MAP3K7 and CARD11

Number of citations: 52 (PubMedID 16301747)
Data Source: BioGRID (affinity chromatography technology), HPRD (in vitro)

		MAP3K7	CARD11
Name		mitogen-activated protein kinase kinase kinase 7	caspase recruitment domain family member 11
Structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Endoplasmic Reticulum Membrane Cytosol Plasma Membrane Endosome Membrane Membrane ATAC Complex	Immunological Synapse Cytoplasm Cytosol Plasma Membrane Membrane CBM Complex Membrane Raft Extracellular Exosome
	Molecular Function	Nucleotide Binding Magnesium Ion Binding Transcription Coactivator Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity MAP Kinase Activity MAP Kinase Kinase Kinase Activity Signaling Receptor Binding Type II Transforming Growth Factor Beta Receptor Binding Protein Binding ATP Binding MAP Kinase Kinase Kinase Kinase Activity Kinase Activity Transferase Activity Protein Kinase Binding Receptor Tyrosine Kinase Binding Ubiquitin Protein Ligase Binding Histone Kinase Activity Identical Protein Binding Metal Ion Binding Scaffold Protein Binding Protein Serine Kinase Activity Protein Serine/threonine Kinase Binding DNA-binding Transcription Factor Binding Linear Polyubiquitin Binding	GMP Kinase Activity Protein Binding CARD Domain Binding
	Biological Process	MAPK Cascade Response To Hypoxia Stimulatory C-type Lectin Receptor Signaling Pathway Positive Regulation Of T Cell Cytokine Production Cytoplasmic Pattern Recognition Receptor Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway Chromatin Remodeling Apoptotic Process Inflammatory Response Immune Response Signal Transduction Transforming Growth Factor Beta Receptor Signaling Pathway Canonical NF-kappaB Signal Transduction I-kappaB Phosphorylation JNK Cascade Positive Regulation Of Metabolic Process Positive Regulation Of Autophagy Negative Regulation Of Gene Expression Positive Regulation Of Macroautophagy Signal Transduction Involved In Regulation Of Gene Expression SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Type I Interferon Production Protein Exit From Endoplasmic Reticulum Positive Regulation Of Interleukin-2 Production Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Non-canonical NF-kappaB Signal Transduction P38MAPK Cascade Fc-epsilon Receptor Signaling Pathway Interleukin-33-mediated Signaling Pathway Interleukin-17A-mediated Signaling Pathway Defense Response To Bacterium Signal Transduction In Response To DNA Damage Positive Regulation Of Canonical NF-kappaB Signal Transduction Negative Regulation Of Canonical NF-kappaB Signal Transduction Anoikis Positive Regulation Of MAPK Cascade Positive Regulation Of JUN Kinase Activity Positive Regulation Of Cell Cycle Positive Regulation Of Cell Size T Cell Receptor Signaling Pathway Stress-activated MAPK Cascade Interleukin-1-mediated Signaling Pathway Cellular Response To Tumor Necrosis Factor Cellular Response To Hypoxia Cellular Response To Transforming Growth Factor Beta Stimulus CGAS/STING Signaling Pathway Positive Regulation Of CGAS/STING Signaling Pathway Negative Regulation Of Cytokine Production Involved In Inflammatory Response Positive Regulation Of Non-canonical NF-kappaB Signal Transduction Cellular Response To Angiotensin Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Positive Regulation Of Vascular Associated Smooth Muscle Cell Migration Response To Angiotensin	Immune System Process Signal Transduction Canonical NF-kappaB Signal Transduction B Cell Differentiation Positive Regulation Of B Cell Proliferation T Cell Costimulation Positive Regulation Of Interleukin-2 Production