SYK and PTK2

Number of citations of the paper that reports this interaction (PubMedID 9169439)
0

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology)
HPRD (in vivo)

		SYK	PTK2
Description		spleen associated tyrosine kinase	protein tyrosine kinase 2
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Plasma Membrane Membrane B Cell Receptor Complex Early Phagosome Protein-containing Complex T Cell Receptor Complex	Stress Fiber Nucleus Cytoplasm Centrosome Cytosol Cytoskeleton Plasma Membrane Focal Adhesion Cilium Cell Cortex Membrane Ciliary Basal Body Cell Projection Perinuclear Region Of Cytoplasm Anchoring Junction
	Molecular Function	Nucleotide Binding Phosphotyrosine Residue Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Signaling Receptor Binding Integrin Binding Protein Binding ATP Binding Interleukin-15 Receptor Binding Kinase Activity Transferase Activity Protein Kinase Binding Phosphatase Binding Toll-like Receptor Binding SH2 Domain Binding Phospholipase Binding Scaffold Protein Binding	Nucleotide Binding Actin Binding Protein Kinase Activity Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Protein Tyrosine Phosphatase Activity Integrin Binding Protein Binding ATP Binding JUN Kinase Binding Kinase Activity Transferase Activity Protein Kinase Binding Protein Phosphatase Binding SH2 Domain Binding Molecular Function Activator Activity
	Biological Process	Autophagosome Assembly Angiogenesis Cell Activation Positive Regulation Of Cytokine Production Serotonin Secretion Lymph Vessel Development Positive Regulation Of Receptor Internalization Stimulatory C-type Lectin Receptor Signaling Pathway Adaptive Immune Response Macrophage Activation Involved In Immune Response Neutrophil Activation Involved In Immune Response Leukocyte Activation Involved In Immune Response Immune System Process Serotonin Secretion By Platelet Cell Surface Pattern Recognition Receptor Signaling Pathway Negative Regulation Of Inflammatory Response To Antigenic Stimulus Protein Phosphorylation Protein Import Into Nucleus Leukocyte Cell-cell Adhesion Cell Surface Receptor Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Integrin-mediated Signaling Pathway Animal Organ Morphogenesis Negative Regulation Of Autophagy Positive Regulation Of Autophagy Regulation Of Platelet Activation Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Peptidyl-tyrosine Phosphorylation Leukotriene Biosynthetic Process Calcium-mediated Signaling Platelet Activation B Cell Differentiation Neutrophil Chemotaxis Positive Regulation Of Protein-containing Complex Assembly Receptor Internalization Cellular Response To Nutrient Levels Positive Regulation Of Type I Interferon Production Positive Regulation Of Granulocyte Macrophage Colony-stimulating Factor Production Positive Regulation Of Interleukin-10 Production Positive Regulation Of Interleukin-12 Production Positive Regulation Of Interleukin-3 Production Positive Regulation Of Interleukin-4 Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Interleukin-8 Production Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Mast Cell Cytokine Production Regulation Of Superoxide Anion Generation Positive Regulation Of Superoxide Anion