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SYK and TUBA1A
Number of citations of the paper that reports this interaction (PubMedID
10862713
)
0
Data Source:
HPRD
(in vitro)
SYK
TUBA1A
Description
spleen associated tyrosine kinase
tubulin alpha 1a
Image
GO Annotations
Cellular Component
Nucleus
Cytoplasm
Cytosol
Plasma Membrane
Membrane
B Cell Receptor Complex
Early Phagosome
Protein-containing Complex
T Cell Receptor Complex
Condensed Chromosome
Nucleus
Cytoplasm
Cytosol
Cytoskeleton
Microtubule
Axonemal Microtubule
Cytoplasmic Microtubule
Plasma Membrane
Cilium
Microtubule Cytoskeleton
Motile Cilium
Neuromuscular Junction
Sperm Flagellum
Cytoplasmic Ribonucleoprotein Granule
Cell Projection
Synapse
Recycling Endosome
Extracellular Exosome
Molecular Function
Nucleotide Binding
Phosphotyrosine Residue Binding
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
Protein Tyrosine Kinase Activity
Non-membrane Spanning Protein Tyrosine Kinase Activity
Signaling Receptor Binding
Integrin Binding
Protein Binding
ATP Binding
Interleukin-15 Receptor Binding
Kinase Activity
Transferase Activity
Protein Kinase Binding
Phosphatase Binding
Toll-like Receptor Binding
SH2 Domain Binding
Phospholipase Binding
Scaffold Protein Binding
Nucleotide Binding
Structural Molecule Activity
Structural Constituent Of Cytoskeleton
Protein Binding
GTP Binding
Hydrolase Activity
Identical Protein Binding
Protein-containing Complex Binding
Metal Ion Binding
Protein Heterodimerization Activity
Biological Process
Autophagosome Assembly
Angiogenesis
Cell Activation
Positive Regulation Of Cytokine Production
Serotonin Secretion
Lymph Vessel Development
Positive Regulation Of Receptor Internalization
Stimulatory C-type Lectin Receptor Signaling Pathway
Adaptive Immune Response
Macrophage Activation Involved In Immune Response
Neutrophil Activation Involved In Immune Response
Leukocyte Activation Involved In Immune Response
Immune System Process
Serotonin Secretion By Platelet
Cell Surface Pattern Recognition Receptor Signaling Pathway
Negative Regulation Of Inflammatory Response To Antigenic Stimulus
Protein Phosphorylation
Protein Import Into Nucleus
Leukocyte Cell-cell Adhesion
Cell Surface Receptor Signaling Pathway
Enzyme-linked Receptor Protein Signaling Pathway
Integrin-mediated Signaling Pathway
Animal Organ Morphogenesis
Negative Regulation Of Autophagy
Positive Regulation Of Autophagy
Regulation Of Platelet Activation
Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway
Peptidyl-tyrosine Phosphorylation
Leukotriene Biosynthetic Process
Calcium-mediated Signaling
Platelet Activation
B Cell Differentiation
Neutrophil Chemotaxis
Positive Regulation Of Protein-containing Complex Assembly
Receptor Internalization
Cellular Response To Nutrient Levels
Positive Regulation Of Type I Interferon Production
Positive Regulation Of Granulocyte Macrophage Colony-stimulating Factor Production
Positive Regulation Of Interleukin-10 Production
Positive Regulation Of Interleukin-12 Production
Positive Regulation Of Interleukin-3 Production
Positive Regulation Of Interleukin-4 Production
Positive Regulation Of Interleukin-6 Production
Positive Regulation Of Interleukin-8 Production
Positive Regulation Of Tumor Necrosis Factor Production
Positive Regulation Of Mast Cell Cytokine Production
Regulation Of Superoxide Anion Generation
Positive Regulation Of Superoxide Anion Generation
Positive Regulation Of Cell Adhesion Mediated By Integrin
Intracellular Signal Transduction
Collagen-activated Tyrosine Kinase Receptor Signaling Pathway
Fc-epsilon Receptor Signaling Pathway
Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis
Interleukin-3-mediated Signaling Pathway
TORC1 Signaling
Gamma-delta T Cell Differentiation
Defense Response To Bacterium
