INPP5D and FGR

Number of citations of the paper that reports this interaction (PMID 10229804)
10

Data Source:
HPRD (in vivo)

		INPP5D	FGR
Gene Name		inositol polyphosphate-5-phosphatase, 145kDa	FGR proto-oncogene, Src family tyrosine kinase
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol Membrane	Mitochondrial Inner Membrane Mitochondrial Intermembrane Space Cytosol Cytoskeleton Plasma Membrane Actin Cytoskeleton Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Ruffle Membrane Extracellular Vesicular Exosome
	Molecular Function	Inositol-polyphosphate 5-phosphatase Activity Protein Binding SH3 Domain Binding	Phosphotyrosine Binding Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Protein Binding ATP Binding Protein Kinase Binding Immunoglobulin Receptor Binding Fc-gamma Receptor I Complex Binding
	Biological Process	Phospholipid Metabolic Process Phosphatidylinositol Biosynthetic Process Phosphate-containing Compound Metabolic Process Apoptotic Process Signal Transduction Blood Coagulation Inositol Phosphate Metabolic Process Small Molecule Metabolic Process Phosphatidylinositol Dephosphorylation T Cell Receptor Signaling Pathway Leukocyte Migration	Immune Response-regulating Cell Surface Receptor Signaling Pathway Protein Phosphorylation Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Integrin-mediated Signaling Pathway Blood Coagulation Regulation Of Cell Shape Response To Virus Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Cell Migration Peptidyl-tyrosine Phosphorylation Cell Differentiation Positive Regulation Of Cell Migration Peptidyl-tyrosine Autophosphorylation Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Regulation Of Cell Proliferation Positive Regulation Of Mast Cell Degranulation Positive Regulation Of Phosphatidylinositol 3-kinase Activity Innate Immune Response Regulation Of Innate Immune Response Regulation Of Protein Kinase Activity Protein Autophosphorylation Positive Regulation Of Cytokine Secretion Regulation Of Phagocytosis Defense Response To Gram-positive Bacterium Cellular Response To Peptide Hormone Stimulus
Pathways		Downstream TCR signaling Metabolism of lipids and lipoproteins Cytokine Signaling in Immune system Inositol phosphate metabolism PECAM1 interactions Cell surface interactions at the vascular wall Synthesis of PIPs at the plasma membrane Signaling by Interleukins TCR signaling Interleukin receptor SHC signaling Synthesis of IP3 and IP4 in the cytosol Interleukin receptor SHC signaling Interleukin-2 signaling Phospholipid metabolism Interleukin-3, 5 and GM-CSF signaling PI Metabolism Adaptive Immune System	Platelet homeostasis Platelet sensitization by LDL Fcgamma receptor (FCGR) dependent phagocytosis FCGR activation Innate Immune System
Drugs
Diseases
GWAS		Crohn's disease ( 22412388 23128233)
Protein-Protein Interactions		40 interactors: ARAP1 CD22 CD300LF CRKL CSF1R CSF3R DAB1 DAB2 DOK1 DOK2 DOK3 EPOR FCGR2B FGR FLT3 GAB1 GAB2 GRB2 HCK IL4R JAK1 JAK3 KHDRBS3 KIT KRT31 KRT40 KRTAP10-3 KRTAP10-7 KRTAP10-9 LILRB4 LYN MET NOTCH2NL PECAM1 PLCG1 PTPN11 SH3KBP1 SHC1 XIAP ZDHHC17	22 interactors: ARRB1 CBL CCR3 CSK DAB2 DOK1 ERBB2 FASLG HCLS1 IKBKG INPP5D KHDRBS1 NR1I2 PTK2 SLAMF1 SNCA SRC STAT3 SYK VDR WAS YWHAQ
Entrez ID		3635	2268
HPRD ID		09033	01288
Ensembl ID		ENSG00000168918	ENSG00000000938
Uniprot IDs		Q92835	P09769 P78453
PDB IDs		2YSX
