USP2 and ENPP1

Number of citations of the paper that reports this interaction (PubMedID 27226596)
76

Data Source:
BioGRID (enzymatic study)

		USP2	ENPP1
Description		ubiquitin specific peptidase 2	ectonucleotide pyrophosphatase/phosphodiesterase 1
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Centrosome Membrane Perinuclear Region Of Cytoplasm	Extracellular Region Extracellular Space Lysosomal Membrane Plasma Membrane Cell Surface Membrane Basolateral Plasma Membrane
	Molecular Function	Cysteine-type Endopeptidase Activity Cysteine-type Deubiquitinase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity Cyclin Binding Ubiquitin Protein Ligase Binding Identical Protein Binding Metal Ion Binding	Nucleic Acid Binding 3',5'-cyclic-AMP Phosphodiesterase Activity Exonuclease Activity Phosphodiesterase I Activity Dinucleotide Phosphatase Activity Scavenger Receptor Activity Insulin Receptor Binding Calcium Ion Binding Protein Binding ATP Binding Zinc Ion Binding Hydrolase Activity Phosphatase Activity Polysaccharide Binding GTP Diphosphatase Activity UTP Diphosphatase Activity Protein Homodimerization Activity Metal Ion Binding Nucleoside Triphosphate Diphosphatase Activity ATP Diphosphatase Activity 3'-phosphoadenosine 5'-phosphosulfate Binding Cyclic-GMP-AMP Hydrolase Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Proteolysis Muscle Organ Development Protein Deubiquitination Circadian Regulation Of Gene Expression Entrainment Of Circadian Clock By Photoperiod Locomotor Rhythm Positive Regulation Of Mitotic Cell Cycle Rhythmic Process Circadian Behavior Protein Stabilization Regulation Of Signal Transduction By P53 Class Mediator	Generation Of Precursor Metabolites And Energy Phosphate-containing Compound Metabolic Process Immune Response Nucleoside Triphosphate Catabolic Process Gene Expression Vesicle-mediated Transport Bone Mineralization Negative Regulation Of Cell Growth Melanocyte Differentiation Regulation Of Bone Mineralization Negative Regulation Of Bone Mineralization Inorganic Diphosphate Transport Intracellular Phosphate Ion Homeostasis Biomineral Tissue Development Cellular Response To Insulin Stimulus Response To ATP Negative Regulation Of Fat Cell Differentiation Negative Regulation Of Glycogen Biosynthetic Process ATP Metabolic Process Negative Regulation Of D-glucose Import Negative Regulation Of Insulin Receptor Signaling Pathway Animal Organ Development 3'-phosphoadenosine 5'-phosphosulfate Metabolic Process Phosphate Ion Homeostasis Nucleic Acid Metabolic Process Negative Regulation Of Hh Target Transcription Factor Activity
Pathways		TNFR1-induced proapoptotic signaling Regulation of TNFR1 signaling TNFR1-induced NF-kappa-B signaling pathway Ub-specific processing proteases Regulation of TP53 Degradation	Vitamin B2 (riboflavin) metabolism Vitamin B5 (pantothenate) metabolism
Drugs			Taribavirin Polyethylene glycol 400
Diseases			Ossification of the posterior longitudinal ligament of spine (OPLL) Generalized arterial calcification of infancy Type II diabetes mellitus
GWAS		Refractive error ( 32231278) Serum uric acid levels ( 30993211) Urate levels ( 23263486 31578528 31985003)	Height ( 28552196) Obesity-related traits ( 23251661)
Interacting Genes		178 interacting genes: ABI2 ACTN1 ACTN2 ACTN3 APP AR ASPG ATG14 ATN1 AURKA BAP1 BCAR1 BCL2L2-PABPN1 BEGAIN BEND5 BICD2 BIRC7 BRCA1 CADPS CALCOCO2 CARD9 CBLC CCDC136 CCDC57 CCDC85B CCDC88B CDC34 CEP63 CEP70 CRACR2A CRACR2B CRY1 DCAF1 DDI1 DEPDC5 DISC1 DSCR4 DTX3 DUSP21 DYDC1 E2F4 EFHC2 EIF4ENIF1 ENPP1 ERBB2 EXOC5 EXOSC8 FANCD2 FBXW7 G3BP1 GEMIN4 GOLGA2 GOLGA6A GOLGA6L9 GPRASP3 GRB7 GRIPAP1 H2AC20 H2AC4 H2BC3 HOMER3 HOOK1 HOOK2 IHO1 IKBKG IKZF3 IL1RL2 INTS11 JAKMIP1 JRK KAZN KIFC3 KRT15 KRT27 KRT31 KRT33B KRT34 KRT35 KRT40 LHX3 LHX4 LMNA LMNB2 LNX2 LONRF1 LRSAM1 LZTS2 MALT1 MAP3K2 MDM2 MID2 MLKL MNAT1 MORN5 MRPL28 MTUS2 MYC NAB2 NDEL1 NEFL NFKB2 NOTCH1 NR3C1 OIP5 OPTN ORC3 ORC5 PALB2 PCGF6 PEX5 PIBF1 PICK1 PIK3R3 PLA2G2A PLEKHG4 PML PNMA1 POU2AF1 PRDM14 PRR5L RABEP1 RAD18 RBCK1 RFX6 RNF125 RNF126 RNF144B RNF149 RNF166 RUNDC3A S100A10 SH2B2 SLC2A1 SMAD7 SNCA SORBS3 SPAG8 SPDYE4 STAT5B TAX1BP1 TEKT4 TFIP11 TGFBR1 TLE5 TNFAIP2 TRAF1 TRAF2 TRAF6 TRAIP TRIM21 TRIM23 TRIM27 TRIM34 TRIM35 TRIM39 TRIM46 TRIM5 TRIM50 TRIM54 TRIM63 TRIM74 TRIM8 TRIM9 TRIP6 UBC UBE2S UBOX5 USHBP1 USP15 USP21 USP54 VCAM1 VPS28 VPS52 ZAP70 ZBED1 ZIM2 ZRANB1	2 interacting genes: INSR USP2
