SYK and ERBB4

Number of citations of the paper that reports this interaction (PMID 16273093)
170

Data Source:
BioGRID (unspecified method)

		SYK	ERBB4
Gene Name		spleen tyrosine kinase	erb-b2 receptor tyrosine kinase 4
Image
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Plasma Membrane B Cell Receptor Complex Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Early Phagosome T Cell Receptor Complex Protein Complex	Extracellular Region Nucleus Nucleoplasm Mitochondrion Mitochondrial Matrix Cytosol Plasma Membrane Integral Component Of Membrane Basolateral Plasma Membrane Receptor Complex
	Molecular Function	Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Receptor Signaling Protein Tyrosine Kinase Activity Integrin Binding Protein Binding ATP Binding Protein Kinase Binding	Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Receptor Signaling Protein Tyrosine Kinase Activity Epidermal Growth Factor Receptor Binding Protein Binding ATP Binding Protein Homodimerization Activity Transcription Regulatory Region DNA Binding
	Biological Process	Angiogenesis Lymph Vessel Development Adaptive Immune Response Macrophage Activation Involved In Immune Response Neutrophil Activation Involved In Immune Response Leukocyte Activation Involved In Immune Response Serotonin Secretion By Platelet Protein Phosphorylation Inflammatory Response Leukocyte Cell-cell Adhesion Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Integrin-mediated Signaling Pathway Activation Of JUN Kinase Activity Blood Coagulation Cell Proliferation Organ Morphogenesis Regulation Of Platelet Activation Viral Process Leukotriene Biosynthetic Process Platelet Activation Neutrophil Chemotaxis Regulation Of Superoxide Anion Generation Positive Regulation Of Cell Adhesion Mediated By Integrin Peptidyl-tyrosine Autophosphorylation Fc-epsilon Receptor Signaling Pathway Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Defense Response To Bacterium Transcription Factor Import Into Nucleus Positive Regulation Of Mast Cell Degranulation Regulation Of Neutrophil Degranulation Beta Selection Innate Immune Response Positive Regulation Of Interleukin-3 Biosynthetic Process Positive Regulation Of Granulocyte Macrophage Colony-stimulating Factor Biosynthetic Process Positive Regulation Of B Cell Differentiation Positive Regulation Of Gamma-delta T Cell Differentiation Positive Regulation Of Bone Resorption Positive Regulation Of Alpha-beta T Cell Differentiation Positive Regulation Of Alpha-beta T Cell Proliferation Blood Vessel Morphogenesis Positive Regulation Of Cytokine Secretion Positive Regulation Of Peptidyl-tyrosine Phosphorylation Regulation Of Phagocytosis Positive Regulation Of Calcium-mediated Signaling B Cell Receptor Signaling Pathway Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of ERK1 And ERK2 Cascade Cellular Response To Molecule Of Fungal Origin Regulation Of Arachidonic Acid Secretion Regulation Of Platelet Aggregation	Neural Crest Cell Migration Positive Regulation Of Protein Phosphorylation Transcription, DNA-templated Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway Nervous System Development Heart Development Lactation Cell Proliferation Positive Regulation Of Cell Proliferation Negative Regulation Of Cell Proliferation Fibroblast Growth Factor Receptor Signaling Pathway Embryonic Pattern Specification Cell Migration Peptidyl-tyrosine Phosphorylation Central Nervous System Morphogenesis Olfactory Bulb Interneuron Differentiation Signal Transduction By Phosphorylation Regulation Of Cell Migration Fc-epsilon Receptor Signaling Pathway Positive Regulation Of Tyrosine Phosphorylation Of Stat5 Protein Negative Regulation