SYK and BTK

Number of citations of the paper that reports this interaction (PubMedID 11598012)
35

Data Source:
HPRD (in vitro, in vivo)

		SYK	BTK
Description		spleen associated tyrosine kinase	Bruton tyrosine kinase
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Plasma Membrane Membrane B Cell Receptor Complex Early Phagosome Protein-containing Complex T Cell Receptor Complex	Nucleus Cytoplasm Cytosol Plasma Membrane Membrane Cytoplasmic Vesicle Membrane Raft Perinuclear Region Of Cytoplasm
	Molecular Function	Nucleotide Binding Phosphotyrosine Residue Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Signaling Receptor Binding Integrin Binding Protein Binding ATP Binding Interleukin-15 Receptor Binding Kinase Activity Transferase Activity Protein Kinase Binding Phosphatase Binding Toll-like Receptor Binding SH2 Domain Binding Phospholipase Binding Scaffold Protein Binding	Nucleotide Binding Protein Kinase Activity Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Protein Binding ATP Binding Phosphatidylinositol-3,4,5-trisphosphate Binding Zinc Ion Binding Lipid Binding Phospholipase Activator Activity Kinase Activity Transferase Activity Identical Protein Binding Phospholipase Binding Metal Ion Binding
	Biological Process	Autophagosome Assembly Angiogenesis Cell Activation Positive Regulation Of Cytokine Production Serotonin Secretion Lymph Vessel Development Positive Regulation Of Receptor Internalization Stimulatory C-type Lectin Receptor Signaling Pathway Adaptive Immune Response Macrophage Activation Involved In Immune Response Neutrophil Activation Involved In Immune Response Leukocyte Activation Involved In Immune Response Immune System Process Serotonin Secretion By Platelet Cell Surface Pattern Recognition Receptor Signaling Pathway Negative Regulation Of Inflammatory Response To Antigenic Stimulus Protein Phosphorylation Protein Import Into Nucleus Leukocyte Cell-cell Adhesion Cell Surface Receptor Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Integrin-mediated Signaling Pathway Animal Organ Morphogenesis Negative Regulation Of Autophagy Positive Regulation Of Autophagy Regulation Of Platelet Activation Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Peptidyl-tyrosine Phosphorylation Leukotriene Biosynthetic Process Calcium-mediated Signaling Platelet Activation B Cell Differentiation Neutrophil Chemotaxis Positive Regulation Of Protein-containing Complex Assembly Receptor Internalization Cellular Response To Nutrient Levels Positive Regulation Of Type I Interferon Production Positive Regulation Of Granulocyte Macrophage Colony-stimulating Factor Production Positive Regulation Of Interleukin-10 Production Positive Regulation Of Interleukin-12 Production Positive Regulation Of Interleukin-3 Production Positive Regulation Of Interleukin-4 Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Interleukin-8 Production Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Mast Cell Cytokine Production Regulation Of Superoxide Anion Generation Positive Regulation Of Superoxide Anion Generation Positive Regulation Of Cell Adhesion Mediated By Integrin Intracellular Signal Transduction Collagen-activated Tyrosine Kinase