INPP5D and CD300LF

Number of citations of the paper that reports this interaction (PMID 15184070)
6

Data Source:
HPRD (in vitro)

		INPP5D	CD300LF
Gene Name		inositol polyphosphate-5-phosphatase, 145kDa	CD300 molecule-like family member f
Image
Gene Ontology Annotations	Cellular Component	Cytosol Membrane	Plasma Membrane Integral Component Of Membrane
	Molecular Function	Inositol-polyphosphate 5-phosphatase Activity Protein Binding SH3 Domain Binding
	Biological Process	Phospholipid Metabolic Process Phosphatidylinositol Biosynthetic Process Phosphate-containing Compound Metabolic Process Apoptotic Process Signal Transduction Blood Coagulation Inositol Phosphate Metabolic Process Small Molecule Metabolic Process Phosphatidylinositol Dephosphorylation T Cell Receptor Signaling Pathway Leukocyte Migration	Immune System Process
Pathways		Downstream TCR signaling Metabolism of lipids and lipoproteins Cytokine Signaling in Immune system Inositol phosphate metabolism PECAM1 interactions Cell surface interactions at the vascular wall Synthesis of PIPs at the plasma membrane Signaling by Interleukins TCR signaling Interleukin receptor SHC signaling Synthesis of IP3 and IP4 in the cytosol Interleukin receptor SHC signaling Interleukin-2 signaling Phospholipid metabolism Interleukin-3, 5 and GM-CSF signaling PI Metabolism Adaptive Immune System
Drugs
Diseases
GWAS		Crohn's disease ( 22412388 23128233)	Fibrinogen ( 20031577)
Protein-Protein Interactions		40 interactors: ARAP1 CD22 CD300LF CRKL CSF1R CSF3R DAB1 DAB2 DOK1 DOK2 DOK3 EPOR FCGR2B FGR FLT3 GAB1 GAB2 GRB2 HCK IL4R JAK1 JAK3 KHDRBS3 KIT KRT31 KRT40 KRTAP10-3 KRTAP10-7 KRTAP10-9 LILRB4 LYN MET NOTCH2NL PECAM1 PLCG1 PTPN11 SH3KBP1 SHC1 XIAP ZDHHC17	3 interactors: APP INPP5D PTPN6
Entrez ID		3635	146722
HPRD ID		09033	17635
Ensembl ID		ENSG00000168918	ENSG00000186074
Uniprot IDs		Q92835	J3KS52 Q8TDQ1
PDB IDs		2YSX	2NMS
Enriched GO Terms of Interacting Partners?		Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Signal Transduction Signaling Cell Communication Immune System Process Cell Migration Positive Regulation Of Signal Transduction Cell Motility Intracellular Signal Transduction Cell Surface Receptor Signaling Pathway Cellular Response To Stimulus Regulation Of Immune System Process Positive Regulation Of Kinase Activity Regulation Of Signal Transduction Locomotion Regulation Of Immune Response Positive Regulation Of Transferase Activity Leukocyte Migration Cytokine-mediated Signaling Pathway Regulation Of Signaling Cellular Response To Organic Substance Positive Regulation Of Intracellular Signal Transduction Fc Receptor Signaling Pathway Peptidyl-tyrosine Phosphorylation Movement Of Cell Or Subcellular Component Regulation Of Intracellular Signal Transduction Positive Regulation Of Phosphorylation Response To Cytokine Response To Stimulus Positive Regulation Of Protein Phosphorylation Positive Regulation Of Protein Modification Process Protein Autophosphorylation Regulation Of Protein Kinase Activity Cellular Response To Cytokine Stimulus Response To Organic Substance Positive Regulation Of Protein Kinase Activity Regulation Of MAPK Cascade Regulation Of Kinase Activity Innate Immune Response Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Protein Phosphorylation Immune Response Regulation Of Phosphorylation Defense Response Positive Regulation Of Cellular Protein Metabolic Process Cellular Response To Hormone Stimulus Cellular Response To Peptide Hormone Stimulus Positive Regulation Of MAPK Cascade Cellular Response To Peptide	Regulation Of B Cell Differentiation Blood Coagulation Hemostasis Regulation Of Body Fluid Levels Wound Healing Response To Wounding Negative Regulation Of Lymphocyte Proliferation Negative Regulation Of Mononuclear Cell Proliferation Negative Regulation Of Leukocyte Proliferation Negative Regulation Of Protein Metabolic Process Apoptotic Process Programmed Cell Death Negative Regulation Of Immune Response Cell Death Death Negative Regulation Of Lymphocyte Activation Antigen Receptor-mediated Signaling Pathway Regulation Of Lymphocyte Differentiation Negative Regulation Of Leukocyte Activation Locomotion Immune Response Platelet Activation Regulation Of Peptidyl-tyrosine Phosphorylation Abortive Mitotic Cell Cycle Synaptic Growth At Neuromuscular Junction Regulation Of Mitotic Cell Cycle Phase Transition Movement Of Cell Or Subcellular Component Leukocyte Migration Regulation Of Cell Cycle Phase Transition Regulation Of Cell Differentiation Collateral Sprouting In Absence Of Injury Leukocyte Mediated Immunity Immune Response-activating Cell Surface Receptor Signaling Pathway Positive Regulation Of Cell Activation Collateral Sprouting Axon Midline Choice Point Recognition Negative Regulation Of B Cell Receptor Signaling Pathway Alcohol Metabolic Process Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Negative Regulation Of Interleukin-6 Biosynthetic Process Negative Regulation Of Humoral Immune Response Mediated By Circulating Immunoglobulin Negative Regulation Of Cellular Metabolic Process Immune Response-regulating Cell Surface Receptor Signaling Pathway Negative Regulation Of Immune System Process Immune System Process Negative Regulation Of Monocyte Differentiation Axon Choice Point Recognition Regulation Of Lymphocyte Activation Regulation Of Protein Metabolic Process Regulation Of Cellular Amino Acid Metabolic Process
Tagcloud ?		cytoskeleton dataset deposited dysregulation exerts expand heterodimeric http identifier inositol mapkapk2 nad nadk nonreceptor org pertaining phosphatases phosphoproteome phosphoproteomic polyphosphate proteomecentral proteomexchange ptpn12 pxd000984 reorganization ripk1 silac threonine tnfrsf
Tagcloud (Difference) ?		cytoskeleton dataset deposited dysregulation exerts expand heterodimeric http identifier inositol mapkapk2 nad nadk nonreceptor org pertaining phosphatases phosphoproteome phosphoproteomic polyphosphate proteomecentral proteomexchange ptpn12 pxd000984 reorganization ripk1 silac threonine tnfrsf
Tagcloud (Intersection) ?