HTR2B and ABCA3

Number of citations: 90 (PubMedID 28298427)
Data Source: BioGRID (two hybrid)

		HTR2B	ABCA3
Name		5-hydroxytryptamine receptor 2B	ATP binding cassette subfamily A member 3
Structure
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Plasma Membrane Membrane Dendrite Neuron Projection Synapse G Protein-coupled Serotonin Receptor Complex	Extracellular Space Cytoplasm Lysosome Lysosomal Membrane Endosome Late Endosome Plasma Membrane Endomembrane System Membrane Cytoplasmic Vesicle Membrane Cytoplasmic Vesicle Late Endosome Membrane Multivesicular Body Membrane Lamellar Body Intracellular Membrane-bounded Organelle Alveolar Lamellar Body Lamellar Body Membrane Alveolar Lamellar Body Membrane
	Molecular Function	Gq/11-coupled Serotonin Receptor Activity G-protein Alpha-subunit Binding G Protein-coupled Receptor Activity G Protein-coupled Serotonin Receptor Activity GTPase Activator Activity Protein Binding Neurotransmitter Receptor Activity Serotonin Binding Serotonin Receptor Activity	Nucleotide Binding Lipid Transporter Activity ATP Binding ABC-type Xenobiotic Transporter Activity ATP Hydrolysis Activity ATPase-coupled Transmembrane Transporter Activity Phosphatidylcholine Transfer Activity ATPase-coupled Intramembrane Lipid Transporter Activity Phosphatidylcholine Flippase Activity ABC-type Transporter Activity
	Biological Process	Neural Crest Cell Migration Positive Regulation Of Cytokine Production Positive Regulation Of Endothelial Cell Proliferation Heart Morphogenesis Cardiac Muscle Hypertrophy Intracellular Calcium Ion Homeostasis Smooth Muscle Contraction Signal Transduction G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Phospholipase C-activating Serotonin Receptor Signaling Pathway Serotonin Receptor Signaling Pathway Chemical Synaptic Transmission Heart Development Positive Regulation Of Cell Population Proliferation Response To Xenobiotic Stimulus Positive Regulation Of Phosphatidylinositol Biosynthetic Process Neural Crest Cell Differentiation Intestine Smooth Muscle Contraction Calcium-mediated Signaling CGMP-mediated Signaling Vasoconstriction Negative Regulation Of Apoptotic Process Positive Regulation Of Canonical NF-kappaB Signal Transduction Embryonic Morphogenesis Regulation Of Behavior Release Of Sequestered Calcium Ion Into Cytosol Positive Regulation Of Cell Division ERK1 And ERK2 Cascade Positive Regulation Of ERK1 And ERK2 Cascade G Protein-coupled Serotonin Receptor Signaling Pathway	Xenobiotic Transmembrane Transport Lipid Transport Response To Xenobiotic Stimulus Positive Regulation Of Cholesterol Efflux Phospholipid Transport Lung Development Regulation Of Lipid Transport Positive Regulation Of Protein Homooligomerization Lipid Translocation Xenobiotic Transport Surfactant Homeostasis Phosphatidylcholine Metabolic Process Phosphatidylglycerol Metabolic Process Xenobiotic Export From Cell Regulation Of Lipid Biosynthetic Process Response To Glucocorticoid Transmembrane Transport Phospholipid Homeostasis Organelle Assembly Intermembrane Lipid Transfer Regulation Of Phosphatidylcholine Metabolic Process Positive Regulation Of Phospholipid Efflux Positive Regulation Of Phospholipid Transport
Pathways		Serotonin receptors G alpha (q) signalling events	ABC transporters in lipid homeostasis Defective ABCA3 causes SMDP3 Surfactant metabolism Defective ABCA3 causes SMDP3
Drugs		Methysergide Cabergoline Zolmitriptan Dihydroergotamine Methylergometrine Cyproheptadine Chlorpromazine Triflupromazine Amoxapine Fenfluramine Lisuride Ergotamine Apomorphine Paroxetine Paroxetine Minaprine Cyclobenzaprine Ergoloid mesylate Tegaserod Doxepin Pergolide Bromocriptine Ketamine Aripiprazole Chlorprothixene Clomipramine Yohimbine Midomafetamine Lysergic acid diethylamide OPC-28326 Epicept NP-1 PRX-08066 Cariprazine Mianserin Pizotifen Asenapine Ocaperidone Esmirtazapine Nandrolone decanoate Viloxazine Pipamperone Setiptiline Dihydroergocornine Gilteritinib Tiapride Dihydroergocristine	None
Diseases		None	Pulmonary surfactant metabolism dysfunction (SMDP)
GWAS		Proportion of activated microglia (midfrontal cortex) ( 30679421 ) Thiazide-induced adverse metabolic effects in hypertensive patients ( 23400010 )	Birth weight ( 31043758 ) RR interval (tricyclic/tetracyclic antidepressant use interaction) ( 28039329 ) Triglyceride levels x SSRI defined daily dose interaction in schizophrenia or bipolar disorder ( 33824429 ) Trunk fat mass ( 28552196 )
