INPP5D and FCGR1BP

Number of citations of the paper that reports this interaction (PubMedID 9232445)
0

Data Source:
BioGRID (unspecified method)

		INPP5D	FCGR1BP
Description		inositol polyphosphate-5-phosphatase D	Fc gamma receptor Ib, pseudogene
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Cytoskeleton Plasma Membrane Membrane Membrane Raft	Plasma Membrane External Side Of Plasma Membrane Membrane Clathrin-coated Endocytic Vesicle Membrane Early Endosome Membrane
	Molecular Function	Phosphatidylinositol-4,5-bisphosphate 5-phosphatase Activity Inositol-polyphosphate 5-phosphatase Activity Protein Binding Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase Activity Hydrolase Activity Phosphatase Activity SH3 Domain Binding Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase Activity Inositol-1,3,4,5-tetrakisphosphate 5-phosphatase Activity	Immunoglobulin Receptor Activity IgG Receptor Activity IgG Binding
	Biological Process	Immune System Process Lipid Metabolic Process Phosphatidylinositol Biosynthetic Process Phosphate-containing Compound Metabolic Process Apoptotic Process Signal Transduction Determination Of Adult Lifespan Negative Regulation Of Signal Transduction Immunoglobulin Mediated Immune Response Negative Regulation Of Granulocyte Differentiation Negative Regulation Of B Cell Proliferation Negative Regulation Of Interleukin-6 Production Intracellular Signal Transduction Natural Killer Cell Mediated Cytotoxicity Positive Regulation Of Apoptotic Process Positive Regulation Of B Cell Differentiation Positive Regulation Of Lymphocyte Differentiation Positive Regulation Of Erythrocyte Differentiation Negative Regulation Of Monocyte Differentiation Negative Regulation Of Neutrophil Differentiation Negative Regulation Of Osteoclast Differentiation Negative Regulation Of Bone Resorption Negative Regulation Of Natural Killer Cell Mediated Cytotoxicity Phosphatidylinositol Dephosphorylation Regulation Of Immune Response Negative Regulation Of Immune Response T Cell Receptor Signaling Pathway Negative Regulation Of B Cell Activation	Antibody-dependent Cellular Cytotoxicity Adaptive Immune Response Immune System Process Immune Response Cell Surface Receptor Signaling Pathway Positive Regulation Of Tumor Necrosis Factor Production Fc Receptor Signaling Pathway Fc-gamma Receptor Signaling Pathway Positive Regulation Of Phagocytosis
Pathways		Synthesis of PIPs at the plasma membrane Synthesis of IP3 and IP4 in the cytosol Downstream TCR signaling PECAM1 interactions Interleukin receptor SHC signaling Signaling by CSF1 (M-CSF) in myeloid cells
Drugs
Diseases
GWAS		Allergic disease (asthma, hay fever or eczema) ( 29083406) Alzheimer's disease (late onset) ( 24162737 30617256) Alzheimer's disease or family history of Alzheimer's disease ( 30617256) Contrast sensitivity ( 24152035) Crohn's disease ( 23128233 22412388) Eosinophil count ( 32888494 27863252) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 27863252 32888494) Family history of Alzheimer's disease ( 30617256) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Immature fraction of reticulocytes ( 32888494) Monocyte count ( 32888494) Neutrophil count ( 32888494) Neutrophil percentage of granulocytes ( 27863252) Perceived unattractiveness to mosquitoes ( 28199695) Response to bronchodilator in chronic obstructive pulmonary disease (change in FEV1) ( 26503814) Serum alkaline phosphatase levels ( 33547301) Sum eosinophil basophil counts ( 27863252)
Interacting Genes		47 interacting genes: ARAP1 CD22 CD300LF CEBPA CRK CRKL CSF1R CSF3R CYSRT1 DAB1 DAB2 DOK1 DOK2 DOK3 EPOR FCGR1BP FCGR2B FGR FLT3 GAB1 GAB2 GRB2 HCK IL4R JAK1 JAK3 KHDRBS3 KIT KRT31 KRT40 KRTAP1-3 KRTAP10-3 KRTAP10-7 KRTAP10-9 KRTAP6-3 LILRB4 LYN MET NOTCH2NLA PECAM1 PLCG1 PTPN11 SH3KBP1 SHC1 SLAMF1 XIAP ZDHHC17	2 interacting genes: INPP5D PTPN11
Entrez ID		3635	2210
HPRD ID		09033
Ensembl ID		ENSG00000168918	ENSG00000291135
Uniprot IDs		Q92835
PDB IDs		2YSX 5RW2 5RW3 5RW4 5RW5 5RW6 5RW7 5RW8 5RW9 5RWA 5RWB 5RWC 5RWD 5RWE 5RWF 5RWG 5RWH 5RWI 5RWJ 5RWK 5RWL 5RWM 5RWN 5RWO 5RWP 5RWQ 5RWR 5RWS 5RWT 5RWU 5RWV 5RWW 5RWX 5RWY 5RWZ 5RX0 5RX1 5RX2 5RX3 5RX4 5RX5 5RX6 5RX7 5RX8 5RX9 5RXA 5RXB 5RXC 5RXD 5RXE 5RXF 5RXG 5RXH 5RXI 5RXJ 5RXK 5RXL 5RXM 5RXO 5RXP 5RXQ 5RXR 5RXS 5RXT 5RXU 5RXV 5RXW 5RXX 5RXY 5RXZ 5RY0 5RY1 5RY2 5RY3 5RY4 5RY5 5RY6 5RY7 5RY8 5RY9 5RYA 5RYB 5RYC 5RYD 5RYE 5RYF 5RYG 5RYH 5RYI 5RYJ 5RYK 5RYL 6IBD 6XY7 8PDG 8PDH 8PDI 8PDJ 8UM5
