EPS8L2

Description		EPS8 signaling adaptor L2
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GO Annotations	Cellular Component	Cytoplasm Centrosome Cytosol Plasma Membrane Vesicle Stereocilium Stereocilium Bundle Stereocilium Tip Ruffle Membrane Protein-containing Complex Cell Projection Organelle Extracellular Exosome
	Molecular Function	Actin Binding Guanyl-nucleotide Exchange Factor Activity Protein Binding Cadherin Binding
	Biological Process	Rho Protein Signal Transduction Sensory Perception Of Sound Regulation Of Rho Protein Signal Transduction Positive Regulation Of Ruffle Assembly
Pathways		Sensory processing of sound by inner hair cells of the cochlea Sensory processing of sound by outer hair cells of the cochlea
Drugs
Diseases
GWAS		Keratoconus ( 33649486)
Interacting Genes		9 interacting genes: APP PTK2 RIN3 RPL23 SASH1 SOS1 TNS2 TRIM55 TRIM63
Entrez ID		64787
HPRD ID		10940
Ensembl ID		ENSG00000177106
Uniprot IDs		Q9H6S3
PDB IDs		1WWU 1WXB
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Non-canonical NF-kappaB Signal Transduction Regulation Of Non-canonical NF-kappaB Signal Transduction Positive Regulation Of Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling Molecular Function Activator Activity Regulation Of Phosphorus Metabolic Process Protein Metabolic Process Regulation Of Chemotaxis Regulation Of Signal Transduction Regulation Of Intracellular Signal Transduction Regulation Of Leukocyte Migration Amyloid-beta Complex Positive Regulation Of Phosphate Metabolic Process Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Regulation Of Carbohydrate Catabolic Process Regulation Of Glycolytic Process Amylin Binding Positive Regulation Of Toll Signaling Pathway Regulation Of Cell Communication Cytoplasm Glial Cell Development Regulation Of Signaling Fc Receptor Signaling Pathway Heart Morphogenesis Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of Mast Cell Chemotaxis Regulation Of Epithelial Cell Migration Regulation Of ATP Metabolic Process Regulation Of Receptor Internalization Protein Modification Process ERBB Signaling Pathway Developmental Growth Response To Interleukin-1 Regulation Of Cell Population Proliferation Regulation Of Purine Nucleotide Metabolic Process Regulation Of Proteolysis Acetylcholine Receptor Activator Activity Positive Regulation Of Mononuclear Cell Migration Regulation Of Cell Migration Positive Regulation Of Leukocyte Chemotaxis Lipoprotein Particle Positive Regulation Of Protein Import Protein Tyrosine Phosphatase Activity GTPase Complex Response To Electrical Stimulus Involved In Regulation Of Muscle Adaptation Focal Adhesion PTB Domain Binding
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