INPP5D and FCGR2B

Number of citations of the paper that reports this interaction (PMID 9148918)
30

Data Source:
HPRD (in vitro)

		INPP5D	FCGR2B
Gene Name		inositol polyphosphate-5-phosphatase, 145kDa	Fc fragment of IgG, low affinity IIb, receptor (CD32)
Image
Gene Ontology Annotations	Cellular Component	Cytosol Membrane	Plasma Membrane Integral Component Of Membrane
	Molecular Function	Inositol-polyphosphate 5-phosphatase Activity Protein Binding SH3 Domain Binding	Protein Binding IgG Binding
	Biological Process	Phospholipid Metabolic Process Phosphatidylinositol Biosynthetic Process Phosphate-containing Compound Metabolic Process Apoptotic Process Signal Transduction Blood Coagulation Inositol Phosphate Metabolic Process Small Molecule Metabolic Process Phosphatidylinositol Dephosphorylation T Cell Receptor Signaling Pathway Leukocyte Migration	Immune Response Signal Transduction Viral Process Regulation Of Immune Response
Pathways		Downstream TCR signaling Metabolism of lipids and lipoproteins Cytokine Signaling in Immune system Inositol phosphate metabolism PECAM1 interactions Cell surface interactions at the vascular wall Synthesis of PIPs at the plasma membrane Signaling by Interleukins TCR signaling Interleukin receptor SHC signaling Synthesis of IP3 and IP4 in the cytosol Interleukin receptor SHC signaling Interleukin-2 signaling Phospholipid metabolism Interleukin-3, 5 and GM-CSF signaling PI Metabolism Adaptive Immune System	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Adaptive Immune System
Drugs
Diseases
GWAS		Crohn's disease ( 22412388 23128233)	Inflammatory bowel disease ( 23128233) Lipid metabolism phenotypes ( 22286219) Ulcerative colitis ( 21297633)
Protein-Protein Interactions		40 interactors: ARAP1 CD22 CD300LF CRKL CSF1R CSF3R DAB1 DAB2 DOK1 DOK2 DOK3 EPOR FCGR2B FGR FLT3 GAB1 GAB2 GRB2 HCK IL4R JAK1 JAK3 KHDRBS3 KIT KRT31 KRT40 KRTAP10-3 KRTAP10-7 KRTAP10-9 LILRB4 LYN MET NOTCH2NL PECAM1 PLCG1 PTPN11 SH3KBP1 SHC1 XIAP ZDHHC17	11 interactors: APCS BLK C14orf1 CRP INPP5D INPPL1 LY6E LYN MAPK1 MAPK3 PTPN6
Entrez ID		3635	2213
HPRD ID		09033	06849
Ensembl ID		ENSG00000168918	ENSG00000072694
Uniprot IDs		Q92835	P31994
PDB IDs		2YSX	2FCB
Enriched GO Terms of Interacting Partners?		Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Signal Transduction Signaling Cell Communication Immune System Process Cell Migration Positive Regulation Of Signal Transduction Cell Motility Intracellular Signal Transduction Cell Surface Receptor Signaling Pathway Cellular Response To Stimulus Regulation Of Immune System Process Positive Regulation Of Kinase Activity Regulation Of Signal Transduction Locomotion Regulation Of Immune Response Positive Regulation Of Transferase Activity Leukocyte Migration Cytokine-mediated Signaling Pathway Regulation Of Signaling Cellular Response To Organic Substance Positive Regulation Of Intracellular Signal Transduction Fc Receptor Signaling Pathway Peptidyl-tyrosine Phosphorylation Movement Of Cell Or Subcellular Component Regulation Of Intracellular Signal Transduction Positive Regulation Of Phosphorylation Response To Cytokine Response To Stimulus Positive Regulation Of Protein Phosphorylation Positive Regulation Of Protein Modification Process Protein Autophosphorylation Regulation Of Protein Kinase Activity Cellular Response To Cytokine Stimulus Response To Organic Substance Positive Regulation Of Protein Kinase Activity Regulation Of MAPK Cascade Regulation Of Kinase Activity Innate Immune Response Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Protein Phosphorylation Immune Response Regulation Of Phosphorylation Defense Response Positive Regulation Of Cellular Protein Metabolic Process Cellular Response To Hormone Stimulus Cellular Response To Peptide Hormone Stimulus Positive Regulation Of MAPK Cascade Cellular Response To Peptide	JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway Growth Hormone Receptor Signaling Pathway Cellular Response To Growth Hormone Stimulus Immune Response-activating Cell Surface Receptor Signaling Pathway B Cell Receptor Signaling Pathway Response To Growth Hormone Antigen Receptor-mediated Signaling Pathway Positive Regulation Of Immune Response Immune Response-regulating Cell Surface Receptor Signaling Pathway JAK-STAT Cascade Immune Response Regulation Of Immune System Process Response To Peptide Hormone Immune System Process Immune Response-regulating Signaling Pathway Regulation Of Immune Response Response To Peptide Positive Regulation Of Immune System Process Wound Healing Cellular Response To Peptide Hormone Stimulus Cellular Response To Peptide Response To Wounding Defense Response Lipopolysaccharide-mediated Signaling Pathway Innate Immune Response Peptidyl-tyrosine Autophosphorylation Response To Organonitrogen Compound Blood Coagulation Hemostasis Regulation Of Golgi Inheritance Cellular Response To Organonitrogen Compound Platelet Activation Response To Hormone Negative Regulation Of Myeloid Leukocyte Differentiation Caveolin-mediated Endocytosis Regulation Of Cellular Localization Cellular Response To Heat Regulation Of Body Fluid Levels Negative Regulation Of Monocyte Differentiation Cellular Response To Hormone Stimulus Negative Regulation Of Lymphocyte Proliferation Negative Regulation Of Mononuclear Cell Proliferation Phagocytosis Regulation Of Golgi Organization Leukocyte Mediated Immunity Negative Regulation Of Leukocyte Proliferation Peptidyl-tyrosine Phosphorylation Endocytosis Response To Insulin Regulation Of MAP Kinase Activity
Tagcloud ?		cytoskeleton dataset deposited dysregulation exerts expand heterodimeric http identifier inositol mapkapk2 nad nadk nonreceptor org pertaining phosphatases phosphoproteome phosphoproteomic polyphosphate proteomecentral proteomexchange ptpn12 pxd000984 reorganization ripk1 silac threonine tnfrsf	arm arms benefit carriers concurrently deriving dfs equivocal fcgammar fcgr3a genotypes genotypic genotyping i232t igg1 killer log n9831 polymorphisms pooled portion proportional r131h rank sequentially superior trastuzumab v158f
Tagcloud (Difference) ?		cytoskeleton dataset deposited dysregulation exerts expand heterodimeric http identifier inositol mapkapk2 nad nadk nonreceptor org pertaining phosphatases phosphoproteome phosphoproteomic polyphosphate proteomecentral proteomexchange ptpn12 pxd000984 reorganization ripk1 silac threonine tnfrsf	arm arms benefit carriers concurrently deriving dfs equivocal fcgammar fcgr3a genotypes genotypic genotyping i232t igg1 killer log n9831 polymorphisms pooled portion proportional r131h rank sequentially superior trastuzumab v158f
Tagcloud (Intersection) ?