Generation Positive Regulation Of Cell Adhesion Mediated By Integrin Intracellular Signal Transduction Collagen-activated Tyrosine Kinase Receptor Signaling Pathway Fc-epsilon Receptor Signaling Pathway Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Interleukin-3-mediated Signaling Pathway TORC1 Signaling Gamma-delta T Cell Differentiation Defense Response To Bacterium Mast Cell Degranulation Positive Regulation Of Mast Cell Degranulation Regulation Of Neutrophil Degranulation Beta Selection Positive Regulation Of MAPK Cascade Innate Immune Response Positive Regulation Of B Cell Differentiation Positive Regulation Of Gamma-delta T Cell Differentiation Positive Regulation Of Lymphocyte Differentiation Positive Regulation Of Bone Resorption Positive Regulation Of Alpha-beta T Cell Differentiation Positive Regulation Of Alpha-beta T Cell Proliferation Blood Vessel Morphogenesis Regulation Of Phagocytosis Regulation Of Immune Response Positive Regulation Of Calcium-mediated Signaling B Cell Receptor Signaling Pathway Leukocyte Migration Regulation Of DNA-binding Transcription Factor Activity Establishment Of Localization In Cell Regulation Of ERK1 And ERK2 Cascade Cellular Response To Molecule Of Fungal Origin Cellular Response To Lipid Cellular Response To Low-density Lipoprotein Particle Stimulus Positive Regulation Of Monocyte Chemotactic Protein-1 Production Regulation Of Arachidonate Secretion Regulation Of Platelet Aggregation Apoptotic Signaling Pathway Amyloid-beta Clearance Positive Regulation Of Cold-induced Thermogenesis Negative Regulation Of TORC1 Signaling Positive Regulation Of TORC1 Signaling Cellular Response To Amyloid-beta Cellular Response To Lectin	Angiogenesis Placenta Development Regulation Of Protein Phosphorylation Positive Regulation Of Protein Phosphorylation Regulation Of Cell-matrix Adhesion Heart Morphogenesis Signal Complex Assembly Epidermal Growth Factor Receptor Signaling Pathway Transforming Growth Factor Beta Receptor Signaling Pathway Integrin-mediated Signaling Pathway Axon Guidance Positive Regulation Of Cell Population Proliferation Regulation Of Cell Shape Regulation Of Endothelial Cell Migration Regulation Of Epithelial Cell Migration Positive Regulation Of Epithelial Cell Migration Positive Regulation Of Epithelial To Mesenchymal Transition Positive Regulation Of Macrophage Chemotaxis Positive Regulation Of Fibroblast Migration Cell Migration Peptidyl-tyrosine Phosphorylation Negative Regulation Of Cell-cell Adhesion Establishment Of Cell Polarity Cell Differentiation Regulation Of Cell Adhesion Positive Regulation Of Cell Migration Regulation Of Cell Adhesion Mediated By Integrin Detection Of Muscle Stretch Netrin-activated Signaling Pathway Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Regulation Of Cell Population Proliferation Negative Regulation Of Apoptotic Process Regulation Of GTPase Activity Regulation Of Cell Differentiation Regulation Of Osteoblast Differentiation Positive Regulation Of Protein Kinase Activity Protein Autophosphorylation Vascular Endothelial Growth Factor Receptor Signaling Pathway Ephrin Receptor Signaling Pathway Cell Motility Regulation Of Multicellular Organismal Process Regulation Of Cytoskeleton Organization Regulation Of Focal Adhesion Assembly Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Growth Hormone Receptor Signaling Pathway Positive Regulation Of Wound Healing Vascular Endothelial Cell Response To Oscillatory Fluid Shear Stress Positive Regulation Of Macrophage Proliferation Regulation Of Substrate Adhesion-dependent Cell Spreading Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Anoikis
