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SUMO3 and UBE3A
Number of citations of the paper that reports this interaction (PubMedID
21900206
)
0
Data Source:
BioGRID
(two hybrid)
SUMO3
UBE3A
Description
small ubiquitin like modifier 3
ubiquitin protein ligase E3A
Image
GO Annotations
Cellular Component
Kinetochore
Nucleus
Nucleoplasm
Cytoplasm
PML Body
Proteasome Complex
Nucleus
Cytoplasm
Cytosol
Synaptic Vesicle
Glutamatergic Synapse
Postsynaptic Cytosol
Molecular Function
Protein Binding
Protein Tag Activity
Ubiquitin-like Protein Ligase Binding
Transcription Coactivator Activity
Ubiquitin-protein Transferase Activity
Protein Binding
Zinc Ion Binding
Transferase Activity
Metal Ion Binding
Ubiquitin Protein Ligase Activity
Biological Process
Protein Sumoylation
Negative Regulation Of DNA Binding
Regulation Of Protein Localization To Nucleus
Protein Polyubiquitination
Ovarian Follicle Development
Proteolysis
Ubiquitin-dependent Protein Catabolic Process
Brain Development
Positive Regulation Of Macromolecule Metabolic Process
Protein Ubiquitination
Nuclear Receptor-mediated Steroid Hormone Signaling Pathway
Androgen Receptor Signaling Pathway
Positive Regulation Of Protein Ubiquitination
Cellular Response To Nutrient Levels
Response To Progesterone
Sperm Entry
Regulation Of Circadian Rhythm
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of Transcription By RNA Polymerase II
Regulation Of Synaptic Plasticity
Rhythmic Process
Animal Organ Development
System Development
Modulation Of Chemical Synaptic Transmission
Progesterone Receptor Signaling Pathway
Protein Autoubiquitination
Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Prostate Gland Growth
Protein K48-linked Ubiquitination
Regulation Of Primary Metabolic Process
Positive Regulation Of Protein Localization To Lysosome
Negative Regulation Of TORC1 Signaling
Positive Regulation Of TORC1 Signaling
Positive Regulation Of Golgi Lumen Acidification
Regulation Of Ubiquitin-dependent Protein Catabolic Process
Pathways
SUMO is conjugated to E1 (UBA2:SAE1)
SUMO is transferred from E1 to E2 (UBE2I, UBC9)
SUMO is proteolytically processed
SUMOylation of DNA damage response and repair proteins
SUMOylation of transcription factors
SUMOylation of transcription cofactors
SUMOylation of intracellular receptors
SUMOylation of intracellular receptors
SUMOylation of chromatin organization proteins
SUMOylation of DNA replication proteins
SUMOylation of immune response proteins
Formation of Incision Complex in GG-NER
Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
Prader-Willi and Angelman syndromes, including: Angelman syndrome (AS); Prader-Willi syndrome (PWS)
GWAS
Delirium (
29631748
)
Cardiac hypertrophy (
21348951
)
Gene methylation in lung tissue (
25713168
)
Obesity-related traits (
23251661
)
Interacting Genes
62 interacting genes:
ANXA7
BLM
CCNE2
CDKN1A
CEBPA
CHAF1A
COPS5
CUL3
DAXX
EGLN3
FAM221A
FOS
HIPK1
HIPK2
HOMEZ
HSF1
HSF2
JUN
KALRN
MAPKAPK3
MORC3
PAX6
PCGF2
PFDN1
PIAS1
PIAS2
PIAS3
PIAS4
PML
RAD54L2
RANGAP1
RNF111
RNF8
SAE1
SENP1
SENP2
SENP5
SMN1
SNRNP70
SOX10
SOX6
SP100
TDG
TDP2
TK1
TP53BP2
TTR
UBA2
UBE2I
UBE3A
UPF2
USP25
USPL1
VIM
WWTR1
YAP1
ZBTB33
ZBTB39
ZCCHC12
ZMYM2
ZNF451
ZNF496
165 interacting genes:
ACTA2
ACTB
ACTBL2
ACTR3
ADRM1
AFG3L1P
AFTPH
AHSP
ALDH1A2
ANXA1
APP
AR
ARC
ARHGDIB
ASAP3
ATG9A
BAK1
BARD1
BLK
BPY2
BPY2B
BPY2C
BRCA1
CALR
CAPN3
CDK1
CDK4
CDKN1B
CEBPZ
CGGBP1
CKB
CRP
CSTPP1
CTNNB1
DAZAP2
DDI2
DLG1
DLG4
E2F1
EAPP
EEF1A2
EID1
EIF4G1
EML1
ENO1
ENO2
ESR1
FAF2
GFAP
GOPC
GTF3C1
HBA1
HPCAL4
HSP90AB1
HSPA2
HSPA4
HSPA5
IL24
JADE1
KLHL38
KRT1
KRT5
KRT7
KRT9
LCK
LCN2
MAGEA12
MAGEA8
MAPK1
MAPK10
MARF1
MCM2
MCM4
MCM6
MCM7
MDM1
MDM2
MDM4
MEOX2
MSTO1
MYCBP
MYCN
NBPF14
NDUFA13
NELFCD
NFX1
NHERF1
NOMO2
NR3C1
NR4A3
NUMBL
PAICS
PARVA
PAX5
PAX6
PBRM1
PDE1B
PDIA3
PDIA6
PGK1
PGR
PKM
PML
POLE4
PPIA
PPP1R3F
PRAG1
PRDX1
PRKACA
PRMT5
PRSS1
PSAP
PTCD3
RAD23A
RAD23B
RARA
RMI1
RNF152
RNF2
RPS15A
RYBP
SACS
SCAMP1
SCRIB
SERPINB2
SET
SHBG
SIPA1L1
SIRT6
SMAD9
SNAPC3
SOD1
SPINK1
SUMO3
TALDO1
TAT
TBC1D14
TCF19
TMEM14B
TP53
TP53BP2
TRIM65
TSC2
TTC23L