CD4-positive, Alpha-beta T Cell Proliferation TORC1 Signaling B Cell Proliferation T Cell Activation Regulation Of Apoptotic Process Positive Regulation Of Canonical NF-kappaB Signal Transduction Thymic T Cell Selection Regulation Of B Cell Differentiation Regulation Of T Cell Differentiation GMP Metabolic Process Lymphocyte Activation GDP Metabolic Process Homeostasis Of Number Of Cells Regulation Of Immune Response Positive Regulation Of T Cell Receptor Signaling Pathway Positive Regulation Of T Cell Activation Positive Regulation Of NF-kappaB Transcription Factor Activity Protein Homooligomerization Positive Regulation Of CD4-positive, Alpha-beta T Cell Proliferation
Pathways		Activation of NF-kappaB in B cells NOD1/2 Signaling Pathway Downstream TCR signaling FCERI mediated NF-kB activation Ca2+ pathway TAK1-dependent IKK and NF-kappa-B activation activated TAK1 mediates p38 MAPK activation JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 TNFR1-induced NF-kappa-B signaling pathway CLEC7A (Dectin-1) signaling Ub-specific processing proteases TICAM1,TRAF6-dependent induction of TAK1 complex Interleukin-1 signaling IRAK2 mediated activation of TAK1 complex TRAF6-mediated induction of TAK1 complex within TLR4 complex Alpha-protein kinase 1 signaling pathway SARS-CoV-2 activates/modulates innate and adaptive immune responses IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation	Activation of NF-kappaB in B cells Activation of NF-kappaB in B cells Downstream TCR signaling FCERI mediated NF-kB activation FCERI mediated NF-kB activation CLEC7A (Dectin-1) signaling
GWAS		Amyotrophic lateral sclerosis (sporadic) ( 24529757 ) Asthma ( 29273806 31959851 ) Asthma (adult onset) ( 31036433 ) Asthma (childhood onset) ( 31036433 ) Bone mineral density (hip) ( 30172743 ) Celiac disease ( 20190752 ) Cortical surface area ( 32963231 ) Cortical volume ( 32963231 ) Graves' disease ( 21841780 ) Response to anti-TNF therapy in rheumatoid arthritis ( 26776603 ) Response to inhaled corticosteroid treatment in asthma (change in FEV1) ( 24792382 ) Severity of nausea and vomiting of pregnancy ( 29563502 )	Asthma ( 34103634 ) Atopic dermatitis ( 23042114 ) Cadmium levels ( 26025379 ) Daytime sleep phenotypes ( 27126917 ) Dupuytren's disease ( 28886342 ) Intracranial aneurysm ( 29531279 ) Multiple sclerosis ( 24076602 31604244 ) Response to fenofibrate (total cholesterol levels) ( 27002377 ) Schizophrenia, bipolar disorder or major depressive disorder x sex interaction ( 34099189 ) Schizophrenia, bipolar disorder or major depressive disorder x sex interaction (3df) ( 34099189 ) Schizophrenia, bipolar disorder or recurrent major depressive disorder x sex interaction ( 34099189 ) Ulcerative colitis ( 23128233 ) White matter integrity ( 23218918 )
Novel Interactors		2 novel interactors: ATIC FBXL4	None recorded
Interacting Genes		73 interacting genes: AKTIP BBS10 BCL10 CALML6 CAMK2G CARD11 CHUK COPS5 CYLD EIF2AK2 ELP1 EZH2 FOS GPR25 HGS HIPK2 IKBKB IL17RD IRAK1 MAILR MAP2K4 MAP2K6 MAP3K14 MAP3K3 MAP3K5 MAP4K1 MAP4K4 MAPK14 MAPK6 MAPK8 MAPK8IP1 MAVS MUL1 NAIP NDUFS6 NFKBIA NOD2 NRIP1 PEBP1 PELI3 PINK1 PPM1B PPM1L PPP2R1A PPP5C PRKAB1 RBX1 RELA RNF19A ROR2 SMAD3 SMAD6 SMAD7 STAT3 STRADB SUPT20H TAB1 TAB2 TGFBR1 TNFAIP8L2 TNFRSF11A TRAF3 TRAF3IP2 TRAF6 UBASH3A UBC USP29 USP4 USP8 VRK2 XIAP ZNF593 ZNF746	15 interacting genes: BCL10 IKBKG MAP3K7 MAP4K1 PDPK1 PPP2CA PPP2R1A PRKCB PRKCQ RNF181 SH2D3C SRPK2 TAB1 WDR1 ZAP70
Entrez ID		6885	84433
HPRD ID		04011	06234
Ensembl ID		ENSG00000135341	ENSG00000198286
Uniprot IDs		O43318	Q9BXL7
