USP2 and MNAT1

Number of citations of the paper that reports this interaction (PubMedID 23105109)
42

Data Source:
BioGRID (two hybrid)

		USP2	MNAT1
Description		ubiquitin specific peptidase 2	MNAT1 component of CDK activating kinase
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Centrosome Membrane Perinuclear Region Of Cytoplasm	Cyclin-dependent Protein Kinase Holoenzyme Complex Transcription Factor TFIIH Core Complex Nucleus Nucleoplasm Transcription Factor TFIIH Holo Complex CAK-ERCC2 Complex Transcription Factor TFIIK Complex
	Molecular Function	Cysteine-type Endopeptidase Activity Cysteine-type Deubiquitinase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity Cyclin Binding Ubiquitin Protein Ligase Binding Identical Protein Binding Metal Ion Binding	Protein Binding Zinc Ion Binding Metal Ion Binding Cyclin-dependent Protein Serine/threonine Kinase Activator Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Proteolysis Muscle Organ Development Protein Deubiquitination Circadian Regulation Of Gene Expression Entrainment Of Circadian Clock By Photoperiod Locomotor Rhythm Positive Regulation Of Mitotic Cell Cycle Rhythmic Process Circadian Behavior Protein Stabilization Regulation Of Signal Transduction By P53 Class Mediator	G1/S Transition Of Mitotic Cell Cycle DNA Repair Nucleotide-excision Repair Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Transcription Initiation At RNA Polymerase II Promoter Adult Heart Development Ventricular System Development Negative Regulation Of Apoptotic Process Positive Regulation Of Smooth Muscle Cell Proliferation Response To Calcium Ion Regulation Of G1/S Transition Of Mitotic Cell Cycle
Pathways		TNFR1-induced proapoptotic signaling Regulation of TNFR1 signaling TNFR1-induced NF-kappa-B signaling pathway Ub-specific processing proteases Regulation of TP53 Degradation	Formation of RNA Pol II elongation complex Formation of the Early Elongation Complex Formation of HIV elongation complex in the absence of HIV Tat Formation of the HIV-1 Early Elongation Complex RNA Pol II CTD phosphorylation and interaction with CE during HIV infection HIV Transcription Initiation RNA Polymerase II HIV Promoter Escape Transcription of the HIV genome Formation of HIV-1 elongation complex containing HIV-1 Tat Tat-mediated elongation of the HIV-1 transcript NoRC negatively regulates rRNA expression Formation of Incision Complex in GG-NER RNA Polymerase II Pre-transcription Events Formation of TC-NER Pre-Incision Complex Transcription-Coupled Nucleotide Excision Repair (TC-NER) Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER TP53 Regulates Transcription of DNA Repair Genes Cyclin E associated events during G1/S transition Cyclin D associated events in G1 Cyclin A/B1/B2 associated events during G2/M transition Cyclin A:Cdk2-associated events at S phase entry mRNA Capping RNA Polymerase I Transcription Initiation RNA Polymerase I Promoter Escape RNA Polymerase II Promoter Escape RNA Polymerase II Transcription Pre-Initiation And Promoter Opening RNA Polymerase I Transcription Termination RNA Polymerase II Transcription Initiation RNA Polymerase II Transcription Elongation RNA Polymerase II Transcription Initiation And Promoter Clearance RNA Pol II CTD phosphorylation and interaction with CE RUNX1 regulates transcription of genes involved in differentiation of HSCs
Drugs
Diseases
GWAS		Refractive error ( 32231278) Serum uric acid levels ( 30993211) Urate levels ( 23263486 31578528 31985003)	Exhaled carbon monoxide levels in smokers with chronic obstructive pulmonary disease ( 29631575) Gut microbiota (bacterial taxa, rank normal transformation method) ( 32572223) Immune reponse to smallpox (secreted IFN-alpha) ( 22610502) Refractive error ( 32231278)
