta-catenin-TCF7L2 Complex Catenin-TCF7L2 Complex Beta-catenin-TCF Complex	Nucleus Cytoplasm Lysosome Lysosomal Membrane Lipid Droplet Cytosol Actin Filament Plasma Membrane Cell Cortex Postsynaptic Density Membrane Lamellipodium Protein-containing Complex TSC1-TSC2 Complex Ciliary Basal Body Perinuclear Region Of Cytoplasm Protein Folding Chaperone Complex
	Molecular Function	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Transcription Corepressor Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Beta-catenin Binding Nuclear Receptor Binding Protein Kinase Binding Sequence-specific DNA Binding Gamma-catenin Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding Armadillo Repeat Domain Binding Promoter-specific Chromatin Binding	Protein Binding Hsp70 Protein Binding ATPase Inhibitor Activity Protein Folding Chaperone Protein-folding Chaperone Binding Hsp90 Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Blood Vessel Development Regulation Of Transcription By RNA Polymerase II Response To Glucose Positive Regulation Of Epithelial To Mesenchymal Transition Positive Regulation Of Heparan Sulfate Proteoglycan Biosynthetic Process Wnt Signaling Pathway Pancreas Development Positive Regulation Of Insulin Secretion Regulation Of Hormone Metabolic Process Glucose Homeostasis Maintenance Of DNA Repeat Elements Fat Cell Differentiation Negative Regulation Of Gluconeogenesis Negative Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Myoblast Fate Commitment Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Epithelial Cell Proliferation Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Canonical Wnt Signaling Pathway Negative Regulation Of Androgen Receptor Signaling Pathway Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Protein Localization To Nucleus Negative Regulation Of Type B Pancreatic Cell Apoptotic Process Negative Regulation Of Extrinsic Apoptotic Signaling Pathway	Kidney Development Neural Tube Closure Regulation Of Cell-matrix Adhesion Adaptive Immune Response Protein Folding Potassium Ion Transport Cell-matrix Adhesion Nervous System Development Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Associative Learning Adult Locomotory Behavior Cellular Response To Starvation Negative Regulation Of Macroautophagy Hippocampus Development Cerebral Cortex Development Cell Projection Organization Negative Regulation Of TOR Signaling Negative Regulation Of ATP-dependent Activity Response To Insulin Cellular Response To Decreased Oxygen Levels TORC1 Signaling Myelination Memory T Cell Differentiation Negative Regulation Of Cell Size D-glucose Import Synapse Organization Protein Stabilization Regulation Of Stress Fiber Assembly Regulation Of Cell Cycle Positive Regulation Of Focal Adhesion Assembly Cardiac Muscle Cell Differentiation Activation Of GTPase Activity Negative Regulation Of TORC1 Signaling Positive Regulation Of TORC1 Signaling
Pathways		Formation of the beta-catenin:TCF transactivating complex Formation of the beta-catenin:TCF transactivating complex Deactivation of the beta-catenin transactivating complex Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) Ca2+ pathway Binding of TCF/LEF:CTNNB1 to target gene promoters Repression of WNT target genes Repression of WNT target genes Signaling by TCF7L2 mutants Transcriptional Regulation by VENTX RUNX3 regulates WNT signaling Formation of definitive endoderm Regulation of MITF-M-dependent genes involved in cell cycle and proliferation Regulation of PD-L1(CD274) transcription	Macroautophagy Inhibition of TSC complex formation by PKB Energy dependent regulation of mTOR by LKB1-AMPK TP53 Regulates Metabolic Genes TBC/RABGAPs
Drugs
Diseases		Type II diabetes mellitus	Lymphangioleiomyomatosis (LAM) Tuberous sclerosis complex (TSC); Bourneville-Pringle disease
