IPO5 and NOSIP

Number of citations of the paper that reports this interaction (PubMedID 36690276)
66

Data Source:
BioGRID (pull down)

		IPO5	NOSIP
Description		importin 5	nitric oxide synthase interacting protein
Image
GO Annotations	Cellular Component	Nucleus Nuclear Pore Nucleoplasm Nucleolus Cytoplasm Golgi Apparatus Cytosol Membrane Nuclear Membrane	Golgi Membrane Nucleus Nucleoplasm Cytoplasm Cytosol
	Molecular Function	RNA Binding GTPase Inhibitor Activity Protein Binding Nuclear Localization Sequence Binding Small GTPase Binding Nuclear Import Signal Receptor Activity	RNA Binding Protein Binding Transferase Activity Ubiquitin Protein Ligase Activity Molecular Sequestering Activity
	Biological Process	Cytoplasmic Pattern Recognition Receptor Signaling Pathway Protein Import Into Nucleus NLS-bearing Protein Import Into Nucleus Ribosomal Protein Import Into Nucleus Intracellular Protein Transport Protein Transport Positive Regulation Of Protein Import Into Nucleus Negative Regulation Of Cell Cycle Cellular Response To Amino Acid Stimulus	Negative Regulation Of Catalytic Activity Regulation Of Nitric Oxide Biosynthetic Process Nitric Oxide Metabolic Process Negative Regulation Of Nitric-oxide Synthase Activity
Pathways		vRNP Assembly	NOSIP mediated eNOS trafficking
Drugs
Diseases
GWAS		Peripheral artery disease ( 26488411) Smooth-surface caries ( 24556642)	Hematocrit ( 27863252 32888494) Hemoglobin ( 32888494) Red blood cell count ( 27863252) Schizophrenia ( 25056061) Waist-hip ratio ( 28552196) Waist-to-hip ratio adjusted for BMI ( 28552196)
Interacting Genes		31 interacting genes: ACD CAB39 CDC42 DPPA3 DTNBP1 GPRASP3 H1-0 NOSIP NRIP1 NUP153 NUP214 NUP62 NUP98 OGT PRRC2B PTEN RAG2 RAN RANBP2 RNF10 RPL13 RPL23 RPL23A RPL5 RPL7 RPS7 SRP19 SUMO2 TERF1 TINF2 WASL	13 interacting genes: CEBPA IPO13 IPO5 IPO7 KPNA1 KPNB1 NOS1 NOS3 PPP2CA UBC UBE2D3 XPO1 ZNF410
Entrez ID		3843	51070
HPRD ID		03597	17642
Ensembl ID		ENSG00000065150	ENSG00000142546
Uniprot IDs		B3KWG6 O00410 Q9BVS9	A0A075B6F9 Q9Y314
PDB IDs		6XTE 6XU2 9IM6	8C6J 9FMD
Enriched GO Terms of Interacting Partners?		Cytosolic Ribosome Import Into Nucleus Protein Import Into Nucleus Cytoplasmic Translation Establishment Of Protein Localization To Organelle Nuclear Pore Nucleus Ribonucleoprotein Complex Protein Localization To Nucleus Cytosolic Large Ribosomal Subunit Structural Constituent Of Nuclear Pore RNA Binding Protein Localization To Organelle Nuclear Export Shelterin Complex Nuclear Transport Nucleocytoplasmic Transport RNA Transport Structural Constituent Of Ribosome RNA Export From Nucleus Nucleolus Negative Regulation Of Ubiquitin Protein Ligase Activity Nuclear Telomere Cap Complex Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Ubiquitin-protein Transferase Activity Nucleoplasm Ribosome Nuclear Inclusion Body Ubiquitin Ligase Inhibitor Activity Telomere Capping Nuclear Pore Nuclear Basket Nucleobase-containing Compound Transport Nuclear Envelope Translation MRNA Transport Intracellular Transport Intracellular Protein Transport Dendritic Spine Morphogenesis Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Cellular Localization Negative Regulation Of Telomere Maintenance Via Telomerase Nuclear Localization Sequence Binding Negative Regulation Of Protein Ubiquitination Negative Regulation Of Proteolysis Involved In Protein Catabolic Process Regulation Of Ubiquitin-protein Transferase Activity Organelle Localization Nuclear Pore Cytoplasmic Filaments Negative Regulation Of RNA Export From Nucleus Telomeric DNA Binding Negative Regulation Of Telomere Maintenance Via Telomere Lengthening	Protein Localization To Nucleus Nuclear Transport Nucleocytoplasmic Transport Protein Import Into Nucleus Import Into Nucleus Nuclear Pore Intracellular Protein Transport Establishment Of Protein Localization To Organelle Protein Localization To Organelle Establishment Of Localization In Cell Nuclear Import Signal Receptor Activity Nuclear Localization Sequence Binding Nucleus NLS-bearing Protein Import Into Nucleus Nitric-oxide Synthase Activity Tetrahydrobiopterin Binding Small GTPase Binding Ribosomal Protein Import Into Nucleus Cadmium Ion Binding Protein Transport L-arginine Catabolic Process Intracellular Transport Arginine Binding Nuclear Envelope Establishment Of Protein Localization NLS-dependent Protein Nuclear Import Complex Nuclear Membrane FMN Binding Cellular Localization Arginine Metabolic Process Regulation Of Cell Cycle Nitric Oxide Mediated Signal Transduction Nitric Oxide Biosynthetic Process Nucleoplasm Regulation Of The Force Of Heart Contraction Intracellular Protein Localization RNA Transport Nitric Oxide Metabolic Process Negative Regulation Of Potassium Ion Transport Reactive Nitrogen Species Metabolic Process NADP Binding Hsp90 Protein Binding Blood Circulation Cell Redox Homeostasis Regulation Of Protein Localization Response To Fluid Shear Stress Nucleobase-containing Compound Transport Regulation Of Hippo Signaling Mitotic Metaphase Chromosome Alignment Negative Regulation Of Blood Pressure
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