Interacting Genes		178 interacting genes: ABI2 ACTN1 ACTN2 ACTN3 APP AR ASPG ATG14 ATN1 AURKA BAP1 BCAR1 BCL2L2-PABPN1 BEGAIN BEND5 BICD2 BIRC7 BRCA1 CADPS CALCOCO2 CARD9 CBLC CCDC136 CCDC57 CCDC85B CCDC88B CDC34 CEP63 CEP70 CRACR2A CRACR2B CRY1 DCAF1 DDI1 DEPDC5 DISC1 DSCR4 DTX3 DUSP21 DYDC1 E2F4 EFHC2 EIF4ENIF1 ENPP1 ERBB2 EXOC5 EXOSC8 FANCD2 FBXW7 G3BP1 GEMIN4 GOLGA2 GOLGA6A GOLGA6L9 GPRASP3 GRB7 GRIPAP1 H2AC20 H2AC4 H2BC3 HOMER3 HOOK1 HOOK2 IHO1 IKBKG IKZF3 IL1RL2 INTS11 JAKMIP1 JRK KAZN KIFC3 KRT15 KRT27 KRT31 KRT33B KRT34 KRT35 KRT40 LHX3 LHX4 LMNA LMNB2 LNX2 LONRF1 LRSAM1 LZTS2 MALT1 MAP3K2 MDM2 MID2 MLKL MNAT1 MORN5 MRPL28 MTUS2 MYC NAB2 NDEL1 NEFL NFKB2 NOTCH1 NR3C1 OIP5 OPTN ORC3 ORC5 PALB2 PCGF6 PEX5 PIBF1 PICK1 PIK3R3 PLA2G2A PLEKHG4 PML PNMA1 POU2AF1 PRDM14 PRR5L RABEP1 RAD18 RBCK1 RFX6 RNF125 RNF126 RNF144B RNF149 RNF166 RUNDC3A S100A10 SH2B2 SLC2A1 SMAD7 SNCA SORBS3 SPAG8 SPDYE4 STAT5B TAX1BP1 TEKT4 TFIP11 TGFBR1 TLE5 TNFAIP2 TRAF1 TRAF2 TRAF6 TRAIP TRIM21 TRIM23 TRIM27 TRIM34 TRIM35 TRIM39 TRIM46 TRIM5 TRIM50 TRIM54 TRIM63 TRIM74 TRIM8 TRIM9 TRIP6 UBC UBE2S UBOX5 USHBP1 USP15 USP21 USP54 VCAM1 VPS28 VPS52 ZAP70 ZBED1 ZIM2 ZRANB1	50 interacting genes: BEX3 BRCA1 CDK7 COPS6 DMAP1 DSCAM E2F1 EEF1A1 ERCC3 ERG ESR1 FOXP1 GOLGA2 GTF2E2 GTF2H1 HMGB1 HPS6 LRIF1 MAGEC2 MAGEE2 MCM7 MDM4 MKRN3 MTA1 NKX3-1 POLR2A POU2F1 POU2F2 POU5F1 RB1 RBM48 RNF32 RNF41 RNF7 SUPT5H TET2 TP53 TRIM14 TRIM17 TRIM2 TRIM21 TRIM26 TRIM31 TRIM34 TRIM39 TRIM5 TRIM9 TRIML1 UBC USP2
Entrez ID		9099	4331
HPRD ID		05287	04042
Ensembl ID		ENSG00000036672	ENSG00000020426
Uniprot IDs		O75604	A0A024R688 P51948
PDB IDs		2HD5 2IBI 3NHE 3V6C 3V6E 5XU8 5XVE 6DGF	1G25 6NMI 6O9L 6O9M 6TUN 6XBZ 6XD3 7B5O 7B5Q 7EGB 7EGC 7ENA 7ENC 7LBM 7NVR 7NVW 7NVX 7NVY 7NVZ 7NW0 8BVW 8BYQ 8GXQ 8GXS 8ORM 8P6V 8P6W 8P6X 8P6Y 8P6Z 8P70 8P71 8P72 8P73 8P74 8P75 8P76 8P77 8P78 8P79 8P7L 8PLZ 8PYR 8S0R 8S0T 8WAK 8WAL 8WAN 8WAO 8WAP 8WAQ 8WAR 8WAS
Enriched GO Terms of Interacting Partners?		Ubiquitin Protein Ligase Activity Post-translational Protein Modification Protein Modification By Small Protein Conjugation Protein Ubiquitination Identical Protein Binding Ubiquitin-protein Transferase Activity Protein Modification Process Cytoskeleton Cytoplasm Cytosol Zinc Ion Binding Regulation Of Apoptotic Process Innate Immune Response Suppression Of Viral Release By Host Regulation Of Programmed Cell Death Protein Binding Defense Response To Other Organism Immune Response Immune System Process Protein Metabolic Process Defense Response To Symbiont Organelle Organization Response To External Biotic Stimulus Protein Polyubiquitination Response To Other Organism Metal Ion Binding Positive Regulation Of Catabolic Process Cytoskeleton Organization Cell Death Ubiquitin Protein Ligase Binding Defense Response Proteolysis Involved In Protein Catabolic Process Transferase Activity Transcription Coactivator Activity Programmed Cell Death Intermediate Filament Cytoskeleton Organization Apoptotic Process Intermediate Filament-based Process Regulation Of Metabolic Process Response To Stress Regulation Of Macromolecule Metabolic Process Intermediate Filament Organization Regulation Of Signal Transduction Protein K63-linked Ubiquitination Negative Regulation Of Signal Transduction Positive Regulation Of Metabolic Process Negative Regulation Of Cell Communication Negative Regulation Of Signaling Signaling Adaptor Activity Negative Regulation Of Programmed Cell Death	Ubiquitin Protein Ligase Activity Macromolecule Metabolic Process Post-translational Protein Modification Protein Modification By Small Protein Conjugation Protein Ubiquitination Regulation Of Primary Metabolic Process Regulation Of Macromolecule Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Metabolic Process Zinc Ion Binding Nucleoplasm Protein Modification Process Positive Regulation Of RNA Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Biosynthetic Process Positive Regulation Of Macromolecule Metabolic Process Protein Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Macromolecule Biosynthetic Process Nucleus DNA Damage Response Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of DNA-templated Transcription Regulation Of Gene Expression Negative Regulation Of RNA Biosynthetic Process Protein Polyubiquitination Negative Regulation Of RNA Metabolic Process DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Cellular Response To Xenobiotic Stimulus Positive Regulation Of Transcription By RNA Polymerase II Response To Stress Transcription By RNA Polymerase II Innate Immune Response Ubiquitin Protein Ligase Binding DNA Binding Negative Regulation Of Macromolecule Metabolic Process Transcription Factor TFIIH Core Complex Metal Ion Binding Cellular Response To Stress Transcription Factor TFIIH Holo Complex Sequence-specific DNA Binding
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