Entrez ID		9099	5167
HPRD ID		05287	01415
Ensembl ID		ENSG00000036672	ENSG00000197594
Uniprot IDs		O75604	P22413
PDB IDs		2HD5 2IBI 3NHE 3V6C 3V6E 5XU8 5XVE 6DGF	2YS0 6WET 6WEU 6WEV 6WEW 6WFJ 8GHR
Enriched GO Terms of Interacting Partners?		Ubiquitin Protein Ligase Activity Post-translational Protein Modification Protein Modification By Small Protein Conjugation Protein Ubiquitination Identical Protein Binding Ubiquitin-protein Transferase Activity Protein Modification Process Cytoskeleton Cytoplasm Cytosol Zinc Ion Binding Regulation Of Apoptotic Process Innate Immune Response Suppression Of Viral Release By Host Regulation Of Programmed Cell Death Protein Binding Defense Response To Other Organism Immune Response Immune System Process Protein Metabolic Process Defense Response To Symbiont Organelle Organization Response To External Biotic Stimulus Protein Polyubiquitination Response To Other Organism Metal Ion Binding Positive Regulation Of Catabolic Process Cytoskeleton Organization Cell Death Ubiquitin Protein Ligase Binding Defense Response Proteolysis Involved In Protein Catabolic Process Transferase Activity Transcription Coactivator Activity Programmed Cell Death Intermediate Filament Cytoskeleton Organization Apoptotic Process Intermediate Filament-based Process Regulation Of Metabolic Process Response To Stress Regulation Of Macromolecule Metabolic Process Intermediate Filament Organization Regulation Of Signal Transduction Protein K63-linked Ubiquitination Negative Regulation Of Signal Transduction Positive Regulation Of Metabolic Process Negative Regulation Of Cell Communication Negative Regulation Of Signaling Signaling Adaptor Activity Negative Regulation Of Programmed Cell Death	Regulation Of Female Gonad Development PTB Domain Binding Insulin-like Growth Factor II Binding Exocrine Pancreas Development Regulation Of Mitotic Cell Cycle Phosphatidylinositol 3-kinase Binding Positive Regulation Of Glycolytic Process Adrenal Gland Development Sex Determination Neuron Projection Maintenance Insulin Receptor Complex Male Sex Determination Positive Regulation Of Glycogen Biosynthetic Process Insulin-like Growth Factor I Binding Neuronal Cell Body Membrane Positive Regulation Of Respiratory Burst Dendritic Spine Maintenance Regulation Of Respiratory Burst Insulin Receptor Substrate Binding Insulin-like Growth Factor Receptor Binding Positive Regulation Of Cell Cycle Positive Regulation Of Meiotic Cell Cycle Insulin Binding Insulin Receptor Activity Locomotor Rhythm Circadian Behavior Entrainment Of Circadian Clock By Photoperiod Rhythmic Behavior Cargo Receptor Activity Dendrite Membrane Positive Regulation Of Receptor Internalization Regulation Of Glycogen Biosynthetic Process Amyloid-beta Clearance Photoperiodism Entrainment Of Circadian Clock Nuclear Lumen Positive Regulation Of Protein-containing Complex Disassembly Positive Regulation Of D-glucose Import Positive Regulation Of Nitric Oxide Biosynthetic Process Dendritic Spine Organization Positive Regulation Of ATP Metabolic Process Regulation Of Cell Cycle Regulation Of Glycogen Metabolic Process Cyclin Binding Neuron Projection Organization Positive Regulation Of Nitric Oxide Metabolic Process Postsynapse Organization Positive Regulation Of D-glucose Transmembrane Transport Protein Kinase Activator Activity Positive Regulation Of Glucose Metabolic Process
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