SYK and TLR4

Number of citations of the paper that reports this interaction (PubMedID 23962979)
0

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo)

		SYK	TLR4
Description		spleen associated tyrosine kinase	toll like receptor 4
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Plasma Membrane Membrane B Cell Receptor Complex Early Phagosome Protein-containing Complex T Cell Receptor Complex	Ruffle Phagocytic Cup Cytoplasm Endosome Early Endosome Plasma Membrane External Side Of Plasma Membrane Cell Surface Endosome Membrane Membrane Cell Projection Receptor Complex Lipopolysaccharide Receptor Complex Perinuclear Region Of Cytoplasm
	Molecular Function	Nucleotide Binding Phosphotyrosine Residue Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Signaling Receptor Binding Integrin Binding Protein Binding ATP Binding Interleukin-15 Receptor Binding Kinase Activity Transferase Activity Protein Kinase Binding Phosphatase Binding Toll-like Receptor Binding SH2 Domain Binding Phospholipase Binding Scaffold Protein Binding	Lipopolysaccharide Binding Amyloid-beta Binding Lipopolysaccharide Immune Receptor Activity Transmembrane Signaling Receptor Activity Signaling Receptor Binding Protein Binding Signaling Receptor Activity Identical Protein Binding Protein Heterodimerization Activity NAD+ Nucleosidase Activity, Cyclic ADP-ribose Generating
	Biological Process	Autophagosome Assembly Angiogenesis Cell Activation Positive Regulation Of Cytokine Production Serotonin Secretion Lymph Vessel Development Positive Regulation Of Receptor Internalization Stimulatory C-type Lectin Receptor Signaling Pathway Adaptive Immune Response Macrophage Activation Involved In Immune Response Neutrophil Activation Involved In Immune Response Leukocyte Activation Involved In Immune Response Immune System Process Serotonin Secretion By Platelet Cell Surface Pattern Recognition Receptor Signaling Pathway Negative Regulation Of Inflammatory Response To Antigenic Stimulus Protein Phosphorylation Protein Import Into Nucleus Leukocyte Cell-cell Adhesion Cell Surface Receptor Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Integrin-mediated Signaling Pathway Animal Organ Morphogenesis Negative Regulation Of Autophagy Positive Regulation Of Autophagy Regulation Of Platelet Activation Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Peptidyl-tyrosine Phosphorylation Leukotriene Biosynthetic Process Calcium-mediated Signaling Platelet Activation B Cell Differentiation Neutrophil Chemotaxis Positive Regulation Of Protein-containing Complex Assembly Receptor Internalization Cellular Response To Nutrient Levels Positive Regulation Of Type I Interferon Production Positive Regulation Of Granulocyte Macrophage Colony-stimulating Factor Production Positive Regulation Of Interleukin-10 Production Positive Regulation Of Interleukin-12 Production Positive Regulation Of Interleukin-3 Production Positive Regulation Of Interleukin-4 Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Interleukin-8 Production Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Mast Cell Cytokine Production Regulation Of Superoxide Anion Generation Positive Regulation Of Superoxide Anion Generation Positive Regulation Of Cell Adhesion Mediated By Integrin Intracellular Signal Transduction Collagen-activated Tyrosine Kinase Receptor Signaling Pathway Fc-epsilon Receptor Signaling Pathway Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Interleukin-3-mediated Signaling Pathway TORC1 Signaling Gamma-delta T Cell Differentiation Defense Response To Bacterium Mast Cell Degranulation Positive Regulation Of Mast Cell Degranulation Regulation Of Neutrophil Degranulation Beta Selection Positive Regulation Of MAPK Cascade Innate Immune Response Positive Regulation