Mast Cell Degranulation
Positive Regulation Of Mast Cell Degranulation
Regulation Of Neutrophil Degranulation
Beta Selection
Positive Regulation Of MAPK Cascade
Innate Immune Response
Positive Regulation Of B Cell Differentiation
Positive Regulation Of Gamma-delta T Cell Differentiation
Positive Regulation Of Lymphocyte Differentiation
Positive Regulation Of Bone Resorption
Positive Regulation Of Alpha-beta T Cell Differentiation
Positive Regulation Of Alpha-beta T Cell Proliferation
Blood Vessel Morphogenesis
Regulation Of Phagocytosis
Regulation Of Immune Response
Positive Regulation Of Calcium-mediated Signaling
B Cell Receptor Signaling Pathway
Leukocyte Migration
Regulation Of DNA-binding Transcription Factor Activity
Establishment Of Localization In Cell
Regulation Of ERK1 And ERK2 Cascade
Cellular Response To Molecule Of Fungal Origin
Cellular Response To Lipid
Cellular Response To Low-density Lipoprotein Particle Stimulus
Positive Regulation Of Monocyte Chemotactic Protein-1 Production
Regulation Of Arachidonate Secretion
Regulation Of Platelet Aggregation
Apoptotic Signaling Pathway
Amyloid-beta Clearance
Positive Regulation Of Cold-induced Thermogenesis
Negative Regulation Of TORC1 Signaling
Positive Regulation Of TORC1 Signaling
Cellular Response To Amyloid-beta
Cellular Response To Lectin
Microtubule Cytoskeleton Organization
Mitotic Cell Cycle
Neuron Migration
Startle Response
Intracellular Protein Transport
Microtubule-based Process
Centrosome Cycle
Smoothened Signaling Pathway
Memory
Locomotory Behavior
Adult Locomotory Behavior
Visual Learning
Response To Mechanical Stimulus
Glial Cell Differentiation
Gene Expression
Dentate Gyrus Development
Cerebellar Cortex Morphogenesis
Hippocampus Development
Pyramidal Neuron Differentiation
Cerebral Cortex Development
Neurogenesis
Neuron Differentiation
Flagellated Sperm Motility
Adult Behavior
Cytoskeleton-dependent Intracellular Transport
Response To Tumor Necrosis Factor
Locomotory Exploration Behavior
Microtubule Polymerization
Forebrain Morphogenesis
Homeostasis Of Number Of Cells Within A Tissue
Regulation Of Synapse Organization
Synapse Organization
Cell Division
Neuron Apoptotic Process
Motor Behavior
Cellular Response To Calcium Ion
Organelle Transport Along Microtubule
Neuron Projection Arborization
Response To L-glutamate
Pathways
GPVI-mediated activation cascade
GPVI-mediated activation cascade
FCGR activation
FCGR activation
Regulation of actin dynamics for phagocytic cup formation
Role of phospholipids in phagocytosis
DAP12 signaling
Fc epsilon receptor (FCERI) signaling
Fc epsilon receptor (FCERI) signaling
Role of LAT2/NTAL/LAB on calcium mobilization
Role of LAT2/NTAL/LAB on calcium mobilization
FCERI mediated MAPK activation
FCERI mediated Ca+2 mobilization
FCERI mediated Ca+2 mobilization
Integrin signaling
CLEC7A (Dectin-1) signaling
Dectin-2 family
Dectin-2 family
Interleukin-2 signaling
Regulation of signaling by CBL
Regulation of signaling by CBL
FCGR3A-mediated IL10 synthesis
FCGR3A-mediated phagocytosis
Signaling by CSF3 (G-CSF)
Signaling by CSF3 (G-CSF)
Potential therapeutics for SARS
Inactivation of CSF3 (G-CSF) signaling
Inactivation of CSF3 (G-CSF) signaling
FLT3 signaling through SRC family kinases
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
Translocation of SLC2A4 (GLUT4) to the plasma membrane
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane
Gap junction assembly
MHC class II antigen presentation
Separation of Sister Chromatids
Resolution of Sister Chromatid Cohesion
Regulation of PLK1 Activity at G2/M Transition
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand
Loss of Nlp from mitotic centrosomes
Recruitment of mitotic centrosome proteins and complexes
