INPP5D and KHDRBS3

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		INPP5D	KHDRBS3
Gene Name		inositol polyphosphate-5-phosphatase, 145kDa	KH domain containing, RNA binding, signal transduction associated 3
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol Membrane	Nucleus Nucleoplasm
	Molecular Function	Inositol-polyphosphate 5-phosphatase Activity Protein Binding SH3 Domain Binding	RNA Binding Protein Binding SH3 Domain Binding Poly(A) RNA Binding
	Biological Process	Phospholipid Metabolic Process Phosphatidylinositol Biosynthetic Process Phosphate-containing Compound Metabolic Process Apoptotic Process Signal Transduction Blood Coagulation Inositol Phosphate Metabolic Process Small Molecule Metabolic Process Phosphatidylinositol Dephosphorylation T Cell Receptor Signaling Pathway Leukocyte Migration	Transcription, DNA-templated Regulation Of Transcription, DNA-templated Spermatogenesis
Pathways		Downstream TCR signaling Metabolism of lipids and lipoproteins Cytokine Signaling in Immune system Inositol phosphate metabolism PECAM1 interactions Cell surface interactions at the vascular wall Synthesis of PIPs at the plasma membrane Signaling by Interleukins TCR signaling Interleukin receptor SHC signaling Synthesis of IP3 and IP4 in the cytosol Interleukin receptor SHC signaling Interleukin-2 signaling Phospholipid metabolism Interleukin-3, 5 and GM-CSF signaling PI Metabolism Adaptive Immune System
Drugs
Diseases
GWAS		Crohn's disease ( 22412388 23128233)
Protein-Protein Interactions		40 interactors: ARAP1 CD22 CD300LF CRKL CSF1R CSF3R DAB1 DAB2 DOK1 DOK2 DOK3 EPOR FCGR2B FGR FLT3 GAB1 GAB2 GRB2 HCK IL4R JAK1 JAK3 KHDRBS3 KIT KRT31 KRT40 KRTAP10-3 KRTAP10-7 KRTAP10-9 LILRB4 LYN MET NOTCH2NL PECAM1 PLCG1 PTPN11 SH3KBP1 SHC1 XIAP ZDHHC17	30 interactors: BAHD1 CACNA1A CCDC33 DMRT3 FUS HNRNPC HNRNPK INPP5D KHDRBS1 KHDRBS2 LNX1 MARK4 NCOA5 NELFB NUDT18 PRMT1 PRPF31 PSMF1 PTBP2 RBBP6 RBM7 RBMX RBMY1A1 SGSM2 SIAH1 SNRPC SRSF9 U2AF2 YTHDC1 ZNF408
Entrez ID		3635	10656
HPRD ID		09033	10007
Ensembl ID		ENSG00000168918	ENSG00000131773
Uniprot IDs		Q92835	O75525
PDB IDs		2YSX
Enriched GO Terms of Interacting Partners?		Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Signal Transduction Signaling Cell Communication Immune System Process Cell Migration Positive Regulation Of Signal Transduction Cell Motility Intracellular Signal Transduction Cell Surface Receptor Signaling Pathway Cellular Response To Stimulus Regulation Of Immune System Process Positive Regulation Of Kinase Activity Regulation Of Signal Transduction Locomotion Regulation Of Immune Response Positive Regulation Of Transferase Activity Leukocyte Migration Cytokine-mediated Signaling Pathway Regulation Of Signaling Cellular Response To Organic Substance Positive Regulation Of Intracellular Signal Transduction Fc Receptor Signaling Pathway Peptidyl-tyrosine Phosphorylation Movement Of Cell Or Subcellular Component Regulation Of Intracellular Signal Transduction Positive Regulation Of Phosphorylation Response To Cytokine Response To Stimulus Positive Regulation Of Protein Phosphorylation Positive Regulation Of Protein Modification Process Protein Autophosphorylation Regulation Of Protein Kinase Activity Cellular Response To Cytokine Stimulus Response To Organic Substance Positive Regulation Of Protein Kinase Activity Regulation Of MAPK Cascade Regulation Of Kinase Activity Innate Immune Response Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Protein Phosphorylation Immune Response Regulation Of Phosphorylation Defense Response Positive Regulation Of Cellular Protein Metabolic Process Cellular Response To Hormone Stimulus Cellular Response To Peptide Hormone Stimulus Positive Regulation Of MAPK Cascade Cellular Response To Peptide	MRNA Processing MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions RNA Splicing MRNA Metabolic Process RNA Processing Gene Expression RNA Metabolic Process Negative Regulation Of RNA Splicing Cellular Metabolic Process Nitrogen Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of RNA Splicing MRNA Splice Site Selection Spliceosomal Complex Assembly Negative Regulation Of MRNA Splicing, Via Spliceosome Regulation Of MRNA Splicing, Via Spliceosome Ribonucleoprotein Complex Assembly Regulation Of MRNA Processing Metabolic Process Regulation Of Metabolic Process Ribonucleoprotein Complex Biogenesis Regulation Of Gene Expression Transcription, DNA-templated Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process RNA Biosynthetic Process Negative Regulation Of Cellular Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Regulation Of RNA Metabolic Process Cellular Component Assembly Regulation Of Alternative MRNA Splicing, Via Spliceosome Negative Regulation Of Gene Expression Cellular Macromolecular Complex Assembly Positive Regulation Of RNA Splicing Spliceosomal SnRNP Assembly Termination Of RNA Polymerase II Transcription Cerebellar Molecular Layer Development DGDP Catabolic Process DADP Catabolic Process GDP Catabolic Process Adult Walking Behavior Cellular Process Cellular Macromolecule Biosynthetic Process Ventral Spinal Cord Development Transmission Of Nerve Impulse Macromolecule Biosynthetic Process Vestibular Nucleus Development
Tagcloud ?		cytoskeleton dataset deposited dysregulation exerts expand heterodimeric http identifier inositol mapkapk2 nad nadk nonreceptor org pertaining phosphatases phosphoproteome phosphoproteomic polyphosphate proteomecentral proteomexchange ptpn12 pxd000984 reorganization ripk1 silac threonine tnfrsf
Tagcloud (Difference) ?		cytoskeleton dataset deposited dysregulation exerts expand heterodimeric http identifier inositol mapkapk2 nad nadk nonreceptor org pertaining phosphatases phosphoproteome phosphoproteomic polyphosphate proteomecentral proteomexchange ptpn12 pxd000984 reorganization ripk1 silac threonine tnfrsf
Tagcloud (Intersection) ?