MAP3K7 and FOS

Number of citations of the paper that reports this interaction (PMID 11397816)
4

Data Source:
HPRD (in vivo)

		MAP3K7	FOS
Gene Name		mitogen-activated protein kinase kinase kinase 7	FBJ murine osteosarcoma viral oncogene homolog
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Ada2/Gcn5/Ada3 Transcription Activator Complex Cytoplasm Cytosol Plasma Membrane IkappaB Kinase Complex Endosome Membrane	Nucleus Nucleoplasm Transcription Factor Complex Endoplasmic Reticulum Cytosol Membrane Neuron Projection
	Molecular Function	Magnesium Ion Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity MAP Kinase Kinase Activity MAP Kinase Kinase Kinase Activity Protein Binding ATP Binding Scaffold Protein Binding	RNA Polymerase II Core Promoter Sequence-specific DNA Binding Double-stranded DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Transcription Factor Binding Transcription Regulatory Region DNA Binding R-SMAD Binding
	Biological Process	Activation Of MAPKK Activity Activation Of MAPK Activity Angiogenesis Neural Tube Formation Toll-like Receptor Signaling Pathway Positive Regulation Of T Cell Cytokine Production MyD88-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Transcription, DNA-templated Apoptotic Process Transforming Growth Factor Beta Receptor Signaling Pathway I-kappaB Kinase/NF-kappaB Signaling Activation Of NF-kappaB-inducing Kinase Activity I-kappaB Phosphorylation JNK Cascade Positive Regulation Of Interleukin-2 Production Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Toll-like Receptor 10 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Fc-epsilon Receptor Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of JUN Kinase Activity Histone H3 Acetylation Innate Immune Response T Cell Receptor Signaling Pathway Positive Regulation Of T Cell Activation Positive Regulation Of NF-kappaB Transcription Factor Activity Stress-activated MAPK Cascade Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Negative Regulation Of Ripoptosome Assembly Involved In Necroptotic Process Regulation Of Reactive Oxygen Species Metabolic Process Negative Regulation Of Apoptotic Signaling Pathway	Conditioned Taste Aversion Toll-like Receptor Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway DNA Methylation Regulation Of Transcription From RNA Polymerase II Promoter Transcription From RNA Polymerase II Promoter Inflammatory Response Transforming Growth Factor Beta Receptor Signaling Pathway Nervous System Development Female Pregnancy Aging Response To Cold Response To Light Stimulus Response To Mechanical Stimulus Response To Gravity Response To Toxic Substance Sleep Cellular Response To Extracellular Stimulus Response To Lipopolysaccharide Response To Progesterone Cellular Response To Hormone Stimulus Response To Cytokine Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Cellular Response To Reactive Oxygen Species TRIF-dependent Toll-like Receptor Signaling Pathway Response To Immobilization Stress Skeletal Muscle Cell Differentiation Fc-epsilon Receptor Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Response To Drug Innate Immune Response Positive Regulation Of Osteoclast Differentiation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Stress-activated MAPK Cascade Response To Corticosterone Response To CAMP SMAD Protein Signal Transduction Cellular Response To Calcium Ion