Of B Cell Differentiation Positive Regulation Of Gamma-delta T Cell Differentiation Positive Regulation Of Lymphocyte Differentiation Positive Regulation Of Bone Resorption Positive Regulation Of Alpha-beta T Cell Differentiation Positive Regulation Of Alpha-beta T Cell Proliferation Blood Vessel Morphogenesis Regulation Of Phagocytosis Regulation Of Immune Response Positive Regulation Of Calcium-mediated Signaling B Cell Receptor Signaling Pathway Leukocyte Migration Regulation Of DNA-binding Transcription Factor Activity Establishment Of Localization In Cell Regulation Of ERK1 And ERK2 Cascade Cellular Response To Molecule Of Fungal Origin Cellular Response To Lipid Cellular Response To Low-density Lipoprotein Particle Stimulus Positive Regulation Of Monocyte Chemotactic Protein-1 Production Regulation Of Arachidonate Secretion Regulation Of Platelet Aggregation Apoptotic Signaling Pathway Amyloid-beta Clearance Positive Regulation Of Cold-induced Thermogenesis Negative Regulation Of TORC1 Signaling Positive Regulation Of TORC1 Signaling Cellular Response To Amyloid-beta Cellular Response To Lectin	Activation Of Innate Immune Response Toll-like Receptor Signaling Pathway Wound Healing Involved In Inflammatory Response B Cell Proliferation Involved In Immune Response Immune System Process Nitric Oxide Production Involved In Inflammatory Response Regulation Of Dendritic Cell Cytokine Production MyD88-dependent Toll-like Receptor Signaling Pathway Nitric Oxide Biosynthetic Process Phagocytosis Defense Response Inflammatory Response Immune Response Signal Transduction Canonical NF-kappaB Signal Transduction JNK Cascade Response To Bacterium Gene Expression Positive Regulation Of Platelet Activation Positive Regulation Of Gene Expression Astrocyte Development Microglia Differentiation Positive Regulation Of Smooth Muscle Cell Migration Detection Of Fungus Neurogenesis Signal Transduction Involved In Regulation Of Gene Expression Positive Regulation Of B Cell Proliferation Lipopolysaccharide-mediated Signaling Pathway Response To Lipopolysaccharide Detection Of Lipopolysaccharide Regulation Of Tumor Necrosis Factor Production Negative Regulation Of Type II Interferon Production Negative Regulation Of Interleukin-17 Production Negative Regulation Of Interleukin-23 Production Negative Regulation Of Interleukin-6 Production Negative Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Chemokine Production Positive Regulation Of Interferon-alpha Production Positive Regulation Of Interferon-beta Production Positive Regulation Of Type II Interferon Production Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of Interleukin-1 Production Positive Regulation Of Interleukin-10 Production Positive Regulation Of Interleukin-12 Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Interleukin-8 Production Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Stress-activated MAPK Cascade Toll-like Receptor 4 Signaling Pathway Regulation Of Toll-like Receptor 4 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway Cellular Response To Platelet-derived Growth Factor Stimulus T-helper 1 Type Immune Response B Cell Proliferation Macrophage Activation Defense Response To Bacterium Positive Regulation Of Macrophage Activation Positive Regulation Of Canonical NF-kappaB Signal Transduction Innate Immune Response Leukocyte Activation MHC Class II Biosynthetic Process Positive Regulation Of MHC Class II Biosynthetic Process Positive Regulation Of Nitric Oxide Biosynthetic Process Negative Regulation Of Osteoclast Differentiation Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of JNK Cascade Lymphocyte Proliferation Positive Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Lymphocyte Proliferation Regulation Of