EPS8L2 and TRIM63

Number of citations of the paper that reports this interaction (PubMedID 31391242)
0

Data Source:
BioGRID (two hybrid)

		EPS8L2	TRIM63
Description		EPS8 signaling adaptor L2	tripartite motif containing 63
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GO Annotations	Cellular Component	Cytoplasm Centrosome Cytosol Plasma Membrane Vesicle Stereocilium Stereocilium Bundle Stereocilium Tip Ruffle Membrane Protein-containing Complex Cell Projection Organelle Extracellular Exosome	Nucleus Cytoplasm Microtubule Z Disc M Band Contractile Muscle Fiber
	Molecular Function	Actin Binding Guanyl-nucleotide Exchange Factor Activity Protein Binding Cadherin Binding	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Titin Binding Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Rho Protein Signal Transduction Sensory Perception Of Sound Regulation Of Rho Protein Signal Transduction Positive Regulation Of Ruffle Assembly	Muscle Contraction Signal Transduction Negative Regulation Of Cardiac Muscle Hypertrophy Skeletal Muscle Atrophy Response To Electrical Stimulus Involved In Regulation Of Muscle Adaptation Protein Ubiquitination Innate Immune Response Negative Regulation Of Glycolytic Process Response To Glucocorticoid Response To Interleukin-1
Pathways		Sensory processing of sound by inner hair cells of the cochlea Sensory processing of sound by outer hair cells of the cochlea	FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Keratoconus ( 33649486)	Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098)
Interacting Genes		9 interacting genes: APP PTK2 RIN3 RPL23 SASH1 SOS1 TNS2 TRIM55 TRIM63	331 interacting genes: ACBD4 ACD ACTA1 ADAMTSL4 AEBP2 AGO2 AK1 AKR7A2 ALDOA ALKBH3 ANKRD1 ANKRD39 APLN APOBEC4 APP ARL6IP4 ATP5F1B ATP5F1D ATXN3 ATXN3L ATXN7L1 BAP1 BCAT1 BCHE BRD4 BRWD1 BTBD9 C10orf88 C1orf35 C3orf36 C8orf74 CADPS CAMK2A CAPN3 CARS1 CBX2 CCDC120 CCDC28B CDK3 CDS2 CENPK CHMP7 CKB CKM COA7 COX4I1 CRCT1 CTAG1A CTAG1B CTNNB1 CYB5R2 CYP46A1 CYTOR DAPL1 DCAF11 DCAF6 DECR2 DEF8 DEK DES DMD DNTTIP1 DOCK7 DYNLT2B EED EEF1G EHHADH EIF3E ELAPOR1 ENO3 EPS8L2 ESPL1 EZH2 FAM185A FANK1 FASTKD1 FERRY3 FHL2 FKBP6 FLNC FRMD6 FYN GABPB1 GATA3 GFM1 GLI4 GMEB1 GOLGA2P5 GPRIN2 GPS1 GRB10 HIBADH HID1 HIRA HOXA1 HROB HSPB1 HSPD1 ID1 IFI35 IGF2 IK IL37 ILF3 INCA1 ING4 INKA1 IQUB IRF2 IRF3 ITGB5 JADE3 JOSD1 KBTBD4 KCTD15 KIAA0087 KIAA0408 KIAA0825 KIF5A KLHDC4 KLHL36 KMT2B KYAT1 LAMA2 LAMTOR5 LAPTM4A LIMS2 LINC00518 LINC00663 LINC00905 LINC01588 LMCD1 LMO2 LRRC56 LYN LYNX1 MAGEC3 MALSU1 MAP3K14 MBD4 MBIP MCM7 MIDN MIIP MKI67 MLH3 MPP1 MPZL1 MRPL19 MRPL20-AS1 MRPL41 MSRB3 MYBPC1 MYBPC2 MYBPC3 MYBPHL MYC MYCT1 MYH6 MYL2 MYOT MYOZ1 NDUFA1 NDUFA8 NEB NEBL NEFL NGEF NOMO1 NR1D2 NRAP NSD3 NSUN7 NUFIP2 ODF2 OGFOD2 OTUB1 OTUB2 P3H3 PACRGL PAFAH1B2 PCGF3 PCGF6 PDHB PDK4 PELI3 PELO PHC2 PHF23 PIAS1 PIAS2 PIAS3 PIP4K2B PKM PLEKHG4 PLXNA3 POLR2E PPA2 PPARA PPIE PRKAB2 PRKACA PRR30 PRRT1 PSMD4 PYGM RAI2 RBM14 RELA REX1BD RGR RHEB RHPN1 RING1 RNASEH1 RNF10 RPS4X RRAS RUSC1 RUSC1-AS1 SEC23B SENP2 SENP3 SET SGCB SHFL SLC6A13 SLFN12 SNAPIN SNW1 SPATS1 SPRYD7 SPSB1 SPSB2 SQSTM1 SRF STAM SUMO2 SYMPK SYNCRIP TCAP TCEAL4 TCP10L TEX19 THAP3 THRA TIGD5 TIMM17B TMBIM1 TMEM35A TNIP3 TNNC1 TNNI1 TNNI2 TNNI3 TNNT1 TNNT3 TOR1AIP2 TPD52L3 TRAF3IP2 TRIB3 TRIM23 TRIM35 TRIM41 TRIM54 TRIM55 TRIM69 TRMT10B TSC2 TSC22D4 TTN TUBGCP4 UBA3 UBE2D1 UBE2D2 UBE2D3 UBE2E3 UBE2G1 UBE2I UBE2J1 UBE2K UBE2N UBE2U UBE2V2 UCHL1 UCHL3 UCHL5 UNKL UQCRC1 USP13 USP15 USP2 USP21 USP28 USP33 USP4 USP5 USP7 USP8 UXT VAC14 VPS37A WT1 XAGE1B YJU2B YOD1 YPEL3 ZBTB17 ZC2HC1C ZC3H12A ZC3HC1 ZFYVE19 ZNF124 ZNF20 ZNF302 ZNF333 ZNF345 ZNF431 ZNF436 ZNF460 ZNF566 ZNF57 ZNF581 ZNF597 ZNF649 ZNF653 ZNF667-AS1 ZNF767P ZNF775 ZNF83 ZSCAN16
