HTR2B and SLC44A2

Number of citations of the paper that reports this interaction (PubMedID 28298427)
90

Data Source:
BioGRID (two hybrid)

		HTR2B	SLC44A2
Description		5-hydroxytryptamine receptor 2B	solute carrier family 44 member 2 (CTL2 blood group)
Image			No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Plasma Membrane Membrane Dendrite Neuron Projection Synapse G Protein-coupled Serotonin Receptor Complex	Mitochondrion Mitochondrial Outer Membrane Lysosomal Membrane Plasma Membrane Membrane Specific Granule Membrane Extracellular Exosome
	Molecular Function	Gq/11-coupled Serotonin Receptor Activity G-protein Alpha-subunit Binding G Protein-coupled Receptor Activity G Protein-coupled Serotonin Receptor Activity GTPase Activator Activity Protein Binding Neurotransmitter Receptor Activity Serotonin Binding Serotonin Receptor Activity	Choline Transmembrane Transporter Activity Antiporter Activity Transmembrane Transporter Activity Ethanolamine Transmembrane Transporter Activity
	Biological Process	Neural Crest Cell Migration Positive Regulation Of Cytokine Production Positive Regulation Of Endothelial Cell Proliferation Heart Morphogenesis Cardiac Muscle Hypertrophy Intracellular Calcium Ion Homeostasis Smooth Muscle Contraction Signal Transduction G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Phospholipase C-activating Serotonin Receptor Signaling Pathway Serotonin Receptor Signaling Pathway Chemical Synaptic Transmission Heart Development Positive Regulation Of Cell Population Proliferation Response To Xenobiotic Stimulus Positive Regulation Of Phosphatidylinositol Biosynthetic Process Neural Crest Cell Differentiation Intestine Smooth Muscle Contraction Calcium-mediated Signaling CGMP-mediated Signaling Vasoconstriction Negative Regulation Of Apoptotic Process Positive Regulation Of Canonical NF-kappaB Signal Transduction Embryonic Morphogenesis Regulation Of Behavior Release Of Sequestered Calcium Ion Into Cytosol Positive Regulation Of Cell Division ERK1 And ERK2 Cascade Positive Regulation Of ERK1 And ERK2 Cascade G Protein-coupled Serotonin Receptor Signaling Pathway	Phosphatidylcholine Biosynthetic Process Choline Transport Ethanolamine Transport Positive Regulation Of Canonical NF-kappaB Signal Transduction Transmembrane Transport
Pathways		Serotonin receptors G alpha (q) signalling events	Synthesis of PC Neutrophil degranulation SLC-mediated bile acid transport
Drugs		Methysergide Cabergoline Zolmitriptan Dihydroergotamine Methylergometrine Cyproheptadine Chlorpromazine Triflupromazine Amoxapine Fenfluramine Lisuride Ergotamine Apomorphine Paroxetine Paroxetine Minaprine Cyclobenzaprine Ergoloid mesylate Tegaserod Doxepin Pergolide Bromocriptine Ketamine Aripiprazole Chlorprothixene Clomipramine Yohimbine Midomafetamine Lysergic acid diethylamide OPC-28326 Epicept NP-1 PRX-08066 Cariprazine Mianserin Pizotifen Asenapine Ocaperidone Esmirtazapine Nandrolone decanoate Viloxazine Pipamperone Setiptiline Dihydroergocornine Gilteritinib Tiapride Dihydroergocristine
Diseases
GWAS		Proportion of activated microglia (midfrontal cortex) ( 30679421) Thiazide-induced adverse metabolic effects in hypertensive patients ( 23400010)	Age at first sexual intercourse ( 34211149) Appendicular lean mass ( 33097823) Bipolar disorder ( 31043756) Height ( 31562340) High light scatter reticulocyte count ( 32888494 27863252) High light scatter reticulocyte percentage of red cells ( 27863252 32888494) Hip circumference adjusted for BMI ( 34021172) Immature fraction of reticulocytes ( 32888494 27863252) Mean spheric corpuscular volume ( 32888494) Multiple sclerosis ( 24076602) Platelet count ( 29403010 32888494) Platelet distribution width ( 27863252 32888494) Reticulocyte count ( 27863252 32888494) Reticulocyte fraction of red cells ( 27863252 32888494) Thrombosis ( 26908601) Venous thromboembolism ( 31676865 25772935)
Interacting Genes		27 interacting genes: ABCA3 ATP1B1 BNIP3 BNIP3L CBR1 CHPT1 G6PC3 GNA11 GNAQ HAT1 HDGFL2 INSIG1 KIF19 LNX1 MATR3 METRN NAT14 NIPA2 OAZ1 PLLP PPP1R3F RAE1 SLC31A2 SLC37A1 SLC44A2 SNTA1 TRAM1L1	2 interacting genes: BDKRB1 HTR2B
