HTR2B

Gene Name		5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled
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Gene Ontology Annotations	Cellular Component	Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane Cell Junction Neuron Projection Synapse
	Molecular Function	G-protein Alpha-subunit Binding Serotonin Receptor Activity Ras GTPase Activator Activity Drug Binding Serotonin Binding
	Biological Process	Neural Crest Cell Migration Positive Regulation Of Cytokine Production Positive Regulation Of Endothelial Cell Proliferation G-protein Coupled Receptor Internalization Heart Morphogenesis Cardiac Muscle Hypertrophy CGMP Biosynthetic Process Cellular Calcium Ion Homeostasis G-protein Coupled Receptor Signaling Pathway Activation Of Phospholipase C Activity Protein Kinase C-activating G-protein Coupled Receptor Signaling Pathway Serotonin Receptor Signaling Pathway Behavior Positive Regulation Of Cell Proliferation Negative Regulation Of Autophagy Positive Regulation Of Phosphatidylinositol Biosynthetic Process Neural Crest Cell Differentiation Phosphatidylinositol 3-kinase Signaling Intestine Smooth Muscle Contraction Phosphorylation Calcium-mediated Signaling Positive Regulation Of Ras GTPase Activity Vasoconstriction Response To Drug Negative Regulation Of Apoptotic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of MAP Kinase Activity Embryonic Morphogenesis Positive Regulation Of Cytokine Secretion Regulation Of Behavior Positive Regulation Of Nitric-oxide Synthase Activity Release Of Sequestered Calcium Ion Into Cytosol Positive Regulation Of Cell Division Negative Regulation Of Cell Death ERK1 And ERK2 Cascade Positive Regulation Of ERK1 And ERK2 Cascade Protein Kinase C Signaling Cellular Response To Temperature Stimulus
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) G alpha (q) signalling events G alpha (q) signalling events Signaling by GPCR GPCR downstream signaling Gastrin-CREB signalling pathway via PKC and MAPK Class A/1 (Rhodopsin-like receptors) Amine ligand-binding receptors Metabolic disorders of biological oxidation enzymes GPCR ligand binding Serotonin receptors
Drugs		Eletriptan Methysergide Cabergoline Ropinirole Dihydroergotamine Pramipexole Triflupromazine Fenfluramine Lisuride Apomorphine Minaprine Tegaserod Doxepin Pergolide Bromocriptine Chlorprothixene Clomipramine 3,4-Methylenedioxymethamphetamine Asenapine
Diseases
GWAS		Thiazide-induced adverse metabolic effects in hypertensive patients ( 23400010)
Protein-protein Interactions		4 interactors: GNA11 GNAQ LNX1 SNTA1
Entrez ID		3357
HPRD ID		03077
Ensembl ID		ENSG00000135914
Uniprot IDs		P41595
PDB IDs		4IB4
Enriched GO Terms of Interacting Partners?		Action Potential Phospholipase C-activating Dopamine Receptor Signaling Pathway Regulation Of Melanocyte Differentiation Regulation Of Developmental Pigmentation Regulation Of Membrane Potential Dopamine Receptor Signaling Pathway Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Developmental Pigmentation Pigmentation Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Regulation Of Vasoconstriction By Circulating Norepinephrine Regulation Of Epithelial Cell Differentiation G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Platelet Activation Negative Regulation Of Peptidyl-cysteine S-nitrosylation Neuron Remodeling Blood Coagulation Hemostasis Regulation Of Ventricular Cardiac Muscle Cell Membrane Repolarization Cellular Response To PH Maternal Behavior Heart Development Skeletal System Development Ventricular Cardiac Muscle Cell Action Potential Regulation Of Body Fluid Levels Wound Healing Regulation Of Membrane Repolarization Regulation Of Catenin Import Into Nucleus Cardiac Muscle Cell Action Potential Involved In Contraction Cell Activation Neuron Maturation Response To Wounding Regulation Of Sodium Ion Transmembrane Transport Response To PH Forebrain Neuron Development Cardiac Muscle Cell Action Potential Negative Regulation Of Cellular Protein Metabolic Process Regulation Of Cardiac Muscle Cell Contraction Cardiovascular System Development Negative Regulation Of Protein Metabolic Process Activation Of Phospholipase C Activity Neuromuscular Junction Development Adenylate Cyclase-activating G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Phospholipase C Activity Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Regulation Of Vasoconstriction Forebrain Neuron Differentiation Glutamate Receptor Signaling Pathway Regulation Of Sodium Ion Transport Embryonic Digit Morphogenesis
Tagcloud ?		alkenes azotic constructions gnai1 gnao1 heterocycle hm hms htr1b htr2a htr4 htr6 htr7 kpnb1 pharmacopeia prkaca prkca prkcb prkcd prkce prkcg prkd1 propertied pubchem rock2 rps6ka1 rps6ka3 tlr8 tradition