SYK and RASA1

Number of citations of the paper that reports this interaction (PMID 9218456)
5

Data Source:
HPRD (in vitro)

		SYK	RASA1
Gene Name		spleen tyrosine kinase	RAS p21 protein activator (GTPase activating protein) 1
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Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Plasma Membrane B Cell Receptor Complex Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Early Phagosome T Cell Receptor Complex Protein Complex	Ruffle Cytoplasm Cytosol Intrinsic Component Of The Cytoplasmic Side Of The Plasma Membrane
	Molecular Function	Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Receptor Signaling Protein Tyrosine Kinase Activity Integrin Binding Protein Binding ATP Binding Protein Kinase Binding	Glycoprotein Binding Ras GTPase Activator Activity Receptor Binding Protein Binding Potassium Channel Inhibitor Activity GTPase Binding
	Biological Process	Angiogenesis Lymph Vessel Development Adaptive Immune Response Macrophage Activation Involved In Immune Response Neutrophil Activation Involved In Immune Response Leukocyte Activation Involved In Immune Response Serotonin Secretion By Platelet Protein Phosphorylation Inflammatory Response Leukocyte Cell-cell Adhesion Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Integrin-mediated Signaling Pathway Activation Of JUN Kinase Activity Blood Coagulation Cell Proliferation Organ Morphogenesis Regulation Of Platelet Activation Viral Process Leukotriene Biosynthetic Process Platelet Activation Neutrophil Chemotaxis Regulation Of Superoxide Anion Generation Positive Regulation Of Cell Adhesion Mediated By Integrin Peptidyl-tyrosine Autophosphorylation Fc-epsilon Receptor Signaling Pathway Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Defense Response To Bacterium Transcription Factor Import Into Nucleus Positive Regulation Of Mast Cell Degranulation Regulation Of Neutrophil Degranulation Beta Selection Innate Immune Response Positive Regulation Of Interleukin-3 Biosynthetic Process Positive Regulation Of Granulocyte Macrophage Colony-stimulating Factor Biosynthetic Process Positive Regulation Of B Cell Differentiation Positive Regulation Of Gamma-delta T Cell Differentiation Positive Regulation Of Bone Resorption Positive Regulation Of Alpha-beta T Cell Differentiation Positive Regulation Of Alpha-beta T Cell Proliferation Blood Vessel Morphogenesis Positive Regulation Of Cytokine Secretion Positive Regulation Of Peptidyl-tyrosine Phosphorylation Regulation Of Phagocytosis Positive Regulation Of Calcium-mediated Signaling B Cell Receptor Signaling Pathway Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of ERK1 And ERK2 Cascade Cellular Response To Molecule Of Fungal Origin Regulation Of Arachidonic Acid Secretion Regulation Of Platelet Aggregation	Mitotic Cytokinesis Vasculogenesis Negative Regulation Of Cell-matrix Adhesion Negative Regulation Of Cell Adhesion Signal Transduction Axon Guidance Regulation Of Cell Shape Embryo Development Regulation Of Actin Filament Polymerization Positive Regulation Of Ras GTPase Activity Intracellular Signal Transduction Negative Regulation Of Neuron Apoptotic Process Negative Regulation Of Ras Protein Signal Transduction Vascular Endothelial Growth Factor Receptor Signaling Pathway Ephrin Receptor Signaling Pathway Blood Vessel Morphogenesis Regulation Of RNA Metabolic Process
