TCF7L2 and FBLN1

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		TCF7L2	FBLN1
Gene Name		transcription factor 7-like 2 (T-cell specific, HMG-box)	fibulin 1
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nuclear Chromatin Nucleus Nucleoplasm Transcription Factor Complex Cytoplasm PML Body Protein-DNA Complex Beta-catenin-TCF7L2 Complex	Extracellular Region Proteinaceous Extracellular Matrix Basement Membrane Extracellular Space Extracellular Matrix Extracellular Vesicular Exosome
	Molecular Function	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Repressing Transcription Factor Binding Chromatin Binding Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Beta-catenin Binding Transcription Factor Binding Protein Kinase Binding Nuclear Hormone Receptor Binding Sequence-specific DNA Binding Transcription Regulatory Region DNA Binding Gamma-catenin Binding Armadillo Repeat Domain Binding	Extracellular Matrix Structural Constituent Calcium Ion Binding Peptidase Activator Activity
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Blood Vessel Development Glycogen Metabolic Process Glucose Metabolic Process Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter Cell Cycle Arrest Brain Development Cell Proliferation Cellular Response To Starvation Response To Glucose Post-embryonic Development Positive Regulation Of Triglyceride Biosynthetic Process Positive Regulation Of Heparan Sulfate Proteoglycan Biosynthetic Process Oligodendrocyte Development Neural Tube Development Pituitary Gland Development Bone Mineralization Negative Regulation Of BMP Signaling Pathway Embryonic Genitalia Morphogenesis Pancreas Development Regulation Of Myelination Positive Regulation Of Insulin Secretion Positive Regulation Of Protein Binding Secretory Granule Localization Regulation Of Hormone Metabolic Process Somatic Stem Cell Maintenance Multicellular Organism Growth Catenin Import Into Nucleus Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Odontogenesis Of Dentin-containing Tooth Glucose Homeostasis Positive Regulation Of Apoptotic Process Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Maintenance Of DNA Repeat Elements Skin Development Canonical Wnt Signaling Pathway Involved In Positive Regulation Of Epithelial To Mesenchymal Transition Fat Cell Differentiation Negative Regulation Of Fat Cell Differentiation Positive Regulation Of Gluconeogenesis Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Organ Growth Positive Regulation Of Protein Export From Nucleus Embryonic Digestive Tract Morphogenesis Embryonic Hindgut Morphogenesis Myoblast Fate Commitment Regulation Of Skeletal Muscle Tissue Development Regulation Of Smooth Muscle Cell Proliferation Generation Of Neurons Regulation Of Oligodendrocyte Differentiation Positive Regulation Of Epithelial Cell Proliferation Positive Regulation Of Protein Kinase B Signaling Canonical Wnt Signaling Pathway Face Morphogenesis Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Negative Regulation Of Canonical Wnt Signaling Pathway Insulin Metabolic Process Negative Regulation Of Type B Pancreatic Cell Apoptotic Process Negative Regulation Of Extrinsic Apoptotic Signaling Pathway	Embryo Implantation Positive Regulation Of Peptidase Activity Viral Process Extracellular Matrix Organization
Pathways		APC truncation mutants have impaired AXIN binding misspliced GSK3beta mutants stabilize beta-catenin T41 mutants of beta-catenin aren't phosphorylated TCF7L2 mutants don't bind CTBP truncated APC mutants destabilize the destruction complex Signaling by Wnt binding of TCF/LEF:CTNNB1 to target gene promoters deactivation of the beta-catenin transactivating complex APC truncation mutants are not K63 polyubiquitinated S37 mutants of beta-catenin aren't phosphorylated Peptide hormone metabolism Degradation of beta-catenin by the destruction complex S33 mutants of beta-catenin aren't phosphorylated AXIN mutants destabilize the destruction complex, activating WNT signaling RNF mutants show enhanced WNT signaling and proliferation XAV939 inhibits tankyrase, stabilizing AXIN Incretin synthesis, secretion, and inactivation truncations of AMER1 destabilize the destruction complex misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling formation of the beta-catenin:TCF transactivating complex phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex AXIN missense mutants destabilize the destruction complex S45 mutants of beta-catenin aren't phosphorylated repression of WNT target genes beta-catenin independent WNT signaling deletions in the AMER1 gene destabilize the destruction complex Ca2+ pathway AMER1 mutants destabilize the destruction complex TCF dependent signaling in response to WNT deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling Signaling by WNT in cancer Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)	Molecules associated with elastic fibres Elastic fibre formation
Drugs
Diseases
GWAS		Breast cancer ( 23535729) Breast Cancer in BRCA1 mutation carriers ( 23544013) Coronary heart disease ( 21347282) Fasting glucose-related traits ( 20081858) Fasting glucose-related traits (interaction with BMI) ( 22581228) Fasting insulin-related traits (interaction with BMI) ( 22581228) Glycated hemoglobin levels ( 20849430) Metabolic syndrome ( 20694148) Proinsulin levels ( 21873549) Two-hour glucose challenge ( 20081857) Type 2 diabetes ( 17668382 18372903 17293876 22693455 17554300 23300278 20581827 19401414 17463246 17463248 17463249 22101970 17460697 19056611 23209189) Type 2 diabetes and other traits ( 19734900)	Temperament (bipolar disorder) ( 22365631)