Entrez ID		64787	84676
HPRD ID		10940	05843
Ensembl ID		ENSG00000177106	ENSG00000158022
Uniprot IDs		Q9H6S3	Q969Q1
PDB IDs		1WWU 1WXB	2D8U 3DDT 4M3L
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Non-canonical NF-kappaB Signal Transduction Regulation Of Non-canonical NF-kappaB Signal Transduction Positive Regulation Of Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling Molecular Function Activator Activity Regulation Of Phosphorus Metabolic Process Protein Metabolic Process Regulation Of Chemotaxis Regulation Of Signal Transduction Regulation Of Intracellular Signal Transduction Regulation Of Leukocyte Migration Amyloid-beta Complex Positive Regulation Of Phosphate Metabolic Process Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Regulation Of Carbohydrate Catabolic Process Regulation Of Glycolytic Process Amylin Binding Positive Regulation Of Toll Signaling Pathway Regulation Of Cell Communication Cytoplasm Glial Cell Development Regulation Of Signaling Fc Receptor Signaling Pathway Heart Morphogenesis Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of Mast Cell Chemotaxis Regulation Of Epithelial Cell Migration Regulation Of ATP Metabolic Process Regulation Of Receptor Internalization Protein Modification Process ERBB Signaling Pathway Developmental Growth Response To Interleukin-1 Regulation Of Cell Population Proliferation Regulation Of Purine Nucleotide Metabolic Process Regulation Of Proteolysis Acetylcholine Receptor Activator Activity Positive Regulation Of Mononuclear Cell Migration Regulation Of Cell Migration Positive Regulation Of Leukocyte Chemotaxis Lipoprotein Particle Positive Regulation Of Protein Import Protein Tyrosine Phosphatase Activity GTPase Complex Response To Electrical Stimulus Involved In Regulation Of Muscle Adaptation Focal Adhesion PTB Domain Binding	Post-translational Protein Modification Cysteine-type Deubiquitinase Activity Protein Modification By Small Protein Removal Protein Deubiquitination Cysteine-type Peptidase Activity Protein Binding Sarcomere Organization Protein Modification By Small Protein Conjugation Protein Modification Process Structural Constituent Of Muscle Troponin Complex Nucleus Actomyosin Structure Organization Striated Muscle Contraction Z Disc Cardiac Muscle Contraction Ubiquitin Conjugating Enzyme Activity Protein K48-linked Deubiquitination Ubiquitin Protein Ligase Binding Contractile Muscle Fiber Sarcomere Protein Ubiquitination Troponin T Binding Protein Metabolic Process Myofibril Negative Regulation Of Nucleobase-containing Compound Metabolic Process Skeletal Muscle Contraction Regulation Of DNA-templated Transcription Negative Regulation Of DNA-templated Transcription Deubiquitinase Activity Proteolysis Negative Regulation Of RNA Biosynthetic Process Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Metabolic Process TORC1 Signaling Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process TOR Signaling K48-linked Deubiquitinase Activity Regulation Of Nucleobase-containing Compound Metabolic Process Myofibril Assembly Nucleoplasm Cardiac Muscle Tissue Morphogenesis Negative Regulation Of Metabolic Process Negative Regulation Of Biosynthetic Process Regulation Of RNA Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Muscle Contraction Cytosol Titin Binding
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