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MAP3K7 and PPP2R1A
Number of citations of the paper that reports this interaction (PubMedID
17079228
)
33
Data Source:
BioGRID
(enzymatic study)
MAP3K7
PPP2R1A
Description
mitogen-activated protein kinase kinase kinase 7
protein phosphatase 2 scaffold subunit Aalpha
Image
GO Annotations
Cellular Component
Nucleus
Cytoplasm
Endoplasmic Reticulum Membrane
Cytosol
Plasma Membrane
Endosome Membrane
Membrane
ATAC Complex
Protein Phosphatase Type 2A Complex
Chromosome, Centromeric Region
Chromatin
Nucleus
Chromosome
Cytoplasm
Mitochondrion
Cytosol
Plasma Membrane
Microtubule Cytoskeleton
Membrane
Lateral Plasma Membrane
Dendrite
Cell Projection
Neuron Projection
Neuronal Cell Body
Synapse
Extracellular Exosome
FAR/SIN/STRIPAK Complex
Glutamatergic Synapse
INTAC Complex
Molecular Function
Nucleotide Binding
Magnesium Ion Binding
Transcription Coactivator Binding
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
MAP Kinase Activity
MAP Kinase Kinase Kinase Activity
Signaling Receptor Binding
Type II Transforming Growth Factor Beta Receptor Binding
Protein Binding
ATP Binding
MAP Kinase Kinase Kinase Kinase Activity
Kinase Activity
Transferase Activity
Protein Kinase Binding
Receptor Tyrosine Kinase Binding
Ubiquitin Protein Ligase Binding
Histone Kinase Activity
Identical Protein Binding
Metal Ion Binding
Scaffold Protein Binding
Protein Serine Kinase Activity
Protein Serine/threonine Kinase Binding
DNA-binding Transcription Factor Binding
Linear Polyubiquitin Binding
Protein Serine/threonine Phosphatase Activity
Protein Binding
Protein Phosphatase Regulator Activity
Protein Heterodimerization Activity
Protein Antigen Binding
Biological Process
MAPK Cascade
Response To Hypoxia
Stimulatory C-type Lectin Receptor Signaling Pathway
Positive Regulation Of T Cell Cytokine Production
Cytoplasmic Pattern Recognition Receptor Signaling Pathway
MyD88-dependent Toll-like Receptor Signaling Pathway
Chromatin Remodeling
Apoptotic Process
Inflammatory Response
Immune Response
Signal Transduction
Transforming Growth Factor Beta Receptor Signaling Pathway
Canonical NF-kappaB Signal Transduction
I-kappaB Phosphorylation
JNK Cascade
Positive Regulation Of Metabolic Process
Positive Regulation Of Autophagy
Negative Regulation Of Gene Expression
Positive Regulation Of Macroautophagy
Signal Transduction Involved In Regulation Of Gene Expression
SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of Type I Interferon Production
Protein Exit From Endoplasmic Reticulum
Positive Regulation Of Interleukin-2 Production
Toll-like Receptor 3 Signaling Pathway
Toll-like Receptor 4 Signaling Pathway
TRIF-dependent Toll-like Receptor Signaling Pathway
Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway
Non-canonical NF-kappaB Signal Transduction
P38MAPK Cascade
Fc-epsilon Receptor Signaling Pathway
Interleukin-33-mediated Signaling Pathway
Interleukin-17A-mediated Signaling Pathway
Defense Response To Bacterium
Signal Transduction In Response To DNA Damage
Positive Regulation Of Canonical NF-kappaB Signal Transduction
Negative Regulation Of Canonical NF-kappaB Signal Transduction
Anoikis
Positive Regulation Of MAPK Cascade
Positive Regulation Of JUN Kinase Activity
Positive Regulation Of Cell Cycle
