USP2 and EXOSC8

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		USP2	EXOSC8
Description		ubiquitin specific peptidase 2	exosome component 8
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Centrosome Membrane Perinuclear Region Of Cytoplasm	Nuclear Exosome (RNase Complex) Cytoplasmic Exosome (RNase Complex) Exosome (RNase Complex) Fibrillar Center Nucleus Nucleoplasm Chromosome Nucleolus Cytoplasm Cytosol Nucleolar Exosome (RNase Complex) Exoribonuclease Complex
	Molecular Function	Cysteine-type Endopeptidase Activity Cysteine-type Deubiquitinase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity Cyclin Binding Ubiquitin Protein Ligase Binding Identical Protein Binding Metal Ion Binding	RNA Binding RNA Exonuclease Activity Protein Binding MRNA 3'-UTR AU-rich Region Binding Identical Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Proteolysis Muscle Organ Development Protein Deubiquitination Circadian Regulation Of Gene Expression Entrainment Of Circadian Clock By Photoperiod Locomotor Rhythm Positive Regulation Of Mitotic Cell Cycle Rhythmic Process Circadian Behavior Protein Stabilization Regulation Of Signal Transduction By P53 Class Mediator	Exonucleolytic Trimming To Generate Mature 3'-end Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) RRNA Processing RNA Processing RNA Catabolic Process RRNA Catabolic Process U1 SnRNA 3'-end Processing U4 SnRNA 3'-end Processing U5 SnRNA 3'-end Processing Nuclear MRNA Surveillance Nuclear Polyadenylation-dependent RRNA Catabolic Process TRAMP-dependent TRNA Surveillance Pathway
Pathways		TNFR1-induced proapoptotic signaling Regulation of TNFR1 signaling TNFR1-induced NF-kappa-B signaling pathway Ub-specific processing proteases Regulation of TP53 Degradation	ATF4 activates genes in response to endoplasmic reticulum stress mRNA decay by 3' to 5' exoribonuclease Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA KSRP (KHSRP) binds and destabilizes mRNA Major pathway of rRNA processing in the nucleolus and cytosol Nuclear RNA decay
Drugs
Diseases
GWAS		Refractive error ( 32231278) Serum uric acid levels ( 30993211) Urate levels ( 23263486 31578528 31985003)
Interacting Genes		178 interacting genes: ABI2 ACTN1 ACTN2 ACTN3 APP AR ASPG ATG14 ATN1 AURKA BAP1 BCAR1 BCL2L2-PABPN1 BEGAIN BEND5 BICD2 BIRC7 BRCA1 CADPS CALCOCO2 CARD9 CBLC CCDC136 CCDC57 CCDC85B CCDC88B CDC34 CEP63 CEP70 CRACR2A CRACR2B CRY1 DCAF1 DDI1 DEPDC5 DISC1 DSCR4 DTX3 DUSP21 DYDC1 E2F4 EFHC2 EIF4ENIF1 ENPP1 ERBB2 EXOC5 EXOSC8 FANCD2 FBXW7 G3BP1 GEMIN4 GOLGA2 GOLGA6A GOLGA6L9 GPRASP3 GRB7 GRIPAP1 H2AC20 H2AC4 H2BC3 HOMER3 HOOK1 HOOK2 IHO1 IKBKG IKZF3 IL1RL2 INTS11 JAKMIP1 JRK KAZN KIFC3 KRT15 KRT27 KRT31 KRT33B KRT34 KRT35 KRT40 LHX3 LHX4 LMNA LMNB2 LNX2 LONRF1 LRSAM1 LZTS2 MALT1 MAP3K2 MDM2 MID2 MLKL MNAT1 MORN5 MRPL28 MTUS2 MYC NAB2 NDEL1 NEFL NFKB2 NOTCH1 NR3C1 OIP5 OPTN ORC3 ORC5 PALB2 PCGF6 PEX5 PIBF1 PICK1 PIK3R3 PLA2G2A PLEKHG4 PML PNMA1 POU2AF1 PRDM14 PRR5L RABEP1 RAD18 RBCK1 RFX6 RNF125 RNF126 RNF144B RNF149 RNF166 RUNDC3A S100A10 SH2B2 SLC2A1 SMAD7 SNCA SORBS3 SPAG8 SPDYE4 STAT5B TAX1BP1 TEKT4 TFIP11 TGFBR1 TLE5 TNFAIP2 TRAF1 TRAF2 TRAF6 TRAIP TRIM21 TRIM23 TRIM27 TRIM34 TRIM35 TRIM39 TRIM46 TRIM5 TRIM50 TRIM54 TRIM63 TRIM74 TRIM8 TRIM9 TRIP6 UBC UBE2S UBOX5 USHBP1 USP15 USP21 USP54 VCAM1 VPS28 VPS52 ZAP70 ZBED1 ZIM2 ZRANB1	112 interacting genes: AEN ANKHD1 ATF2 C22orf39 CCDC28A-AS1 CCL14 CCSER2 CNNM3 COL23A1 COX5A CPSF7 CRMP1 CWC22 DDIT4L DIS3 DUSP23 ERAL1 EXOSC1 EXOSC10 EXOSC2 EXOSC4 EXOSC5 EXOSC6 EXOSC7 EXOSC9 FAM161B FAM90A1 FHOD1 FOXD4L1 FOXN3 FRG1 FSAF1 FYTTD1 GEM HAPLN2 HOXB9 ILF2 INCA1 KANK2 KCNJ11 LENG1 LMO4 LNX1 LSM1 LSM4 LSM7 MACIR METTL14 MKRN1 MORN4 MRPL2 MTREX MYOZ1 NEDD9 NTAQ1 NXF1 OTUD4 PACSIN2 PALS2 PHF21A PIAS2 PKP2 POLDIP3 PRC1 PRPF31 PRPF6 PRR3 RASD1 RASSF1 RBBP4 RBM22 RBM7 REL RFC5 RPL3 RPLP0 RPP14 RPS28 RUSC1 RXRB SARNP SF1 SFPQ SGO2 SLAIN1 SLIRP SNAI1 SNRPA SNRPB SNRPC SNRPN SNW1 SOCS7 SPATC1L SRPK2 SRSF10 SUGP2 TBRG1 TCEA2 TFAP4 TFIP11 TXNDC17 TXNDC9 UBC UNKL UPF2 USP2 USP6 UTP14A XRN1 XRN2 ZFP36
