TCF7L2 and CTNNB1

Number of citations of the paper that reports this interaction (PMID 11713476)
33

Data Source:
HPRD (in vivo, in vitro)

		TCF7L2	CTNNB1
Gene Name		transcription factor 7-like 2 (T-cell specific, HMG-box)	catenin (cadherin-associated protein), beta 1, 88kDa
Image
Gene Ontology Annotations	Cellular Component	Nuclear Chromatin Nucleus Nucleoplasm Transcription Factor Complex Cytoplasm PML Body Protein-DNA Complex Beta-catenin-TCF7L2 Complex	Spindle Pole Nucleus Nucleoplasm Transcription Factor Complex Nuclear Euchromatin Cytoplasm Centrosome Cytosol Plasma Membrane Cell-cell Junction Adherens Junction Cell-cell Adherens Junction Fascia Adherens Tight Junction Focal Adhesion Cell Cortex Membrane Basolateral Plasma Membrane Lateral Plasma Membrane Catenin Complex Z Disc Lamellipodium Cell Junction Beta-catenin Destruction Complex Microvillus Membrane Protein-DNA Complex Scrib-APC-beta-catenin Complex Dendritic Shaft Apical Part Of Cell Synapse Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome Beta-catenin-TCF7L2 Complex Cell Periphery
	Molecular Function	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Repressing Transcription Factor Binding Chromatin Binding Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Beta-catenin Binding Transcription Factor Binding Protein Kinase Binding Nuclear Hormone Receptor Binding Sequence-specific DNA Binding Transcription Regulatory Region DNA Binding Gamma-catenin Binding Armadillo Repeat Domain Binding	RNA Polymerase II Activating Transcription Factor Binding Double-stranded DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Transcription Coactivator Activity Signal Transducer Activity Protein Binding Protein C-terminus Binding Transcription Factor Binding Enzyme Binding Kinase Binding Protein Phosphatase Binding Estrogen Receptor Binding Protein Complex Binding Ionotropic Glutamate Receptor Binding Nuclear Hormone Receptor Binding Transcription Regulatory Region DNA Binding Ion Channel Binding Alpha-catenin Binding Cadherin Binding SMAD Binding Androgen Receptor Binding Nitric-oxide Synthase Binding I-SMAD Binding R-SMAD Binding Repressing Transcription Factor Binding Euchromatin Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Blood Vessel Development Glycogen Metabolic Process Glucose Metabolic Process Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter Cell Cycle Arrest Brain Development Cell Proliferation Cellular Response To Starvation Response To Glucose Post-embryonic Development Positive Regulation Of Triglyceride Biosynthetic Process Positive Regulation Of Heparan Sulfate Proteoglycan Biosynthetic Process Oligodendrocyte Development Neural Tube Development Pituitary Gland Development Bone Mineralization Negative Regulation Of BMP Signaling Pathway Embryonic Genitalia Morphogenesis Pancreas Development Regulation Of Myelination Positive Regulation Of Insulin Secretion Positive Regulation Of Protein Binding Secretory Granule Localization Regulation Of Hormone Metabolic Process Somatic Stem Cell Maintenance Multicellular Organism Growth Catenin Import Into Nucleus Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Odontogenesis Of Dentin-containing Tooth Glucose Homeostasis Positive Regulation Of Apoptotic Process Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Maintenance Of DNA Repeat Elements Skin Development Canonical Wnt Signaling Pathway Involved In Positive Regulation Of Epithelial To Mesenchymal Transition Fat Cell Differentiation Negative Regulation Of Fat Cell Differentiation Positive Regulation Of Gluconeogenesis Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Organ Growth Positive Regulation Of Protein Export From Nucleus Embryonic Digestive Tract Morphogenesis Embryonic Hindgut Morphogenesis Myoblast Fate Commitment Regulation