SUMO3 and TDP2

Number of citations of the paper that reports this interaction (PMID 16524884)
113

Data Source:
BioGRID (pull down)

		SUMO3	TDP2
Gene Name		small ubiquitin-like modifier 3	tyrosyl-DNA phosphodiesterase 2
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Kinetochore Nucleus Nucleoplasm Cytoplasm PML Body Extracellular Vesicular Exosome	Nucleus Nucleoplasm Nucleolus Cytoplasm PML Body Intercellular Bridge
	Molecular Function	Protein Binding SUMO Transferase Activity	Magnesium Ion Binding Single-stranded DNA Binding Transcription Corepressor Activity Nuclease Activity Protein Binding Manganese Ion Binding Tyrosyl-RNA Phosphodiesterase Activity 5'-tyrosyl-DNA Phosphodiesterase Activity
	Biological Process	Protein Sumoylation Protein Localization To Nucleus Post-translational Protein Modification Cellular Protein Metabolic Process Positive Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process	Double-strand Break Repair Cell Surface Receptor Signaling Pathway Nucleic Acid Phosphodiester Bond Hydrolysis Negative Regulation Of Nucleic Acid-templated Transcription
Pathways		SUMO is proteolytically processed Post-translational protein modification SUMOylation SUMO is conjugated to E1 (UBA2:SAE1) SUMO is transferred from E1 to E2 (UBE2I, UBC9) Processing and activation of SUMO
Drugs
Diseases
GWAS
Protein-Protein Interactions		53 interactors: ANXA7 ARL13A ARNTL ATF3 ATF7IP BCL11A BLM CCNE2 CDKN1A CEBPA CHAF1A CUL3 FOS HSF1 HSF2 JUN KALRN KCNA5 KRT14 KRT5 KRT8 MAPKAPK3 NFKBIA PFDN1 PIAS1 PIAS2 PIAS3 PIAS4 PML RANGAP1 SAE1 SATB1 SENP1 SENP2 SENP5 SH3KBP1 SMN1 SOX10 SOX6 SP100 STAB2 STK24 TDG TDP2 TK1 TP53BP2 TTR UBA2 UBE2I UBE3A UPF2 USPL1 VIM	29 interactors: AKAP9 ATP5G2 ATXN1 C2orf88 CD40 DLX3 EPS8 ETS1 ETS2 FLI1 JAM2 MAPK6 PSEN1 RAB11A SKIL SMAD3 SNX13 SRPK2 SUMO1 SUMO2 SUMO3 TAP1 TNFRSF1B TNFRSF8 TRAF2 TRAF3 TRAF5 TRAF6 UBE2I
Entrez ID		6612	51567
HPRD ID		03754	05771
Ensembl ID		ENSG00000184900	ENSG00000111802
Uniprot IDs		B4DUW4 P55854	O95551
PDB IDs		1U4A 2IO1
Enriched GO Terms of Interacting Partners?		Protein Sumoylation Positive Regulation Of Metabolic Process Peptidyl-lysine Modification Positive Regulation Of Gene Expression Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Cellular Metabolic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Gene Expression Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Regulation Of Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Protein Modification By Small Protein Conjugation Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Cellular Metabolic Process Regulation Of Gene Expression Positive Regulation Of Transcription From RNA Polymerase II Promoter Response To Stimulus Negative Regulation Of Transcription From RNA Polymerase II Promoter Anatomical Structure Development Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Transcription, DNA-templated Regulation Of Transcription, DNA-templated Regulation Of Nitrogen Compound Metabolic Process Protein Desumoylation Cellular Metabolic Process Apoptotic Signaling Pathway RNA Biosynthetic Process Peptidyl-amino Acid Modification Developmental Process Apoptotic Process Programmed Cell Death Viral Process Transcription From RNA Polymerase II Promoter Cell Death Death RNA Metabolic Process Multicellular Organismal Development Response To Abiotic Stimulus System Development Regulation Of Cellular Process Cellular Response To Stimulus Cellular Response To Stress Regulation Of Cell Cycle Cellular Macromolecule Biosynthetic Process Nucleobase-containing Compound Metabolic Process	Positive Regulation Of Metabolic Process Immune System Process Positive Regulation Of Cellular Metabolic Process Protein Sumoylation Positive Regulation Of Proteolysis Positive Regulation Of Protein Metabolic Process Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Cellular Process Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Cellular Protein Metabolic Process Protein Modification By Small Protein Conjugation Regulation Of Apoptotic Process Positive Regulation Of Cell Death Regulation Of Metabolic Process Regulation Of Immunoglobulin Secretion Regulation Of Cell Death Regulation Of Proteolysis Regulation Of Protein Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Gene Expression Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Nitrogen Compound Metabolic Process Regulation Of Protein Catabolic Process Positive Regulation Of Protein Catabolic Process Regulation Of RNA Metabolic Process Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Signal Transduction PML Body Organization Immune Response Regulation Of Binding Response To Organic Substance Response To Stimulus Response To Cytokine Positive Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Signaling Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Transcription, DNA-templated Negative Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Negative Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Intracellular Signal Transduction Signaling Regulation Of Signal Transduction Positive Regulation Of Cellular Protein Catabolic Process Negative Regulation Of Nucleic Acid-templated Transcription Regulation Of Cytokine Production Negative Regulation Of RNA Biosynthetic Process
Tagcloud ?		aphidicolin attachment break breakage budding cfs covalent excessive fields fragile hallmark modifier ortholog perturbed pol32 pold3 polypeptides proteomic recombinational replication resource rpa ssdna stresses subfamily sumo1 sumo2 sumoylation	accrued akin ape2 aprataxin aptx apurinic arsenal cleansing ctip endonucleases environ fen1 mre11 mutagen nucleolytic phosphodiesterases pnk polbeta polynucleotide rad50 rddr splintered ssbs tailor tdp1 termini topoisomerases toxicants transactions
Tagcloud (Difference) ?		aphidicolin attachment break breakage budding cfs covalent excessive fields fragile hallmark modifier ortholog perturbed pol32 pold3 polypeptides proteomic recombinational replication resource rpa ssdna stresses subfamily sumo1 sumo2 sumoylation	accrued akin ape2 aprataxin aptx apurinic arsenal cleansing ctip endonucleases environ fen1 mre11 mutagen nucleolytic phosphodiesterases pnk polbeta polynucleotide rad50 rddr splintered ssbs tailor tdp1 termini topoisomerases toxicants transactions
Tagcloud (Intersection) ?