SUMO3 and RNF8

Number of citations of the paper that reports this interaction (PubMedID 28983621)
0

Data Source:
BioGRID (pull down, affinity chromatography technology, imaging technique)

		SUMO3	RNF8
Description		small ubiquitin like modifier 3	ring finger protein 8
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GO Annotations	Cellular Component	Kinetochore Nucleus Nucleoplasm Cytoplasm PML Body	Ubiquitin Ligase Complex Chromosome, Telomeric Region Nucleus Nucleoplasm Chromosome Cytoplasm Cytosol Midbody Site Of Double-strand Break
	Molecular Function	Protein Binding Protein Tag Activity Ubiquitin-like Protein Ligase Binding	Chromatin Binding Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Ubiquitin Protein Ligase Binding Histone Binding Identical Protein Binding Protein Homodimerization Activity Ubiquitin Binding Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Protein Sumoylation Negative Regulation Of DNA Binding Regulation Of Protein Localization To Nucleus	DNA Repair Double-strand Break Repair Double-strand Break Repair Via Nonhomologous End Joining Chromatin Organization Ubiquitin-dependent Protein Catabolic Process DNA Damage Response Response To Ionizing Radiation Protein Ubiquitination Negative Regulation Of Transcription Elongation By RNA Polymerase II Sperm DNA Condensation Interstrand Cross-link Repair Epigenetic Regulation Of Gene Expression Signal Transduction In Response To DNA Damage Isotype Switching Positive Regulation Of DNA Repair Cell Division Protein Autoubiquitination Protein K63-linked Ubiquitination Protein K48-linked Ubiquitination Protein K6-linked Ubiquitination DNA Repair-dependent Chromatin Remodeling Positive Regulation Of Double-strand Break Repair Via Homologous Recombination Protein Localization To Site Of Double-strand Break
Pathways		SUMO is conjugated to E1 (UBA2:SAE1) SUMO is transferred from E1 to E2 (UBE2I, UBC9) SUMO is proteolytically processed SUMOylation of DNA damage response and repair proteins SUMOylation of transcription factors SUMOylation of transcription cofactors SUMOylation of intracellular receptors SUMOylation of intracellular receptors SUMOylation of chromatin organization proteins SUMOylation of DNA replication proteins SUMOylation of immune response proteins Formation of Incision Complex in GG-NER	Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Nonhomologous End-Joining (NHEJ) Processing of DNA double-strand break ends G2/M DNA damage checkpoint
Drugs
Diseases
GWAS		Delirium ( 29631748)	Acne (severe) ( 24927181) Restless legs syndrome ( 29029846)
Interacting Genes		62 interacting genes: ANXA7 BLM CCNE2 CDKN1A CEBPA CHAF1A COPS5 CUL3 DAXX EGLN3 FAM221A FOS HIPK1 HIPK2 HOMEZ HSF1 HSF2 JUN KALRN MAPKAPK3 MORC3 PAX6 PCGF2 PFDN1 PIAS1 PIAS2 PIAS3 PIAS4 PML RAD54L2 RANGAP1 RNF111 RNF8 SAE1 SENP1 SENP2 SENP5 SMN1 SNRNP70 SOX10 SOX6 SP100 TDG TDP2 TK1 TP53BP2 TTR UBA2 UBE2I UBE3A UPF2 USP25 USPL1 VIM WWTR1 YAP1 ZBTB33 ZBTB39 ZCCHC12 ZMYM2 ZNF451 ZNF496	78 interacting genes: AMOTL2 BLM CALCOCO1 CATSPERT CCDC14 CCDC50 CCDC85B CEP44 CEP85 CFLAR CHD4 CHEK2 CLK2 CLK3 DNM2 DNTTIP2 EPN2 EPN3 EXOSC2 FAM9B FSD2 GPRASP2 H2AC20 H2AC4 H2AX H2BC21 H2BC3 HOMEZ JMJD1C KDM4A KIF24 KMT5A KRTAP10-1 KRTAP10-8 KRTAP9-2 KRTAP9-8 LMO4 MAD1L1 MAGED1 MAPK1 MDC1 MDM2 NONO PCYT1A PGRMC2 PICK1 PNMA2 POLD4 RBFOX2 RECQL4 RXRA RYBP SCN3B SEPTIN3 SH3GL3 STX11 SUMO2 SUMO3 TMEM79 TNIP1 TOMM20L TRIM29 UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2E2 UBE2E3 UBE2N UBE2V2 UBE2W VCP WASL XRN2 YEATS4 ZBTB10 ZNF346 ZNF496
Entrez ID		6612	9025
HPRD ID		03754	11521
Ensembl ID		ENSG00000184900	ENSG00000112130
Uniprot IDs		P55854	O76064
PDB IDs		1U4A 2IO1 2MP2 6K5R 6NNQ 7R2E 7ZJU	2CSW 2PIE 4AYC 4ORH 4WHV
Enriched GO Terms of Interacting Partners?		PML Body Protein Sumoylation Nucleus Nucleoplasm Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Metabolic Process Negative Regulation Of Metabolic Process Protein Modification By Small Protein Conjugation Regulation Of Primary Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Post-translational Protein Modification Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Biosynthetic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Regulation Of Metabolic Process Protein Modification Process Regulation Of Transcription By RNA Polymerase II SUMO Transferase Activity Regulation Of Gene Expression Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Macromolecule Biosynthetic Process SUMO Binding SMAD Protein Signal Transduction Cellular Response To Stress SUMO Ligase Activity Positive Regulation Of Protein Sumoylation Postsynaptic Cytosol Ubiquitin Protein Ligase Binding Macromolecule Metabolic Process Regulation Of Post-translational Protein Modification Positive Regulation Of Post-translational Protein Modification Transcription Corepressor Activity Positive Regulation Of Macromolecule Metabolic Process DeSUMOylase Activity Positive Regulation Of Nucleobase-containing Compound Metabolic Process DNA Damage Response Regulation Of Protein Sumoylation Protein Desumoylation Transcription Coregulator Activity Chromatin Positive Regulation Of RNA Metabolic Process Regulation Of Protein Metabolic Process Positive Regulation Of Metabolic Process Presynaptic Cytosol	Ubiquitin Conjugating Enzyme Activity Nucleus Protein Polyubiquitination Nucleoplasm DNA Damage Response DNA Repair Protein Modification By Small Protein Conjugation Protein Monoubiquitination Protein Ubiquitination DNA Metabolic Process Post-translational Protein Modification Protein K63-linked Ubiquitination Protein Binding Identical Protein Binding Ubiquitin-protein Transferase Activity Negative Regulation Of Biosynthetic Process Protein Modification Process Double-strand Break Repair Protein K48-linked Ubiquitination Regulation Of Nucleobase-containing Compound Metabolic Process Chromosome DNA Recombination Negative Regulation Of Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Gene Expression Chromosome, Telomeric Region Nucleosome Negative Regulation Of Membrane Tubulation Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Biosynthetic Process Protein K11-linked Ubiquitination Double-strand Break Repair Via Homologous Recombination Negative Regulation Of Macromolecule Metabolic Process Recombinational Repair Structural Constituent Of Chromatin DNA/DNA Annealing Activity Regulation Of Double-strand Break Repair UBC13-MMS2 Complex Cellular Response To Stress Ubiquitin Protein Ligase Binding Positive Regulation Of Protein Polyubiquitination Regulation Of Metabolic Process Positive Regulation Of Double-strand Break Repair Telomeric D-loop Binding ISG15 Transferase Activity Ubiquitin Conjugating Enzyme Complex Regulation Of RNA Metabolic Process ATP Binding
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