TTC3
TUBB
UBC
UBE2D1
UBE2D2
UBE2D3
UBE2E1
UBE2G1
UBE2G2
UBE2L3
UBE2L6
UBE2N
UBQLN2
UBR5
WBP2
WDR4
YOD1
YWHAE
YWHAG
ZNF250
ZNF446
Entrez ID
6612
7337
HPRD ID
03754
03375
Ensembl ID
ENSG00000184900
ENSG00000114062
Uniprot IDs
P55854
A0A6Q8PHE5
Q05086
Q9H2G0
PDB IDs
1U4A
2IO1
2MP2
6K5R
6NNQ
7R2E
7ZJU
1C4Z
1D5F
1EQX
2KR1
4GIZ
4XR8
6SJV
6SLM
6TGK
6U19
7Q41
7QPB
8ENP
8EPT
8GCR
8JRN
8JRO
8JRP
8JRQ
8JRR
8R1F
8R1G
9CHT
Enriched GO Terms of Interacting Partners
?
PML Body
Protein Sumoylation
Nucleus
Nucleoplasm
Negative Regulation Of Macromolecule Metabolic Process
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Negative Regulation Of DNA-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Negative Regulation Of RNA Metabolic Process
Negative Regulation Of Metabolic Process
Protein Modification By Small Protein Conjugation
Regulation Of Primary Metabolic Process
Regulation Of RNA Metabolic Process
Regulation Of Macromolecule Metabolic Process
Regulation Of DNA-templated Transcription
Post-translational Protein Modification
Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of RNA Biosynthetic Process
Negative Regulation Of Macromolecule Biosynthetic Process
Negative Regulation Of Biosynthetic Process
Regulation Of Metabolic Process
Protein Modification Process
Regulation Of Transcription By RNA Polymerase II
SUMO Transferase Activity
Regulation Of Gene Expression
Negative Regulation Of Transcription By RNA Polymerase II
Regulation Of Macromolecule Biosynthetic Process
SUMO Binding
SMAD Protein Signal Transduction
Cellular Response To Stress
SUMO Ligase Activity
Positive Regulation Of Protein Sumoylation
Postsynaptic Cytosol
Ubiquitin Protein Ligase Binding
Macromolecule Metabolic Process
Regulation Of Post-translational Protein Modification
Positive Regulation Of Post-translational Protein Modification
Transcription Corepressor Activity
Positive Regulation Of Macromolecule Metabolic Process
DeSUMOylase Activity
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
DNA Damage Response
Regulation Of Protein Sumoylation
Protein Desumoylation
Transcription Coregulator Activity
Chromatin
Positive Regulation Of RNA Metabolic Process
Regulation Of Protein Metabolic Process
Positive Regulation Of Metabolic Process
Presynaptic Cytosol
Cytosol
Nucleus
Cytoplasm
Ubiquitin Protein Ligase Binding
Cellular Response To Stress
Proteolysis Involved In Protein Catabolic Process
Ubiquitin Conjugating Enzyme Activity
Protein Polyubiquitination
Ubiquitin-protein Transferase Activity
Nucleoplasm
Regulation Of Cell Cycle
Regulation Of Macromolecule Metabolic Process
Response To Stress
Protein-containing Complex
Proteasomal Protein Catabolic Process
Modification-dependent Protein Catabolic Process
Regulation Of Mitotic Cell Cycle
Extracellular Exosome
Ubiquitin-dependent Protein Catabolic Process
Regulation Of Metabolic Process
Positive Regulation Of Macromolecule Metabolic Process
Regulation Of Programmed Cell Death
Nuclear Receptor-mediated Signaling Pathway
Protein Metabolic Process
Regulation Of Gene Expression
Regulation Of Apoptotic Process
Protein Catabolic Process
Regulation Of Macromolecule Biosynthetic Process
Regulation Of Primary Metabolic Process
Post-translational Protein Modification
Positive Regulation Of Metabolic Process
Macromolecule Metabolic Process
Protein Binding
Protein Modification By Small Protein Conjugation
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Negative Regulation Of RNA Metabolic Process
Negative Regulation Of DNA-templated Transcription
Positive Regulation Of Programmed Cell Death
Negative Regulation Of RNA Biosynthetic Process
Negative Regulation Of Biosynthetic Process
Negative Regulation Of Macromolecule Biosynthetic Process
Protein Ubiquitination
Positive Regulation Of Biosynthetic Process
Intracellular Signal Transduction
Positive Regulation Of Apoptotic Process
Negative Regulation Of Macromolecule Metabolic Process
Macromolecule Catabolic Process
Enzyme Binding
Identical Protein Binding
Regulation Of DNA-templated Transcription
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