IPO5 and NUP98

Number of citations of the paper that reports this interaction (PubMedID 9114010)
34

Data Source:
HPRD (in vitro, in vivo)

		IPO5	NUP98
Description		importin 5	nucleoporin 98 and 96 precursor
Image
GO Annotations	Cellular Component	Nucleus Nuclear Pore Nucleoplasm Nucleolus Cytoplasm Golgi Apparatus Cytosol Membrane Nuclear Membrane	Kinetochore Nucleus Nuclear Envelope Nuclear Pore Nucleoplasm Cytosol Membrane Nuclear Body Nuclear Pore Outer Ring Nuclear Membrane Nuclear Periphery Nuclear Inclusion Body Nuclear Pore Cytoplasmic Filaments Nuclear Pore Nuclear Basket Ribonucleoprotein Complex
	Molecular Function	RNA Binding GTPase Inhibitor Activity Protein Binding Nuclear Localization Sequence Binding Small GTPase Binding Nuclear Import Signal Receptor Activity	Transcription Coactivator Activity RNA Binding MRNA Binding Protein Binding Nuclear Localization Sequence Binding Peptidase Activity Serine-type Peptidase Activity Hydrolase Activity Structural Constituent Of Nuclear Pore Peptide Binding Molecular Condensate Scaffold Activity Promoter-specific Chromatin Binding
	Biological Process	Cytoplasmic Pattern Recognition Receptor Signaling Pathway Protein Import Into Nucleus NLS-bearing Protein Import Into Nucleus Ribosomal Protein Import Into Nucleus Intracellular Protein Transport Protein Transport Positive Regulation Of Protein Import Into Nucleus Negative Regulation Of Cell Cycle Cellular Response To Amino Acid Stimulus	Post-transcriptional Tethering Of RNA Polymerase II Gene DNA At Nuclear Periphery RNA Export From Nucleus Proteolysis Protein Import Into Nucleus Nucleocytoplasmic Transport Nuclear Pore Organization Protein Transport Telomere Tethering At Nuclear Periphery Positive Regulation Of DNA-templated Transcription Positive Regulation Of MRNA Splicing, Via Spliceosome MRNA Transport Nuclear Pore Complex Assembly
Pathways		vRNP Assembly
Drugs
Diseases
GWAS		Peripheral artery disease ( 26488411) Smooth-surface caries ( 24556642)	Malaria ( 31844061) Metabolite levels (Dihydroxy docosatrienoic acid) ( 23934736)
Interacting Genes		31 interacting genes: ACD CAB39 CDC42 DPPA3 DTNBP1 GPRASP3 H1-0 NOSIP NRIP1 NUP153 NUP214 NUP62 NUP98 OGT PRRC2B PTEN RAG2 RAN RANBP2 RNF10 RPL13 RPL23 RPL23A RPL5 RPL7 RPS7 SRP19 SUMO2 TERF1 TINF2 WASL	19 interacting genes: APC CREBBP CSNK2A1 EP300 HDAC1 IPO5 KPNB1 NUP133 NUP188 NUP205 NUP62 NUP88 NXF1 RAE1 RCC1 SEC13 TNPO1 TNPO2 TPR
Entrez ID		3843	4928
HPRD ID		03597	03012
Ensembl ID		ENSG00000065150	ENSG00000110713
Uniprot IDs		B3KWG6 O00410 Q9BVS9	A0A8V8TR21 H0YCR0 H0YEN4 P52948
PDB IDs		6XTE 6XU2 9IM6	1KO6 2Q5X 2Q5Y 3MMY 4OWR 5A9Q 6BZM 7F60 7F90 7MNI 7PEQ 7Q64 7Q65 7Q66 7Q67 7VPG 7VPH 8CI8
Enriched GO Terms of Interacting Partners?		Cytosolic Ribosome Import Into Nucleus Protein Import Into Nucleus Cytoplasmic Translation Establishment Of Protein Localization To Organelle Nuclear Pore Nucleus Ribonucleoprotein Complex Protein Localization To Nucleus Cytosolic Large Ribosomal Subunit Structural Constituent Of Nuclear Pore RNA Binding Protein Localization To Organelle Nuclear Export Shelterin Complex Nuclear Transport Nucleocytoplasmic Transport RNA Transport Structural Constituent Of Ribosome RNA Export From Nucleus Nucleolus Negative Regulation Of Ubiquitin Protein Ligase Activity Nuclear Telomere Cap Complex Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Ubiquitin-protein Transferase Activity Nucleoplasm Ribosome Nuclear Inclusion Body Ubiquitin Ligase Inhibitor Activity Telomere Capping Nuclear Pore Nuclear Basket Nucleobase-containing Compound Transport Nuclear Envelope Translation MRNA Transport Intracellular Transport Intracellular Protein Transport Dendritic Spine Morphogenesis Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Cellular Localization Negative Regulation Of Telomere Maintenance Via Telomerase Nuclear Localization Sequence Binding Negative Regulation Of Protein Ubiquitination Negative Regulation Of Proteolysis Involved In Protein Catabolic Process Regulation Of Ubiquitin-protein Transferase Activity Organelle Localization Nuclear Pore Cytoplasmic Filaments Negative Regulation Of RNA Export From Nucleus Telomeric DNA Binding Negative Regulation Of Telomere Maintenance Via Telomere Lengthening	Nuclear Pore Nuclear Transport Nucleocytoplasmic Transport Protein Import Into Nucleus Import Into Nucleus Nuclear Envelope RNA Transport Structural Constituent Of Nuclear Pore Protein Localization To Nucleus MRNA Transport Nucleobase-containing Compound Transport Establishment Of Protein Localization To Organelle RNA Export From Nucleus Protein Localization To Organelle Intracellular Transport Nuclear Export Intracellular Protein Transport Protein Transport Nuclear Localization Sequence Binding Cellular Localization Establishment Of Protein Localization Establishment Of Localization In Cell MRNA Export From Nucleus Intracellular Protein Localization Regulation Of Mitotic Spindle Organization Nuclear Import Signal Receptor Activity Regulation Of Microtubule Cytoskeleton Organization Nucleoplasm Cytosol Nuclear Pore Organization Histone H3K27 Acetyltransferase Activity Regulation Of Cytoskeleton Organization Nucleus Regulation Of Microtubule-based Process Nuclear Membrane Regulation Of Mitotic Spindle Assembly Histone H3K18 Acetyltransferase Activity N-terminal Peptidyl-lysine Acetylation Peptide Lactyltransferase (CoA-dependent) Activity Nuclear Pore Inner Ring Small GTPase Binding Regulation Of Cell Cycle Kinetochore Ribosomal Protein Import Into Nucleus RNA Import Into Nucleus Nucleus Organization Regulation Of Spindle Assembly Positive Regulation Of Protein Localization To Nucleus Regulation Of Cell Cycle Process Positive Regulation Of Protein Import Into Nucleus
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