Pathways		Signaling by the B Cell Receptor (BCR) FCERI mediated MAPK activation Platelet Aggregation (Plug Formation) DAP12 signaling Regulation of signaling by CBL Role of phospholipids in phagocytosis Fcgamma receptor (FCGR) dependent phagocytosis FCGR activation Regulation of actin dynamics for phagocytic cup formation Antigen activates B Cell Receptor (BCR) leading to generation of second messengers Innate Immune System DAP12 interactions Integrin alphaIIb beta3 signaling Cytokine Signaling in Immune system Role of LAT2/NTAL/LAB on calcium mobilization Signaling by Interleukins Fc epsilon receptor (FCERI) signaling GPVI-mediated activation cascade Interleukin-2 signaling FCERI mediated Ca+2 mobilization Platelet activation, signaling and aggregation Interleukin-3, 5 and GM-CSF signaling Adaptive Immune System	Signaling by PDGF EPHB-mediated forward signaling Axon guidance VEGFR2 mediated cell proliferation Signaling by VEGF Downstream signal transduction EPH-Ephrin signaling VEGFA-VEGFR2 Pathway
Drugs		Staurosporine N-(2-hydroxy-1,1-dimethylethyl)-1-methyl-3-(1H-pyrrolo[2,3-b]pyridin-2-yl)-1H-indole-5-carboxamide 6-({5-fluoro-2-[(3,4,5-trimethoxyphenyl)amino]pyrimidin-4-yl}amino)-2,2-dimethyl-2H-pyrido[3,2-b][1,4]oxazin-3(4H)-one 2-{2-[(3,5-dimethylphenyl)amino]pyrimidin-4-yl}-N-[(1S)-2-hydroxy-1-methylethyl]-4-methyl-1,3-thiazole-5-carboxamide 2-{[(1R,2S)-2-aminocyclohexyl]amino}-4-[(3-methylphenyl)amino]pyrimidine-5-carboxamide Ellagic Acid
Diseases
GWAS		Multiple sclerosis ( 21833088) Prostate cancer (gene x gene interaction) ( 22219177) Type 2 diabetes ( 22456796) Vascular dementia ( 23480133)	Major depressive disorder ( 23377640) Personality dimensions ( 21173776)
Protein-Protein Interactions		98 interactors: APP BLNK BTK CALM1 CBL CBLB CD19 CD22 CD3E CD72 CD79A CD79B CRKL CSF2RB CSF3R CTTN DBNL DUSP3 EGFR EPOR ERBB2 ERBB3 ERBB4 FCER1G FCGR1A FCGR2A FCGR3A FCRL3 FGR FYN GAB2 GRB2 HCLS1 HDAC1 HDAC2 HDAC3 HDAC4 HDAC6 HDAC9 HNRNPU IL15RA IL2RB ITGB2 JAK1 LAT LAX1 LCK LCP2 LYN MAP4K1 MAPK3 MAPT MS4A2 NEDD4 NFAM1 PAG1 PIK3AP1 PIK3R1 PIK3R2 PLCG1 PLCG2 POU2AF1 PRKCA PRKD1 PTK2 PTK2B PTPN6 PXN RASA1 RPS10 RPS6KA1 RPS6KB1 RPS6KB2 SELPLG SH2B2 SH2D2A SH3BP2 SHC1 SIT1 SLA SLC4A1 SNCA SRC STAT1 STAT3 STAT5A TERF1 TLR4 TNFRSF1A TRAF6 TUBA1A TUBA4A TYROBP UBASH3B UBB USP25 VAV1 VAV2	73 interactors: ABL1 AFAP1L2 ANXA6 APP ARHGAP1 ARHGAP5 AURKB BBS10 BCR BIRC5 CASP3 CASP7 CAV2 CD5 CSF1R CSK DNAJA3 DOK1 DOK2 DOK4 EGFR EIF1 EPHA2 EPHB2 EPHB3 ERBB2 ERBB3 ERBB4 EZH2 FES G3BP1 GNB2L1 GRB2 HCK HRAS HSPD1 HTT IGF1R INSR KDR KHDRBS1 KIT LCK LYN MAGI1 MAP4K4 NCK1 NTRK1 PAG1 PDE6D PDGFRB PIK3R1 PTK2B PTPRC PXN RAB5A RAP1A SERPINA4 SHC1 SLC9A2 SOCS3 SPSB1 SRC STAU1 SYK SYN1 TRMT2A WWP1 WWP2 XRCC6 YES1 ZAP70 ZNF579
Entrez ID		6850	5921
HPRD ID		02514	00745
Ensembl ID		ENSG00000165025	ENSG00000145715
Uniprot IDs		A8K4G2 P43405	B4DTL2 E9PGC0 P20936 Q59GK3
PDB IDs		1A81 1CSY 1CSZ 1XBA 1XBB 1XBC 3BUW 3EMG 3FQE 3FQH 3FQS 3SRV 3TUB 3TUC 3TUD 3VF8 3VF9 4DFL 4DFN 4F4P 4FL1 4FL2 4FL3 4FYN 4FYO 4FZ6 4FZ7 4GFG	1WER 1WQ1 2GQI 2GSB 2J05 2J06 2M51 4FSS
Enriched GO Terms of Interacting Partners?		Immune Response-regulating Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Immune System Process Regulation Of Immune Response Regulation Of Immune System Process Cell Surface Receptor Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Innate Immune Response Defense Response Fc Receptor Signaling Pathway Immune Response Signal Transduction Cellular Response To Organic Substance Immune Response-activating Cell Surface Receptor Signaling Pathway Cell Communication Positive Regulation Of Immune Response Signaling Positive Regulation Of Immune System Process Cellular Response To Stimulus Cell Activation Neurotrophin TRK Receptor Signaling Pathway Response To Organic Substance Neurotrophin