MAP3K7 and MAP3K14

Number of citations of the paper that reports this interaction (PMID 10094049)
226

Data Source:
HPRD (in vitro, in vivo)

		MAP3K7	MAP3K14
Gene Name		mitogen-activated protein kinase kinase kinase 7	mitogen-activated protein kinase kinase kinase 14
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Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Ada2/Gcn5/Ada3 Transcription Activator Complex Cytoplasm Cytosol Plasma Membrane IkappaB Kinase Complex Endosome Membrane	Cytosol
	Molecular Function	Magnesium Ion Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity MAP Kinase Kinase Activity MAP Kinase Kinase Kinase Activity Protein Binding ATP Binding Scaffold Protein Binding	Protein Kinase Activity Receptor Signaling Protein Serine/threonine Kinase Activity NF-kappaB-inducing Kinase Activity MAP Kinase Kinase Activity MAP Kinase Kinase Kinase Activity Protein Binding ATP Binding
	Biological Process	Activation Of MAPKK Activity Activation Of MAPK Activity Angiogenesis Neural Tube Formation Toll-like Receptor Signaling Pathway Positive Regulation Of T Cell Cytokine Production MyD88-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Transcription, DNA-templated Apoptotic Process Transforming Growth Factor Beta Receptor Signaling Pathway I-kappaB Kinase/NF-kappaB Signaling Activation Of NF-kappaB-inducing Kinase Activity I-kappaB Phosphorylation JNK Cascade Positive Regulation Of Interleukin-2 Production Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Toll-like Receptor 10 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Fc-epsilon Receptor Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of JUN Kinase Activity Histone H3 Acetylation Innate Immune Response T Cell Receptor Signaling Pathway Positive Regulation Of T Cell Activation Positive Regulation Of NF-kappaB Transcription Factor Activity Stress-activated MAPK Cascade Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Negative Regulation Of Ripoptosome Assembly Involved In Necroptotic Process Regulation Of Reactive Oxygen Species Metabolic Process Negative Regulation Of Apoptotic Signaling Pathway	MAPK Cascade Activation Of MAPKK Activity Activation Of MAPK Activity Protein Phosphorylation Immune Response I-kappaB Kinase/NF-kappaB Signaling Signal Transduction By Phosphorylation T Cell Costimulation NIK/NF-kappaB Signaling Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Cellular Response To Mechanical Stimulus
Pathways		Signaling by the B Cell Receptor (BCR) Downstream TCR signaling IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation TRAF6 mediated induction of TAK1 complex Toll Like Receptor 7/8 (TLR7/8) Cascade Signaling by Wnt Toll Like Receptor TLR6:TLR2 Cascade Downstream signaling events of B Cell Receptor (BCR) Toll Like Receptor TLR1:TLR2 Cascade Activated TLR4 signalling FCERI mediated NF-kB activation MyD88 cascade initiated on plasma membrane Toll Like Receptor 5 (TLR5) Cascade NOD1/2 Signaling Pathway MyD88 dependent cascade initiated on endosome MyD88:Mal cascade initiated on plasma membrane TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation Toll Like Receptor 9 (TLR9) Cascade activated TAK1 mediates p38 MAPK activation JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 Innate Immune System IRAK2 mediated activation of TAK1 complex IRAK2 mediated activation of TAK1 complex MAP kinase activation in TLR cascade TRIF-mediated TLR3/TLR4 signaling Cytokine Signaling in Immune system MyD88-independent cascade beta-catenin independent WNT signaling Toll Like Receptor 2 (TLR2) Cascade Signaling by Interleukins TCR signaling Toll-Like Receptors Cascades Toll Like Receptor 10 (TLR10) Cascade Ca2+ pathway Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways Activation of NF-kappaB in B cells Toll Like Receptor 4 (TLR4) Cascade Toll Like Receptor 3 (TLR3) Cascade Fc epsilon receptor (FCERI) signaling Interleukin-1 signaling Adaptive Immune System TAK1 activates NFkB by phosphorylation and activation of IKKs complex	Costimulation by the CD28 family CD28 co-stimulation CD28 dependent PI3K/Akt signaling Adaptive Immune System
Drugs
Diseases
GWAS		Celiac disease ( 20190752) Graves' disease ( 21841780)	Multiple sclerosis ( 21833088)
Protein-Protein Interactions		60 interactors: BBS10 BCL10 CARD11 CHUK COPS5 EIF2AK2 EZH2 FOS GPR25 HGS HIPK2 IKBKAP IKBKB IL17RD IRAK1 MAP2K4 MAP2K6 MAP3K14 MAP3K3 MAP3K5 MAP4K1 MAP4K4 MAPK14 MAPK6 MAPK8 MAPK8IP1 MAVS NAIP NDUFS6 NOD2 NRIP1 PEBP1 PELI3 PINK1 PPM1B PPM1L PPP2R1A PPP5C PRKAA1 PRKAB1 RBX1 RELA RNF19A ROR2 SMAD3 SMAD6 SMAD7 STAT3 STRADB TAB1 TAB2 TGFBR1 TNFRSF11A TRAF3IP2 TRAF6 TRIM8 VRK2 XIAP ZNF593 ZNF746	39 interactors: ALPL BIRC3 BRCA1 CASP8 CDC37 CHUK EDAR EEF1A1 EGFR FBL GRB10 GRB14 GRB7 HSP90AA1 HSP90AB1 IKBKAP IKBKB IKBKG MAP2K4 MAP3K7 MAP3K8 MAPK3 NFKB2 NFKBIA PEBP1 PELI3 RIPK1 RPL30 RPL4 RPL5 RPL6 RPS11 RPS13 TRAF1 TRAF2 TRAF3 TRAF5 TRAF6 ZFP91
