INPP5D and DOK2

Number of citations of the paper that reports this interaction (PMID 10822173)
3

Data Source:
HPRD (in vivo)

		INPP5D	DOK2
Gene Name		inositol polyphosphate-5-phosphatase, 145kDa	docking protein 2, 56kDa
Image
Gene Ontology Annotations	Cellular Component	Cytosol Membrane	Cytosol
	Molecular Function	Inositol-polyphosphate 5-phosphatase Activity Protein Binding SH3 Domain Binding	Receptor Signaling Protein Activity Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity Insulin Receptor Binding
	Biological Process	Phospholipid Metabolic Process Phosphatidylinositol Biosynthetic Process Phosphate-containing Compound Metabolic Process Apoptotic Process Signal Transduction Blood Coagulation Inositol Phosphate Metabolic Process Small Molecule Metabolic Process Phosphatidylinositol Dephosphorylation T Cell Receptor Signaling Pathway Leukocyte Migration	Signal Transduction Cell Surface Receptor Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Ras Protein Signal Transduction Blood Coagulation Leukocyte Migration
Pathways		Downstream TCR signaling Metabolism of lipids and lipoproteins Cytokine Signaling in Immune system Inositol phosphate metabolism PECAM1 interactions Cell surface interactions at the vascular wall Synthesis of PIPs at the plasma membrane Signaling by Interleukins TCR signaling Interleukin receptor SHC signaling Synthesis of IP3 and IP4 in the cytosol Interleukin receptor SHC signaling Interleukin-2 signaling Phospholipid metabolism Interleukin-3, 5 and GM-CSF signaling PI Metabolism Adaptive Immune System	Tie2 Signaling Cell surface interactions at the vascular wall
Drugs
Diseases
GWAS		Crohn's disease ( 22412388 23128233)	Entorhinal cortical thickness ( 21116278) Mean corpuscular volume ( 20139978)
Protein-Protein Interactions		40 interactors: ARAP1 CD22 CD300LF CRKL CSF1R CSF3R DAB1 DAB2 DOK1 DOK2 DOK3 EPOR FCGR2B FGR FLT3 GAB1 GAB2 GRB2 HCK IL4R JAK1 JAK3 KHDRBS3 KIT KRT31 KRT40 KRTAP10-3 KRTAP10-7 KRTAP10-9 LILRB4 LYN MET NOTCH2NL PECAM1 PLCG1 PTPN11 SH3KBP1 SHC1 XIAP ZDHHC17	14 interactors: ABL1 EGFR HCK IL4R INPP5D KIAA1279 LCK LYN NCK1 POT1 RASA1 RET SRC TEK
Entrez ID		3635	9046
HPRD ID		09033	05411
Ensembl ID		ENSG00000168918	ENSG00000147443
Uniprot IDs		Q92835	G3V1Q1 O60496
PDB IDs		2YSX	2D9W 2DLW
Enriched GO Terms of Interacting Partners?		Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Signal Transduction Signaling Cell Communication Immune System Process Cell Migration Positive Regulation Of Signal Transduction Cell Motility Intracellular Signal Transduction Cell Surface Receptor Signaling Pathway Cellular Response To Stimulus Regulation Of Immune System Process Positive Regulation Of Kinase Activity Regulation Of Signal Transduction Locomotion Regulation Of Immune Response Positive Regulation Of Transferase Activity Leukocyte Migration Cytokine-mediated Signaling Pathway Regulation Of Signaling Cellular Response To Organic Substance Positive Regulation Of Intracellular Signal Transduction Fc Receptor Signaling Pathway Peptidyl-tyrosine Phosphorylation Movement Of Cell Or Subcellular Component Regulation Of Intracellular Signal Transduction Positive Regulation Of Phosphorylation Response To Cytokine Response To Stimulus Positive Regulation Of Protein Phosphorylation Positive Regulation Of Protein Modification Process Protein Autophosphorylation Regulation Of Protein Kinase Activity Cellular Response To Cytokine Stimulus Response To Organic Substance Positive Regulation Of Protein Kinase Activity Regulation Of MAPK Cascade Regulation Of Kinase Activity Innate Immune Response Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Protein Phosphorylation Immune Response Regulation Of Phosphorylation Defense Response Positive Regulation Of Cellular Protein Metabolic Process Cellular Response To Hormone Stimulus Cellular Response To Peptide Hormone Stimulus Positive Regulation Of MAPK Cascade Cellular Response To Peptide	Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Peptidyl-tyrosine Phosphorylation Cell Migration Locomotion Regulation Of Immune Response Enzyme Linked Receptor Protein Signaling Pathway Cell Motility Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Cell Adhesion Protein Autophosphorylation Positive Regulation Of Immune Response Regulation Of Apoptotic Process Peptidyl-tyrosine Autophosphorylation Movement Of Cell Or Subcellular Component Leukocyte Migration Regulation Of Cell Death Immune Response-regulating Signaling Pathway Fc Receptor Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Regulation Of Immune System Process Positive Regulation Of Immune System Process Positive Regulation Of Cell Adhesion Regulation Of Cell Proliferation Immune System Process Cell Surface Receptor Signaling Pathway Response To Lipid Immune Response Intracellular Signal Transduction Single Organismal Cell-cell Adhesion Regulation Of Cytokine Secretion Positive Regulation Of Cell Activation Antigen Receptor-mediated Signaling Pathway Peptidyl-amino Acid Modification Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc Receptor Mediated Stimulatory Signaling Pathway Fc-gamma Receptor Signaling Pathway Positive Regulation Of Catalytic Activity Regulation Of Cell-cell Adhesion Regulation Of Lymphocyte Activation Axon Guidance Regulation Of Cellular Amino Acid Metabolic Process Positive Regulation Of Cellular Protein Metabolic Process Regulation Of ERK1 And ERK2 Cascade Cell Morphogenesis Involved In Differentiation Regulation Of Catalytic Activity Cellular Response To Lipid Blood Coagulation
Tagcloud ?		cytoskeleton dataset deposited dysregulation exerts expand heterodimeric http identifier inositol mapkapk2 nad nadk nonreceptor org pertaining phosphatases phosphoproteome phosphoproteomic polyphosphate proteomecentral proteomexchange ptpn12 pxd000984 reorganization ripk1 silac threonine tnfrsf	adcy3 angptl2 annotated beadchip bmi boston boys c18orf8 corrected correction cpg epigenomic fdr generational humanmethylation27 illumina infant lends maternal mother offspring plac1 prepregnancy prr16 sapcd2 separately stated wnt16 zcchc10
Tagcloud (Difference) ?		cytoskeleton dataset deposited dysregulation exerts expand heterodimeric http identifier inositol mapkapk2 nad nadk nonreceptor org pertaining phosphatases phosphoproteome phosphoproteomic polyphosphate proteomecentral proteomexchange ptpn12 pxd000984 reorganization ripk1 silac threonine tnfrsf	adcy3 angptl2 annotated beadchip bmi boston boys c18orf8 corrected correction cpg epigenomic fdr generational humanmethylation27 illumina infant lends maternal mother offspring plac1 prepregnancy prr16 sapcd2 separately stated wnt16 zcchc10
Tagcloud (Intersection) ?