INPP5D and FLT3

Number of citations of the paper that reports this interaction (PMID 9918857)
9

Data Source:
HPRD (in vivo)

		INPP5D	FLT3
Gene Name		inositol polyphosphate-5-phosphatase, 145kDa	fms-related tyrosine kinase 3
Image
Gene Ontology Annotations	Cellular Component	Cytosol Membrane	Nucleus Endoplasmic Reticulum Lumen Cytosol Integral Component Of Plasma Membrane External Side Of Plasma Membrane Protein Complex
	Molecular Function	Inositol-polyphosphate 5-phosphatase Activity Protein Binding SH3 Domain Binding	Transmembrane Receptor Protein Tyrosine Kinase Activity Cytokine Receptor Activity Vascular Endothelial Growth Factor-activated Receptor Activity Protein Binding ATP Binding Protein Complex Binding Glucocorticoid Receptor Binding Protein Homodimerization Activity Phosphatidylinositol 3-kinase Binding
	Biological Process	Phospholipid Metabolic Process Phosphatidylinositol Biosynthetic Process Phosphate-containing Compound Metabolic Process Apoptotic Process Signal Transduction Blood Coagulation Inositol Phosphate Metabolic Process Small Molecule Metabolic Process Phosphatidylinositol Dephosphorylation T Cell Receptor Signaling Pathway Leukocyte Migration	Leukocyte Homeostasis Myeloid Progenitor Cell Differentiation Pro-B Cell Differentiation Pro-T Cell Differentiation Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Cell Proliferation Negative Regulation Of Cell Proliferation Response To Organonitrogen Compound Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Peptidyl-tyrosine Phosphorylation Cytokine-mediated Signaling Pathway Hemopoiesis B Cell Differentiation Organ Regeneration Common Myeloid Progenitor Cell Proliferation Vascular Endothelial Growth Factor Signaling Pathway Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Regulation Of Apoptotic Process Positive Regulation Of MAP Kinase Activity Positive Regulation Of MAPK Cascade Positive Regulation Of Phosphatidylinositol 3-kinase Activity Negative Regulation Of B Cell Differentiation Lymphocyte Proliferation Protein Autophosphorylation Cellular Response To Cytokine Stimulus Cellular Response To Glucocorticoid Stimulus Dendritic Cell Differentiation
Pathways		Downstream TCR signaling Metabolism of lipids and lipoproteins Cytokine Signaling in Immune system Inositol phosphate metabolism PECAM1 interactions Cell surface interactions at the vascular wall Synthesis of PIPs at the plasma membrane Signaling by Interleukins TCR signaling Interleukin receptor SHC signaling Synthesis of IP3 and IP4 in the cytosol Interleukin receptor SHC signaling Interleukin-2 signaling Phospholipid metabolism Interleukin-3, 5 and GM-CSF signaling PI Metabolism Adaptive Immune System
Drugs			Sorafenib Sunitinib Ponatinib
Diseases
GWAS		Crohn's disease ( 22412388 23128233)
Protein-Protein Interactions		40 interactors: ARAP1 CD22 CD300LF CRKL CSF1R CSF3R DAB1 DAB2 DOK1 DOK2 DOK3 EPOR FCGR2B FGR FLT3 GAB1 GAB2 GRB2 HCK IL4R JAK1 JAK3 KHDRBS3 KIT KRT31 KRT40 KRTAP10-3 KRTAP10-7 KRTAP10-9 LILRB4 LYN MET NOTCH2NL PECAM1 PLCG1 PTPN11 SH3KBP1 SHC1 XIAP ZDHHC17	14 interactors: CBL CBLB FIZ1 FLT3LG GRB2 IKBKG INPP5D NCK1 PTPN12 PTPN6 SH3BP2 SLA SOCS1 UBE2L6
Entrez ID		3635	2322
HPRD ID		09033	00635
Ensembl ID		ENSG00000168918	ENSG00000122025
Uniprot IDs		Q92835	P36888
PDB IDs		2YSX	1RJB 3QS7 3QS9
Enriched GO Terms of Interacting Partners?		Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Signal Transduction Signaling Cell Communication Immune System Process Cell Migration Positive Regulation Of Signal Transduction Cell Motility Intracellular Signal Transduction Cell Surface Receptor Signaling Pathway Cellular Response To Stimulus Regulation Of Immune System Process Positive Regulation Of Kinase Activity Regulation Of Signal Transduction Locomotion Regulation Of Immune Response Positive Regulation Of Transferase Activity Leukocyte Migration Cytokine-mediated Signaling Pathway Regulation Of Signaling Cellular Response To Organic Substance Positive Regulation Of Intracellular