Entrez ID		3357	57153
HPRD ID		03077	16198
Ensembl ID		ENSG00000135914	ENSG00000129353
Uniprot IDs		P41595	A0A088QCU6 Q8IWA5
PDB IDs		4IB4 4NC3 5TUD 5TVN 6DRX 6DRY 6DRZ 6DS0 7SRQ 7SRR 7SRS
Enriched GO Terms of Interacting Partners?		Glucose-6-phosphate Transport Phosphatidylcholine Metabolic Process Mitochondrial Protein Catabolic Process Negative Regulation Of Membrane Potential Negative Regulation Of Mitochondrial Membrane Potential Mitochondrial Outer Membrane Permeabilization Phospholipase C-activating Serotonin Receptor Signaling Pathway Phototransduction, Visible Light Lysosomal Membrane Positive Regulation Of Mitochondrial Membrane Permeability Involved In Apoptotic Process Mitochondrial Envelope Mitochondrial Outer Membrane Permeabilization Involved In Programmed Cell Death Guanyl Nucleotide Binding Regulation Of Membrane Potential G Protein-coupled Acetylcholine Receptor Signaling Pathway G-protein Beta/gamma-subunit Complex Binding G Protein-coupled Serotonin Receptor Signaling Pathway Phosphatidylcholine Biosynthetic Process Regulation Of Mitochondrial Membrane Permeability Involved In Apoptotic Process Detection Of Visible Light Positive Regulation Of Mitochondrial Membrane Permeability Cellular Response To PH Entrainment Of Circadian Clock Enzyme Regulator Activity Positive Regulation Of Protein Homooligomerization Organophosphate Ester Transport Transmembrane Transport Glycerolipid Metabolic Process Lamellar Body Membrane Membrane Positive Regulation Of Membrane Permeability Mitochondrion Autophagosome Adaptor Activity Prostaglandin E2 9-reductase Activity 15-hydroxyprostaglandin Dehydrogenase (NADP+) Activity Regulation Of Copper Ion Transmembrane Transport Heterotrimeric G-protein Complex Negative Regulation Of Cargo Loading Into COPII-coated Vesicle Plus-end Specific Microtubule Depolymerization Axonemal Microtubule Depolymerization Regulation Of Sodium Ion Transmembrane Transport Response To PH Phototransduction Acetylcholine Receptor Signaling Pathway	Phylloquinone Catabolic Process Menaquinone Metabolic Process Menaquinone Catabolic Process Vitamin K Catabolic Process Vitamin K Metabolic Process Ketone Catabolic Process Vitamin Metabolic Process Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, Reduced Flavin Or Flavoprotein As One Donor, And Incorporation Of One Atom Of Oxygen Regulation Of Biological Quality Arachidonate Metabolic Process Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen Monooxygenase Activity Ketone Metabolic Process Unsaturated Fatty Acid Metabolic Process Long-chain Fatty Acid Metabolic Process Icosanoid Metabolic Process Bradykinin Receptor Activity Oxylipin Biosynthetic Process Iron Ion Binding Heme Binding Regulation Of Sequestering Of Calcium Ion Gq/11-coupled Serotonin Receptor Activity Positive Regulation Of Phosphatidylinositol Biosynthetic Process Olefinic Compound Metabolic Process Pressure Natriuresis G Protein-coupled Serotonin Receptor Complex Intestine Smooth Muscle Contraction Arachidonate Omega-hydroxylase Activity Cytochrome Metabolic Process Leukotriene B4 Catabolic Process Leukotriene B4 Metabolic Process Leukotriene-B4 20-monooxygenase Activity Alkane 1-monooxygenase Activity Vitamin E Metabolic Process Long-chain Fatty Acid Omega-hydroxylase Activity Positive Regulation Of Nuclear Cell Cycle DNA Replication Phospholipase C-activating Serotonin Receptor Signaling Pathway Long-chain Fatty Acid Catabolic Process Serotonin Binding Serotonin Receptor Signaling Pathway Omega-hydroxylase P450 Pathway Arachidonate Epoxygenase Activity Positive Regulation Of Phospholipid Biosynthetic Process Serotonin Receptor Activity Neural Crest Cell Differentiation GTPase Inhibitor Activity Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, NAD(P)H As One Donor, And Incorporation Of One Atom Of Oxygen G Protein-coupled Serotonin Receptor Activity Regulation Of Nuclear Cell Cycle DNA Replication Regulation Of Body Fluid Levels
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