HTR2B and GNAQ

Number of citations of the paper that reports this interaction (PMID 11916537)
71

Data Source:
HPRD (in vivo)

		HTR2B	GNAQ
Gene Name		5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled	guanine nucleotide binding protein (G protein), q polypeptide
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane Cell Junction Neuron Projection Synapse	Cytoplasm Lysosomal Membrane Heterotrimeric G-protein Complex Plasma Membrane Nuclear Membrane Extracellular Vesicular Exosome
	Molecular Function	G-protein Alpha-subunit Binding Serotonin Receptor Activity Ras GTPase Activator Activity Drug Binding Serotonin Binding	GTPase Activity Signal Transducer Activity GTPase Activator Activity Protein Binding GTP Binding G-protein Beta/gamma-subunit Complex Binding Type 2A Serotonin Receptor Binding Metal Ion Binding
	Biological Process	Neural Crest Cell Migration Positive Regulation Of Cytokine Production Positive Regulation Of Endothelial Cell Proliferation G-protein Coupled Receptor Internalization Heart Morphogenesis Cardiac Muscle Hypertrophy CGMP Biosynthetic Process Cellular Calcium Ion Homeostasis G-protein Coupled Receptor Signaling Pathway Activation Of Phospholipase C Activity Protein Kinase C-activating G-protein Coupled Receptor Signaling Pathway Serotonin Receptor Signaling Pathway Behavior Positive Regulation Of Cell Proliferation Negative Regulation Of Autophagy Positive Regulation Of Phosphatidylinositol Biosynthetic Process Neural Crest Cell Differentiation Phosphatidylinositol 3-kinase Signaling Intestine Smooth Muscle Contraction Phosphorylation Calcium-mediated Signaling Positive Regulation Of Ras GTPase Activity Vasoconstriction Response To Drug Negative Regulation Of Apoptotic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of MAP Kinase Activity Embryonic Morphogenesis Positive Regulation Of Cytokine Secretion Regulation Of Behavior Positive Regulation Of Nitric-oxide Synthase Activity Release Of Sequestered Calcium Ion Into Cytosol Positive Regulation Of Cell Division Negative Regulation Of Cell Death ERK1 And ERK2 Cascade Positive Regulation Of ERK1 And ERK2 Cascade Protein Kinase C Signaling Cellular Response To Temperature Stimulus	Skeletal System Development Action Potential Negative Regulation Of Protein Kinase Activity Adenylate Cyclase-activating G-protein Coupled Receptor Signaling Pathway Activation Of Phospholipase C Activity Glutamate Receptor Signaling Pathway Heart Development Blood Coagulation Post-embryonic Development Neuron Remodeling Forebrain Neuron Development Platelet Activation Regulation Of Catenin Import Into Nucleus Maternal Behavior Embryonic Digit Morphogenesis Positive Regulation Of GTPase Activity Regulation Of Melanocyte Differentiation Developmental Pigmentation Protein Stabilization Phospholipase C-activating Dopamine Receptor Signaling Pathway
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) G alpha (q) signalling events G alpha (q) signalling events Signaling by GPCR GPCR downstream signaling Gastrin-CREB signalling pathway via PKC and MAPK Class A/1 (Rhodopsin-like receptors) Amine ligand-binding receptors Metabolic disorders of biological oxidation enzymes GPCR ligand binding Serotonin receptors	G alpha (q) signalling events Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion Signaling by GPCR ADP signalling through P2Y purinoceptor 1 Integration of energy metabolism Regulation of insulin secretion Signal amplification Thrombin signalling through proteinase activated receptors (PARs) G alpha (q) signalling events GPCR downstream signaling Acetylcholine regulates insulin secretion Gastrin-CREB signalling pathway via PKC and MAPK Thromboxane signalling through TP receptor Platelet activation, signaling and aggregation Free fatty acids regulate insulin secretion
Drugs		Eletriptan Methysergide Cabergoline Ropinirole Dihydroergotamine Pramipexole Triflupromazine Fenfluramine Lisuride Apomorphine Minaprine Tegaserod Doxepin Pergolide Bromocriptine Chlorprothixene Clomipramine 3,4-Methylenedioxymethamphetamine Asenapine
Diseases
GWAS		Thiazide-induced adverse metabolic effects in hypertensive patients ( 23400010)
Protein-Protein Interactions		4 interactors: GNA11 GNAQ LNX1 SNTA1	48 interactors: ADHFE1 ADRA1B ADRBK1 AIP AKAP13 BDKRB1 BTK CCR5 CHRM3 CRHR1 CYTH1 CYTH2 FFAR1 FFAR2 GALR2 GRM2 GRM4 GRM7 HTR2A HTR2B HTR2C HTR6 KDR LUM MRGPRX1 NT5C3A PIK3CA PLCB1 PLCB2 PPT1 PTGIR RGS13 RGS16 RGS18 RGS2 RGS4 RGS5 RGS7 RIC8A RIC8B S1PR2 S1PR3 SLC9A3R1 TBXA2R TSHR TTC1 TUB VIPR1
