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MAP3K7 and MAP4K1
Number of citations of the paper that reports this interaction (PubMedID
10224067
)
0
Data Source:
BioGRID
(affinity chromatography technology)
HPRD
(in vitro, in vivo)
MAP3K7
MAP4K1
Description
mitogen-activated protein kinase kinase kinase 7
mitogen-activated protein kinase kinase kinase kinase 1
Image
GO Annotations
Cellular Component
Nucleus
Cytoplasm
Endoplasmic Reticulum Membrane
Cytosol
Plasma Membrane
Endosome Membrane
Membrane
ATAC Complex
Cytoplasm
Membrane
Molecular Function
Nucleotide Binding
Magnesium Ion Binding
Transcription Coactivator Binding
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
MAP Kinase Activity
MAP Kinase Kinase Kinase Activity
Signaling Receptor Binding
Type II Transforming Growth Factor Beta Receptor Binding
Protein Binding
ATP Binding
MAP Kinase Kinase Kinase Kinase Activity
Kinase Activity
Transferase Activity
Protein Kinase Binding
Receptor Tyrosine Kinase Binding
Ubiquitin Protein Ligase Binding
Histone Kinase Activity
Identical Protein Binding
Metal Ion Binding
Scaffold Protein Binding
Protein Serine Kinase Activity
Protein Serine/threonine Kinase Binding
DNA-binding Transcription Factor Binding
Linear Polyubiquitin Binding
Nucleotide Binding
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
Protein Binding
ATP Binding
MAP Kinase Kinase Kinase Kinase Activity
Kinase Activity
Transferase Activity
Protein Serine Kinase Activity
Biological Process
MAPK Cascade
Response To Hypoxia
Stimulatory C-type Lectin Receptor Signaling Pathway
Positive Regulation Of T Cell Cytokine Production
Cytoplasmic Pattern Recognition Receptor Signaling Pathway
MyD88-dependent Toll-like Receptor Signaling Pathway
Chromatin Remodeling
Apoptotic Process
Inflammatory Response
Immune Response
Signal Transduction
Transforming Growth Factor Beta Receptor Signaling Pathway
Canonical NF-kappaB Signal Transduction
I-kappaB Phosphorylation
JNK Cascade
Positive Regulation Of Metabolic Process
Positive Regulation Of Autophagy
Negative Regulation Of Gene Expression
Positive Regulation Of Macroautophagy
Signal Transduction Involved In Regulation Of Gene Expression
SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of Type I Interferon Production
Protein Exit From Endoplasmic Reticulum
Positive Regulation Of Interleukin-2 Production
Toll-like Receptor 3 Signaling Pathway
Toll-like Receptor 4 Signaling Pathway
TRIF-dependent Toll-like Receptor Signaling Pathway
Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway
Non-canonical NF-kappaB Signal Transduction
P38MAPK Cascade
Fc-epsilon Receptor Signaling Pathway
Interleukin-33-mediated Signaling Pathway
Interleukin-17A-mediated Signaling Pathway
Defense Response To Bacterium
Signal Transduction In Response To DNA Damage
Positive Regulation Of Canonical NF-kappaB Signal Transduction
Negative Regulation Of Canonical NF-kappaB Signal Transduction
Anoikis
Positive Regulation Of MAPK Cascade
Positive Regulation Of JUN Kinase Activity
Positive Regulation Of Cell Cycle
Positive Regulation Of Cell Size
T Cell Receptor Signaling Pathway
Stress-activated MAPK Cascade
Interleukin-1-mediated Signaling Pathway
Cellular Response To Tumor Necrosis Factor
Cellular Response To Hypoxia
Cellular Response To Transforming Growth Factor Beta Stimulus
CGAS/STING Signaling Pathway
Positive Regulation Of CGAS/STING Signaling Pathway