Signaling Pathway Intracellular Signal Transduction Response To Stress Fc-epsilon Receptor Signaling Pathway Regulation Of Signal Transduction Response To Growth Factor Epidermal Growth Factor Receptor Signaling Pathway Response To Stimulus ERBB Signaling Pathway Positive Regulation Of Signal Transduction Cellular Response To Growth Factor Stimulus Regulation Of Signaling Antigen Receptor-mediated Signaling Pathway Regulation Of Cell Activation Response To Wounding Blood Coagulation Hemostasis Wound Healing Regulation Of Body Fluid Levels Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Fibroblast Growth Factor Receptor Signaling Pathway Leukocyte Activation Regulation Of Phosphorylation Regulation Of Protein Metabolic Process Platelet Activation Positive Regulation Of Intracellular Signal Transduction	Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Peptidyl-tyrosine Phosphorylation Protein Autophosphorylation Regulation Of Signaling Regulation Of Phosphorylation Regulation Of Signal Transduction Peptidyl-tyrosine Autophosphorylation Regulation Of Phosphorus Metabolic Process Positive Regulation Of Signal Transduction Regulation Of Catalytic Activity Regulation Of Kinase Activity Regulation Of Intracellular Signal Transduction Regulation Of MAPK Cascade Intracellular Signal Transduction Regulation Of Protein Phosphorylation Positive Regulation Of Intracellular Signal Transduction Regulation Of Protein Kinase Activity Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Cellular Protein Metabolic Process ERBB Signaling Pathway Peptidyl-amino Acid Modification Cell Surface Receptor Signaling Pathway Signal Transduction Protein Phosphorylation Immune Response-regulating Cell Surface Receptor Signaling Pathway Signaling Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Cell Communication Regulation Of Cell Proliferation Immune Response-regulating Signaling Pathway Positive Regulation Of Catalytic Activity Innate Immune Response Positive Regulation Of MAPK Cascade Cellular Response To Stimulus Immune System Process Locomotion Regulation Of Protein Metabolic Process Positive Regulation Of Phosphorylation Regulation Of ERK1 And ERK2 Cascade Regulation Of Immune Response Regulation Of Cell Adhesion Positive Regulation Of Protein Phosphorylation Phosphorylation Response To Stimulus Regulation Of Cellular Component Organization Regulation Of Immune System Process Fc Receptor Signaling Pathway Cellular Response To Organonitrogen Compound
Tagcloud ?		belongs bind binds blotting coimmunoprecipitation contribution cytokine domains epo epor erythroid erythropoietin far homology individually interaction jak2 mediate paper participated propose recombinant regulates sh2 src tandem tyrosine tyrosines ut7	adaptors assumptions combinatorial complexity cooperativity dealt demodification descriptions disallow hinders hoc lumped modelling obstacle ode odes ordinary pharmacology phosphatases plcgamma1 reasonably relaxed retaining shc1 shp2 simulate subdomains tyrosines unphosphorylated
Tagcloud (Difference) ?		belongs bind binds blotting coimmunoprecipitation contribution cytokine domains epo epor erythroid erythropoietin far homology individually interaction jak2 mediate paper participated propose recombinant regulates sh2 src tandem tyrosine ut7	adaptors assumptions combinatorial complexity cooperativity dealt demodification descriptions disallow hinders hoc lumped modelling obstacle ode odes ordinary pharmacology phosphatases plcgamma1 reasonably relaxed retaining shc1 shp2 simulate subdomains unphosphorylated
Tagcloud (Intersection) ?		tyrosines