Inflammatory Response Positive Regulation Of Inflammatory Response Defense Response To Gram-negative Bacterium Positive Regulation Of NF-kappaB Transcription Factor Activity NK T Cell Activation Stress-activated MAPK Cascade Detection Of Stimulus Intestinal Epithelial Structure Maintenance Positive Regulation Of Macrophage Cytokine Production ERK1 And ERK2 Cascade Negative Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of ERK1 And ERK2 Cascade Nucleotide-binding Oligomerization Domain Containing 1 Signaling Pathway Positive Regulation Of Nucleotide-binding Oligomerization Domain Containing 1 Signaling Pathway Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway Positive Regulation Of Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway Cellular Response To Lipopolysaccharide Cellular Response To Lipoteichoic Acid Cellular Response To Mechanical Stimulus Cellular Response To Type II Interferon Negative Regulation Of Cold-induced Thermogenesis Cellular Response To Oxidised Low-density Lipoprotein Particle Stimulus Negative Regulation Of Cytokine Production Involved In Inflammatory Response Positive Regulation Of Cytokine Production Involved In Inflammatory Response Positive Regulation Of NLRP3 Inflammasome Complex Assembly Positive Regulation Of Reactive Oxygen Species Biosynthetic Process Positive Regulation Of Cellular Response To Macrophage Colony-stimulating Factor Stimulus Positive Regulation Of Matrix Metallopeptidase Secretion Cellular Response To Amyloid-beta Positive Regulation Of Chemokine (C-X-C Motif) Ligand 2 Production Positive Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways		GPVI-mediated activation cascade GPVI-mediated activation cascade FCGR activation FCGR activation Regulation of actin dynamics for phagocytic cup formation Role of phospholipids in phagocytosis DAP12 signaling Fc epsilon receptor (FCERI) signaling Fc epsilon receptor (FCERI) signaling Role of LAT2/NTAL/LAB on calcium mobilization Role of LAT2/NTAL/LAB on calcium mobilization FCERI mediated MAPK activation FCERI mediated Ca+2 mobilization FCERI mediated Ca+2 mobilization Integrin signaling CLEC7A (Dectin-1) signaling Dectin-2 family Dectin-2 family Interleukin-2 signaling Regulation of signaling by CBL Regulation of signaling by CBL FCGR3A-mediated IL10 synthesis FCGR3A-mediated phagocytosis Signaling by CSF3 (G-CSF) Signaling by CSF3 (G-CSF) Potential therapeutics for SARS Inactivation of CSF3 (G-CSF) signaling Inactivation of CSF3 (G-CSF) signaling FLT3 signaling through SRC family kinases Antigen activates B Cell Receptor (BCR) leading to generation of second messengers Antigen activates B Cell Receptor (BCR) leading to generation of second messengers	ER-Phagosome pathway Caspase activation via Death Receptors in the presence of ligand Toll Like Receptor 4 (TLR4) Cascade MyD88:MAL(TIRAP) cascade initiated on plasma membrane MyD88-independent TLR4 cascade TRIF-mediated programmed cell death MyD88 deficiency (TLR2/4) IRAK4 deficiency (TLR2/4) Regulation of TLR by endogenous ligand Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) IKK complex recruitment mediated by RIP1 TRAF6-mediated induction of TAK1 complex within TLR4 complex Heme signaling IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation Respiratory syncytial virus (RSV) attachment and entry Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 RSV-host interactions
Drugs		Staurosporine N-(2-hydroxy-1,1-dimethylethyl)-1-methyl-3-(1H-pyrrolo[2,3-b]pyridin-2-yl)-1H-indole-5-carboxamide Tamatinib 2-{2-[(3,5-dimethylphenyl)amino]pyrimidin-4-yl}-N-[(1S)-2-hydroxy-1-methylethyl]-4-methyl-1,3-thiazole-5-carboxamide 2-{[(1R,2S)-2-aminocyclohexyl]amino}-4-[(3-methylphenyl)amino]pyrimidine-5-carboxamide Ellagic acid Fostamatinib Entospletinib	Cyclobenzaprine Naloxone (R)-3-hydroxytetradecanoic acid Lauric acid Eritoran Golotimod E5531 Myristic acid Papain Mifamurtide