Interacting Genes		27 interacting genes: ABCA3 ATP1B1 BNIP3 BNIP3L CBR1 CHPT1 G6PC3 GNA11 GNAQ HAT1 HDGFL2 INSIG1 KIF19 LNX1 MATR3 METRN NAT14 NIPA2 OAZ1 PLLP PPP1R3F RAE1 SLC31A2 SLC37A1 SLC44A2 SNTA1 TRAM1L1	1 interacting genes: HTR2B
Entrez ID		3357	21
HPRD ID		03077	03369
Ensembl ID		ENSG00000135914	ENSG00000167972
Uniprot IDs		P41595	Q99758
PDB IDs		4IB4 4NC3 5TUD 5TVN 6DRX 6DRY 6DRZ 6DS0 7SRQ 7SRR 7SRS	7W01 7W02
GO Terms Enriched among Interactors		Glucose-6-phosphate Transport Phosphatidylcholine Metabolic Process Mitochondrial Protein Catabolic Process Negative Regulation Of Membrane Potential Negative Regulation Of Mitochondrial Membrane Potential Mitochondrial Outer Membrane Permeabilization Phospholipase C-activating Serotonin Receptor Signaling Pathway Phototransduction, Visible Light Lysosomal Membrane Positive Regulation Of Mitochondrial Membrane Permeability Involved In Apoptotic Process Mitochondrial Envelope Mitochondrial Outer Membrane Permeabilization Involved In Programmed Cell Death Guanyl Nucleotide Binding Regulation Of Membrane Potential G Protein-coupled Acetylcholine Receptor Signaling Pathway G-protein Beta/gamma-subunit Complex Binding G Protein-coupled Serotonin Receptor Signaling Pathway Phosphatidylcholine Biosynthetic Process Regulation Of Mitochondrial Membrane Permeability Involved In Apoptotic Process Detection Of Visible Light Positive Regulation Of Mitochondrial Membrane Permeability Cellular Response To PH Entrainment Of Circadian Clock Enzyme Regulator Activity Positive Regulation Of Protein Homooligomerization Organophosphate Ester Transport Transmembrane Transport Glycerolipid Metabolic Process Lamellar Body Membrane Membrane Positive Regulation Of Membrane Permeability Mitochondrion Autophagosome Adaptor Activity Prostaglandin E2 9-reductase Activity 15-hydroxyprostaglandin Dehydrogenase (NADP+) Activity Regulation Of Copper Ion Transmembrane Transport Heterotrimeric G-protein Complex Negative Regulation Of Cargo Loading Into COPII-coated Vesicle Plus-end Specific Microtubule Depolymerization Axonemal Microtubule Depolymerization Regulation Of Sodium Ion Transmembrane Transport Response To PH Phototransduction Acetylcholine Receptor Signaling Pathway	Gq/11-coupled Serotonin Receptor Activity Positive Regulation Of Phosphatidylinositol Biosynthetic Process G Protein-coupled Serotonin Receptor Complex Intestine Smooth Muscle Contraction Serotonin Binding Phospholipase C-activating Serotonin Receptor Signaling Pathway Serotonin Receptor Activity Neural Crest Cell Differentiation Positive Regulation Of Phospholipid Biosynthetic Process Serotonin Receptor Signaling Pathway G Protein-coupled Serotonin Receptor Activity Regulation Of Phospholipid Biosynthetic Process Neurotransmitter Receptor Activity G Protein-coupled Serotonin Receptor Signaling Pathway Cardiac Muscle Hypertrophy G-protein Alpha-subunit Binding CGMP-mediated Signaling Muscle Hypertrophy Vasoconstriction Regulation Of Phospholipid Metabolic Process Smooth Muscle Contraction ERK1 And ERK2 Cascade Release Of Sequestered Calcium Ion Into Cytosol G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Heart Morphogenesis Neural Crest Cell Migration Negative Regulation Of Sequestering Of Calcium Ion Mesenchymal Cell Migration Regulation Of Behavior Calcium Ion Transmembrane Import Into Cytosol Positive Regulation Of Cell Division Positive Regulation Of Endothelial Cell Proliferation Positive Regulation Of Lipid Biosynthetic Process Stem Cell Differentiation Mesenchymal Cell Differentiation Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Regulation Of Sequestering Of Calcium Ion Ameboidal-type Cell Migration Positive Regulation Of Lipid Metabolic Process Blood Vessel Diameter Maintenance Regulation Of Tube Size Regulation Of Endothelial Cell Proliferation Calcium-mediated Signaling Regulation Of Cell Division Intracellular Calcium Ion Homeostasis Positive Regulation Of ERK1 And ERK2 Cascade Regulation Of Lipid Biosynthetic Process Calcium Ion Transmembrane Transport Positive Regulation Of Epithelial Cell Proliferation Muscle Contraction