Positive Regulation Of Cell Size
T Cell Receptor Signaling Pathway
Stress-activated MAPK Cascade
Interleukin-1-mediated Signaling Pathway
Cellular Response To Tumor Necrosis Factor
Cellular Response To Hypoxia
Cellular Response To Transforming Growth Factor Beta Stimulus
CGAS/STING Signaling Pathway
Positive Regulation Of CGAS/STING Signaling Pathway
Negative Regulation Of Cytokine Production Involved In Inflammatory Response
Positive Regulation Of Non-canonical NF-kappaB Signal Transduction
Cellular Response To Angiotensin
Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation
Positive Regulation Of Vascular Associated Smooth Muscle Cell Migration
Response To Angiotensin
Transcription By RNA Polymerase II
Transcription Elongation By RNA Polymerase II
Chromosome Segregation
Female Meiotic Nuclear Division
Negative Regulation Of Hippo Signaling
Intracellular Signal Transduction
Regulation Of Growth
T Cell Homeostasis
Regulation Of Cell Differentiation
Spindle Assembly
Meiotic Spindle Elongation
Mitotic Sister Chromatid Separation
Meiotic Sister Chromatid Cohesion, Centromeric
Negative Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Protein-containing Complex Assembly
RNA Polymerase II Transcription Initiation Surveillance
Regulation Of Meiotic Cell Cycle Process Involved In Oocyte Maturation
Positive Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Pathways
Activation of NF-kappaB in B cells
NOD1/2 Signaling Pathway
Downstream TCR signaling
FCERI mediated NF-kB activation
Ca2+ pathway
TAK1-dependent IKK and NF-kappa-B activation
activated TAK1 mediates p38 MAPK activation
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
TNFR1-induced NF-kappa-B signaling pathway
CLEC7A (Dectin-1) signaling
Ub-specific processing proteases
TICAM1,TRAF6-dependent induction of TAK1 complex
Interleukin-1 signaling
IRAK2 mediated activation of TAK1 complex
TRAF6-mediated induction of TAK1 complex within TLR4 complex
Alpha-protein kinase 1 signaling pathway
SARS-CoV-2 activates/modulates innate and adaptive immune responses
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
Inhibition of replication initiation of damaged DNA by RB1/E2F1
Spry regulation of FGF signaling
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
PP2A-mediated dephosphorylation of key metabolic factors
DARPP-32 events
Degradation of beta-catenin by the destruction complex
Beta-catenin phosphorylation cascade
ERK/MAPK targets
ERKs are inactivated
MASTL Facilitates Mitotic Progression
Separation of Sister Chromatids
Resolution of Sister Chromatid Cohesion
Regulation of PLK1 Activity at G2/M Transition
Initiation of Nuclear Envelope (NE) Reformation
Loss of Nlp from mitotic centrosomes
Recruitment of mitotic centrosome proteins and complexes
Loss of proteins required for interphase microtubule organization from the centrosome
Recruitment of NuMA to mitotic centrosomes
Co-stimulation by CD28
Co-inhibition by CTLA4
Platelet sensitization by LDL
Disassembly of the destruction complex and recruitment of AXIN to the membrane
Disassembly of the destruction complex and recruitment of AXIN to the membrane
Signaling by GSK3beta mutants
CTNNB1 S33 mutants aren't phosphorylated
CTNNB1 S37 mutants aren't phosphorylated