Pathways		GPVI-mediated activation cascade GPVI-mediated activation cascade FCGR activation FCGR activation Regulation of actin dynamics for phagocytic cup formation Role of phospholipids in phagocytosis DAP12 signaling Fc epsilon receptor (FCERI) signaling Fc epsilon receptor (FCERI) signaling Role of LAT2/NTAL/LAB on calcium mobilization Role of LAT2/NTAL/LAB on calcium mobilization FCERI mediated MAPK activation FCERI mediated Ca+2 mobilization FCERI mediated Ca+2 mobilization Integrin signaling CLEC7A (Dectin-1) signaling Dectin-2 family Dectin-2 family Interleukin-2 signaling Regulation of signaling by CBL Regulation of signaling by CBL FCGR3A-mediated IL10 synthesis FCGR3A-mediated phagocytosis Signaling by CSF3 (G-CSF) Signaling by CSF3 (G-CSF) Potential therapeutics for SARS Inactivation of CSF3 (G-CSF) signaling Inactivation of CSF3 (G-CSF) signaling FLT3 signaling through SRC family kinases Antigen activates B Cell Receptor (BCR) leading to generation of second messengers Antigen activates B Cell Receptor (BCR) leading to generation of second messengers	Apoptotic cleavage of cellular proteins Regulation of actin dynamics for phagocytic cup formation Integrin signaling GRB2:SOS provides linkage to MAPK signaling for Integrins p130Cas linkage to MAPK signaling for integrins NCAM signaling for neurite out-growth NCAM signaling for neurite out-growth Signal regulatory protein family interactions EPHB-mediated forward signaling EPHB-mediated forward signaling DCC mediated attractive signaling DCC mediated attractive signaling VEGFA-VEGFR2 Pathway VEGFA-VEGFR2 Pathway RHO GTPases Activate WASPs and WAVEs RAF/MAP kinase cascade MET activates PTK2 signaling Extra-nuclear estrogen signaling Estrogen-dependent nuclear events downstream of ESR-membrane signaling FCGR3A-mediated phagocytosis Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells
Drugs		Staurosporine N-(2-hydroxy-1,1-dimethylethyl)-1-methyl-3-(1H-pyrrolo[2,3-b]pyridin-2-yl)-1H-indole-5-carboxamide Tamatinib 2-{2-[(3,5-dimethylphenyl)amino]pyrimidin-4-yl}-N-[(1S)-2-hydroxy-1-methylethyl]-4-methyl-1,3-thiazole-5-carboxamide 2-{[(1R,2S)-2-aminocyclohexyl]amino}-4-[(3-methylphenyl)amino]pyrimidine-5-carboxamide Ellagic acid Fostamatinib Entospletinib	Endostatin 7-PYRIDIN-2-YL-N-(3,4,5-TRIMETHOXYPHENYL)-7H-PYRROLO[2,3-D]PYRIMIDIN-2-AMINE 2-({5-CHLORO-2-[(2-METHOXY-4-MORPHOLIN-4-YLPHENYL)AMINO]PYRIMIDIN-4-YL}AMINO)-N-METHYLBENZAMIDE Fostamatinib
Diseases