Entrez ID		3357	2776
HPRD ID		03077	02998
Ensembl ID		ENSG00000135914
Uniprot IDs		P41595	P50148
PDB IDs		4IB4
Enriched GO Terms of Interacting Partners?		Action Potential Phospholipase C-activating Dopamine Receptor Signaling Pathway Regulation Of Melanocyte Differentiation Regulation Of Developmental Pigmentation Regulation Of Membrane Potential Dopamine Receptor Signaling Pathway Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Developmental Pigmentation Pigmentation Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Regulation Of Vasoconstriction By Circulating Norepinephrine Regulation Of Epithelial Cell Differentiation G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Platelet Activation Negative Regulation Of Peptidyl-cysteine S-nitrosylation Neuron Remodeling Blood Coagulation Hemostasis Regulation Of Ventricular Cardiac Muscle Cell Membrane Repolarization Cellular Response To PH Maternal Behavior Heart Development Skeletal System Development Ventricular Cardiac Muscle Cell Action Potential Regulation Of Body Fluid Levels Wound Healing Regulation Of Membrane Repolarization Regulation Of Catenin Import Into Nucleus Cardiac Muscle Cell Action Potential Involved In Contraction Cell Activation Neuron Maturation Response To Wounding Regulation Of Sodium Ion Transmembrane Transport Response To PH Forebrain Neuron Development Cardiac Muscle Cell Action Potential Negative Regulation Of Cellular Protein Metabolic Process Regulation Of Cardiac Muscle Cell Contraction Cardiovascular System Development Negative Regulation Of Protein Metabolic Process Activation Of Phospholipase C Activity Neuromuscular Junction Development Adenylate Cyclase-activating G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Phospholipase C Activity Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Regulation Of Vasoconstriction Forebrain Neuron Differentiation Glutamate Receptor Signaling Pathway Regulation Of Sodium Ion Transport Embryonic Digit Morphogenesis	G-protein Coupled Receptor Signaling Pathway Cell Surface Receptor Signaling Pathway Regulation Of Catalytic Activity G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Positive Regulation Of Catalytic Activity Cell-cell Signaling Signal Transduction Signaling Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Regulation Of Signaling Cell Communication Positive Regulation Of Hydrolase Activity Positive Regulation Of GTPase Activity Positive Regulation Of Metabolic Process Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Regulation Of GTPase Activity Negative Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Termination Of G-protein Coupled Receptor Signaling Pathway Termination Of Signal Transduction Cellular Response To Stimulus Regulation Of Phosphorus Metabolic Process Positive Regulation Of Cytosolic Calcium Ion Concentration Response To Stimulus Regulation Of Signal Transduction Single-organism Behavior Regulation Of Cellular Process Chemical Homeostasis Behavior Learning Or Memory Cytosolic Calcium Ion Homeostasis Cognition Calcium Ion Homeostasis Regulation Of Metabolic Process Ion Homeostasis Cellular Ion Homeostasis Synaptic Transmission Regulation Of Secretion Neurological System Process Cellular Chemical Homeostasis Cellular Calcium Ion Homeostasis Learning Cellular Cation Homeostasis Serotonin Receptor Signaling Pathway Regulation Of Intracellular Signal Transduction Regulation Of Phospholipase Activity Metal Ion Homeostasis Regulation Of MAPK Cascade Positive Regulation Of Phosphatidylinositol Biosynthetic Process Homeostatic Process Negative Regulation Of Signaling
Tagcloud ?		alkenes azotic constructions gnai1 gnao1 heterocycle hm hms htr1b htr2a htr4 htr6 htr7 kpnb1 pharmacopeia prkaca prkca prkcb prkcd prkce prkcg prkd1 propertied pubchem rock2 rps6ka1 rps6ka3 tlr8 tradition	adaptor contributing driving extensively flies gna11 gpcrs gq guan hippo lats1 malignancy mammals melanoma mob1 mst1 ocular oncogenes oncotarget opportunity persistently phosphorylates represents sav1 taz team uveal ww45 yap
Tagcloud (Difference) ?		alkenes azotic constructions gnai1 gnao1 heterocycle hm hms htr1b htr2a htr4 htr6 htr7 kpnb1 pharmacopeia prkaca prkca prkcb prkcd prkce prkcg prkd1 propertied pubchem rock2 rps6ka1 rps6ka3 tlr8 tradition	adaptor contributing driving extensively flies gna11 gpcrs gq guan hippo lats1 malignancy mammals melanoma mob1 mst1 ocular oncogenes oncotarget opportunity persistently phosphorylates represents sav1 taz team uveal ww45 yap
Tagcloud (Intersection) ?