PDB IDs		2EVA 2YIY 4GS6 4L3P 4L52 4L53 4O91 5E7R 5GJD 5GJF 5GJG 5J7S 5J8I 5J9L 5JGA 5JGB 5JGD 5JH6 5JK3 5V5N 7NTH 7NTI 8GW3 9FPD	4JUP 4LWD
GO Terms Enriched among Interactors		Intracellular Signaling Cassette Intracellular Signal Transduction MAPK Cascade Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Intracellular Signal Transduction Positive Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Signal Transduction Positive Regulation Of Intracellular Signal Transduction Canonical NF-kappaB Signal Transduction Regulation Of Cell Communication Regulation Of Signaling Positive Regulation Of Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling Pattern Recognition Receptor Signaling Pathway Negative Regulation Of Signal Transduction Signal Transduction Innate Immune Response-activating Signaling Pathway Protein Kinase Activity Regulation Of Cytokine Production Negative Regulation Of Cell Communication Negative Regulation Of Signaling Protein Serine/threonine Kinase Activity Non-canonical NF-kappaB Signal Transduction Activation Of Innate Immune Response Protein Modification Process Regulation Of Defense Response Negative Regulation Of Intracellular Signal Transduction Protein Serine Kinase Activity Positive Regulation Of Innate Immune Response Response To Stress Regulation Of MAPK Cascade Negative Regulation Of Canonical NF-kappaB Signal Transduction Cytoplasm Cytoplasmic Pattern Recognition Receptor Signaling Pathway Positive Regulation Of Defense Response Regulation Of Immune Response Regulation Of DNA-binding Transcription Factor Activity Kinase Activity Positive Regulation Of Macromolecule Metabolic Process Regulation Of JNK Cascade Immune Response-regulating Signaling Pathway Cytosol Regulation Of Apoptotic Process Tumor Necrosis Factor-mediated Signaling Pathway Regulation Of Innate Immune Response Regulation Of Immune System Process Regulation Of Programmed Cell Death Positive Regulation Of Metabolic Process Transferase Activity	Intracellular Signal Transduction Immune System Process Intracellular Signaling Cassette Immune Response-regulating Signaling Pathway Protein Kinase Activity Immune Response-regulating Cell Surface Receptor Signaling Pathway Antigen Receptor-mediated Signaling Pathway Protein Serine Kinase Activity Protein Phosphorylation Immune Response-activating Signaling Pathway Regulation Of Immune Response Kinase Activity Phosphorylation Positive Regulation Of Immune System Process Protein Serine/threonine Kinase Activity Positive Regulation Of Immune Response Regulation Of Intracellular Signal Transduction Signal Transduction Activation Of Immune Response Positive Regulation Of Signal Transduction Cytoplasm Positive Regulation Of Intracellular Signal Transduction Immune Response-activating Cell Surface Receptor Signaling Pathway T Cell Receptor Signaling Pathway Linear Polyubiquitin Binding Non-canonical NF-kappaB Signal Transduction Regulation Of Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Canonical NF-kappaB Signal Transduction Immunological Synapse MAP Kinase Kinase Kinase Kinase Activity Regulation Of Cell Communication Regulation Of Signaling Cytosol Canonical NF-kappaB Signal Transduction Regulation Of Immune System Process JNK Cascade Positive Regulation Of CGAS/STING Signaling Pathway Lymphocyte Homeostasis Protein Modification Process Transferase Activity Positive Regulation Of Canonical NF-kappaB Signal Transduction Leukocyte Homeostasis Positive Regulation Of NF-kappaB Transcription Factor Activity Anoikis Protein Serine/threonine Phosphatase Activity Kinase Activator Activity Positive Regulation Of T Cell Activation Phosphate-containing Compound Metabolic Process