GWAS		Alzheimer's disease ( 30636644) Anti-saccade response ( 29064472) Atrial fibrillation ( 28416822) Chromosomal aberration frequency (total) ( 31586183) Frontal pole volume ( 31530798) Mean platelet volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Metabolite levels ( 23823483) Monocyte count ( 32888494) Multiple sclerosis ( 21833088) Multiple sclerosis and HDL levels (pleiotropy) ( 26920376) Platelet count ( 32888494) Platelet distribution width ( 32888494 27863252) Plateletcrit ( 32888494) Type 2 diabetes ( 22456796) Vascular dementia ( 23480133)	Acute graft versus host disease in bone marrow transplantation (recipient effect) ( 27595289) Apolipoprotein B levels ( 32203549) Appendicular lean mass ( 33097823) Atrial fibrillation ( 29892015 30061737) Deep white matter hyperintensities ( 32517579) Diastolic blood pressure ( 30224653) LDL cholesterol levels ( 32203549) Mean corpuscular hemoglobin ( 27863252) Mood instability ( 31168069) Multisite chronic pain ( 33830993) Nickel levels ( 26025379) PR interval ( 32439900) Red cell distribution width ( 32888494) Response to interferon beta therapy ( 21502966) Smoking status (ever vs never smokers) ( 30643258)
Interacting Genes		110 interacting genes: APP AR BLNK BTK CALM1 CBL CBLB CD19 CD22 CD3E CD72 CD79A CD79B CEBPA COASY CRKL CRYAA CSF2RB CSF3R CTTN DBNL DPP9 DUSP3 EGFR EPOR ERBB2 ERBB3 ERBB4 FCER1G FCGR1A FCGR2A FCGR3A FCRL3 FGR FYN GAB1 GAB2 GRB2 HCLS1 HDAC1 HDAC2 HDAC3 HDAC4 HDAC6 HDAC9 HGS HNRNPU IL15RA IL2RB ITGB2 JAK1 KIT LAT LAX1 LCK LCP2 LYN MAP4K1 MAPK3 MAPT MET MS4A2 NEDD4 NFAM1 PAG1 PIK3AP1 PIK3R1 PIK3R2 PLCG1 PLCG2 POU2AF1 PRKCA PRKD1 PTK2 PTK2B PTPN6 PXN RASA1 RHOU RPS10 RPS6KA1 RPS6KB1 RPS6KB2 SELPLG SH2B2 SH2D2A SH3BP2 SHC1 SIT1 SLA SLC4A1 SNCA SRC STAT1 STAT3 STAT5A TERF1 TLR4 TNFRSF1A TRAF6 TRIM15 TRIM31 TUBA1A TUBA4A TYROBP UBASH3B UBB USP25 VAV1 VAV2	117 interacting genes: ACTN1 APP ARHGAP26 ASAP1 ATG12 BBS10 BCAR1 BIN1 BMX CCR5 CD47 CD79B CIB1 CRK CSK CSPG4 CXCR4 DCC DDX39A DEF6 DLGAP3 DNM2 DOK4 EEF1G EFS EGFR EPHA2 EPHB2 EPS8L2 ERBB2 ERBB3 EZR FBP1 FGR FLT1 FLT4 FYN GIT1 GRB2 GRB7 GSK3B GZMB HES1 HSPA13 IGHM INSR IRS1 ITGAV ITGB1 ITGB2 ITGB3 ITGB4 ITGB5 JAK2 KCNB1 KCNMA1 LCK LPXN LYN MAPK8IP3 MDM2 MICAL1 MISP MORC3 NACAD NASP NCK1 NCK2 NEDD8 NEDD9 NEO1 PDGFRB PIAS1 PIK3R1 PIK3R3 PKD1 PLCG1 PPP1CB PTK2B PTPN11 PTPN12 PTPRH PXN RAC1 RB1CC1 RET RIPK1 ROCK1 SAE1 SELE SH2D1A SH2D1B SHC1 SKP2 SOCS1 SOCS2 SOCS3 SORBS1 SRC SRPK1 STAT1 SYK TGFB1I1 TLN1 TNFRSF1A TNS1 TNS3 TP53 TRIM15 TRIO TRIP6 TSC2 VCL WEE2-AS1 YES1 ZFYVE21 ZNF331
Entrez ID		6850	5747
HPRD ID		02514	02859
Ensembl ID		ENSG00000165025	ENSG00000169398
Uniprot IDs		C3W981 P43405	A0A8Q3WLM4 B4DWJ1 E5RFW9 E7ESA6 Q05397 Q59GM6 Q59GN8
PDB IDs		1A81 1CSY 1CSZ 1XBA 1XBB 1XBC 3BUW 3EMG 3FQE 3FQH 3FQS 3SRV 3TUB 3TUC 3TUD 3VF8 3VF9 4DFL 4DFN 4F4P 4FL1 4FL2 4FL3 4FYN 4FYO 4FZ6 4FZ7 4GFG 4I0R 4I0S 4I0T 4PUZ 4PV0 4PX6 4RSS 4RX7 4RX8 4RX9 4WNM 4XG2 4XG3 4XG4 4XG6 4XG7 4XG8 4XG9 4YJO 4YJP 4YJQ 4YJR 4YJS 4YJT 4YJU 4YJV 5C26 5C27 5CXH 5CXZ 5CY3 5GHV 5LMA 5LMB 5T68 5TIU 5TR6 5TT7 5Y5T 5Y5U 6HM6 6HM7 6SSB 6VOV 6ZC0 6ZCP 6ZCQ 6ZCR 6ZCS 6ZCU 6ZCX 6ZCY 7Q5T 7Q5U 7Q5W 7Q63 7SA7 8BI2 8RRQ 8RRZ 8WYW 8X5K 8XQ0 8XQ1 8XQ2	1K04 1K05 1MP8 1OW6 1OW7 1OW8 2ETM 2IJM 3B71 3BZ3 3PXK 3S9O 4EBV 4EBW 4GU6 4GU9 4I4E 4I4F 4K8A 4K9Y 4KAB 4KAO 4NY0 4Q9S 6I8Z 6LES 6PW8 6YOJ 6YQ1 6YR9 6YT6 6YVS 6YVY 6YXV 7PI4 7W7Z 7W8B 7W8I 7W9U