Of Apoptotic Process Positive Regulation Of Phosphatidylinositol 3-kinase Activity Mitochondrial Fragmentation Involved In Apoptotic Process Innate Immune Response Cell Fate Commitment Positive Regulation Of Transcription, DNA-templated Protein Autophosphorylation Neurotrophin TRK Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling Positive Regulation Of Cardiac Muscle Cell Proliferation Mammary Gland Epithelial Cell Differentiation Mammary Gland Alveolus Development Cardiac Muscle Tissue Regeneration Positive Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of STAT Protein Import Into Nucleus
Pathways		Signaling by the B Cell Receptor (BCR) FCERI mediated MAPK activation Platelet Aggregation (Plug Formation) DAP12 signaling Regulation of signaling by CBL Role of phospholipids in phagocytosis Fcgamma receptor (FCGR) dependent phagocytosis FCGR activation Regulation of actin dynamics for phagocytic cup formation Antigen activates B Cell Receptor (BCR) leading to generation of second messengers Innate Immune System DAP12 interactions Integrin alphaIIb beta3 signaling Cytokine Signaling in Immune system Role of LAT2/NTAL/LAB on calcium mobilization Signaling by Interleukins Fc epsilon receptor (FCERI) signaling GPVI-mediated activation cascade Interleukin-2 signaling FCERI mediated Ca+2 mobilization Platelet activation, signaling and aggregation Interleukin-3, 5 and GM-CSF signaling Adaptive Immune System
Drugs		Staurosporine N-(2-hydroxy-1,1-dimethylethyl)-1-methyl-3-(1H-pyrrolo[2,3-b]pyridin-2-yl)-1H-indole-5-carboxamide 6-({5-fluoro-2-[(3,4,5-trimethoxyphenyl)amino]pyrimidin-4-yl}amino)-2,2-dimethyl-2H-pyrido[3,2-b][1,4]oxazin-3(4H)-one 2-{2-[(3,5-dimethylphenyl)amino]pyrimidin-4-yl}-N-[(1S)-2-hydroxy-1-methylethyl]-4-methyl-1,3-thiazole-5-carboxamide 2-{[(1R,2S)-2-aminocyclohexyl]amino}-4-[(3-methylphenyl)amino]pyrimidine-5-carboxamide Ellagic Acid
Diseases
GWAS		Multiple sclerosis ( 21833088) Prostate cancer (gene x gene interaction) ( 22219177) Type 2 diabetes ( 22456796) Vascular dementia ( 23480133)	Breast cancer ( 22452962) Type 1 diabetes nephropathy ( 23028342)
Protein-Protein Interactions		98 interactors: APP BLNK BTK CALM1 CBL CBLB CD19 CD22 CD3E CD72 CD79A CD79B CRKL CSF2RB CSF3R CTTN DBNL DUSP3 EGFR EPOR ERBB2 ERBB3 ERBB4 FCER1G FCGR1A FCGR2A FCGR3A FCRL3 FGR FYN GAB2 GRB2 HCLS1 HDAC1 HDAC2 HDAC3 HDAC4 HDAC6 HDAC9 HNRNPU IL15RA IL2RB ITGB2 JAK1 LAT LAX1 LCK LCP2 LYN MAP4K1 MAPK3 MAPT MS4A2 NEDD4 NFAM1 PAG1 PIK3AP1 PIK3R1 PIK3R2 PLCG1 PLCG2 POU2AF1 PRKCA PRKD1 PTK2 PTK2B PTPN6 PXN RASA1 RPS10 RPS6KA1 RPS6KB1 RPS6KB2 SELPLG SH2B2 SH2D2A SH3BP2 SHC1 SIT1 SLA SLC4A1 SNCA SRC STAT1 STAT3 STAT5A TERF1 TLR4 TNFRSF1A TRAF6 TUBA1A TUBA4A TYROBP UBASH3B UBB USP25 VAV1 VAV2	39 interactors: ABL1 ABL2 ADAM17 ANKS1A ANKS1B BTC CD44 CRK CTGF DLG1 DLG2 DLG3 DLG4 EGFR ERBB2 ERBB3 EREG GRB2 HBEGF HDAC6 ITCH MUC1 NEDD4 NRG1 NRG2 NRG3 NRG4 PIK3R2 RASA1 RNF41 SHC1 SNTB2 STAT5A STAT5B SYK TAB2 TGFA TRO YAP1
Entrez ID		6850	2066
HPRD ID		02514	02767
Ensembl ID		ENSG00000165025	ENSG00000178568
Uniprot IDs		A8K4G2 P43405	Q15303
PDB IDs		1A81 1CSY 1CSZ 1XBA 1XBB 1XBC 3BUW 3EMG 3FQE 3FQH 3FQS 3SRV 3TUB 3TUC 3TUD 3VF8 3VF9 4DFL 4DFN 4F4P 4FL1 4FL2 4FL3 4FYN 4FYO 4FZ6 4FZ7 4GFG	2AHX 2L2T 2LCX 2R4B 3BBT 3BBW 3BCE 3U2P 3U7U 3U9U