CTNNB1 S45 mutants aren't phosphorylated
CTNNB1 T41 mutants aren't phosphorylated
APC truncation mutants have impaired AXIN binding
AXIN missense mutants destabilize the destruction complex
Truncations of AMER1 destabilize the destruction complex
Anchoring of the basal body to the plasma membrane
RHO GTPases Activate Formins
RAF activation
Negative regulation of MAPK pathway
Regulation of TP53 Degradation
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
Mitotic Prometaphase
Cyclin D associated events in G1
Cyclin A/B1/B2 associated events during G2/M transition
AURKA Activation by TPX2
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism
EML4 and NUDC in mitotic spindle formation
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
PKR-mediated signaling
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells
Drugs
2,6,8-Trimethyl-3-Amino-9-Benzyl-9-Methoxynonanoic Acid
(2S,3S,4E,6E,8S,9S)-3-amino-9-methoxy-2,6,8-trimethyl-10-phenyldeca-4,6-dienoic acid
Diseases
GWAS
Amyotrophic lateral sclerosis (sporadic) (
24529757
)
Asthma (
29273806
31959851
)
Asthma (adult onset) (
31036433
)
Asthma (childhood onset) (
31036433
)
Bone mineral density (hip) (
30172743
)
Celiac disease (
20190752
)
Cortical surface area (
32963231
)
Cortical volume (
32963231
)
Graves' disease (
21841780
)
Response to anti-TNF therapy in rheumatoid arthritis (
26776603
)
Response to inhaled corticosteroid treatment in asthma (change in FEV1) (
24792382
)
Severity of nausea and vomiting of pregnancy (
29563502
)
Interacting Genes
73 interacting genes:
AKTIP
BBS10
BCL10
CALML6
CAMK2G
CARD11
CHUK
COPS5
CYLD
EIF2AK2
ELP1
EZH2
FOS
GPR25
HGS
HIPK2
IKBKB
IL17RD
IRAK1
MAILR
MAP2K4
MAP2K6
MAP3K14
MAP3K3
MAP3K5
MAP4K1
MAP4K4
MAPK14
MAPK6
MAPK8
MAPK8IP1
MAVS
MUL1
NAIP
NDUFS6
NFKBIA
NOD2
NRIP1
PEBP1
PELI3
PINK1
PPM1B
PPM1L
PPP2R1A
PPP5C
PRKAB1
RBX1
RELA
RNF19A
ROR2
SMAD3
SMAD6
SMAD7
STAT3
STRADB
SUPT20H
TAB1
TAB2
TGFBR1
TNFAIP8L2
TNFRSF11A
TRAF3
TRAF3IP2
TRAF6
UBASH3A
UBC
USP29
USP4
USP8
VRK2
XIAP
ZNF593
ZNF746
59 interacting genes:
AIMP2
AKT1
AMOTL2
ARIH2
ATM
CARD11
CARHSP1
CDC42
CDK1
CSDC2
CSNK2B
DAPK1
DELEC1
DUX4
EEF2
ESR1
FBXO43
GNA12
GOLGA6A
GOLGA8F
GRIN1
GRIN2D
HSF2
HSPD1
IPO9
LINC01554
MAP3K7
MAPK6
MCM3
OGT
PARK7
PLAAT3
PPP2CA
PPP2R2A
PPP2R3B
PPP2R5A
PPP2R5B
PPP4C
PPP5C
PRDX1
PRDX2
PTPA
RAB11A
RAB18
RAB7A
RAP1A
RORC
SGO1
SGO2
SLC25A21-AS1
SLC6A2
SMAD2
SMAD3
STRN
STRN3
SUMO2
TAB1
TRADD
ZFYVE9
Entrez ID
6885
5518
HPRD ID
04011
16184
Ensembl ID
ENSG00000135341
ENSG00000105568
Uniprot IDs
O43318
A8K7B7
B3KQV6
P30153
PDB IDs
2EVA
2YIY
4GS6
4L3P
4L52
4L53
4O91
5E7R
5GJD
5GJF
5GJG
5J7S
5J8I
5J9L
5JGA
5JGB
5JGD
5JH6
5JK3
5V5N
7NTH
7NTI
8GW3
9FPD
1B3U
2IE3
2IE4
2NPP
2NYL
2NYM
2PKG
3C5W
3DW8
3K7V
3K7W
4I5L
4I5N
4LAC
5W0W
6IUR
6NTS
7CUN
7K36
7PKS
7SOY
7YCX
8RBX
8RBZ
8RC4
8SO0
8TTB
8TWE
8TWI
8U1X
8U89
8UWB
8YJB
Enriched GO Terms of Interacting Partners
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Intracellular Signaling Cassette
Intracellular Signal Transduction
MAPK Cascade
Regulation Of Canonical NF-kappaB Signal Transduction
Regulation Of Intracellular Signal Transduction
Positive Regulation Of Canonical NF-kappaB Signal Transduction
Regulation Of Signal Transduction
Positive Regulation Of Intracellular Signal Transduction
Canonical NF-kappaB Signal Transduction