Loss of proteins required for interphase microtubule organization from the centrosome
Recruitment of NuMA to mitotic centrosomes
Prefoldin mediated transfer of substrate to CCT/TriC
Formation of tubulin folding intermediates by CCT/TriC
Post-chaperonin tubulin folding pathway
Recycling pathway of L1
Recycling pathway of L1
Hedgehog 'off' state
Anchoring of the basal body to the plasma membrane
Cargo trafficking to the periciliary membrane
Intraflagellar transport
RHO GTPases activate IQGAPs
RHO GTPases Activate Formins
COPI-mediated anterograde transport
COPI-dependent Golgi-to-ER retrograde traffic
COPI-independent Golgi-to-ER retrograde traffic
Mitotic Prometaphase
The role of GTSE1 in G2/M progression after G2 checkpoint
AURKA Activation by TPX2
Carboxyterminal post-translational modifications of tubulin
Carboxyterminal post-translational modifications of tubulin
HCMV Early Events
Assembly and cell surface presentation of NMDA receptors
Activation of AMPK downstream of NMDARs
Aggrephagy
Aggrephagy
EML4 and NUDC in mitotic spindle formation
Sealing of the nuclear envelope (NE) by ESCRT-III
Kinesins
PKR-mediated signaling
Drugs
Staurosporine
N-(2-hydroxy-1,1-dimethylethyl)-1-methyl-3-(1H-pyrrolo[2,3-b]pyridin-2-yl)-1H-indole-5-carboxamide
Tamatinib
2-{2-[(3,5-dimethylphenyl)amino]pyrimidin-4-yl}-N-[(1S)-2-hydroxy-1-methylethyl]-4-methyl-1,3-thiazole-5-carboxamide
2-{[(1R,2S)-2-aminocyclohexyl]amino}-4-[(3-methylphenyl)amino]pyrimidine-5-carboxamide
Ellagic acid
Fostamatinib
Entospletinib
Albendazole
Vinblastine
Mebendazole
Epothilone D
Patupilone
CYT997
2-MERCAPTO-N-[1,2,3,10-TETRAMETHOXY-9-OXO-5,6,7,9-TETRAHYDRO-BENZO[A]HEPTALEN-7-YL]ACETAMIDE
Artenimol
Phenethyl Isothiocyanate
Colchiceine
Diseases
Lissencephaly (LIS); Miller-Dieker syndrome (MDLS)
GWAS
Alzheimer's disease (
30636644
)
Anti-saccade response (
29064472
)
Atrial fibrillation (
28416822
)
Chromosomal aberration frequency (total) (
31586183
)
Frontal pole volume (
31530798
)
Mean platelet volume (
32888494
)
Mean spheric corpuscular volume (
32888494
)
Metabolite levels (
23823483
)
Monocyte count (
32888494
)
Multiple sclerosis (
21833088
)
Multiple sclerosis and HDL levels (pleiotropy) (
26920376
)
Platelet count (
32888494
)
Platelet distribution width (
32888494
27863252
)
Plateletcrit (
32888494
)
Type 2 diabetes (
22456796
)
Vascular dementia (
23480133
)
Brain morphology (MOSTest) (
32665545
)
Composite immunoglobulin trait (IgG/IgM) (
28628107
)
Interacting Genes
110 interacting genes:
APP
AR
BLNK
BTK
CALM1
CBL
CBLB
CD19
CD22
CD3E
CD72
CD79A
CD79B
CEBPA
COASY
CRKL
CRYAA
CSF2RB
CSF3R
CTTN
DBNL
DPP9
DUSP3
EGFR
EPOR
ERBB2
ERBB3
ERBB4
FCER1G
FCGR1A
FCGR2A
FCGR3A
FCRL3
FGR
FYN
GAB1
GAB2
GRB2
HCLS1
HDAC1
HDAC2
HDAC3
HDAC4
HDAC6
HDAC9
HGS
HNRNPU
IL15RA
IL2RB
ITGB2
JAK1
KIT
LAT
LAX1
LCK
LCP2
LYN
MAP4K1
MAPK3
MAPT
MET
MS4A2
NEDD4
NFAM1
PAG1
PIK3AP1
PIK3R1
PIK3R2
PLCG1
PLCG2
POU2AF1
PRKCA
PRKD1
PTK2
PTK2B
PTPN6
PXN
RASA1
RHOU
RPS10
RPS6KA1
RPS6KB1
RPS6KB2
SELPLG
SH2B2
SH2D2A
SH3BP2
SHC1
SIT1
SLA
SLC4A1
SNCA
SRC
STAT1
STAT3
STAT5A
TERF1
TLR4
TNFRSF1A
TRAF6
TRIM15
TRIM31
TUBA1A
TUBA4A
TYROBP
UBASH3B
UBB
USP25
VAV1
VAV2
66 interacting genes:
ANXA7
ARL3
ATXN3
B4GALT1
BTG1
C8orf33
CDKN1A
CDKN2A
CEP20
CLIP1
CNP
CPEB2
CXCR1
CYLD
DAG1
DUSP23
EGFR
EIF4ENIF1
EML1
ENO1
GEMIN7
GRM7
GSK3B
GZMB
HTRA2
KEL
KPNB1
LINC01554
LRRK2
MAP7D3
MAPK6
MAPRE1
MAX
MX1
MYC
NFATC1
NUDT3
OGT
PAFAH1B1
PGK1
PLA2G7
PLK2
S100A8
S100A9
SDC3
SIAH1
SMN1
SNCA
SOCS6
SOCS7
SPART
STARD13
STK11
SYK
SYTL4
TAOK2
TIMM17A
TK1
TLN1
TTR
TUBB
UBE2D3
VAV1
VCL
YWHAQ
ZAP70
Entrez ID
6850
7846
HPRD ID
02514
03959
Ensembl ID
ENSG00000165025
ENSG00000167552
Uniprot IDs
C3W981
P43405
Q71U36
PDB IDs
1A81
1CSY
1CSZ
1XBA
1XBB
1XBC
3BUW
3EMG
3FQE
3FQH
3FQS
3SRV
3TUB
3TUC
3TUD
3VF8
3VF9
4DFL
4DFN
4F4P
4FL1
4FL2
4FL3
4FYN
4FYO
4FZ6
4FZ7
