SUMO3 and FOS

Number of citations of the paper that reports this interaction (PMID 16055710)
44

Data Source:
HPRD (in vitro)

		SUMO3	FOS
Gene Name		small ubiquitin-like modifier 3	FBJ murine osteosarcoma viral oncogene homolog
Image
Gene Ontology Annotations	Cellular Component	Kinetochore Nucleus Nucleoplasm Cytoplasm PML Body Extracellular Vesicular Exosome	Nucleus Nucleoplasm Transcription Factor Complex Endoplasmic Reticulum Cytosol Membrane Neuron Projection
	Molecular Function	Protein Binding SUMO Transferase Activity	RNA Polymerase II Core Promoter Sequence-specific DNA Binding Double-stranded DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Transcription Factor Binding Transcription Regulatory Region DNA Binding R-SMAD Binding
	Biological Process	Protein Sumoylation Protein Localization To Nucleus Post-translational Protein Modification Cellular Protein Metabolic Process Positive Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process	Conditioned Taste Aversion Toll-like Receptor Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway DNA Methylation Regulation Of Transcription From RNA Polymerase II Promoter Transcription From RNA Polymerase II Promoter Inflammatory Response Transforming Growth Factor Beta Receptor Signaling Pathway Nervous System Development Female Pregnancy Aging Response To Cold Response To Light Stimulus Response To Mechanical Stimulus Response To Gravity Response To Toxic Substance Sleep Cellular Response To Extracellular Stimulus Response To Lipopolysaccharide Response To Progesterone Cellular Response To Hormone Stimulus Response To Cytokine Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Cellular Response To Reactive Oxygen Species TRIF-dependent Toll-like Receptor Signaling Pathway Response To Immobilization Stress Skeletal Muscle Cell Differentiation Fc-epsilon Receptor Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Response To Drug Innate Immune Response Positive Regulation Of Osteoclast Differentiation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Stress-activated MAPK Cascade Response To Corticosterone Response To CAMP SMAD Protein Signal Transduction Cellular Response To Calcium Ion
Pathways		SUMO is proteolytically processed Post-translational protein modification SUMOylation SUMO is conjugated to E1 (UBA2:SAE1) SUMO is transferred from E1 to E2 (UBE2I, UBC9) Processing and activation of SUMO	Toll Like Receptor 7/8 (TLR7/8) Cascade Cellular Senescence FCERI mediated MAPK activation Toll Like Receptor TLR6:TLR2 Cascade Activated TLR4 signalling Toll Like Receptor TLR1:TLR2 Cascade Activation of the AP-1 family of transcription factors MyD88 cascade initiated on plasma membrane Toll Like Receptor 5 (TLR5) Cascade MyD88 dependent cascade initiated on endosome TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation MyD88:Mal cascade initiated on plasma membrane Toll Like Receptor 9 (TLR9) Cascade Innate Immune System TRIF-mediated TLR3/TLR4 signaling MAP kinase activation in TLR cascade Senescence-Associated Secretory Phenotype (SASP) MyD88-independent cascade Toll Like Receptor 2 (TLR2) Cascade Toll-Like Receptors Cascades Toll Like Receptor 10 (TLR10) Cascade Oxidative Stress Induced Senescence Toll Like Receptor 3 (TLR3) Cascade Toll Like Receptor 4 (TLR4) Cascade Fc epsilon receptor (FCERI) signaling MAPK targets/ Nuclear events mediated by MAP kinases
Drugs			Nadroparin
Diseases
GWAS			Inflammatory bowel disease ( 23128233) Periodontal microbiota ( 22699663)
Protein-Protein Interactions		53 interactors: ANXA7 ARL13A ARNTL ATF3 ATF7IP BCL11A BLM CCNE2 CDKN1A CEBPA CHAF1A CUL3 FOS HSF1 HSF2 JUN KALRN KCNA5 KRT14 KRT5 KRT8 MAPKAPK3 NFKBIA PFDN1 PIAS1 PIAS2 PIAS3 PIAS4 PML RANGAP1 SAE1 SATB1 SENP1 SENP2 SENP5 SH3KBP1 SMN1 SOX10 SOX6 SP100 STAB2 STK24 TDG TDP2 TK1 TP53BP2 TTR UBA2 UBE2I UBE3A UPF2 USPL1 VIM	108 interactors: ANP32E APP AQP1 ARFGAP1 ARL6IP4 ATF2 ATF3 ATF4 ATF7 ATP5I BATF BCL3 CABP1 CARM1 CEBPA CEBPE CEBPG CENPO CFAP57 CLU COPS4 CREB5 CREBBP CSNK2A1 CSNK2A2 CYTH4 DDIT3 EEF1D ELK1 ELK4 EPHB2 ETS1 ETS2 GAMT GATA4 GLB1 GNG11 GRHPR GTF2E2 GTF2F1 GTF2F2 HNF1A HSPA1A JUN JUNB JUND KDM2A LMNA LMO3 LUZP4 MAF MAFB MAFF MAP1B MAP3K7 MAPK1 MAPK7 MITF MTERF4 NACA NCOA1 NCOA2 NCOA3 NCOA6 NCOR2 NEFM NELFB NFATC3 NFKB1 OPTN PML POLR2E PRKAA2 PRKACA PSMC5 RB1 RELA RPS6KA1 RPS6KA2 RPS6KA4 RUNX1 RUNX2 SCHIP1 SET SIRT1 SMAD3 SMARCD1 SPI1 SRA1 STAT1 SUMO1 SUMO2 SUMO3 SUMO4 TAF1 TBP TRO TSC22D3 TSPAN2 UBE2D1 UBE2I UBE2L3 UBR1 USF1 USF2 VDR XBP1 ZNF133