Pathways		Signaling by the B Cell Receptor (BCR) Downstream TCR signaling IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation TRAF6 mediated induction of TAK1 complex Toll Like Receptor 7/8 (TLR7/8) Cascade Signaling by Wnt Toll Like Receptor TLR6:TLR2 Cascade Downstream signaling events of B Cell Receptor (BCR) Toll Like Receptor TLR1:TLR2 Cascade Activated TLR4 signalling FCERI mediated NF-kB activation MyD88 cascade initiated on plasma membrane Toll Like Receptor 5 (TLR5) Cascade NOD1/2 Signaling Pathway MyD88 dependent cascade initiated on endosome MyD88:Mal cascade initiated on plasma membrane TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation Toll Like Receptor 9 (TLR9) Cascade activated TAK1 mediates p38 MAPK activation JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 Innate Immune System IRAK2 mediated activation of TAK1 complex IRAK2 mediated activation of TAK1 complex MAP kinase activation in TLR cascade TRIF-mediated TLR3/TLR4 signaling Cytokine Signaling in Immune system MyD88-independent cascade beta-catenin independent WNT signaling Toll Like Receptor 2 (TLR2) Cascade Signaling by Interleukins TCR signaling Toll-Like Receptors Cascades Toll Like Receptor 10 (TLR10) Cascade Ca2+ pathway Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways Activation of NF-kappaB in B cells Toll Like Receptor 4 (TLR4) Cascade Toll Like Receptor 3 (TLR3) Cascade Fc epsilon receptor (FCERI) signaling Interleukin-1 signaling Adaptive Immune System TAK1 activates NFkB by phosphorylation and activation of IKKs complex	Toll Like Receptor 7/8 (TLR7/8) Cascade Cellular Senescence FCERI mediated MAPK activation Toll Like Receptor TLR6:TLR2 Cascade Activated TLR4 signalling Toll Like Receptor TLR1:TLR2 Cascade Activation of the AP-1 family of transcription factors MyD88 cascade initiated on plasma membrane Toll Like Receptor 5 (TLR5) Cascade MyD88 dependent cascade initiated on endosome TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation MyD88:Mal cascade initiated on plasma membrane Toll Like Receptor 9 (TLR9) Cascade Innate Immune System TRIF-mediated TLR3/TLR4 signaling MAP kinase activation in TLR cascade Senescence-Associated Secretory Phenotype (SASP) MyD88-independent cascade Toll Like Receptor 2 (TLR2) Cascade Toll-Like Receptors Cascades Toll Like Receptor 10 (TLR10) Cascade Oxidative Stress Induced Senescence Toll Like Receptor 3 (TLR3) Cascade Toll Like Receptor 4 (TLR4) Cascade Fc epsilon receptor (FCERI) signaling MAPK targets/ Nuclear events mediated by MAP kinases
Drugs			Nadroparin
Diseases
GWAS		Celiac disease ( 20190752) Graves' disease ( 21841780)	Inflammatory bowel disease ( 23128233) Periodontal microbiota ( 22699663)
Protein-Protein Interactions		60 interactors: BBS10 BCL10 CARD11 CHUK COPS5 EIF2AK2 EZH2 FOS GPR25 HGS HIPK2 IKBKAP IKBKB IL17RD IRAK1 MAP2K4 MAP2K6 MAP3K14 MAP3K3 MAP3K5 MAP4K1 MAP4K4 MAPK14 MAPK6 MAPK8 MAPK8IP1 MAVS NAIP NDUFS6 NOD2 NRIP1 PEBP1 PELI3 PINK1 PPM1B PPM1L PPP2R1A PPP5C PRKAA1 PRKAB1 RBX1 RELA RNF19A ROR2 SMAD3 SMAD6 SMAD7 STAT3 STRADB TAB1 TAB2 TGFBR1 TNFRSF11A TRAF3IP2 TRAF6 TRIM8 VRK2 XIAP ZNF593 ZNF746	108 interactors: ANP32E APP AQP1 ARFGAP1 ARL6IP4 ATF2 ATF3 ATF4 ATF7 ATP5I BATF BCL3 CABP1 CARM1 CEBPA CEBPE CEBPG CENPO CFAP57 CLU COPS4 CREB5 CREBBP CSNK2A1 CSNK2A2 CYTH4 DDIT3 EEF1D ELK1 ELK4 EPHB2 ETS1 ETS2 GAMT GATA4 GLB1 GNG11 GRHPR GTF2E2 GTF2F1 GTF2F2 HNF1A HSPA1A JUN JUNB JUND KDM2A LMNA LMO3 LUZP4 MAF MAFB MAFF MAP1B MAP3K7 MAPK1 MAPK7 MITF MTERF4 NACA NCOA1 NCOA2 NCOA3 NCOA6 NCOR2 NEFM NELFB NFATC3 NFKB1 OPTN PML POLR2E PRKAA2 PRKACA PSMC5 RB1 RELA RPS6KA1 RPS6KA2 RPS6KA4 RUNX1 RUNX2 SCHIP1 SET SIRT1 SMAD3 SMARCD1 SPI1 SRA1 STAT1 SUMO1 SUMO2 SUMO3 SUMO4 TAF1 TBP TRO TSC22D3 TSPAN2 UBE2D1 UBE2I UBE2L3 UBR1 USF1 USF2 VDR XBP1 ZNF133
Entrez ID		6885	2353
HPRD ID		04011	01275
Ensembl ID		ENSG00000135341	ENSG00000170345
Uniprot IDs		O43318	B4DQ65 P01100 Q6FG41
PDB IDs		2EVA 2YIY 4GS6 4L3P 4L52 4L53	1A02 1FOS 1S9K