Enriched GO Terms of Interacting Partners?		Immune Response-regulating Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Immune System Process Regulation Of Immune Response Regulation Of Immune System Process Cell Surface Receptor Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Innate Immune Response Defense Response Fc Receptor Signaling Pathway Immune Response Signal Transduction Cellular Response To Organic Substance Immune Response-activating Cell Surface Receptor Signaling Pathway Cell Communication Positive Regulation Of Immune Response Signaling Positive Regulation Of Immune System Process Cellular Response To Stimulus Cell Activation Neurotrophin TRK Receptor Signaling Pathway Response To Organic Substance Neurotrophin Signaling Pathway Intracellular Signal Transduction Response To Stress Fc-epsilon Receptor Signaling Pathway Regulation Of Signal Transduction Response To Growth Factor Epidermal Growth Factor Receptor Signaling Pathway Response To Stimulus ERBB Signaling Pathway Positive Regulation Of Signal Transduction Cellular Response To Growth Factor Stimulus Regulation Of Signaling Antigen Receptor-mediated Signaling Pathway Regulation Of Cell Activation Response To Wounding Blood Coagulation Hemostasis Wound Healing Regulation Of Body Fluid Levels Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Fibroblast Growth Factor Receptor Signaling Pathway Leukocyte Activation Regulation Of Phosphorylation Regulation Of Protein Metabolic Process Platelet Activation Positive Regulation Of Intracellular Signal Transduction	Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Fc Receptor Signaling Pathway Cell Communication Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Signaling Neurotrophin TRK Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Neurotrophin Signaling Pathway Response To Growth Factor Fibroblast Growth Factor Receptor Signaling Pathway Fc-epsilon Receptor Signaling Pathway Signal Transduction Regulation Of Signal Transduction Cell Surface Receptor Signaling Pathway Regulation Of Phosphorus Metabolic Process Immune Response Regulation Of Immune System Process Regulation Of Intracellular Signal Transduction Innate Immune Response Cellular Response To Growth Factor Stimulus Intracellular Signal Transduction Regulation Of Immune Response Positive Regulation Of Metabolic Process Positive Regulation Of Protein Metabolic Process Regulation Of Signaling Cellular Response To Stimulus Regulation Of Phosphorylation Immune System Process Phosphatidylinositol-mediated Signaling Locomotion Positive Regulation Of Signal Transduction Regulation Of Cell Proliferation Positive Regulation Of Cellular Metabolic Process Defense Response Response To Stimulus System Development Cellular Response To Organic Substance Response To Stress Positive Regulation Of Phosphorylation Regulation Of Protein Metabolic Process Multicellular Organismal Development Regulation Of Cellular Component Organization Positive Regulation Of Protein Phosphorylation Positive Regulation Of Protein Modification Process Regulation Of MAPK Cascade
Tagcloud ?		belongs bind binds blotting coimmunoprecipitation contribution cytokine domains epo epor erythroid erythropoietin far homology individually interaction jak2 mediate paper participated propose recombinant regulates sh2 src tandem tyrosine tyrosines ut7	180k 185k 45k activates encodes erbb2 exists fails glycoprotein heparin her4 heregulin intrinsic isoforms ligand mb453 mda oncogene p185erbb2 p45 presumed proto recombinant ref refs shares structurally transmembrane
Tagcloud (Difference) ?		belongs bind binds blotting coimmunoprecipitation contribution cytokine domains epo epor erythroid erythropoietin far homology individually interaction jak2 mediate paper participated propose regulates sh2 src tandem tyrosine tyrosines ut7	180k 185k 45k activates encodes erbb2 exists fails glycoprotein heparin her4 heregulin intrinsic isoforms ligand mb453 mda oncogene p185erbb2 p45 presumed proto ref refs shares structurally transmembrane
Tagcloud (Intersection) ?		recombinant