Receptor Signaling Pathway Fc-epsilon Receptor Signaling Pathway Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Interleukin-3-mediated Signaling Pathway TORC1 Signaling Gamma-delta T Cell Differentiation Defense Response To Bacterium Mast Cell Degranulation Positive Regulation Of Mast Cell Degranulation Regulation Of Neutrophil Degranulation Beta Selection Positive Regulation Of MAPK Cascade Innate Immune Response Positive Regulation Of B Cell Differentiation Positive Regulation Of Gamma-delta T Cell Differentiation Positive Regulation Of Lymphocyte Differentiation Positive Regulation Of Bone Resorption Positive Regulation Of Alpha-beta T Cell Differentiation Positive Regulation Of Alpha-beta T Cell Proliferation Blood Vessel Morphogenesis Regulation Of Phagocytosis Regulation Of Immune Response Positive Regulation Of Calcium-mediated Signaling B Cell Receptor Signaling Pathway Leukocyte Migration Regulation Of DNA-binding Transcription Factor Activity Establishment Of Localization In Cell Regulation Of ERK1 And ERK2 Cascade Cellular Response To Molecule Of Fungal Origin Cellular Response To Lipid Cellular Response To Low-density Lipoprotein Particle Stimulus Positive Regulation Of Monocyte Chemotactic Protein-1 Production Regulation Of Arachidonate Secretion Regulation Of Platelet Aggregation Apoptotic Signaling Pathway Amyloid-beta Clearance Positive Regulation Of Cold-induced Thermogenesis Negative Regulation Of TORC1 Signaling Positive Regulation Of TORC1 Signaling Cellular Response To Amyloid-beta Cellular Response To Lectin	Neutrophil Homeostasis Positive Regulation Of Type III Hypersensitivity Positive Regulation Of Type I Hypersensitivity Negative Regulation Of Cytokine Production Adaptive Immune Response B Cell Affinity Maturation Immune System Process Histamine Secretion By Mast Cell Positive Regulation Of Immunoglobulin Production Regulation Of B Cell Cytokine Production MyD88-dependent Toll-like Receptor Signaling Pathway Regulation Of B Cell Apoptotic Process Apoptotic Process Mesoderm Development Peptidyl-tyrosine Phosphorylation Calcium-mediated Signaling Proteoglycan Catabolic Process Negative Regulation Of B Cell Proliferation Positive Regulation Of B Cell Proliferation Positive Regulation Of Type I Interferon Production Response To Lipopolysaccharide Negative Regulation Of Interleukin-10 Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Tumor Necrosis Factor Production Cellular Response To Reactive Oxygen Species Intracellular Signal Transduction Fc-epsilon Receptor Signaling Pathway B Cell Activation Positive Regulation Of Canonical NF-kappaB Signal Transduction Innate Immune Response Positive Regulation Of B Cell Differentiation Cell Maturation Positive Regulation Of Phagocytosis T Cell Receptor Signaling Pathway B Cell Receptor Signaling Pathway Regulation Of B Cell Activation Negative Regulation Of B Cell Activation Positive Regulation Of NF-kappaB Transcription Factor Activity Monocyte Proliferation Negative Regulation Of Leukocyte Proliferation Cellular Response To Molecule Of Fungal Origin Apoptotic Signaling Pathway Cellular Response To Interleukin-7 CGAS/STING Signaling Pathway Positive Regulation Of CGAS/STING Signaling Pathway Positive Regulation Of Interleukin-17A Production Positive Regulation Of NLRP3 Inflammasome Complex Assembly Positive Regulation Of Synoviocyte Proliferation Eosinophil Homeostasis
