SUMO3 and MAPKAPK3

Number of citations of the paper that reports this interaction (PMID 21900206)
27

Data Source:
BioGRID (two hybrid)

		SUMO3	MAPKAPK3
Gene Name		small ubiquitin-like modifier 3	mitogen-activated protein kinase-activated protein kinase 3
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Gene Ontology Annotations	Cellular Component	Kinetochore Nucleus Nucleoplasm Cytoplasm PML Body Extracellular Vesicular Exosome	Nucleus Nucleoplasm Cytoplasm Cytosol Nuclear Membrane
	Molecular Function	Protein Binding SUMO Transferase Activity	Protein Serine/threonine Kinase Activity MAP Kinase Kinase Activity Protein Binding ATP Binding
	Biological Process	Protein Sumoylation Protein Localization To Nucleus Post-translational Protein Modification Cellular Protein Metabolic Process Positive Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process	Activation Of MAPK Activity Toll-like Receptor Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Response To Stress Signal Transduction Ras Protein Signal Transduction Peptidyl-serine Phosphorylation Response To Lipopolysaccharide Response To Cytokine Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Toll-like Receptor 10 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Macropinocytosis Innate Immune Response Vascular Endothelial Growth Factor Receptor Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Stress-activated MAPK Cascade
Pathways		SUMO is proteolytically processed Post-translational protein modification SUMOylation SUMO is conjugated to E1 (UBA2:SAE1) SUMO is transferred from E1 to E2 (UBE2I, UBC9) Processing and activation of SUMO	Signalling to ERKs Toll Like Receptor 7/8 (TLR7/8) Cascade Cellular Senescence VEGFA-VEGFR2 Pathway Toll Like Receptor TLR6:TLR2 Cascade Activated TLR4 signalling Toll Like Receptor TLR1:TLR2 Cascade MyD88 cascade initiated on plasma membrane Toll Like Receptor 5 (TLR5) Cascade p38MAPK events MyD88 dependent cascade initiated on endosome TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation MyD88:Mal cascade initiated on plasma membrane Toll Like Receptor 9 (TLR9) Cascade Innate Immune System activated TAK1 mediates p38 MAPK activation Signalling by NGF TRIF-mediated TLR3/TLR4 signaling MAP kinase activation in TLR cascade NGF signalling via TRKA from the plasma membrane MyD88-independent cascade Toll Like Receptor 2 (TLR2) Cascade Toll-Like Receptors Cascades Toll Like Receptor 10 (TLR10) Cascade Signaling by VEGF Oxidative Stress Induced Senescence Signalling to RAS Toll Like Receptor 4 (TLR4) Cascade Toll Like Receptor 3 (TLR3) Cascade
Drugs
Diseases
GWAS
Protein-Protein Interactions		53 interactors: ANXA7 ARL13A ARNTL ATF3 ATF7IP BCL11A BLM CCNE2 CDKN1A CEBPA CHAF1A CUL3 FOS HSF1 HSF2 JUN KALRN KCNA5 KRT14 KRT5 KRT8 MAPKAPK3 NFKBIA PFDN1 PIAS1 PIAS2 PIAS3 PIAS4 PML RANGAP1 SAE1 SATB1 SENP1 SENP2 SENP5 SH3KBP1 SMN1 SOX10 SOX6 SP100 STAB2 STK24 TDG TDP2 TK1 TP53BP2 TTR UBA2 UBE2I UBE3A UPF2 USPL1 VIM	16 interactors: APP COPS6 EEF2 EEF2K EZH2 HSPB1 IGHM MAPK11 MAPK13 MAPK14 NEDD4 NEDD4L RAB2A SMS SUMO3 TCF3
Entrez ID		6612	7867
HPRD ID		03754	03678
Ensembl ID		ENSG00000184900	ENSG00000114738
Uniprot IDs		B4DUW4 P55854	Q16644
PDB IDs		1U4A 2IO1	3FHR 3FXW 3R1N 3SHE
Enriched GO Terms of Interacting Partners?		Protein Sumoylation Positive Regulation Of Metabolic Process Peptidyl-lysine Modification Positive Regulation Of Gene Expression Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Cellular Metabolic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Gene Expression Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Regulation Of Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Protein Modification By Small Protein Conjugation Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Cellular Metabolic Process Regulation Of Gene Expression Positive Regulation Of Transcription