Negative Regulation Of Cytokine Production Involved In Inflammatory Response
Positive Regulation Of Non-canonical NF-kappaB Signal Transduction
Cellular Response To Angiotensin
Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation
Positive Regulation Of Vascular Associated Smooth Muscle Cell Migration
Response To Angiotensin
Protein Phosphorylation
JNK Cascade
Cell Population Proliferation
Peptidyl-serine Phosphorylation
Intracellular Signal Transduction
Positive Regulation Of MAPK Cascade
Protein Autophosphorylation
Cellular Response To Phorbol 13-acetate 12-myristate
Pathways
Activation of NF-kappaB in B cells
NOD1/2 Signaling Pathway
Downstream TCR signaling
FCERI mediated NF-kB activation
Ca2+ pathway
TAK1-dependent IKK and NF-kappa-B activation
activated TAK1 mediates p38 MAPK activation
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
TNFR1-induced NF-kappa-B signaling pathway
CLEC7A (Dectin-1) signaling
Ub-specific processing proteases
TICAM1,TRAF6-dependent induction of TAK1 complex
Interleukin-1 signaling
IRAK2 mediated activation of TAK1 complex
TRAF6-mediated induction of TAK1 complex within TLR4 complex
Alpha-protein kinase 1 signaling pathway
SARS-CoV-2 activates/modulates innate and adaptive immune responses
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
Drugs
Fostamatinib
Diseases
GWAS
Amyotrophic lateral sclerosis (sporadic) (
24529757
)
Asthma (
29273806
31959851
)
Asthma (adult onset) (
31036433
)
Asthma (childhood onset) (
31036433
)
Bone mineral density (hip) (
30172743
)
Celiac disease (
20190752
)
Cortical surface area (
32963231
)
Cortical volume (
32963231
)
Graves' disease (
21841780
)
Response to anti-TNF therapy in rheumatoid arthritis (
26776603
)
Response to inhaled corticosteroid treatment in asthma (change in FEV1) (
24792382
)
Severity of nausea and vomiting of pregnancy (
29563502
)
Diisocyanate-induced asthma (
25918132
)
Interacting Genes
73 interacting genes:
AKTIP
BBS10
BCL10
CALML6
CAMK2G
CARD11
CHUK
COPS5
CYLD
EIF2AK2
ELP1
EZH2
FOS
GPR25
HGS
HIPK2
IKBKB
IL17RD
IRAK1
MAILR
MAP2K4
MAP2K6
MAP3K14
MAP3K3
MAP3K5
MAP4K1
MAP4K4
MAPK14
MAPK6
MAPK8
MAPK8IP1
MAVS
MUL1
NAIP
NDUFS6
NFKBIA
NOD2
NRIP1
PEBP1
PELI3
PINK1
PPM1B
PPM1L
PPP2R1A
PPP5C
PRKAB1
RBX1
RELA
RNF19A
ROR2
SMAD3
SMAD6
SMAD7
STAT3
STRADB
SUPT20H
TAB1
TAB2
TGFBR1
TNFAIP8L2
TNFRSF11A
TRAF3
TRAF3IP2
TRAF6
UBASH3A
UBC
USP29
USP4
USP8
VRK2
XIAP
ZNF593
ZNF746
24 interacting genes:
ABL1
BLNK
CARD11
CASP3
CRK
CRKL
DAPP1
DBNL
EGFR
GRAP2
GRB2
H2AC4
HCLS1
LAT
LCP2
LYN
MAP3K11
MAP3K7
NCK1
PPP2CA
SHC1
STRN4
SYK
TMEM101
Entrez ID
6885
11184
HPRD ID
04011
03583
Ensembl ID
ENSG00000135341
ENSG00000104814
Uniprot IDs
O43318
Q92918
PDB IDs
2EVA
2YIY
4GS6
4L3P
4L52
4L53
4O91
5E7R
5GJD
5GJF
5GJG
5J7S
5J8I
5J9L
5JGA
5JGB
5JGD
5JH6
5JK3
5V5N
7NTH
7NTI
8GW3
9FPD
6CQD
6CQE
6CQF
6NFY
6NFZ
6NG0
7KAC
7L24
7L25
7L26
7M0K
7M0L
7M0M
7R9L
7R9N
7R9P
7R9T
7SIU
8CDW
8CIJ
8EEC
8FH4
8FJZ
8FKO
8PAR
8PAS
8PAU
8XN7
9BI8
9BIK
9BJ1
9CZT
9CZU
9CZW
9CZX
9D00
9H8D
9H8E
9H8F
Enriched GO Terms of Interacting Partners
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Intracellular Signaling Cassette
Intracellular Signal Transduction
MAPK Cascade
Regulation Of Canonical NF-kappaB Signal Transduction
Regulation Of Intracellular Signal Transduction
Positive Regulation Of Canonical NF-kappaB Signal Transduction
Regulation Of Signal Transduction