Signal Transduction Fc Receptor Signaling Pathway Peptidyl-tyrosine Phosphorylation Movement Of Cell Or Subcellular Component Regulation Of Intracellular Signal Transduction Positive Regulation Of Phosphorylation Response To Cytokine Response To Stimulus Positive Regulation Of Protein Phosphorylation Positive Regulation Of Protein Modification Process Protein Autophosphorylation Regulation Of Protein Kinase Activity Cellular Response To Cytokine Stimulus Response To Organic Substance Positive Regulation Of Protein Kinase Activity Regulation Of MAPK Cascade Regulation Of Kinase Activity Innate Immune Response Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Protein Phosphorylation Immune Response Regulation Of Phosphorylation Defense Response Positive Regulation Of Cellular Protein Metabolic Process Cellular Response To Hormone Stimulus Cellular Response To Peptide Hormone Stimulus Positive Regulation Of MAPK Cascade Cellular Response To Peptide	Negative Regulation Of Signal Transduction Regulation Of Lymphocyte Activation Negative Regulation Of Signaling Regulation Of Cell Activation Immune Response Regulation Of Immune System Process Positive Regulation Of Immune System Process Regulation Of Signal Transduction Immune Response-activating Cell Surface Receptor Signaling Pathway Immune System Process Positive Regulation Of Cell Activation Regulation Of Signaling Antigen Receptor-mediated Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Positive Regulation Of Signal Transduction Regulation Of Phosphorylation Innate Immune Response Immune Response-regulating Signaling Pathway Regulation Of Immune Response Regulation Of Phosphorus Metabolic Process Regulation Of Protein Metabolic Process Negative Regulation Of Lymphocyte Proliferation Negative Regulation Of Mononuclear Cell Proliferation Negative Regulation Of Leukocyte Proliferation Signal Transduction Cell Surface Receptor Signaling Pathway Regulation Of Protein Phosphorylation Regulation Of T Cell Activation Positive Regulation Of Immune Response Signaling Cell Communication Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cell Activation T Cell Receptor Signaling Pathway Regulation Of Cell-cell Adhesion Negative Regulation Of T Cell Receptor Signaling Pathway Negative Regulation Of Lymphocyte Activation Defense Response Regulation Of Interferon-gamma-mediated Signaling Pathway Regulation Of T Cell Proliferation JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway Regulation Of Response To Interferon-gamma Regulation Of Lymphocyte Differentiation Negative Regulation Of Leukocyte Activation Growth Hormone Receptor Signaling Pathway Cellular Response To Growth Hormone Stimulus Enzyme Linked Receptor Protein Signaling Pathway Cellular Response To Stimulus Dephosphorylation Regulation Of B Cell Differentiation
Tagcloud ?		cytoskeleton dataset deposited dysregulation exerts expand heterodimeric http identifier inositol mapkapk2 nad nadk nonreceptor org pertaining phosphatases phosphoproteome phosphoproteomic polyphosphate proteomecentral proteomexchange ptpn12 pxd000984 reorganization ripk1 silac threonine tnfrsf	action clonal clone contrasts differentiate divisions enforced evident flk2 interfered leukemic lif m1 macrophage morphologic overcame parental perturbed physiologic renewal renewing rescued responsiveness satisfies stimulating striking suppression unstimulated
Tagcloud (Difference) ?		cytoskeleton dataset deposited dysregulation exerts expand heterodimeric http identifier inositol mapkapk2 nad nadk nonreceptor org pertaining phosphatases phosphoproteome phosphoproteomic polyphosphate proteomecentral proteomexchange ptpn12 pxd000984 reorganization ripk1 silac threonine tnfrsf	action clonal clone contrasts differentiate divisions enforced evident flk2 interfered leukemic lif m1 macrophage morphologic overcame parental perturbed physiologic renewal renewing rescued responsiveness satisfies stimulating striking suppression unstimulated
Tagcloud (Intersection) ?