Pathways		GPVI-mediated activation cascade GPVI-mediated activation cascade FCGR activation FCGR activation Regulation of actin dynamics for phagocytic cup formation Role of phospholipids in phagocytosis DAP12 signaling Fc epsilon receptor (FCERI) signaling Fc epsilon receptor (FCERI) signaling Role of LAT2/NTAL/LAB on calcium mobilization Role of LAT2/NTAL/LAB on calcium mobilization FCERI mediated MAPK activation FCERI mediated Ca+2 mobilization FCERI mediated Ca+2 mobilization Integrin signaling CLEC7A (Dectin-1) signaling Dectin-2 family Dectin-2 family Interleukin-2 signaling Regulation of signaling by CBL Regulation of signaling by CBL FCGR3A-mediated IL10 synthesis FCGR3A-mediated phagocytosis Signaling by CSF3 (G-CSF) Signaling by CSF3 (G-CSF) Potential therapeutics for SARS Inactivation of CSF3 (G-CSF) signaling Inactivation of CSF3 (G-CSF) signaling FLT3 signaling through SRC family kinases Antigen activates B Cell Receptor (BCR) leading to generation of second messengers Antigen activates B Cell Receptor (BCR) leading to generation of second messengers	ER-Phagosome pathway MyD88:MAL(TIRAP) cascade initiated on plasma membrane Regulation of actin dynamics for phagocytic cup formation DAP12 signaling FCERI mediated Ca+2 mobilization FCERI mediated Ca+2 mobilization G alpha (q) signalling events G alpha (12/13) signalling events MyD88 deficiency (TLR2/4) IRAK4 deficiency (TLR2/4) RHO GTPases Activate WASPs and WAVEs G beta:gamma signalling through BTK FCGR3A-mediated phagocytosis Potential therapeutics for SARS Antigen activates B Cell Receptor (BCR) leading to generation of second messengers Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
Drugs		Staurosporine N-(2-hydroxy-1,1-dimethylethyl)-1-methyl-3-(1H-pyrrolo[2,3-b]pyridin-2-yl)-1H-indole-5-carboxamide Tamatinib 2-{2-[(3,5-dimethylphenyl)amino]pyrimidin-4-yl}-N-[(1S)-2-hydroxy-1-methylethyl]-4-methyl-1,3-thiazole-5-carboxamide 2-{[(1R,2S)-2-aminocyclohexyl]amino}-4-[(3-methylphenyl)amino]pyrimidine-5-carboxamide Ellagic acid Fostamatinib Entospletinib	Dasatinib Inositol 1,3,4,5-Tetrakisphosphate XL418 Ibrutinib Acalabrutinib Spebrutinib Fostamatinib Fenebrutinib Zanubrutinib Evobrutinib Tirabrutinib Abivertinib Branebrutinib Vecabrutinib
Diseases			Pituitary Dwarfism (PD); Isolated growth hormone deficiency (IGHD); Short Stature and Pituitary Defects (SSPD); Insulin-like growth factor 1 deficiency (IGFD) Agammaglobulinemias, including the following six diseases: X-linked agammaglobulinemia (Bruton's agammaglobulinemia, XLA); IgM heavy chain gene deletions; Ig-alpha defect; Autosomal recessive agammaglobulinaemia; B cell-linker protein (BLNK) deficiency; Leucine-rich repeat-containing 8
GWAS		Alzheimer's disease ( 30636644) Anti-saccade response ( 29064472) Atrial fibrillation ( 28416822) Chromosomal aberration frequency (total) ( 31586183) Frontal pole volume ( 31530798) Mean platelet volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Metabolite levels ( 23823483) Monocyte count ( 32888494) Multiple sclerosis ( 21833088) Multiple sclerosis and HDL levels (pleiotropy) ( 26920376) Platelet count ( 32888494) Platelet distribution width ( 32888494 27863252) Plateletcrit ( 32888494) Type 2 diabetes ( 22456796) Vascular dementia ( 23480133)