4GFG
4I0R
4I0S
4I0T
4PUZ
4PV0
4PX6
4RSS
4RX7
4RX8
4RX9
4WNM
4XG2
4XG3
4XG4
4XG6
4XG7
4XG8
4XG9
4YJO
4YJP
4YJQ
4YJR
4YJS
4YJT
4YJU
4YJV
5C26
5C27
5CXH
5CXZ
5CY3
5GHV
5LMA
5LMB
5T68
5TIU
5TR6
5TT7
5Y5T
5Y5U
6HM6
6HM7
6SSB
6VOV
6ZC0
6ZCP
6ZCQ
6ZCR
6ZCS
6ZCU
6ZCX
6ZCY
7Q5T
7Q5U
7Q5W
7Q63
7SA7
8BI2
8RRQ
8RRZ
8WYW
8X5K
8XQ0
8XQ1
8XQ2
5JCO
6J8F
6WSL
7C1M
7UN1
7UNG
8J07
8SH7
Enriched GO Terms of Interacting Partners
?
Cell Surface Receptor Signaling Pathway
Signal Transduction
Immune Response-regulating Cell Surface Receptor Signaling Pathway
Leukocyte Activation
Cell Activation
Immune System Process
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Regulation Of Immune System Process
Immune Response-activating Cell Surface Receptor Signaling Pathway
Immune Response-regulating Signaling Pathway
Positive Regulation Of Immune System Process
Lymphocyte Activation
Regulation Of Intracellular Signal Transduction
Regulation Of Immune Response
Enzyme-linked Receptor Protein Signaling Pathway
Intracellular Signal Transduction
Phosphotyrosine Residue Binding
Regulation Of Signal Transduction
Positive Regulation Of Intracellular Signal Transduction
Regulation Of Multicellular Organismal Process
Immune Response-activating Signaling Pathway
Fc Receptor Signaling Pathway
Regulation Of Cell Activation
Activation Of Immune Response
Regulation Of Signaling
Regulation Of Cell Communication
Plasma Membrane
Antigen Receptor-mediated Signaling Pathway
Positive Regulation Of Multicellular Organismal Process
Positive Regulation Of Signal Transduction
Positive Regulation Of Immune Response
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
Immune Response
Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Immune Effector Process
B Cell Activation
Cellular Developmental Process
Adaptive Immune Response
Fc-gamma Receptor Signaling Pathway
Regulation Of Lymphocyte Activation
Positive Regulation Of Cell Population Proliferation
Intracellular Signaling Cassette
Membrane Raft
Cytokine-mediated Signaling Pathway
Regulation Of Developmental Process
Regulation Of Programmed Cell Death
Leukocyte Differentiation
Cell Differentiation
Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Cytoplasm
Cytosol
Regulation Of Cell Growth
Intracellular Signaling Cassette
Microtubule Binding
Regulation Of Growth
Microtubule Cytoskeleton Organization
Intracellular Signal Transduction
Regulation Of Cellular Component Organization
Organelle Organization
Negative Regulation Of Cell Communication
Negative Regulation Of Signaling
Positive Regulation Of Programmed Cell Death
Protein-containing Complex
Regulation Of Signal Transduction
Positive Regulation Of Signal Transduction
Cytoskeleton
Positive Regulation Of Cell Communication
Regulation Of Cell Communication
Kinase Activity
Positive Regulation Of Signaling
Regulation Of Signaling
Protein Metabolic Process
Regulation Of Developmental Process
Regulation Of Intrinsic Apoptotic Signaling Pathway
Myeloid Leukocyte Migration
Regulation Of Intracellular Signal Transduction
Positive Regulation Of Intracellular Signal Transduction
Negative Regulation Of Signal Transduction
Cell Migration
Neutrophil Chemotaxis
Developmental Process
Cytoplasmic Microtubule
Microtubule-based Process
Ubiquitin Protein Ligase Binding
Catabolic Process
Leukocyte Migration
Protein Serine/threonine Kinase Activity
Protein Kinase Activity
Tubulin Binding
Negative Regulation Of Cell Growth
Cytoskeleton Organization
Neutrophil Migration
Protein Localization To Nucleus
Cellular Developmental Process
Microtubule Cytoskeleton
Microtubule
Positive Regulation Of Apoptotic Process
Leukocyte Aggregation
Regulation Of Microtubule-based Process
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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