Of Skeletal Muscle Tissue Development Regulation Of Smooth Muscle Cell Proliferation Generation Of Neurons Regulation Of Oligodendrocyte Differentiation Positive Regulation Of Epithelial Cell Proliferation Positive Regulation Of Protein Kinase B Signaling Canonical Wnt Signaling Pathway Face Morphogenesis Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Negative Regulation Of Canonical Wnt Signaling Pathway Insulin Metabolic Process Negative Regulation Of Type B Pancreatic Cell Apoptotic Process Negative Regulation Of Extrinsic Apoptotic Signaling Pathway	Negative Regulation Of Transcription From RNA Polymerase II Promoter Embryonic Axis Specification Patterning Of Blood Vessels Branching Involved In Ureteric Bud Morphogenesis In Utero Embryonic Development Gastrulation With Mouth Forming Second Cell Fate Specification Endodermal Cell Fate Commitment Neuron Migration Epithelial To Mesenchymal Transition Neural Plate Development Liver Development Positive Regulation Of Neuroblast Proliferation Positive Regulation Of Mesenchymal Cell Proliferation Lens Morphogenesis In Camera-type Eye Regulation Of Secondary Heart Field Cardioblast Proliferation Mesenchymal To Epithelial Transition Involved In Metanephros Morphogenesis Transcription, DNA-templated Apoptotic Process Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Cell Adhesion Cell-matrix Adhesion Ectoderm Development Glial Cell Fate Determination Midgut Development Negative Regulation Of Cell Proliferation Anterior/posterior Axis Specification Dorsal/ventral Axis Specification Proximal/distal Pattern Formation Positive Regulation Of Epithelial To Mesenchymal Transition Positive Regulation Of Heparan Sulfate Proteoglycan Biosynthetic Process Schwann Cell Proliferation Wnt Signaling Pathway Single Organismal Cell-cell Adhesion Stem Cell Maintenance Layer Formation In Cerebral Cortex Central Nervous System Vasculogenesis Osteoclast Differentiation Androgen Receptor Signaling Pathway Male Genitalia Development Regulation Of Centriole-centriole Cohesion Pancreas Development Hair Follicle Morphogenesis Regulation Of Myelination Negative Regulation Of Chondrocyte Differentiation Response To Estradiol Positive Regulation Of Type I Interferon Production T Cell Differentiation In Thymus Negative Regulation Of Protein Sumoylation Response To Cytokine Adherens Junction Assembly Protein Localization To Cell Surface Embryonic Heart Tube Development Genitalia Morphogenesis Embryonic Forelimb Morphogenesis Embryonic Hindlimb Morphogenesis Hair Cell Differentiation Embryonic Skeletal Limb Joint Morphogenesis Regulation Of T Cell Proliferation Odontogenesis Of Dentin-containing Tooth Response To Drug Regulation Of Cell Fate Specification Muscle Cell Differentiation Embryonic Digit Morphogenesis Positive Regulation Of Apoptotic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of MAPK Cascade Canonical Wnt Signaling Pathway Involved In Positive Regulation Of Epithelial To Mesenchymal Transition Canonical Wnt Signaling Pathway Involved In Negative Regulation Of Apoptotic Process Innate Immune Response Myoblast Differentiation Bone Resorption Positive Regulation Of Endothelial Cell Differentiation Positive Regulation Of Osteoblast Differentiation Negative Regulation Of Osteoclast Differentiation Positive Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Regulation Of Angiogenesis Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Mitotic Cell Cycle, Embryonic Response To Cadmium Ion Regulation Of Fibroblast Proliferation Cell Maturation Synaptic Vesicle Transport Thymus Development Oocyte Development Embryonic Foregut Morphogenesis Regulation Of Smooth Muscle Cell Proliferation Negative Regulation Of Oligodendrocyte Differentiation Synapse Organization Smooth Muscle Cell Differentiation