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MAP3K7 and IRAK1
Number of citations of the paper that reports this interaction (PubMedID
35785771
)
76
Data Source:
BioGRID
(affinity chromatography technology, affinity chromatography technology)
HPRD
(in vivo)
MAP3K7
IRAK1
Description
mitogen-activated protein kinase kinase kinase 7
interleukin 1 receptor associated kinase 1
Image
GO Annotations
Cellular Component
Nucleus
Cytoplasm
Endoplasmic Reticulum Membrane
Cytosol
Plasma Membrane
Endosome Membrane
Membrane
ATAC Complex
Nucleus
Nucleoplasm
Cytoplasm
Lipid Droplet
Cytosol
Plasma Membrane
Cell Surface
Endosome Membrane
Membrane
Protein-containing Complex
Molecular Function
Nucleotide Binding
Magnesium Ion Binding
Transcription Coactivator Binding
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
MAP Kinase Activity
MAP Kinase Kinase Kinase Activity
Signaling Receptor Binding
Type II Transforming Growth Factor Beta Receptor Binding
Protein Binding
ATP Binding
MAP Kinase Kinase Kinase Kinase Activity
Kinase Activity
Transferase Activity
Protein Kinase Binding
Receptor Tyrosine Kinase Binding
Ubiquitin Protein Ligase Binding
Histone Kinase Activity
Identical Protein Binding
Metal Ion Binding
Scaffold Protein Binding
Protein Serine Kinase Activity
Protein Serine/threonine Kinase Binding
DNA-binding Transcription Factor Binding
Linear Polyubiquitin Binding
Nucleotide Binding
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
Protein Binding
ATP Binding
Kinase Activity
Transferase Activity
Protein Kinase Binding
Heat Shock Protein Binding
Identical Protein Binding
Protein Homodimerization Activity
Protein Heterodimerization Activity
Protein Serine Kinase Activity
Biological Process
MAPK Cascade
Response To Hypoxia
Stimulatory C-type Lectin Receptor Signaling Pathway
Positive Regulation Of T Cell Cytokine Production
Cytoplasmic Pattern Recognition Receptor Signaling Pathway
MyD88-dependent Toll-like Receptor Signaling Pathway
Chromatin Remodeling
Apoptotic Process
Inflammatory Response
Immune Response
Signal Transduction
Transforming Growth Factor Beta Receptor Signaling Pathway
Canonical NF-kappaB Signal Transduction
I-kappaB Phosphorylation
JNK Cascade
Positive Regulation Of Metabolic Process
Positive Regulation Of Autophagy
Negative Regulation Of Gene Expression
Positive Regulation Of Macroautophagy
Signal Transduction Involved In Regulation Of Gene Expression
SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of Type I Interferon Production
Protein Exit From Endoplasmic Reticulum
Positive Regulation Of Interleukin-2 Production
Toll-like Receptor 3 Signaling Pathway
Toll-like Receptor 4 Signaling Pathway
TRIF-dependent Toll-like Receptor Signaling Pathway
Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway
Non-canonical NF-kappaB Signal Transduction
P38MAPK Cascade
Fc-epsilon Receptor Signaling Pathway
Interleukin-33-mediated Signaling Pathway
Interleukin-17A-mediated Signaling Pathway
Defense Response To Bacterium
Signal Transduction In Response To DNA Damage
Positive Regulation Of Canonical NF-kappaB Signal Transduction
Negative Regulation Of Canonical NF-kappaB Signal Transduction
Anoikis
Positive Regulation Of MAPK Cascade
Positive Regulation Of JUN Kinase Activity
Positive Regulation Of Cell Cycle
Positive Regulation Of Cell Size
T Cell Receptor Signaling Pathway
Stress-activated MAPK Cascade
Interleukin-1-mediated Signaling Pathway
Cellular Response To Tumor Necrosis Factor
Cellular Response To Hypoxia
Cellular Response To Transforming Growth Factor Beta Stimulus
CGAS/STING Signaling Pathway
Positive Regulation Of CGAS/STING Signaling Pathway
Negative Regulation Of Cytokine Production Involved In Inflammatory Response
Positive Regulation Of Non-canonical NF-kappaB Signal Transduction
Cellular Response To Angiotensin
Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation
Positive Regulation Of Vascular Associated Smooth Muscle Cell Migration
Response To Angiotensin
Regulation Of Cytokine-mediated Signaling Pathway
Toll-like Receptor Signaling Pathway
Immune System Process
MyD88-dependent Toll-like Receptor Signaling Pathway
Regulation Of DNA-templated Transcription
Signal Transduction
Canonical NF-kappaB Signal Transduction
JNK Cascade
Toll Signaling Pathway
Positive Regulation Of Macromolecule Metabolic Process
Cytokine-mediated Signaling Pathway