From RNA Polymerase II Promoter Response To Stimulus Negative Regulation Of Transcription From RNA Polymerase II Promoter Anatomical Structure Development Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Transcription, DNA-templated Regulation Of Transcription, DNA-templated Regulation Of Nitrogen Compound Metabolic Process Protein Desumoylation Cellular Metabolic Process Apoptotic Signaling Pathway RNA Biosynthetic Process Peptidyl-amino Acid Modification Developmental Process Apoptotic Process Programmed Cell Death Viral Process Transcription From RNA Polymerase II Promoter Cell Death Death RNA Metabolic Process Multicellular Organismal Development Response To Abiotic Stimulus System Development Regulation Of Cellular Process Cellular Response To Stimulus Cellular Response To Stress Regulation Of Cell Cycle Cellular Macromolecule Biosynthetic Process Nucleobase-containing Compound Metabolic Process	Positive Regulation Of Protein Metabolic Process Cellular Protein Modification Process Regulation Of Protein Metabolic Process Vascular Endothelial Growth Factor Receptor Signaling Pathway Cellular Protein Metabolic Process Regulation Of Muscle Cell Differentiation Posttranscriptional Regulation Of Gene Expression Ras Protein Signal Transduction Positive Regulation Of Metabolic Process Gene Expression Regulation Of Cellular Protein Metabolic Process Enzyme Linked Receptor Protein Signaling Pathway Protein Metabolic Process Peptidyl-amino Acid Modification Negative Regulation Of Sodium Ion Transport Positive Regulation Of Muscle Cell Differentiation Cellular Response To Growth Factor Stimulus Response To Growth Factor Regulation Of Protein Phosphorylation Cell Surface Receptor Signaling Pathway Positive Regulation Of Cellular Protein Metabolic Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cell Activation Regulation Of Protein Kinase Activity Response To Organic Substance Positive Regulation Of Cellular Metabolic Process Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Cellular Response To Organic Substance Response To Stress Regulation Of Kinase Activity Regulation Of Phosphorylation Skeletal Muscle Tissue Regeneration Regulation Of Potassium Ion Transmembrane Transporter Activity Regulation Of Signal Transduction Regulation Of Phosphorus Metabolic Process Immune System Process Platelet Activation Regulation Of Potassium Ion Transmembrane Transport Regulation Of Gene Expression Protein Monoubiquitination Regulation Of Cell Differentiation Neurotrophin TRK Receptor Signaling Pathway Positive Regulation Of MAP Kinase Activity Cellular Response To Vascular Endothelial Growth Factor Stimulus Regulation Of Signaling Positive Regulation Of Protein Catabolic Process Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Metabolic Process Neurotrophin Signaling Pathway MAPK Cascade
Tagcloud ?		aphidicolin attachment break breakage budding cfs covalent excessive fields fragile hallmark modifier ortholog perturbed pol32 pold3 polypeptides proteomic recombinational replication resource rpa ssdna stresses subfamily sumo1 sumo2 sumoylation	ca1 ca3 carries corresponds dentate depolarization differential display forskolin frame gyrus identical intron kainic library message mitogen ortholog pc12 pheochromocytoma preceded predicted proline rat reading repressed seizures terminus
Tagcloud (Difference) ?		aphidicolin attachment break breakage budding cfs covalent excessive fields fragile hallmark modifier perturbed pol32 pold3 polypeptides proteomic recombinational replication resource rpa ssdna stresses subfamily sumo1 sumo2 sumoylation	ca1 ca3 carries corresponds dentate depolarization differential display forskolin frame gyrus identical intron kainic library message mitogen pc12 pheochromocytoma preceded predicted proline rat reading repressed seizures terminus
Tagcloud (Intersection) ?		ortholog