USP2 and TRIM74

Number of citations of the paper that reports this interaction (PMID 23105109)
4

Data Source:
BioGRID (two hybrid)

		USP2	TRIM74
Gene Name		ubiquitin specific peptidase 2	tripartite motif containing 74
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Centrosome Cell Cortex Perinuclear Region Of Cytoplasm	Intracellular
	Molecular Function	Cysteine-type Endopeptidase Activity Ubiquitin-specific Protease Activity Protein Binding Cyclin Binding Ubiquitin Protein Ligase Binding Identical Protein Binding Metal Ion Binding	Zinc Ion Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Cell Cycle Muscle Organ Development Protein Deubiquitination Circadian Regulation Of Gene Expression Entrainment Of Circadian Clock By Photoperiod Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Locomotor Rhythm Positive Regulation Of Mitotic Cell Cycle Circadian Behavior Negative Regulation Of Skeletal Muscle Tissue Development Positive Regulation Of Skeletal Muscle Tissue Development Protein Stabilization Regulation Of Proteasomal Protein Catabolic Process
Pathways
Drugs
Diseases
GWAS		Urate levels ( 23263486)
Protein-Protein Interactions		67 interactors: APP AURKA BAP1 BEGAIN BEND5 BRCA1 CBLC CCDC136 CCDC36 CCDC57 CCDC85B CCND1 CRY1 DTX3 ERBB2 GOLGA2 HOMER3 HOOK1 HOOK2 IKBKG KIFC3 KRT15 KRT40 LHX4 LNX2 LONRF1 LRSAM1 LZTS2 MAP3K2 MDM2 MNAT1 MTUS2 NDEL1 NEFL NFKB2 PCGF6 PCNA PLA2G2A PNMA1 RAD18 RBCK1 RIPK1 RNF125 RNF126 RNF144B RNF166 TRAF2 TRAF6 TRAIP TRIM21 TRIM23 TRIM27 TRIM34 TRIM35 TRIM39 TRIM46 TRIM5 TRIM54 TRIM63 TRIM74 TRIM8 TRIM9 UBC UBE2S UBOX5 USP21 VPS52	11 interactors: BRCA1 LRSAM1 MGRN1 RBX1 REL RNF32 TSG101 UBE2U USP15 USP2 USP32
Entrez ID		9099	378108
HPRD ID		05287	15567
Ensembl ID		ENSG00000036672	ENSG00000155428
Uniprot IDs		E9PPM2 O75604	Q86UV6
PDB IDs		2HD5 2IBI 3NHE 3V6C 3V6E
Enriched GO Terms of Interacting Partners?		Protein Ubiquitination Protein Modification By Small Protein Conjugation Cellular Protein Modification Process Protein Polyubiquitination Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Cellular Protein Metabolic Process Protein Catabolic Process Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of NF-kappaB Transcription Factor Activity Innate Immune Response Negative Regulation Of Viral Release From Host Cell Protein K63-linked Ubiquitination Protein Metabolic Process Cellular Protein Catabolic Process Defense Response Protein Complex Assembly Regulation Of Viral Release From Host Cell Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Response To Stress Immune Response Proteolysis Involved In Cellular Protein Catabolic Process Cellular Macromolecule Catabolic Process TRIF-dependent Toll-like Receptor Signaling Pathway Regulation Of Cellular Protein Metabolic Process MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Protein Trimerization Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Toll-like Receptor 4 Signaling Pathway Protein Autoubiquitination Activation Of Innate Immune Response Regulation Of Protein Metabolic Process Regulation Of Protein Kinase Activity Immune Response-regulating Signaling Pathway Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Regulation Of Type I Interferon Production Positive Regulation Of Protein Serine/threonine Kinase Activity Regulation Of Kinase Activity Toll-like Receptor Signaling Pathway I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Innate Immune Response Regulation Of MAP Kinase Activity Regulation Of Cytokine Production Catabolic Process Response To Cytokine Positive Regulation Of MAP Kinase Activity	Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Cellular Protein Catabolic Process Proteasomal Protein Catabolic Process Cellular Protein Modification Process Cellular Macromolecule Catabolic Process Protein Polyubiquitination Catabolic Process Protein Ubiquitination Cellular Protein Metabolic Process Protein Modification By Small Protein Conjugation Viral Budding Protein Deubiquitination Proteolysis Protein Modification By Small Protein Removal Protein Metabolic Process Virion Assembly Regulation Of Proteasomal Protein Catabolic Process Protein Monoubiquitination Protein Autoubiquitination Cellular Metabolic Process Positive Regulation Of Histone H4-K20 Methylation Positive Regulation Of Histone H4-K16 Acetylation Ubiquitin-dependent Endocytosis Regulation Of Protein Catabolic Process Membrane Budding Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Signal Transduction Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Positive Regulation Of Histone H3-K9 Acetylation Histone H2B Conserved C-terminal Lysine Deubiquitination Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Signaling Regulation Of Protein Metabolic Process Positive Regulation Of Histone H4 Acetylation Negative Regulation Of Histone H3-K4 Methylation Viral Process Negative Regulation Of Gene Expression DNA Repair Negative Regulation Of Biosynthetic Process Cellular Response To Indole-3-methanol Regulation Of Proteolysis Negative Regulation Of Centriole Replication Regulation Of Extracellular Vesicular Exosome Assembly Viral Life Cycle Dosage Compensation By Inactivation Of X Chromosome
Tagcloud ?		accessory alpha2delta beta2 biotinylation cav cav1 channels counteracted counterpart currents de developmentally gated hek inserted ligases nedd4 paramount precipitated recordings remarkably tsa ubiquitylated ubiquitylates ubiquitylating ubiquitylation usps voltage
Tagcloud (Difference) ?		accessory alpha2delta beta2 biotinylation cav cav1 channels counteracted counterpart currents de developmentally gated hek inserted ligases nedd4 paramount precipitated recordings remarkably tsa ubiquitylated ubiquitylates ubiquitylating ubiquitylation usps voltage
Tagcloud (Intersection) ?