Positive Regulation Of Muscle Cell Differentiation Protein Heterooligomerization Positive Regulation Of Histone H3-K4 Methylation Oviduct Development Canonical Wnt Signaling Pathway Trachea Formation Epithelial Tube Branching Involved In Lung Morphogenesis Lung Cell Differentiation Lung-associated Mesenchyme Development Lung Induction Epithelial Cell Differentiation Involved In Prostate Gland Development Positive Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development Hair Follicle Placode Formation Mesenchymal Cell Proliferation Involved In Lung Development Endothelial Tube Morphogenesis Fungiform Papilla Formation Canonical Wnt Signaling Pathway Involved In Positive Regulation Of Cardiac Outflow Tract Cell Proliferation Sympathetic Ganglion Development Regulation Of Centromeric Sister Chromatid Cohesion Cellular Response To Mechanical Stimulus Cellular Response To Growth Factor Stimulus Cellular Response To Indole-3-methanol Renal Vesicle Formation Renal Inner Medulla Development Renal Outer Medulla Development Nephron Tubule Formation Regulation Of Nephron Tubule Epithelial Cell Differentiation Positive Regulation Of Canonical Wnt Signaling Pathway Regulation Of Calcium Ion Import Negative Regulation Of Neuron Death Cellular Response To Insulin-like Growth Factor Stimulus Regulation Of Protein Localization To Cell Surface Positive Regulation Of Determination Of Dorsal Identity Positive Regulation Of DNA-templated Transcription, Initiation Negative Regulation Of Apoptotic Signaling Pathway
Pathways		APC truncation mutants have impaired AXIN binding misspliced GSK3beta mutants stabilize beta-catenin T41 mutants of beta-catenin aren't phosphorylated TCF7L2 mutants don't bind CTBP truncated APC mutants destabilize the destruction complex Signaling by Wnt binding of TCF/LEF:CTNNB1 to target gene promoters deactivation of the beta-catenin transactivating complex APC truncation mutants are not K63 polyubiquitinated S37 mutants of beta-catenin aren't phosphorylated Peptide hormone metabolism Degradation of beta-catenin by the destruction complex S33 mutants of beta-catenin aren't phosphorylated AXIN mutants destabilize the destruction complex, activating WNT signaling RNF mutants show enhanced WNT signaling and proliferation XAV939 inhibits tankyrase, stabilizing AXIN Incretin synthesis, secretion, and inactivation truncations of AMER1 destabilize the destruction complex misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling formation of the beta-catenin:TCF transactivating complex phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex AXIN missense mutants destabilize the destruction complex S45 mutants of beta-catenin aren't phosphorylated repression of WNT target genes beta-catenin independent WNT signaling deletions in the AMER1 gene destabilize the destruction complex Ca2+ pathway AMER1 mutants destabilize the destruction complex TCF dependent signaling in response to WNT deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling Signaling by WNT in cancer Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)	APC truncation mutants have impaired AXIN binding misspliced GSK3beta mutants stabilize beta-catenin T41 mutants of beta-catenin aren't phosphorylated TCF7L2 mutants don't bind CTBP truncated APC mutants destabilize the destruction complex Signaling by Wnt binding of TCF/LEF:CTNNB1 to target gene promoters deactivation of the beta-catenin transactivating complex APC truncation mutants are not K63 polyubiquitinated disassembly of the destruction complex and recruitment of AXIN to the membrane S37 mutants of beta-catenin aren't phosphorylated Degradation of beta-catenin by the destruction complex AXIN mutants destabilize the destruction complex, activating WNT signaling RNF mutants show enhanced