Entrez ID		6885	9020
HPRD ID		04011	05230
Ensembl ID		ENSG00000135341
Uniprot IDs		O43318	Q99558
PDB IDs		2EVA 2YIY 4GS6 4L3P 4L52 4L53	4DN5 4G3D 4IDT 4IDV
Enriched GO Terms of Interacting Partners?		Regulation Of Signal Transduction Positive Regulation Of Signal Transduction Regulation Of Signaling Regulation Of Intracellular Signal Transduction Positive Regulation Of Intracellular Signal Transduction Signal Transduction By Phosphorylation Signal Transduction Regulation Of Phosphorylation MAPK Cascade Regulation Of Protein Metabolic Process Signaling Regulation Of Phosphorus Metabolic Process Cell Communication Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of MAPK Cascade Phosphorylation Intracellular Signal Transduction Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor 2 Signaling Pathway Regulation Of Protein Phosphorylation Toll-like Receptor 9 Signaling Pathway Stress-activated MAPK Cascade TRIF-dependent Toll-like Receptor Signaling Pathway Stress-activated Protein Kinase Signaling Cascade Regulation Of Cellular Protein Metabolic Process MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Cellular Response To Stimulus MyD88-dependent Toll-like Receptor Signaling Pathway Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Regulation Of I-kappaB Kinase/NF-kappaB Signaling Activation Of Innate Immune Response Toll-like Receptor Signaling Pathway Toll-like Receptor 4 Signaling Pathway Phosphate-containing Compound Metabolic Process Regulation Of Protein Kinase Activity Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Activation Of Protein Kinase Activity Positive Regulation Of Protein Metabolic Process Positive Regulation Of Cellular Metabolic Process Cellular Protein Modification Process Response To Stimulus Regulation Of MAP Kinase Activity Regulation Of Kinase Activity Positive Regulation Of Innate Immune Response	TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway Toll-like Receptor Signaling Pathway Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Regulation Of Innate Immune Response Activation Of Innate Immune Response Positive Regulation Of Innate Immune Response Immune Response-regulating Signaling Pathway Positive Regulation Of NF-kappaB Transcription Factor Activity Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Regulation Of Immune Response Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Positive Regulation Of Immune System Process Positive Regulation Of Signal Transduction Regulation Of Immune System Process Positive Regulation Of Immune Response Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Innate Immune Response MyD88-dependent Toll-like Receptor Signaling Pathway Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Regulation Of Signal Transduction Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Cellular Protein Metabolic Process Regulation Of I-kappaB Kinase/NF-kappaB Signaling NIK/NF-kappaB Signaling Regulation Of Signaling Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Immune Response Fc Receptor Signaling Pathway Defense Response Apoptotic Process Immune System Process Programmed Cell Death Regulation Of Protein Metabolic Process Cell Death Regulation Of Cellular Protein Metabolic Process Death I-kappaB Kinase/NF-kappaB Signaling Regulation Of Type I Interferon Production Activation Of Protein Kinase Activity Immune Response-regulating Cell Surface Receptor Signaling Pathway
Tagcloud ?		abrogated accounts bcr called card card11 carma1 existence feedback generating ikappab ikk ikkbeta implies kappab late maguk mathematical modeling module nf residue scaffolding serine steep switch switchlike tak1 threshold	alternative bcr birc3 called classical conferred dependence driven exclusive hematological ibrutinib insensitive insensitivity insights kappab lymphomas malignancy mantle mcl mutually nf nik profiling refractory sequencing sotrastaurin stratification traf2 transcriptome
Tagcloud (Difference) ?		abrogated accounts card card11 carma1 existence feedback generating ikappab ikk ikkbeta implies late maguk mathematical modeling module residue scaffolding serine steep switch switchlike tak1 threshold	alternative birc3 classical conferred dependence driven exclusive hematological ibrutinib insensitive insensitivity insights lymphomas malignancy mantle mcl mutually nik profiling refractory sequencing sotrastaurin stratification traf2 transcriptome
Tagcloud (Intersection) ?		bcr called kappab nf