HTR2B and OAZ1

Number of citations of the paper that reports this interaction (PubMedID 28298427)
90

Data Source:
BioGRID (two hybrid)

		HTR2B	OAZ1
Description		5-hydroxytryptamine receptor 2B	ornithine decarboxylase antizyme 1
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GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Plasma Membrane Membrane Dendrite Neuron Projection Synapse G Protein-coupled Serotonin Receptor Complex	Nucleus Cytoplasm Cytosol
	Molecular Function	Gq/11-coupled Serotonin Receptor Activity G-protein Alpha-subunit Binding G Protein-coupled Receptor Activity G Protein-coupled Serotonin Receptor Activity GTPase Activator Activity Protein Binding Neurotransmitter Receptor Activity Serotonin Binding Serotonin Receptor Activity	Protein Binding Ornithine Decarboxylase Inhibitor Activity
	Biological Process	Neural Crest Cell Migration Positive Regulation Of Cytokine Production Positive Regulation Of Endothelial Cell Proliferation Heart Morphogenesis Cardiac Muscle Hypertrophy Intracellular Calcium Ion Homeostasis Smooth Muscle Contraction Signal Transduction G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Phospholipase C-activating Serotonin Receptor Signaling Pathway Serotonin Receptor Signaling Pathway Chemical Synaptic Transmission Heart Development Positive Regulation Of Cell Population Proliferation Response To Xenobiotic Stimulus Positive Regulation Of Phosphatidylinositol Biosynthetic Process Neural Crest Cell Differentiation Intestine Smooth Muscle Contraction Calcium-mediated Signaling CGMP-mediated Signaling Vasoconstriction Negative Regulation Of Apoptotic Process Positive Regulation Of Canonical NF-kappaB Signal Transduction Embryonic Morphogenesis Regulation Of Behavior Release Of Sequestered Calcium Ion Into Cytosol Positive Regulation Of Cell Division ERK1 And ERK2 Cascade Positive Regulation Of ERK1 And ERK2 Cascade G Protein-coupled Serotonin Receptor Signaling Pathway	Biogenic Amine Metabolic Process Polyamine Biosynthetic Process Positive Regulation Of Protein Catabolic Process Viral Translational Frameshifting Positive Regulation Of Intracellular Protein Transport Negative Regulation Of Polyamine Transmembrane Transport
Pathways		Serotonin receptors G alpha (q) signalling events	Regulation of ornithine decarboxylase (ODC) Metabolism of polyamines
Drugs		Methysergide Cabergoline Zolmitriptan Dihydroergotamine Methylergometrine Cyproheptadine Chlorpromazine Triflupromazine Amoxapine Fenfluramine Lisuride Ergotamine Apomorphine Paroxetine Paroxetine Minaprine Cyclobenzaprine Ergoloid mesylate Tegaserod Doxepin Pergolide Bromocriptine Ketamine Aripiprazole Chlorprothixene Clomipramine Yohimbine Midomafetamine Lysergic acid diethylamide OPC-28326 Epicept NP-1 PRX-08066 Cariprazine Mianserin Pizotifen Asenapine Ocaperidone Esmirtazapine Nandrolone decanoate Viloxazine Pipamperone Setiptiline Dihydroergocornine Gilteritinib Tiapride Dihydroergocristine	Ornithine
Diseases
GWAS		Proportion of activated microglia (midfrontal cortex) ( 30679421) Thiazide-induced adverse metabolic effects in hypertensive patients ( 23400010)
Interacting Genes		27 interacting genes: ABCA3 ATP1B1 BNIP3 BNIP3L CBR1 CHPT1 G6PC3 GNA11 GNAQ HAT1 HDGFL2 INSIG1 KIF19 LNX1 MATR3 METRN NAT14 NIPA2 OAZ1 PLLP PPP1R3F RAE1 SLC31A2 SLC37A1 SLC44A2 SNTA1 TRAM1L1	13 interacting genes: AGTR1 ATXN1 EGFR HTR2B MYCBP2 NLGN3 NRIP1 OAZ2 OAZ3 ODC1 PIAS4 PSMB4 SMAD1
Entrez ID		3357	4946
HPRD ID		03077	03346
Ensembl ID		ENSG00000135914	ENSG00000104904
Uniprot IDs		P41595	J3QQY4 P54368
PDB IDs		4IB4 4NC3 5TUD 5TVN 6DRX 6DRY 6DRZ 6DS0 7SRQ 7SRR 7SRS	4ZGY 4ZGZ 5BWA