Enriched GO Terms of Interacting Partners?		Regulation Of Signal Transduction Positive Regulation Of Signal Transduction Regulation Of Signaling Regulation Of Intracellular Signal Transduction Positive Regulation Of Intracellular Signal Transduction Signal Transduction By Phosphorylation Signal Transduction Regulation Of Phosphorylation MAPK Cascade Regulation Of Protein Metabolic Process Signaling Regulation Of Phosphorus Metabolic Process Cell Communication Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of MAPK Cascade Phosphorylation Intracellular Signal Transduction Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor 2 Signaling Pathway Regulation Of Protein Phosphorylation Toll-like Receptor 9 Signaling Pathway Stress-activated MAPK Cascade TRIF-dependent Toll-like Receptor Signaling Pathway Stress-activated Protein Kinase Signaling Cascade Regulation Of Cellular Protein Metabolic Process MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Cellular Response To Stimulus MyD88-dependent Toll-like Receptor Signaling Pathway Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Regulation Of I-kappaB Kinase/NF-kappaB Signaling Activation Of Innate Immune Response Toll-like Receptor Signaling Pathway Toll-like Receptor 4 Signaling Pathway Phosphate-containing Compound Metabolic Process Regulation Of Protein Kinase Activity Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Activation Of Protein Kinase Activity Positive Regulation Of Protein Metabolic Process Positive Regulation Of Cellular Metabolic Process Cellular Protein Modification Process Response To Stimulus Regulation Of MAP Kinase Activity Regulation Of Kinase Activity Positive Regulation Of Innate Immune Response	Transcription, DNA-templated RNA Biosynthetic Process Transcription From RNA Polymerase II Promoter Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Gene Expression Gene Expression RNA Metabolic Process Regulation Of RNA Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of RNA Metabolic Process Positive Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Metabolic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Nucleobase-containing Compound Metabolic Process Regulation Of Metabolic Process Cellular Nitrogen Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Nitrogen Compound Metabolic Process Cellular Metabolic Process Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Regulation Of Cell Differentiation Negative Regulation Of Biosynthetic Process Response To Organic Substance Negative Regulation Of Gene Expression Regulation Of Cellular Process Cellular Response To Organic Substance Developmental Process System Development Viral Process Anatomical Structure Development Cell Differentiation Response To Stress Multicellular Organismal Development Response To External Stimulus Organ Development Negative Regulation Of Transcription From RNA Polymerase II Promoter TRIF-dependent Toll-like Receptor Signaling Pathway
Tagcloud ?		abrogated accounts bcr called card card11 carma1 existence feedback generating ikappab ikk ikkbeta implies kappab late maguk mathematical modeling module nf residue scaffolding serine steep switch switchlike tak1 threshold	ap argue capable dimeric dimerization disrupt glucocorticoid heterodimerization homo homodimerization hraralpha hybrid indirect interfere jun liganded occurring promoters protooncoproteins ra raralpha rars repress repression responsive retinoic retinoid rxr rxrs
Tagcloud (Difference) ?		abrogated accounts bcr called card card11 carma1 existence feedback generating ikappab ikk ikkbeta implies kappab late maguk mathematical modeling module nf residue scaffolding serine steep switch switchlike tak1 threshold	ap argue capable dimeric dimerization disrupt glucocorticoid heterodimerization homo homodimerization hraralpha hybrid indirect interfere jun liganded occurring promoters protooncoproteins ra raralpha rars repress repression responsive retinoic retinoid rxr rxrs
Tagcloud (Intersection) ?