Protein-Protein Interactions		13 interactors: CSNK2A1 CSNK2A2 CTBP1 CTNNB1 CTNNBIP1 DAXX DAZAP2 EP300 FBLN1 JUP PSEN1 PSMA3 UBE2I	35 interactors: ACAN ADAMTSL2 ADAMTSL4 APOA1 APP ATN1 BHLHE40 CACNA1A CTGF ECM1 EDC4 ELN FGB FN1 GFI1B HBEGF HSPG2 ITGB1 LTBP4 MFAP5 MOB4 NEDD1 NID1 NOTCH3 NOV PLSCR1 SKIL SMAD3 SMAD4 TAF9 TANK TCF7L2 TDGF1 VCAN YWHAQ
Entrez ID		6934	2192
HPRD ID		03751	00629
Ensembl ID		ENSG00000148737	ENSG00000077942
Uniprot IDs		B4DJZ2 B4DRJ8 B7Z9Z6 B9X074 C6ZRJ7 C6ZRJ8 C6ZRJ9 C6ZRK0 C6ZRK1 C6ZRK2 C6ZRK5 E2GH13 E2GH14 E2GH16 E2GH18 E2GH24 E2GH25 E2GH26 Q6FHW4 Q9NQB0	P23142 Q8NBH6
PDB IDs		1JDH 1JPW 2GL7
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Cellular Metabolic Process Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Metabolic Process Viral Process Apoptotic Process Wnt Signaling Pathway Programmed Cell Death Cell Cycle Process Cell Death Death Regulation Of Wnt Signaling Pathway Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Regulation Of Nitrogen Compound Metabolic Process Negative Regulation Of RNA Biosynthetic Process Mitotic Cell Cycle Process Positive Regulation Of Protein Metabolic Process Regulation Of Signal Transduction Positive Regulation Of Signal Transduction Mitotic Cell Cycle Positive Regulation Of Wnt Signaling Pathway Negative Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Gene Expression Regulation Of Metabolic Process Negative Regulation Of Biosynthetic Process Cell Cycle Negative Regulation Of Cellular Protein Metabolic Process Regulation Of Signaling Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Protein Metabolic Process Cellular Response To Indole-3-methanol Regulation Of Chromosome Organization Regulation Of RNA Metabolic Process Regulation Of Cell Cycle Negative Regulation Of Mitotic Cell Cycle Positive Regulation Of Metabolic Process Anterior/posterior Pattern Specification Negative Regulation Of Cellular Protein Catabolic Process Regulation Of Gene Expression Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Chromosome Segregation Negative Regulation Of Chromosome Organization Regulation Of Proteolysis Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Negative Regulation Of Protein Catabolic Process Cell Surface Receptor Signaling Pathway Positive Regulation Of Canonical Wnt Signaling Pathway Regulation Of Protein Catabolic Process	Extracellular Matrix Organization Extracellular Structure Organization Organ Development Regulation Of Cellular Component Organization System Development Multicellular Organismal Development Positive Regulation Of Cell Morphogenesis Involved In Differentiation Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Cellular Response To Growth Factor Stimulus Anatomical Structure Morphogenesis Anatomical Structure Development Positive Regulation Of Cell-substrate Adhesion Developmental Process Regulation Of Growth Regulation Of Cell Differentiation Regulation Of Cell Development Cardiovascular System Development Regulation Of Cell Growth Regulation Of Signaling Tissue Development Regulation Of Signal Transduction Positive Regulation Of Signal Transduction Regulation Of Cell Death Anatomical Structure Formation Involved In Morphogenesis Transcription Initiation From RNA Polymerase II Promoter Nervous System Development Extracellular Matrix Disassembly Regulation Of Cell-substrate Adhesion Regulation Of Cell Morphogenesis Angiogenesis Positive Regulation Of Cell Development Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Cellular Response To Growth Factor Stimulus Response To Wounding Blood Vessel Development Vasculature Development Negative Regulation Of Cell Death Central Nervous System Development Regulation Of Protein Metabolic Process DNA-templated Transcription, Initiation Locomotion Positive Regulation Of Intracellular Signal Transduction Response To Growth Factor Wound Healing Negative Regulation Of Signal Transduction Blood Vessel Morphogenesis Positive Regulation Of Cell Differentiation Ossification Transcription From RNA Polymerase II Promoter Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Tagcloud ?		3a adenovirus bidirectional c57bl cat complexities consequence exploration foxo foxo1 gluconeogenesis gluconeogenic hepatic hepatocytes ltcfdn mechanistic opposing opposite pck1 picture preferential pyruvate redundant repressive suppressing views wnt	3t3 alters anchorage arntl2 bfsp2 bmp7 celsr1 confocal deregulated etv5 exhibits filopodia fmn2 gfra2 gpm6a gpm6b graffi homologs malignancies mulv nih nln oligonucleotide oncogenes parm peri protrusions punctate semi
Tagcloud (Difference) ?		3a adenovirus bidirectional c57bl cat complexities consequence exploration foxo foxo1 gluconeogenesis gluconeogenic hepatic hepatocytes ltcfdn mechanistic opposing opposite pck1 picture preferential pyruvate redundant repressive suppressing views wnt	3t3 alters anchorage arntl2 bfsp2 bmp7 celsr1 confocal deregulated etv5 exhibits filopodia fmn2 gfra2 gpm6a gpm6b graffi homologs malignancies mulv nih nln oligonucleotide oncogenes parm peri protrusions punctate semi
Tagcloud (Intersection) ?