GWAS		Adult body size ( 32376654) Aging traits (healthspan, parental lifespan or longevity) (multivariate analysis) ( 32678081) Alzheimer's disease or fasting glucose levels (pleiotropy) ( 30805717) Bipolar disorder (body mass index interaction) ( 24322204) Blood glucose levels ( 29615537 31928498) BMI (adjusted for smoking behaviour) ( 28443625) BMI in non-smokers ( 28443625) Body fat percentage and fasting glucose (pairwise) ( 33619380) Body fat percentage and type 2 diabetes (pairwise) ( 33619380) Body mass index ( 25673413 26426971 28448500 28892062 29381148 31453325) Body mass index (age>50) ( 26426971) Body mass index (joint analysis main effects and physical activity interaction) ( 28448500) Body mass index (joint analysis main effects and smoking interaction) ( 28443625) Body mass index and fasting glucose (pairwise) ( 33619380) Body mass index and systole blood pressure (pairwise) ( 33619380) Body mass index and type 2 diabetes (pairwise) ( 33619380) Body mass index in physically active individuals ( 28448500) Body mass index variance ( 31453325) Body mass index x sex x age interaction (4df test) ( 26426971) Brain morphology (MOSTest) ( 32665545) Breast cancer ( 23535729 27117709) Breast Cancer in BRCA1 mutation carriers ( 23544013) Childhood onset type 2 diabetes ( 33479058) Circulating leptin levels or type 2 diabetes ( 32341051) Clinical laboratory measurements ( 27897004) Cognitive decline (age-related) ( 28078323) Colorectal cancer ( 24836286 29471430 30529582) Colorectal cancer or advanced adenoma ( 30510241) Coronary artery disease ( 29212778) Fasting blood glucose ( 20081858 22581228 25631608) Fasting blood glucose (BMI interaction) ( 22581228) Fasting blood insulin ( 22581228) Fasting blood insulin (BMI interaction) ( 22581228) Fasting glucose ( 34059833) Fasting insulin ( 34059833) Femur bone mineral density x serum urate levels interaction ( 34046847) Glucosuria ( 30476138) Glucosuria (mild) ( 30476138) Glucosuria (moderate to severe) ( 30476138) Glycated hemoglobin levels ( 20849430 28898252 34059833) Glycemic traits (pleiotropy) ( 31021400) Granulocyte percentage of myeloid white cells ( 27863252) Gut microbiota relative abundance (Ruminococcus belonging to family Lachnospiraceae) ( 33208821) Heel bone mineral density ( 28869591 30598549) Hemoglobin ( 32888494) Hemoglobin A1c levels ( 29403010) High light scatter reticulocyte count ( 32888494) High myopia ( 31816047 33830181) Hip circumference ( 25673412) Hip circumference adjusted for BMI ( 34021172) Hip index ( 34021172) Hypertrophic cardiomyopathy ( 33495597) Insulin-related traits (multivariate analysis) ( 32002517) Intraocular pressure ( 29617998 29785010) Ischemic stroke ( 26732560) Medication use (drugs used in diabetes) ( 31015401) Medication use (HMG CoA reductase inhibitors) ( 31015401) Metabolic syndrome ( 20694148) Metabolite levels ( 23823483) Mild age-related type 2 diabetes ( 34737425) Mild obesity-related type 2 diabetes ( 34737425) Monocyte count ( 32888494) Monocyte percentage of white cells ( 27863252 32888494) Myopia ( 27182965) Offspring birth weight ( 31043758) Peak insulin response ( 28490609) Peripheral artery disease ( 31285632) Proinsulin levels ( 21873549) Prostate cancer ( 29892016) Pulse pressure ( 27841878 30578418) Refractive error ( 32231278) Retinopathy x type 2 diabetes interaction ( 32541925) Schizophrenia vs type 2 diabetes ( 30470734) Severe insulin-deficient type 2 diabetes ( 34737425) Spherical equivalent or myopia (age of diagnosis) ( 29808027) Systolic blood pressure ( 27841878 30578418) Two-hour glucose ( 34059833) Two-hour glucose challenge ( 20081857) Type 2 diabetes ( 17293876 17460697 17463246 17463248 17463249 17554300 17668382 18372903 19056611 19401414 19734900 20581827 21347282 22101970 22693455 22885922 23209189 23300278 23945395 24390345 24509480 25102180 25483131 26818947 26961502 27189021 28254843 28869590 29358691 30054458 30297969 30470734 30718926 31049640 31118516 31324766 32499647 34737425) Urate levels ( 31578528) Waist circumference ( 25673412) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172) Waist-to-hip ratio adjusted for body mass index ( 28430825)	Migraine without aura ( 23793025) Psoriasis ( 19169254)
Interacting Genes		46 interacting genes: ACTMAP AR BPIFA1 CCNG2 CNFN CRX CSNK2A1 CSNK2A2 CTNNB1 CTNNBIP1 CYSRT1 DAXX DAZAP2 EP300 FAM168B FBLN1 HIC1 INTS11 JUP KCNE4 KMT5A KRTAP19-5 KRTAP19-7 KRTAP21-2 KRTAP6-1 KRTAP6-2 KRTAP6-3 KRTAP7-1 MEN1 MSX2 PRKAB2 PRR20A PRR20B PRR20C PRR20D PRR20E PSEN1 PSMA3 RBPMS RNF138 SMUG1 TLE5 TRAF1 TSC1 UFSP1 ZNF34	169 interacting genes: ABI1 ACTN1 ACTN2 AKT1 ANKIB1 ANKRD24 ANKRD35 APPL2 AQP1 ARAF ARID5A ATN1 ATXN1 AURKA AXIN1 BAG3 BCL11A BECN1 BEND5 C1orf94 CALCOCO2 CASC3 CCDC120 CCDC88B CCL28 CCNB1 CCND2 CCNE1 CDK1 CDK4 CDK6 CDKN2A CDKN2B CDR2 CHCHD2 CNIH1 CNTRL CNTROB COG6 CSTF2 CTNNB1 DACH2 DCTN2 DMRT3 DOK5 EIF3A ENKD1 