Entrez ID		6612	2353
HPRD ID		03754	01275
Ensembl ID		ENSG00000184900	ENSG00000170345
Uniprot IDs		B4DUW4 P55854	B4DQ65 P01100 Q6FG41
PDB IDs		1U4A 2IO1	1A02 1FOS 1S9K
Enriched GO Terms of Interacting Partners?		Protein Sumoylation Positive Regulation Of Metabolic Process Peptidyl-lysine Modification Positive Regulation Of Gene Expression Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Cellular Metabolic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Gene Expression Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Regulation Of Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Protein Modification By Small Protein Conjugation Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Cellular Metabolic Process Regulation Of Gene Expression Positive Regulation Of Transcription From RNA Polymerase II Promoter Response To Stimulus Negative Regulation Of Transcription From RNA Polymerase II Promoter Anatomical Structure Development Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Transcription, DNA-templated Regulation Of Transcription, DNA-templated Regulation Of Nitrogen Compound Metabolic Process Protein Desumoylation Cellular Metabolic Process Apoptotic Signaling Pathway RNA Biosynthetic Process Peptidyl-amino Acid Modification Developmental Process Apoptotic Process Programmed Cell Death Viral Process Transcription From RNA Polymerase II Promoter Cell Death Death RNA Metabolic Process Multicellular Organismal Development Response To Abiotic Stimulus System Development Regulation Of Cellular Process Cellular Response To Stimulus Cellular Response To Stress Regulation Of Cell Cycle Cellular Macromolecule Biosynthetic Process Nucleobase-containing Compound Metabolic Process	Transcription, DNA-templated RNA Biosynthetic Process Transcription From RNA Polymerase II Promoter Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Gene Expression Gene Expression RNA Metabolic Process Regulation Of RNA Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of RNA Metabolic Process Positive Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Metabolic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Nucleobase-containing Compound Metabolic Process Regulation Of Metabolic Process Cellular Nitrogen Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Nitrogen Compound Metabolic Process Cellular Metabolic Process Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Regulation Of Cell Differentiation Negative Regulation Of Biosynthetic Process Response To Organic Substance Negative Regulation Of Gene Expression Regulation Of Cellular Process Cellular Response To Organic Substance Developmental Process System Development Viral Process Anatomical Structure Development Cell Differentiation Response To Stress Multicellular Organismal Development Response To External Stimulus Organ Development Negative Regulation Of Transcription From RNA Polymerase II Promoter TRIF-dependent Toll-like Receptor Signaling Pathway
Tagcloud ?		aphidicolin attachment break breakage budding cfs covalent excessive fields fragile hallmark modifier ortholog perturbed pol32 pold3 polypeptides proteomic recombinational replication resource rpa ssdna stresses subfamily sumo1 sumo2 sumoylation	ap argue capable dimeric dimerization disrupt glucocorticoid heterodimerization homo homodimerization hraralpha hybrid indirect interfere jun liganded occurring promoters protooncoproteins ra raralpha rars repress repression responsive retinoic retinoid rxr rxrs
Tagcloud (Difference) ?		aphidicolin attachment break breakage budding cfs covalent excessive fields fragile hallmark modifier ortholog perturbed pol32 pold3 polypeptides proteomic recombinational replication resource rpa ssdna stresses subfamily sumo1 sumo2 sumoylation	ap argue capable dimeric dimerization disrupt glucocorticoid heterodimerization homo homodimerization hraralpha hybrid indirect interfere jun liganded occurring promoters protooncoproteins ra raralpha rars repress repression responsive retinoic retinoid rxr rxrs
Tagcloud (Intersection) ?