Enriched GO Terms of Interacting Partners?		Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Signal Transduction Signaling Cell Communication Immune System Process Cell Migration Positive Regulation Of Signal Transduction Cell Motility Intracellular Signal Transduction Cell Surface Receptor Signaling Pathway Cellular Response To Stimulus Regulation Of Immune System Process Positive Regulation Of Kinase Activity Regulation Of Signal Transduction Locomotion Regulation Of Immune Response Positive Regulation Of Transferase Activity Leukocyte Migration Cytokine-mediated Signaling Pathway Regulation Of Signaling Cellular Response To Organic Substance Positive Regulation Of Intracellular Signal Transduction Fc Receptor Signaling Pathway Peptidyl-tyrosine Phosphorylation Movement Of Cell Or Subcellular Component Regulation Of Intracellular Signal Transduction Positive Regulation Of Phosphorylation Response To Cytokine Response To Stimulus Positive Regulation Of Protein Phosphorylation Positive Regulation Of Protein Modification Process Protein Autophosphorylation Regulation Of Protein Kinase Activity Cellular Response To Cytokine Stimulus Response To Organic Substance Positive Regulation Of Protein Kinase Activity Regulation Of MAPK Cascade Regulation Of Kinase Activity Innate Immune Response Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Protein Phosphorylation Immune Response Regulation Of Phosphorylation Defense Response Positive Regulation Of Cellular Protein Metabolic Process Cellular Response To Hormone Stimulus Cellular Response To Peptide Hormone Stimulus Positive Regulation Of MAPK Cascade Cellular Response To Peptide	Signaling Cell Communication Positive Regulation Of Signal Transduction Signal Transduction Cellular Response To Stimulus Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Signal Transduction Response To Stimulus Regulation Of Cell Death Positive Regulation Of Protein Metabolic Process Response To Organic Substance Regulation Of Endocytosis Regulation Of Signaling Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Protein Phosphorylation Cell Surface Receptor Signaling Pathway Regulation Of Vesicle-mediated Transport Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Apoptotic Process Cellular Response To Organic Substance Regulation Of Cell Proliferation Positive Regulation Of Phosphorylation Regulation Of Cellular Component Organization Positive Regulation Of Protein Modification Process Regulation Of Tissue Remodeling Positive Regulation Of Cellular Biosynthetic Process Regulation Of Intracellular Transport Positive Regulation Of Protein Serine/threonine Kinase Activity Negative Regulation Of Cellular Metabolic Process Immune Response-activating Cell Surface Receptor Signaling Pathway Positive Regulation Of Protein Kinase Activity Immune Response-regulating Signaling Pathway Immune System Process Positive Regulation Of Kinase Activity Regulation Of Protein Metabolic Process Negative Regulation Of Biosynthetic Process Positive Regulation Of Transport Regulation Of Metabolic Process Regulation Of Protein Phosphorylation Positive Regulation Of Metabolic Process Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transferase Activity Regulation Of Catalytic Activity Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Bone Resorption Positive Regulation Of Catalytic Activity Regulation Of Cellular Protein Metabolic Process
Tagcloud ?		cytoskeleton dataset deposited dysregulation exerts expand heterodimeric http identifier inositol mapkapk2 nad nadk nonreceptor org pertaining phosphatases phosphoproteome phosphoproteomic polyphosphate proteomecentral proteomexchange ptpn12 pxd000984 reorganization ripk1 silac threonine tnfrsf	colocalization confocal edge electrophoretic fyn hck incompletely isre jak jak1 jak3 lyn masses migrating mobility p59 plasminogen polarization ptk ptks src stat1 supershift tyk2 upa upar urokinase utilizes vsmc
Tagcloud (Difference) ?		cytoskeleton dataset deposited dysregulation exerts expand heterodimeric http identifier inositol mapkapk2 nad nadk nonreceptor org pertaining phosphatases phosphoproteome phosphoproteomic polyphosphate proteomecentral proteomexchange ptpn12 pxd000984 reorganization ripk1 silac threonine tnfrsf	colocalization confocal edge electrophoretic fyn hck incompletely isre jak jak1 jak3 lyn masses migrating mobility p59 plasminogen polarization ptk ptks src stat1 supershift tyk2 upa upar urokinase utilizes vsmc
Tagcloud (Intersection) ?