EZR FAM110A FAM222B FBF1 FGFR4 FOXH1 FRS3 GCC1 GEMIN8 GFAP GLIS2 GOLGA2 GPANK1 GPATCH1 HECW1 HGS HNRNPM HOMER3 HOOK2 HOXC8 HR HSH2D ICA1 IGFN1 IKBKB KANSL2 KAT2A KAZN KDM1A KIF1C KIF5A KLC1 KLC4 LATS2 LENG1 LMO2 LRSAM1 LUC7L LZTS2 MAP2K5 MAPK14 MBIP MBP MSANTD3 MSN MT-ND1 MYC MYLIP MYOZ3 NECAB2 NEFL NF2 NINL NKD2 NRBF2 PATL1 PATZ1 PHLDB1 PICK1 PITX1 PLK1 PLK2 POGZ POU6F2 PPFIA2 PPP1R18 PRMT6 RALYL RASSF1 RBPMS RDX RHEB RIN1 RIN3 RUNDC3A SAMD11 SAMD7 SAXO4 SCMH1 SEC31A SELENOW SERTAD1 SH2D2A SHANK1 SHC3 SMG9 SORBS3 SOX4 SPAG5 SPAG8 SUOX TANK TBC1D7 TBX6 TCF7L2 TFAP2D TFIP11 TLE5 TNS2 TRIM3 TRIOBP TSC2 TSGA10IP TSHZ3 USP2-AS1 VENTX VEZF1 VGLL3 VIM VPS37C YPEL3 YWHAB YWHAE YWHAG YWHAH YWHAQ YWHAZ ZIC1 ZNF417 ZNF423 ZNF587 ZNF765
Entrez ID		6934	7248
HPRD ID		03751	05594
Ensembl ID		ENSG00000148737	ENSG00000165699
Uniprot IDs		A0A0A0MTL7 A0A994J711 B4DJZ2 C6ZRJ7 C6ZRK1 C6ZRK2 C6ZRK5 Q5JRY4 Q5VVR7 Q6FHW4 Q9NQB0	A0A2R8Y5M3 A0A2R8Y5N2 A0A2R8Y5S3 A0A2R8Y6S1 A0A2R8YD74 A0A2R8YFV7 Q32NF0 Q86WV8 Q92574 X5D9D2
PDB IDs		1JDH 1JPW 2GL7	4Z6Y 5EJC 7DL2 9C9I 9CE3
Enriched GO Terms of Interacting Partners?		Intermediate Filament Wnt Signaling Pathway Nuclear Receptor Binding Beta-catenin-ICAT Complex Regulation Of Wnt Signaling Pathway Positive Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development Protein Kinase CK2 Complex Catenin-TCF7L2 Complex Keratinization Cellular Response To Indole-3-methanol Response To Indole-3-methanol Transcription Coactivator Activity Cell Surface Receptor Signaling Pathway Beta-catenin Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding Canonical Wnt Signaling Pathway Positive Regulation Of Protein Import Into Nucleus Regulation Of DNA-templated Transcription Negative Regulation Of Transcription By RNA Polymerase II Regulation Of RNA Biosynthetic Process Epithelial Cell Differentiation Involved In Prostate Gland Development DNA Damage Response Protein-DNA Complex Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development Regulation Of Signal Transduction By P53 Class Mediator Alpha-catenin Binding Transcription Coactivator Binding Cytosol Negative Regulation Of Apoptotic Signaling Pathway Genitalia Morphogenesis Beta-catenin Destruction Complex Pre-mRNA Intronic Binding Cornified Envelope Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Canonical Wnt Signaling Pathway Regulation Of Protein Import Into Nucleus Regulation Of Apoptotic Signaling Pathway Positive Regulation Of Nucleocytoplasmic Transport Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Osteoblast Differentiation Regulation Of RNA Metabolic Process Regionalization Osteoblast Development Protein-containing Complex Negative Regulation Of Signal Transduction Negative Regulation Of RNA Metabolic Process Positive Regulation Of Osteoblast Differentiation P53 Binding	Cytoskeleton Protein Domain Specific Binding Regulation Of Primary Metabolic Process Cytoplasm Protein Binding Regulation Of Macromolecule Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Protein Localization To Nucleus Positive Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Negative Regulation Of RNA Metabolic Process Regulation Of Gene Expression Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Regulation Of RNA Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Spindle Pole Microtubule-based Process Negative Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Protein Metabolic Process Positive Regulation Of Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Microtubule Cytoskeleton Organization Negative Regulation Of Biosynthetic Process Protein Kinase Binding Negative Regulation Of Macromolecule Metabolic Process Identical Protein Binding Cytoskeleton Organization Organelle Organization Negative Regulation Of Metabolic Process G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Intracellular Transport Cell Cycle G1/S Phase Transition Mitotic Cell Cycle Phase Transition Cytoskeletal Protein Binding Cytosol Regulation Of Protein Localization Positive Regulation Of Protein Localization To Nucleus Negative Regulation Of Transcription By RNA Polymerase II Microtubule Cytoskeleton Organization Involved In Mitosis MAPK Cascade Cell Cycle Phase Transition Cell Division Positive Regulation Of Early Endosome To Late Endosome Transport Centrosome
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?