Interacting Genes		110 interacting genes: APP AR BLNK BTK CALM1 CBL CBLB CD19 CD22 CD3E CD72 CD79A CD79B CEBPA COASY CRKL CRYAA CSF2RB CSF3R CTTN DBNL DPP9 DUSP3 EGFR EPOR ERBB2 ERBB3 ERBB4 FCER1G FCGR1A FCGR2A FCGR3A FCRL3 FGR FYN GAB1 GAB2 GRB2 HCLS1 HDAC1 HDAC2 HDAC3 HDAC4 HDAC6 HDAC9 HGS HNRNPU IL15RA IL2RB ITGB2 JAK1 KIT LAT LAX1 LCK LCP2 LYN MAP4K1 MAPK3 MAPT MET MS4A2 NEDD4 NFAM1 PAG1 PIK3AP1 PIK3R1 PIK3R2 PLCG1 PLCG2 POU2AF1 PRKCA PRKD1 PTK2 PTK2B PTPN6 PXN RASA1 RHOU RPS10 RPS6KA1 RPS6KB1 RPS6KB2 SELPLG SH2B2 SH2D2A SH3BP2 SHC1 SIT1 SLA SLC4A1 SNCA SRC STAT1 STAT3 STAT5A TERF1 TLR4 TNFRSF1A TRAF6 TRIM15 TRIM31 TUBA1A TUBA4A TYROBP UBASH3B UBB USP25 VAV1 VAV2	77 interacting genes: ABL1 APP AR ARHGAP17 ARID3A ARRB1 AURKA BCL2L11 BECN1 BLNK BMX CAV1 CBL CD19 CMTM3 COASY CPVL DAPP1 ERBB3 EWSR1 FAS FASLG FYN GAB1 GNA12 GNAQ GNG2 GTF2I HCK IBTK IRAK1 ITK JAK1 KHDRBS1 KIT LYN MDM2 MEOX2 MET MRPS22 MYD88 PIK3AP1 PIK3R3 PIP4K2A PIP4K2B PIP4K2C PIP5K1A PIP5K1B PIP5K1C PLAU PLCG1 PLCG2 PRKCA PRKCB PRKCE PRKCQ PRKCZ PRKD1 RELA RPS6KB1 RPS6KB2 SH2B2 SH3BP5 SMURF1 STAT5A SYK TEC TIRAP TLR4 TLR6 TLR8 TLR9 TNFRSF10A TP53 VAV1 WAS WASF2
Entrez ID		6850	695
HPRD ID		02514	02248
Ensembl ID		ENSG00000165025	ENSG00000010671
Uniprot IDs		C3W981 P43405	Q06187 Q5JY90
PDB IDs		1A81 1CSY 1CSZ 1XBA 1XBB 1XBC 3BUW 3EMG 3FQE 3FQH 3FQS 3SRV 3TUB 3TUC 3TUD 3VF8 3VF9 4DFL 4DFN 4F4P 4FL1 4FL2 4FL3 4FYN 4FYO 4FZ6 4FZ7 4GFG 4I0R 4I0S 4I0T 4PUZ 4PV0 4PX6 4RSS 4RX7 4RX8 4RX9 4WNM 4XG2 4XG3 4XG4 4XG6 4XG7 4XG8 4XG9 4YJO 4YJP 4YJQ 4YJR 4YJS 4YJT 4YJU 4YJV 5C26 5C27 5CXH 5CXZ 5CY3 5GHV 5LMA 5LMB 5T68 5TIU 5TR6 5TT7 5Y5T 5Y5U 6HM6 6HM7 6SSB 6VOV 6ZC0 6ZCP 6ZCQ 6ZCR 6ZCS 6ZCU 6ZCX 6ZCY 7Q5T 7Q5U 7Q5W 7Q63 7SA7 8BI2 8RRQ 8RRZ 8WYW 8X5K 8XQ0 8XQ1 8XQ2	1AWW 1AWX 1B55 1BTK 1BWN 1K2P 1QLY 2GE9 2Z0P 3GEN 3K54 3OCS 3OCT 3P08 3PIX 3PIY 3PIZ 3PJ1 3PJ2 3PJ3 4NWM 4OT5 4OT6 4OTF 4OTQ 4OTR 4RFY 4RFZ 4RG0 4RX5 4YHF 4Z3V 4ZLY 4ZLZ 5BPY 5BQ0 5FBN 5FBO 5J87 5JRS 5KUP 5P9F 5P9G 5P9H 5P9I 5P9J 5P9K 5P9L 5P9M 5T18 5U9D 5VFI 5VGO 5XYZ 5ZZ4 6AUA 6AUB 6BIK 6BKE 6BKH 6BKW 6BLN 6DI0 6DI1 6DI3 6DI5 6DI9 6E4F 6EP9 6HRP 6HRT 6HTF 6J6M 6N9P 6NFH 6NFI 6NZM 6O8I 6OMU 6S90 6TFP 6TSE 6TT2 6TUH 6TVN 6VXQ 6W06 6W07 6W7O 6W8I 6X3N 6X3O 6X3P 6XE4 6YYF 6YYG 6YYK 7KXL 7KXM 7KXN 7KXO 7KXP 7KXQ 7L5O 7L5P 7LTY 7LTZ 7N4Q 7N4R 7N4S 7N5O 7N5R 7N5X 7N5Y 7R60 7R61 7YC9 8DSO 8E2M 8EJB 8FLG 8FLH 8FLL 8FLN 8FLV 8GC7 8GC8 8TU3 8TU4 8TU5 8U2D 8U2E 8YVV
Enriched GO Terms of Interacting Partners?		Cell Surface Receptor Signaling Pathway Signal Transduction Immune Response-regulating Cell Surface Receptor Signaling Pathway Leukocyte Activation Cell Activation Immune System Process Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Immune System Process Immune Response-activating Cell Surface Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Positive Regulation Of Immune System Process Lymphocyte Activation Regulation Of Intracellular Signal Transduction Regulation Of Immune