Lipopolysaccharide-mediated Signaling Pathway
Positive Regulation Of Type I Interferon Production
Response To Lipopolysaccharide
Toll-like Receptor 2 Signaling Pathway
Toll-like Receptor 4 Signaling Pathway
Toll-like Receptor 9 Signaling Pathway
Cellular Response To Heat
Intracellular Signal Transduction
Interleukin-33-mediated Signaling Pathway
Positive Regulation Of Canonical NF-kappaB Signal Transduction
Negative Regulation Of Canonical NF-kappaB Signal Transduction
Innate Immune Response
Protein Autophosphorylation
Positive Regulation Of Smooth Muscle Cell Proliferation
Positive Regulation Of NF-kappaB Transcription Factor Activity
Type I Interferon-mediated Signaling Pathway
Interleukin-1-mediated Signaling Pathway
Response To Interleukin-1
Cellular Response To Lipopolysaccharide
Cellular Response To Hypoxia
Positive Regulation Of Intracellular Signal Transduction
Positive Regulation Of Leukocyte Adhesion To Vascular Endothelial Cell
Pathways
Activation of NF-kappaB in B cells
NOD1/2 Signaling Pathway
Downstream TCR signaling
FCERI mediated NF-kB activation
Ca2+ pathway
TAK1-dependent IKK and NF-kappa-B activation
activated TAK1 mediates p38 MAPK activation
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
TNFR1-induced NF-kappa-B signaling pathway
CLEC7A (Dectin-1) signaling
Ub-specific processing proteases
TICAM1,TRAF6-dependent induction of TAK1 complex
Interleukin-1 signaling
IRAK2 mediated activation of TAK1 complex
TRAF6-mediated induction of TAK1 complex within TLR4 complex
Alpha-protein kinase 1 signaling pathway
SARS-CoV-2 activates/modulates innate and adaptive immune responses
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
PIP3 activates AKT signaling
MyD88:MAL(TIRAP) cascade initiated on plasma membrane
NOD1/2 Signaling Pathway
p75NTR recruits signalling complexes
p75NTR recruits signalling complexes
NF-kB is activated and signals survival
TAK1-dependent IKK and NF-kappa-B activation
activated TAK1 mediates p38 MAPK activation
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
Transcriptional Regulation by MECP2
Interleukin-1 signaling
IRAK1 recruits IKK complex
SARS-CoV-2 activates/modulates innate and adaptive immune responses
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation
MyD88 dependent cascade initiated on endosome
MyD88 cascade initiated on plasma membrane
Drugs
Fostamatinib
Diseases
GWAS
Amyotrophic lateral sclerosis (sporadic) (
24529757
)
Asthma (
29273806
31959851
)
Asthma (adult onset) (
31036433
)
Asthma (childhood onset) (
31036433
)
Bone mineral density (hip) (
30172743
)
Celiac disease (
20190752
)
Cortical surface area (
32963231
)
Cortical volume (
32963231
)
Graves' disease (
21841780
)
Response to anti-TNF therapy in rheumatoid arthritis (
26776603
)
Response to inhaled corticosteroid treatment in asthma (change in FEV1) (
24792382
)
Severity of nausea and vomiting of pregnancy (
29563502
)
Celiac disease (
22057235
)
Lymphocyte count (
32888494
)
Lymphocyte percentage of white cells (
32888494
)
Neutrophil percentage of white cells (
32888494
)
Rheumatoid arthritis (
23143596
24390342
32723749
)
Rheumatoid arthritis (ACPA-positive) (
23143596
)
Systemic lupus erythematosus (
19838195
26502338
26606652
26663301
33272962
)
Interacting Genes
73 interacting genes:
AKTIP
BBS10
BCL10
CALML6
CAMK2G
CARD11
CHUK
COPS5
CYLD
EIF2AK2
ELP1
EZH2
FOS
GPR25
HGS
HIPK2
IKBKB
IL17RD
IRAK1
MAILR
MAP2K4
MAP2K6
MAP3K14
MAP3K3
MAP3K5
MAP4K1
MAP4K4
MAPK14
MAPK6
MAPK8
MAPK8IP1
MAVS
MUL1
NAIP
NDUFS6
NFKBIA
NOD2
NRIP1
PEBP1
PELI3
PINK1
PPM1B
PPM1L
PPP2R1A
PPP5C
PRKAB1
RBX1
RELA
RNF19A
ROR2
SMAD3
SMAD6
SMAD7
STAT3
STRADB
SUPT20H
TAB1
TAB2
TGFBR1
TNFAIP8L2
TNFRSF11A
TRAF3
TRAF3IP2
TRAF6
UBASH3A
UBC
USP29
USP4
USP8
VRK2
XIAP
ZNF593
ZNF746
52 interacting genes:
AKT1
BCL10
BTK
CCDC47
FADD
H3-4
HRAS
HSP90AA1
IKBKG
IL1RAP
IRAK1BP1
IRAK2
IRAK3
IRAK4
IRF4
IRF7
ITGAM
JUN
MAP3K7
MAPK14
MAPK8
MBP
MYD88
NLRP12
NTRK3
OPTN
PELI1
PELI2
PELI3
PPP1CC
PPP3CB
PRDX1
PRKCI
PRKCZ
RIPK2
SIGIRR
SQSTM1
STAT3
STING1
SUMO1
TAB2
TBKBP1
TICAM2
TIFA
TLR2
TLR4
TOLLIP
TRAF4
TRAF6
TRIM32
USP20
YTHDC2
Entrez ID
6885
3654
HPRD ID
04011
02235
Ensembl ID
ENSG00000135341
ENSG00000184216
Uniprot IDs
O43318
D3YTB5
P51617
PDB IDs
2EVA
2YIY
4GS6
4L3P
4L52
4L53
4O91
5E7R
5GJD
5GJF
5GJG
5J7S
5J8I
5J9L
5JGA
5JGB
5JGD
5JH6
5JK3
5V5N
7NTH
7NTI
8GW3
9FPD
6BFN
Enriched GO Terms of Interacting Partners
?