Positive Regulation Of Intracellular Signal Transduction
Canonical NF-kappaB Signal Transduction
Regulation Of Cell Communication
Regulation Of Signaling
Positive Regulation Of Signal Transduction
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
Pattern Recognition Receptor Signaling Pathway
Negative Regulation Of Signal Transduction
Signal Transduction
Innate Immune Response-activating Signaling Pathway
Protein Kinase Activity
Regulation Of Cytokine Production
Negative Regulation Of Cell Communication
Negative Regulation Of Signaling
Protein Serine/threonine Kinase Activity
Non-canonical NF-kappaB Signal Transduction
Activation Of Innate Immune Response
Protein Modification Process
Regulation Of Defense Response
Negative Regulation Of Intracellular Signal Transduction
Protein Serine Kinase Activity
Positive Regulation Of Innate Immune Response
Response To Stress
Regulation Of MAPK Cascade
Negative Regulation Of Canonical NF-kappaB Signal Transduction
Cytoplasm
Cytoplasmic Pattern Recognition Receptor Signaling Pathway
Positive Regulation Of Defense Response
Regulation Of Immune Response
Regulation Of DNA-binding Transcription Factor Activity
Kinase Activity
Positive Regulation Of Macromolecule Metabolic Process
Regulation Of JNK Cascade
Immune Response-regulating Signaling Pathway
Cytosol
Regulation Of Apoptotic Process
Tumor Necrosis Factor-mediated Signaling Pathway
Regulation Of Innate Immune Response
Regulation Of Immune System Process
Regulation Of Programmed Cell Death
Positive Regulation Of Metabolic Process
Transferase Activity
Antigen Receptor-mediated Signaling Pathway
Intracellular Signal Transduction
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Phosphotyrosine Residue Binding
Enzyme-linked Receptor Protein Signaling Pathway
Immune Response-activating Cell Surface Receptor Signaling Pathway
Regulation Of MAPK Cascade
Regulation Of Intracellular Signal Transduction
Ephrin Receptor Binding
Immune Response-regulating Cell Surface Receptor Signaling Pathway
Positive Regulation Of MAPK Cascade
Immune Response-activating Signaling Pathway
Positive Regulation Of Intracellular Signal Transduction
Immune Response-regulating Signaling Pathway
Activation Of Immune Response
Signal Transduction
Positive Regulation Of Immune Response
Signaling Adaptor Activity
Regulation Of Immune Response
Regulation Of Signal Transduction
Immune System Process
Positive Regulation Of Immune System Process
Regulation Of Immune System Process
Positive Regulation Of Signal Transduction
Cell Surface Receptor Signaling Pathway
Intracellular Signaling Cassette
T Cell Receptor Signaling Pathway
B Cell Receptor Signaling Pathway
Regulation Of Cell Communication
Regulation Of Signaling
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
Receptor Tyrosine Kinase Binding
Lymphocyte Homeostasis
Leukocyte Activation
Regulation Of T Cell Activation
Leukocyte Homeostasis
Lymphocyte Activation
Cell Activation
Positive Regulation Of Cell Population Proliferation
Homeostasis Of Number Of Cells
Cytosol
Positive Regulation Of Cell Adhesion
SH2 Domain Binding
Regulation Of Lymphocyte Activation
Protein Domain Specific Binding
Regulation Of Cell Population Proliferation
Regulation Of Cell Adhesion Mediated By Integrin
Regulation Of Cell Adhesion
Ephrin Receptor Signaling Pathway
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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