WNT signaling and proliferation S33 mutants of beta-catenin aren't phosphorylated XAV939 inhibits tankyrase, stabilizing AXIN Innate Immune System truncations of AMER1 destabilize the destruction complex CDO in myogenesis misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling Cytosolic sensors of pathogen-associated DNA formation of the beta-catenin:TCF transactivating complex phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex AXIN missense mutants destabilize the destruction complex S45 mutants of beta-catenin aren't phosphorylated repression of WNT target genes beta-catenin independent WNT signaling deletions in the AMER1 gene destabilize the destruction complex Ca2+ pathway Myogenesis AMER1 mutants destabilize the destruction complex TCF dependent signaling in response to WNT LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling Signaling by WNT in cancer
Drugs			Urea
Diseases
GWAS		Breast cancer ( 23535729) Breast Cancer in BRCA1 mutation carriers ( 23544013) Coronary heart disease ( 21347282) Fasting glucose-related traits ( 20081858) Fasting glucose-related traits (interaction with BMI) ( 22581228) Fasting insulin-related traits (interaction with BMI) ( 22581228) Glycated hemoglobin levels ( 20849430) Metabolic syndrome ( 20694148) Proinsulin levels ( 21873549) Two-hour glucose challenge ( 20081857) Type 2 diabetes ( 17668382 18372903 17293876 22693455 17554300 23300278 20581827 19401414 17463246 17463248 17463249 22101970 17460697 19056611 23209189) Type 2 diabetes and other traits ( 19734900)	Bone mineral density ( 22504420) Bone mineral density (hip) ( 19801982)
Protein-Protein Interactions		13 interactors: CSNK2A1 CSNK2A2 CTBP1 CTNNB1 CTNNBIP1 DAXX DAZAP2 EP300 FBLN1 JUP PSEN1 PSMA3 UBE2I	172 interactors: ACP1 AJAP1 AKT1 AMER1 APC APC2 APP AR ARHGAP32 ASH2L AXIN1 AXIN2 BCL3 BCL9 BCL9L BOC BRCA1 BTRC CA9 CARM1 CASP3 CASP8 CBL CBY1 CCND1 CDC27 CDC73 CDH1 CDH11 CDH15 CDH16 CDH2 CDH24 CDH3 CDH5 CDH7 CDH8 CDH9 CDK2 CDK5R1 CDK6 CDON CEBPA CHD8 CHUK CREBBP CSNK1A1 CSNK1D CSNK2A1 CSNK2B CTNNA1 CTNNA3 CTNNBIP1 CTNND2 DLG5 DSC3 DVL1 DVL3 EGFR ELAVL1 EP300 ERBB2 ERBB2IP ESR1 EZR FER FHIT FHL2 FLT1 FOXO1 FOXO4 FSCN1 FUS FYN GLIS2 GNA13 GRIK2 GRIN1 GRIN2D GSK3B HDAC6 HIF1A HIST1H1C HNF1A IGF2BP1 IKBKB IQGAP1 JADE1 KAT2A KAT2B KDR KMT2A KMT2D LATS2 LEF1 LEO1 MAGI1 MAGI2 MAPK8 MAPK9 MEN1 MET MITF MUC1 NCOA2 NDRG1 NEK2 NEURL2 NF2 NFKB1 NOTCH1 NR5A1 PECAM1 PICK1 PIK3R1 PIN1 PITX2 PKD1 PKP2 PLK1 PPM1A PSEN1 PSEN2 PTGS2 PTPN1 PTPN13 PTPN14 PTPN6 PTPRF PTPRJ PTPRK PTPRM PTPRU PTPRZ1 PYGO1 RAPGEF2 RBBP5 RBX1 RUVBL1 RUVBL2 RXRA SALL1 SIAH1 SKP1 SLC9A3R1 SMAD2 SMAD3 SMAD4 SMAD7 SMARCA4 SMARCA5 SOX1 SOX17 SPN SRC TAX1BP3 TBL1X TCF3 TCF4 TCF7L1 TCF7L2 TFAP2A TGFBR1 TGFBR2 TLE1 TRIP10 TRRAP UBE2B UBE2D1 UHRF2 USP9X ZFYVE9
Entrez ID		6934	1499
HPRD ID		03751	00286
Ensembl ID		ENSG00000148737	ENSG00000168036
Uniprot IDs		B4DJZ2 B4DRJ8 B7Z9Z6 B9X074 C6ZRJ7 C6ZRJ8 C6ZRJ9 C6ZRK0 C6ZRK1 C6ZRK2 C6ZRK5 E2GH13 E2GH14 E2GH16 E2GH18 E2GH24 E2GH25 E2GH26 Q6FHW4 Q9NQB0	P35222
PDB IDs		1JDH 1JPW 2GL7	1G3J 1JDH 1JPW 1LUJ 1P22 1QZ7 1T08 1TH1 2G57 2GL7 2Z6H 3DIW 3FQN 3FQR 3SL9 3SLA 3TX7 4DJS
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Cellular Metabolic Process Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Metabolic Process Viral Process Apoptotic Process Wnt Signaling Pathway Programmed Cell Death Cell Cycle Process Cell Death Death Regulation Of Wnt Signaling Pathway Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Regulation Of Nitrogen Compound Metabolic Process Negative Regulation Of RNA Biosynthetic Process Mitotic Cell Cycle Process Positive Regulation Of Protein Metabolic Process Regulation Of Signal Transduction Positive Regulation Of Signal Transduction Mitotic Cell Cycle Positive Regulation Of Wnt Signaling