Enriched GO Terms of Interacting Partners?		Glucose-6-phosphate Transport Phosphatidylcholine Metabolic Process Mitochondrial Protein Catabolic Process Negative Regulation Of Membrane Potential Negative Regulation Of Mitochondrial Membrane Potential Mitochondrial Outer Membrane Permeabilization Phospholipase C-activating Serotonin Receptor Signaling Pathway Phototransduction, Visible Light Lysosomal Membrane Positive Regulation Of Mitochondrial Membrane Permeability Involved In Apoptotic Process Mitochondrial Envelope Mitochondrial Outer Membrane Permeabilization Involved In Programmed Cell Death Guanyl Nucleotide Binding Regulation Of Membrane Potential G Protein-coupled Acetylcholine Receptor Signaling Pathway G-protein Beta/gamma-subunit Complex Binding G Protein-coupled Serotonin Receptor Signaling Pathway Phosphatidylcholine Biosynthetic Process Regulation Of Mitochondrial Membrane Permeability Involved In Apoptotic Process Detection Of Visible Light Positive Regulation Of Mitochondrial Membrane Permeability Cellular Response To PH Entrainment Of Circadian Clock Enzyme Regulator Activity Positive Regulation Of Protein Homooligomerization Organophosphate Ester Transport Transmembrane Transport Glycerolipid Metabolic Process Lamellar Body Membrane Membrane Positive Regulation Of Membrane Permeability Mitochondrion Autophagosome Adaptor Activity Prostaglandin E2 9-reductase Activity 15-hydroxyprostaglandin Dehydrogenase (NADP+) Activity Regulation Of Copper Ion Transmembrane Transport Heterotrimeric G-protein Complex Negative Regulation Of Cargo Loading Into COPII-coated Vesicle Plus-end Specific Microtubule Depolymerization Axonemal Microtubule Depolymerization Regulation Of Sodium Ion Transmembrane Transport Response To PH Phototransduction Acetylcholine Receptor Signaling Pathway	Amine Biosynthetic Process Biogenic Amine Biosynthetic Process Polyamine Biosynthetic Process Biogenic Amine Metabolic Process Polyamine Metabolic Process Amine Metabolic Process Ornithine Decarboxylase Inhibitor Activity Negative Regulation Of Polyamine Transmembrane Transport Positive Regulation Of Metabolic Process Regulation Of Protein Catabolic Process Viral Translational Frameshifting Regulation Of Primary Metabolic Process Regulation Of Metabolic Process Positive Regulation Of Macromolecule Metabolic Process System Process Transcription Coregulator Activity Cellular Response To Estradiol Stimulus Positive Regulation Of Protein Metabolic Process Positive Regulation Of Cell Population Proliferation Positive Regulation Of Epithelial Cell Proliferation Angiotensin Type I Receptor Activity Animal Organ Development Hair Follicle Development Regulation Of Protein Localization Nervous System Process Multivesicular Body, Internal Vesicle Lumen GTP Cyclohydrolase I Activity Ovarian Follicle Rupture Regulation Of Cellular Response To Stress MAPK Cascade Social Behavior Positive Regulation Of MiRNA Transcription Regulation Of Macromolecule Metabolic Process Regulation Of Protein Metabolic Process Positive Regulation Of MiRNA Metabolic Process Bradykinin Receptor Binding Learning Or Memory Shc-EGFR Complex Endocytic Vesicle Homomeric SMAD Protein Complex Circadian Regulation Of Gene Expression Limb Epidermis Development Regulation Of Cell Population Proliferation Phospholipase C-activating Angiotensin-activated Signaling Pathway Renin-angiotensin Regulation Of Aldosterone Production Cytoplasm Cognition Regulation Of MiRNA Transcription Positive Regulation Of Protein Kinase C Signaling Ubiquitin Protein Ligase Binding
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