Enriched GO Terms of Interacting Partners?		Cell Surface Receptor Signaling Pathway Signal Transduction Immune Response-regulating Cell Surface Receptor Signaling Pathway Leukocyte Activation Cell Activation Immune System Process Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Immune System Process Immune Response-activating Cell Surface Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Positive Regulation Of Immune System Process Lymphocyte Activation Regulation Of Intracellular Signal Transduction Regulation Of Immune Response Enzyme-linked Receptor Protein Signaling Pathway Intracellular Signal Transduction Phosphotyrosine Residue Binding Regulation Of Signal Transduction Positive Regulation Of Intracellular Signal Transduction Regulation Of Multicellular Organismal Process Immune Response-activating Signaling Pathway Fc Receptor Signaling Pathway Regulation Of Cell Activation Activation Of Immune Response Regulation Of Signaling Regulation Of Cell Communication Plasma Membrane Antigen Receptor-mediated Signaling Pathway Positive Regulation Of Multicellular Organismal Process Positive Regulation Of Signal Transduction Positive Regulation Of Immune Response Positive Regulation Of Cell Communication Positive Regulation Of Signaling Immune Response Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Immune Effector Process B Cell Activation Cellular Developmental Process Adaptive Immune Response Fc-gamma Receptor Signaling Pathway Regulation Of Lymphocyte Activation Positive Regulation Of Cell Population Proliferation Intracellular Signaling Cassette Membrane Raft Cytokine-mediated Signaling Pathway Regulation Of Developmental Process Regulation Of Programmed Cell Death Leukocyte Differentiation Cell Differentiation Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction	Cell Surface Receptor Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Focal Adhesion Signal Transduction Cell Migration Cell Motility Regulation Of Signal Transduction Regulation Of Cell Communication Regulation Of Signaling Protein Tyrosine Kinase Activity Anchoring Junction Regulation Of Intracellular Signal Transduction Regulation Of Cell Adhesion Positive Regulation Of Signal Transduction Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Positive Regulation Of Locomotion Cell Adhesion Regulation Of MAPK Cascade Positive Regulation Of Cell Communication Positive Regulation Of Signaling Plasma Membrane Regulation Of Apoptotic Process Response To Growth Factor Positive Regulation Of Cell Adhesion Positive Regulation Of MAPK Cascade Phosphotyrosine Residue Binding Regulation Of Programmed Cell Death Peptidyl-tyrosine Phosphorylation Regulation Of Cell Migration Cellular Response To Growth Factor Stimulus Positive Regulation Of Immune System Process Regulation Of Cell Motility Regulation Of Cellular Component Organization Ruffle Membrane Integrin-mediated Signaling Pathway Regulation Of Locomotion Regulation Of Immune System Process Protein Kinase Activity Intracellular Signal Transduction Immune System Process Non-membrane Spanning Protein Tyrosine Kinase Activity Regulation Of Developmental Process Epidermal Growth Factor Receptor Signaling Pathway Cellular Response To Oxygen-containing Compound Protein Phosphorylation Receptor Complex Ephrin Receptor Signaling Pathway
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