Pathway Negative Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Gene Expression Regulation Of Metabolic Process Negative Regulation Of Biosynthetic Process Cell Cycle Negative Regulation Of Cellular Protein Metabolic Process Regulation Of Signaling Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Protein Metabolic Process Cellular Response To Indole-3-methanol Regulation Of Chromosome Organization Regulation Of RNA Metabolic Process Regulation Of Cell Cycle Negative Regulation Of Mitotic Cell Cycle Positive Regulation Of Metabolic Process Anterior/posterior Pattern Specification Negative Regulation Of Cellular Protein Catabolic Process Regulation Of Gene Expression Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Chromosome Segregation Negative Regulation Of Chromosome Organization Regulation Of Proteolysis Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Negative Regulation Of Protein Catabolic Process Cell Surface Receptor Signaling Pathway Positive Regulation Of Canonical Wnt Signaling Pathway Regulation Of Protein Catabolic Process	Positive Regulation Of Cellular Metabolic Process Regulation Of Signal Transduction Positive Regulation Of Metabolic Process Regulation Of Signaling Cell Surface Receptor Signaling Pathway Cellular Response To Stimulus Positive Regulation Of Gene Expression Signaling Cell Communication Signal Transduction Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Cellular Biosynthetic Process Anatomical Structure Development Multicellular Organismal Development Regulation Of Metabolic Process Response To Stimulus Developmental Process Negative Regulation Of Signaling Wnt Signaling Pathway Anatomical Structure Morphogenesis Cell Differentiation Negative Regulation Of Signal Transduction System Development Regulation Of Cell Proliferation Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Gene Expression Organ Development Positive Regulation Of Transcription From RNA Polymerase II Promoter Tissue Development Negative Regulation Of Cellular Metabolic Process Cell Development Regulation Of Wnt Signaling Pathway Regulation Of Cell Differentiation Regulation Of Cellular Process Regulation Of Nitrogen Compound Metabolic Process Response To Organic Substance Regulation Of Protein Metabolic Process Cellular Protein Modification Process Regulation Of Cellular Protein Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Epithelium Development Regulation Of RNA Biosynthetic Process Positive Regulation Of Signal Transduction Regulation Of RNA Metabolic Process Cellular Response To Organic Substance Negative Regulation Of Biosynthetic Process Enzyme Linked Receptor Protein Signaling Pathway Negative Regulation Of Transcription, DNA-templated
Tagcloud ?		3a adenovirus bidirectional c57bl cat complexities consequence exploration foxo foxo1 gluconeogenesis gluconeogenic hepatic hepatocytes ltcfdn mechanistic opposing opposite pck1 picture preferential pyruvate redundant repressive suppressing views wnt	acc acquires adrenal adrenocortical altering came centripetal compr cortex detail examining exome gland igf2 landscape medulla mutational opening perspectives physiol played prognostication progress steroidogenic subcapsular summarizes tracing zonation zones
Tagcloud (Difference) ?		3a adenovirus bidirectional c57bl cat complexities consequence exploration foxo foxo1 gluconeogenesis gluconeogenic hepatic hepatocytes ltcfdn mechanistic opposing opposite pck1 picture preferential pyruvate redundant repressive suppressing views wnt	acc acquires adrenal adrenocortical altering came centripetal compr cortex detail examining exome gland igf2 landscape medulla mutational opening perspectives physiol played prognostication progress steroidogenic subcapsular summarizes tracing zonation zones
Tagcloud (Intersection) ?