Entrez ID		9099	11340
HPRD ID		05287	09351
Ensembl ID		ENSG00000036672	ENSG00000120699
Uniprot IDs		O75604	Q96B26
PDB IDs		2HD5 2IBI 3NHE 3V6C 3V6E 5XU8 5XVE 6DGF	2NN6 6D6Q 6D6R 6H25 9G8M 9G8N 9G8O 9G8P
Enriched GO Terms of Interacting Partners?		Ubiquitin Protein Ligase Activity Post-translational Protein Modification Protein Modification By Small Protein Conjugation Protein Ubiquitination Identical Protein Binding Ubiquitin-protein Transferase Activity Protein Modification Process Cytoskeleton Cytoplasm Cytosol Zinc Ion Binding Regulation Of Apoptotic Process Innate Immune Response Suppression Of Viral Release By Host Regulation Of Programmed Cell Death Protein Binding Defense Response To Other Organism Immune Response Immune System Process Protein Metabolic Process Defense Response To Symbiont Organelle Organization Response To External Biotic Stimulus Protein Polyubiquitination Response To Other Organism Metal Ion Binding Positive Regulation Of Catabolic Process Cytoskeleton Organization Cell Death Ubiquitin Protein Ligase Binding Defense Response Proteolysis Involved In Protein Catabolic Process Transferase Activity Transcription Coactivator Activity Programmed Cell Death Intermediate Filament Cytoskeleton Organization Apoptotic Process Intermediate Filament-based Process Regulation Of Metabolic Process Response To Stress Regulation Of Macromolecule Metabolic Process Intermediate Filament Organization Regulation Of Signal Transduction Protein K63-linked Ubiquitination Negative Regulation Of Signal Transduction Positive Regulation Of Metabolic Process Negative Regulation Of Cell Communication Negative Regulation Of Signaling Signaling Adaptor Activity Negative Regulation Of Programmed Cell Death	RNA Binding MRNA Metabolic Process Exosome (RNase Complex) RNA Processing RNA Metabolic Process Nuclear Exosome (RNase Complex) Cytoplasmic Exosome (RNase Complex) Nucleic Acid Metabolic Process Nucleolar Exosome (RNase Complex) RNA Splicing, Via Transesterification Reactions Nucleus Nuclear-transcribed MRNA Catabolic Process Nuclear MRNA Surveillance RNA Catabolic Process MRNA Splicing, Via Spliceosome MRNA Catabolic Process RNA Exonuclease Activity MRNA Processing RNA Splicing Nucleoplasm Nucleobase-containing Compound Metabolic Process Spliceosomal Complex Nuclear RNA Surveillance U4 SnRNA 3'-end Processing RNA Surveillance RRNA Catabolic Process 3'-5'-RNA Exonuclease Activity Nucleobase-containing Compound Catabolic Process Nucleic Acid Binding SnRNA Metabolic Process RRNA Metabolic Process RRNA Processing Catalytic Step 2 Spliceosome Poly(A)-dependent SnoRNA 3'-end Processing SnRNA 3'-end Processing Ribonucleoprotein Complex U4/U6 X U5 Tri-snRNP Complex Macromolecule Metabolic Process Nucleolus Exoribonuclease Complex Negative Regulation Of Macromolecule Metabolic Process Exonucleolytic Trimming To Generate Mature 3'-end Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) TRNA Surveillance TRAMP-dependent TRNA Surveillance Pathway Nuclear Polyadenylation-dependent RRNA Catabolic Process Sno(s)RNA Metabolic Process SnRNA Processing RNA 3'-end Processing Negative Regulation Of Macromolecule Biosynthetic Process Protein Binding
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