Intracellular Signaling Cassette
Intracellular Signal Transduction
MAPK Cascade
Regulation Of Canonical NF-kappaB Signal Transduction
Regulation Of Intracellular Signal Transduction
Positive Regulation Of Canonical NF-kappaB Signal Transduction
Regulation Of Signal Transduction
Positive Regulation Of Intracellular Signal Transduction
Canonical NF-kappaB Signal Transduction
Regulation Of Cell Communication
Regulation Of Signaling
Positive Regulation Of Signal Transduction
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
Pattern Recognition Receptor Signaling Pathway
Negative Regulation Of Signal Transduction
Signal Transduction
Innate Immune Response-activating Signaling Pathway
Protein Kinase Activity
Regulation Of Cytokine Production
Negative Regulation Of Cell Communication
Negative Regulation Of Signaling
Protein Serine/threonine Kinase Activity
Non-canonical NF-kappaB Signal Transduction
Activation Of Innate Immune Response
Protein Modification Process
Regulation Of Defense Response
Negative Regulation Of Intracellular Signal Transduction
Protein Serine Kinase Activity
Positive Regulation Of Innate Immune Response
Response To Stress
Regulation Of MAPK Cascade
Negative Regulation Of Canonical NF-kappaB Signal Transduction
Cytoplasm
Cytoplasmic Pattern Recognition Receptor Signaling Pathway
Positive Regulation Of Defense Response
Regulation Of Immune Response
Regulation Of DNA-binding Transcription Factor Activity
Kinase Activity
Positive Regulation Of Macromolecule Metabolic Process
Regulation Of JNK Cascade
Immune Response-regulating Signaling Pathway
Cytosol
Regulation Of Apoptotic Process
Tumor Necrosis Factor-mediated Signaling Pathway
Regulation Of Innate Immune Response
Regulation Of Immune System Process
Regulation Of Programmed Cell Death
Positive Regulation Of Metabolic Process
Transferase Activity
Regulation Of Canonical NF-kappaB Signal Transduction
Positive Regulation Of Canonical NF-kappaB Signal Transduction
Pattern Recognition Receptor Signaling Pathway
Immune System Process
Activation Of Innate Immune Response
Positive Regulation Of Defense Response
Positive Regulation Of Innate Immune Response
Innate Immune Response-activating Signaling Pathway
Defense Response
Regulation Of Innate Immune Response
Response To External Biotic Stimulus
Cell Surface Toll-like Receptor Signaling Pathway
Response To Other Organism
Immune Response-activating Signaling Pathway
Immune Response-regulating Signaling Pathway
Regulation Of Immune Response
Activation Of Immune Response
Cell Surface Pattern Recognition Receptor Signaling Pathway
Positive Regulation Of Cytokine Production
Regulation Of Defense Response
Positive Regulation Of Immune Response
Positive Regulation Of Intracellular Signal Transduction
Defense Response To Other Organism
Toll-like Receptor 4 Signaling Pathway
Innate Immune Response
Immune Response-regulating Cell Surface Receptor Signaling Pathway
Response To Stress
Positive Regulation Of Signal Transduction
Innate Immune Response Activating Cell Surface Receptor Signaling Pathway
Immune Response-activating Cell Surface Receptor Signaling Pathway
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
Intracellular Signal Transduction
Lipopolysaccharide-mediated Signaling Pathway
Immune Response
Regulation Of Intracellular Signal Transduction
Defense Response To Symbiont
Regulation Of Signal Transduction
Toll-like Receptor Signaling Pathway
Regulation Of Immune System Process
Regulation Of Cytokine Production
Signal Transduction
Intracellular Signaling Cassette
Signaling Adaptor Activity
Canonical NF-kappaB Signal Transduction
Positive Regulation Of Gene Expression
MyD88-dependent Toll-like Receptor Signaling Pathway
Positive Regulation Of Immune System Process
Regulation Of Signaling
Regulation Of Cell Communication
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Tagcloud (Intersection)
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