Response Enzyme-linked Receptor Protein Signaling Pathway Intracellular Signal Transduction Phosphotyrosine Residue Binding Regulation Of Signal Transduction Positive Regulation Of Intracellular Signal Transduction Regulation Of Multicellular Organismal Process Immune Response-activating Signaling Pathway Fc Receptor Signaling Pathway Regulation Of Cell Activation Activation Of Immune Response Regulation Of Signaling Regulation Of Cell Communication Plasma Membrane Antigen Receptor-mediated Signaling Pathway Positive Regulation Of Multicellular Organismal Process Positive Regulation Of Signal Transduction Positive Regulation Of Immune Response Positive Regulation Of Cell Communication Positive Regulation Of Signaling Immune Response Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Immune Effector Process B Cell Activation Cellular Developmental Process Adaptive Immune Response Fc-gamma Receptor Signaling Pathway Regulation Of Lymphocyte Activation Positive Regulation Of Cell Population Proliferation Intracellular Signaling Cassette Membrane Raft Cytokine-mediated Signaling Pathway Regulation Of Developmental Process Regulation Of Programmed Cell Death Leukocyte Differentiation Cell Differentiation Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction	Immune Response-regulating Signaling Pathway Signal Transduction Immune Response-activating Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Activation Of Immune Response Positive Regulation Of Immune Response Cell Surface Receptor Signaling Pathway Intracellular Signal Transduction Positive Regulation Of Immune System Process Regulation Of Immune Response Kinase Activity Regulation Of Signal Transduction Regulation Of Intracellular Signal Transduction Plasma Membrane Positive Regulation Of Intracellular Signal Transduction Immune System Process Regulation Of Signaling Regulation Of Cell Communication Regulation Of Immune System Process Positive Regulation Of Signal Transduction Innate Immune Response-activating Signaling Pathway Activation Of Innate Immune Response Positive Regulation Of Cellular Component Organization Positive Regulation Of Innate Immune Response Positive Regulation Of Cell Communication Positive Regulation Of Signaling Innate Immune Response Activating Cell Surface Receptor Signaling Pathway Protein Kinase Activity Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway B Cell Receptor Signaling Pathway Pattern Recognition Receptor Signaling Pathway Fc Receptor Signaling Pathway Intracellular Signaling Cassette Leukocyte Activation Cytoplasm Antigen Receptor-mediated Signaling Pathway Regulation Of Innate Immune Response Enzyme-linked Receptor Protein Signaling Pathway Positive Regulation Of Multicellular Organismal Process Positive Regulation Of Cellular Component Biogenesis Cell Activation Regulation Of Programmed Cell Death Positive Regulation Of Defense Response Positive Regulation Of Metabolic Process Toll-like Receptor Signaling Pathway Positive Regulation Of Gene Expression Cell Surface Pattern Recognition Receptor Signaling Pathway Response To Lipid Positive Regulation Of Canonical NF-kappaB Signal Transduction
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