Regulation Of Cell Communication
Regulation Of Signaling
Positive Regulation Of Signal Transduction
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
Pattern Recognition Receptor Signaling Pathway
Negative Regulation Of Signal Transduction
Signal Transduction
Innate Immune Response-activating Signaling Pathway
Protein Kinase Activity
Regulation Of Cytokine Production
Negative Regulation Of Cell Communication
Negative Regulation Of Signaling
Protein Serine/threonine Kinase Activity
Non-canonical NF-kappaB Signal Transduction
Activation Of Innate Immune Response
Protein Modification Process
Regulation Of Defense Response
Negative Regulation Of Intracellular Signal Transduction
Protein Serine Kinase Activity
Positive Regulation Of Innate Immune Response
Response To Stress
Regulation Of MAPK Cascade
Negative Regulation Of Canonical NF-kappaB Signal Transduction
Cytoplasm
Cytoplasmic Pattern Recognition Receptor Signaling Pathway
Positive Regulation Of Defense Response
Regulation Of Immune Response
Regulation Of DNA-binding Transcription Factor Activity
Kinase Activity
Positive Regulation Of Macromolecule Metabolic Process
Regulation Of JNK Cascade
Immune Response-regulating Signaling Pathway
Cytosol
Regulation Of Apoptotic Process
Tumor Necrosis Factor-mediated Signaling Pathway
Regulation Of Innate Immune Response
Regulation Of Immune System Process
Regulation Of Programmed Cell Death
Positive Regulation Of Metabolic Process
Transferase Activity
Protein Phosphatase Type 2A Complex
Intracellular Signal Transduction
Intracellular Signaling Cassette
Cytosol
Protein Phosphatase 2A Binding
Cytoplasm
Protein Phosphatase Regulator Activity
Signal Transduction
Peroxiredoxin Activity
Cellular Response To Oxygen-containing Compound
Canonical NF-kappaB Signal Transduction
Regulation Of Signal Transduction
Glutamatergic Synapse
Response To Oxidative Stress
G Protein Activity
Positive Regulation Of Signal Transduction
Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Protein-containing Complex
Regulation Of Cell Communication
Regulation Of Signaling
Response To Growth Factor
Cellular Response To Nerve Growth Factor Stimulus
Tau Protein Binding
Response To Nerve Growth Factor
Removal Of Superoxide Radicals
Response To Reactive Oxygen Species
Positive Regulation Of Cell Communication
Regulation Of Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of Signaling
Kinase Binding
Positive Regulation Of Intracellular Signal Transduction
Cell Population Proliferation
Regulation Of Programmed Cell Death
Negative Regulation Of Hydrogen Peroxide-induced Neuron Intrinsic Apoptotic Signaling Pathway
Regulation Of Intracellular Signal Transduction
Protein-containing Complex Binding
GTP Binding
Protein Phosphatase Activator Activity
Phosphatase Binding
Paraxial Mesoderm Morphogenesis
Transforming Growth Factor Beta Receptor Signaling Pathway
FAR/SIN/STRIPAK Complex
Regulation Of Protein Catabolic Process
Cellular Response To Growth Factor Stimulus
Peptidyl-threonine Phosphorylation
Calmodulin Binding
Protein Metabolic Process
Positive Regulation Of Cellular Component Biogenesis
Regulation Of Proteasomal Protein Catabolic Process
Regulation Of Cellular Localization
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