Diseases			Macular degeneration, including: Age-related macular degeneration (ARMD); Patterned dystrophy of retinal pigment epithelium (PDREP); Retinal macular dystrophy 2 (MCDR2); X-linked atrophic macular degeneration (MDXLA)
GWAS		Alzheimer's disease ( 30636644) Anti-saccade response ( 29064472) Atrial fibrillation ( 28416822) Chromosomal aberration frequency (total) ( 31586183) Frontal pole volume ( 31530798) Mean platelet volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Metabolite levels ( 23823483) Monocyte count ( 32888494) Multiple sclerosis ( 21833088) Multiple sclerosis and HDL levels (pleiotropy) ( 26920376) Platelet count ( 32888494) Platelet distribution width ( 32888494 27863252) Plateletcrit ( 32888494) Type 2 diabetes ( 22456796) Vascular dementia ( 23480133)	Adult body size ( 32376654) BMI (adjusted for smoking behaviour) ( 28443625) BMI in non-smokers ( 28443625) Body mass index ( 25673413 28448500) Body mass index (joint analysis main effects and physical activity interaction) ( 28448500) Body mass index (joint analysis main effects and smoking interaction) ( 28443625) Body mass index in physically active individuals ( 28448500) Body size at age 10 ( 32376654) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Cognitive decline rate in late mild cognitive impairment ( 26252872) Daytime nap ( 33568662) Experiencing mood swings ( 29500382) Feeling fed-up ( 29500382) Feeling guilty ( 29500382) Impulsivity (motor) ( 30718321) Irritable mood ( 29500382) LDL cholesterol levels in HIV infection ( 33109212) Metabolite levels ( 23823483) Neurociticism ( 29500382) Neuroticism ( 29255261) Obesity-related traits ( 23251661) Osteoarthritis biomarkers ( 25057126) Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid) ( 24823311) Prostate-specific antigen levels ( 28139693) Triglyceride levels in HIV infection ( 33109212) Voxel-wise structural brain imaging measurements in Alzheimer’s disease ( 30584014)
Interacting Genes		110 interacting genes: APP AR BLNK BTK CALM1 CBL CBLB CD19 CD22 CD3E CD72 CD79A CD79B CEBPA COASY CRKL CRYAA CSF2RB CSF3R CTTN DBNL DPP9 DUSP3 EGFR EPOR ERBB2 ERBB3 ERBB4 FCER1G FCGR1A FCGR2A FCGR3A FCRL3 FGR FYN GAB1 GAB2 GRB2 HCLS1 HDAC1 HDAC2 HDAC3 HDAC4 HDAC6 HDAC9 HGS HNRNPU IL15RA IL2RB ITGB2 JAK1 KIT LAT LAX1 LCK LCP2 LYN MAP4K1 MAPK3 MAPT MET MS4A2 NEDD4 NFAM1 PAG1 PIK3AP1 PIK3R1 PIK3R2 PLCG1 PLCG2 POU2AF1 PRKCA PRKD1 PTK2 PTK2B PTPN6 PXN RASA1 RHOU RPS10 RPS6KA1 RPS6KB1 RPS6KB2 SELPLG SH2B2 SH2D2A SH3BP2 SHC1 SIT1 SLA SLC4A1 SNCA SRC STAT1 STAT3 STAT5A TERF1 TLR4 TNFRSF1A TRAF6 TRIM15 TRIM31 TUBA1A TUBA4A TYROBP UBASH3B UBB USP25 VAV1 VAV2	26 interacting genes: BCL10 BTK CD14 CNPY4 DEFB4A FN1 HMGB1 HSP90B1 IRAK1 IRAK2 LY96 MAPK8IP3 MYD88 NOX4 RIPK2 RNF216 SERTAD1 SIGIRR SMAD3 SYK TICAM2 TIRAP TLR1 TLR5 TOLLIP UBQLN1
Entrez ID		6850	7099
HPRD ID		02514	04325
Ensembl ID		ENSG00000165025	ENSG00000136869
Uniprot IDs		C3W981 P43405	O00206
PDB IDs		1A81 1CSY 1CSZ 1XBA 1XBB 1XBC 3BUW 3EMG 3FQE 3FQH 3FQS 3SRV 3TUB 3TUC 3TUD 3VF8 3VF9 4DFL 4DFN 4F4P 4FL1 4FL2 4FL3 4FYN 4FYO 4FZ6 4FZ7 4GFG 4I0R 4I0S 4I0T 4PUZ 4PV0 4PX6 4RSS 4RX7 4RX8 4RX9 4WNM 4XG2 4XG3 4XG4 4XG6 4XG7 4XG8 4XG9 4YJO 4YJP 4YJQ 4YJR 4YJS 4YJT 4YJU 4YJV 5C26 5C27 5CXH 5CXZ 5CY3 5GHV 5LMA 5LMB 5T68 5TIU 5TR6 5TT7 5Y5T 5Y5U 6HM6 6HM7 6SSB 6VOV 6ZC0 6ZCP 6ZCQ 6ZCR 6ZCS 6ZCU 6ZCX 6ZCY 7Q5T 7Q5U 7Q5W 7Q63 7SA7 8BI2 8RRQ 8RRZ 8WYW 8X5K 8XQ0 8XQ1 8XQ2	2Z62 2Z63 2Z65 2Z66 3FXI 3UL7 3UL8 3UL9 3ULA 4G8A 5NAM 5NAO 8WO1 8WTA