Enriched GO Terms of Interacting Partners?		Cell Surface Receptor Signaling Pathway Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Cytokine-mediated Signaling Pathway Signal Transduction Regulation Of Immune System Process Negative Regulation Of Immune System Process Regulation Of MAPK Cascade Negative Regulation Of Immune Response Regulation Of Immune Response Phosphotyrosine Residue Binding Protein Tyrosine Kinase Activity Positive Regulation Of Immune System Process Fc Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Immune System Process Cell Migration Positive Regulation Of MAPK Cascade Immune Response-regulating Cell Surface Receptor Signaling Pathway Peptidyl-tyrosine Phosphorylation Regulation Of Multicellular Organismal Process Protein Phosphatase Binding Cell Motility Regulation Of Cell Activation Regulation Of Intracellular Signal Transduction Regulation Of Developmental Process Negative Regulation Of Inflammatory Response To Antigenic Stimulus Regulation Of Vesicle-mediated Transport Cellular Developmental Process Positive Regulation Of Cell Migration Fc-gamma Receptor Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Multicellular Organismal Process Positive Regulation Of Cell Motility Regulation Of Signal Transduction Positive Regulation Of Locomotion Leukocyte Differentiation Cell Differentiation Negative Regulation Of Leukocyte Activation Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity Immune Effector Process Regulation Of Cell Shape Intracellular Signal Transduction Positive Regulation Of Signaling Positive Regulation Of Signal Transduction Non-membrane Spanning Protein Tyrosine Kinase Activity Regulation Of Lymphocyte Activation Plasma Membrane Negative Regulation Of Cell Activation Regulation Of Cell Population Proliferation	Negative Regulation Of Leukocyte Proliferation Negative Regulation Of Lymphocyte Proliferation Negative Regulation Of Mononuclear Cell Proliferation Dephosphorylation Negative Regulation Of Lymphocyte Activation Negative Regulation Of Cortisol Secretion Negative Regulation Of Growth Hormone Secretion Negative Regulation Of Leukocyte Activation Negative Regulation Of Cell Activation Negative Regulation Of Neutrophil Differentiation Regulation Of Mononuclear Cell Proliferation Intestinal Epithelial Cell Migration Regulation Of Leukocyte Proliferation Positive Regulation Of Lymphocyte Activation Negative Regulation Of Cytokine Production Glycerolipid Metabolic Process Cerebellar Cortex Formation Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase Activity Immune Effector Process Positive Regulation Of Cell Activation Negative Regulation Of Glucocorticoid Secretion Inositol-1,3,4,5-tetrakisphosphate 5-phosphatase Activity Regulation Of Innate Immune Response Negative Regulation Of Monocyte Differentiation Inositol-polyphosphate 5-phosphatase Activity Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase Activity Negative Regulation Of Neutrophil Activation Negative Regulation Of Immune System Process Regulation Of Lymphocyte Activation Microvillus Organization Phosphatidylinositol-4,5-bisphosphate 5-phosphatase Activity Negative Regulation Of Granulocyte Differentiation Atrioventricular Canal Development Bergmann Glial Cell Differentiation Positive Regulation Of Lipopolysaccharide-mediated Signaling Pathway Regulation Of Neutrophil Activation Peptide Hormone Receptor Binding Negative Regulation Of Cell Adhesion Mediated By Integrin Regulation Of Cell Activation Non-membrane Spanning Protein Tyrosine Phosphatase Activity Neutrophil Activation Involved In Immune Response Regulation Of Growth Hormone Secretion Negative Regulation Of Cell Differentiation Negative Regulation Of Bone Resorption Neurotrophin TRK Receptor Signaling Pathway Negative Regulation Of Cell Population Proliferation Regulation Of Granulocyte Differentiation Negative Regulation Of B Cell Proliferation Negative Regulation Of Bone Remodeling Positive Regulation Of B Cell Differentiation
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