Enriched GO Terms of Interacting Partners?		Cell Surface Receptor Signaling Pathway Signal Transduction Immune Response-regulating Cell Surface Receptor Signaling Pathway Leukocyte Activation Cell Activation Immune System Process Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Immune System Process Immune Response-activating Cell Surface Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Positive Regulation Of Immune System Process Lymphocyte Activation Regulation Of Intracellular Signal Transduction Regulation Of Immune Response Enzyme-linked Receptor Protein Signaling Pathway Intracellular Signal Transduction Phosphotyrosine Residue Binding Regulation Of Signal Transduction Positive Regulation Of Intracellular Signal Transduction Regulation Of Multicellular Organismal Process Immune Response-activating Signaling Pathway Fc Receptor Signaling Pathway Regulation Of Cell Activation Activation Of Immune Response Regulation Of Signaling Regulation Of Cell Communication Plasma Membrane Antigen Receptor-mediated Signaling Pathway Positive Regulation Of Multicellular Organismal Process Positive Regulation Of Signal Transduction Positive Regulation Of Immune Response Positive Regulation Of Cell Communication Positive Regulation Of Signaling Immune Response Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Immune Effector Process B Cell Activation Cellular Developmental Process Adaptive Immune Response Fc-gamma Receptor Signaling Pathway Regulation Of Lymphocyte Activation Positive Regulation Of Cell Population Proliferation Intracellular Signaling Cassette Membrane Raft Cytokine-mediated Signaling Pathway Regulation Of Developmental Process Regulation Of Programmed Cell Death Leukocyte Differentiation Cell Differentiation Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction	Activation Of Innate Immune Response Positive Regulation Of Innate Immune Response Pattern Recognition Receptor Signaling Pathway Toll-like Receptor Signaling Pathway Innate Immune Response-activating Signaling Pathway Regulation Of Innate Immune Response Cell Surface Pattern Recognition Receptor Signaling Pathway Regulation Of Defense Response Innate Immune Response Activating Cell Surface Receptor Signaling Pathway Cell Surface Toll-like Receptor Signaling Pathway Positive Regulation Of Defense Response Defense Response Regulation Of Cytokine Production Activation Of Immune Response Positive Regulation Of Tumor Necrosis Factor Superfamily Cytokine Production Immune Response-activating Cell Surface Receptor Signaling Pathway Toll-like Receptor 4 Signaling Pathway Immune Response-activating Signaling Pathway Regulation Of Immune Response Response To Stress Cellular Response To Molecule Of Bacterial Origin Regulation Of Type I Interferon Production Innate Immune Response Immune Response-regulating Cell Surface Receptor Signaling Pathway Positive Regulation Of Cytokine Production Positive Regulation Of Immune Response Inflammatory Response Immune Response-regulating Signaling Pathway Response To Other Organism Response To Molecule Of Bacterial Origin Defense Response To Symbiont Positive Regulation Of Interleukin-8 Production Defense Response To Other Organism Positive Regulation Of Tumor Necrosis Factor Production Lipopolysaccharide-mediated Signaling Pathway Cellular Response To Oxygen-containing Compound Response To External Biotic Stimulus Regulation Of Immune System Process Response To Lipopolysaccharide Positive Regulation Of Signal Transduction Regulation Of Interleukin-8 Production Positive Regulation Of Type I Interferon Production Positive Regulation Of Interleukin-6 Production Immune Response Positive Regulation Of Immune System Process Positive Regulation Of Pattern Recognition Receptor Signaling Pathway Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Tumor Necrosis Factor Production Cellular Response To Lipopolysaccharide
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