INPP5D and CSF3R

Number of citations of the paper that reports this interaction (PMID 15470047)
10

Data Source:
HPRD (in vitro, in vivo)

		INPP5D	CSF3R
Gene Name		inositol polyphosphate-5-phosphatase, 145kDa	colony stimulating factor 3 receptor (granulocyte)
Image
Gene Ontology Annotations	Cellular Component	Cytosol Membrane	Extracellular Region Integral Component Of Plasma Membrane
	Molecular Function	Inositol-polyphosphate 5-phosphatase Activity Protein Binding SH3 Domain Binding	Receptor Activity Cytokine Receptor Activity Protein Binding
	Biological Process	Phospholipid Metabolic Process Phosphatidylinositol Biosynthetic Process Phosphate-containing Compound Metabolic Process Apoptotic Process Signal Transduction Blood Coagulation Inositol Phosphate Metabolic Process Small Molecule Metabolic Process Phosphatidylinositol Dephosphorylation T Cell Receptor Signaling Pathway Leukocyte Migration	Defense Response Cell Adhesion Signal Transduction Cytokine-mediated Signaling Pathway Neutrophil Chemotaxis Amelogenesis
Pathways		Downstream TCR signaling Metabolism of lipids and lipoproteins Cytokine Signaling in Immune system Inositol phosphate metabolism PECAM1 interactions Cell surface interactions at the vascular wall Synthesis of PIPs at the plasma membrane Signaling by Interleukins TCR signaling Interleukin receptor SHC signaling Synthesis of IP3 and IP4 in the cytosol Interleukin receptor SHC signaling Interleukin-2 signaling Phospholipid metabolism Interleukin-3, 5 and GM-CSF signaling PI Metabolism Adaptive Immune System
Drugs			Pegfilgrastim Filgrastim
Diseases
GWAS		Crohn's disease ( 22412388 23128233)
Protein-Protein Interactions		40 interactors: ARAP1 CD22 CD300LF CRKL CSF1R CSF3R DAB1 DAB2 DOK1 DOK2 DOK3 EPOR FCGR2B FGR FLT3 GAB1 GAB2 GRB2 HCK IL4R JAK1 JAK3 KHDRBS3 KIT KRT31 KRT40 KRTAP10-3 KRTAP10-7 KRTAP10-9 LILRB4 LYN MET NOTCH2NL PECAM1 PLCG1 PTPN11 SH3KBP1 SHC1 XIAP ZDHHC17	19 interactors: CISH CSF3 ELANE FTH1 GRB2 HCK INPP5D JAK1 JAK2 LCK LYN PLA2G1B PTPN11 SHC1 SOCS3 STAT3 SYK WSB1 WSB2
Entrez ID		3635	1441
HPRD ID		09033	00737
Ensembl ID		ENSG00000168918	ENSG00000119535
Uniprot IDs		Q92835	Q99062
PDB IDs		2YSX	1AZ7 2D9Q
Enriched GO Terms of Interacting Partners?		Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Signal Transduction Signaling Cell Communication Immune System Process Cell Migration Positive Regulation Of Signal Transduction Cell Motility Intracellular Signal Transduction Cell Surface Receptor Signaling Pathway Cellular Response To Stimulus Regulation Of Immune System Process Positive Regulation Of Kinase Activity Regulation Of Signal Transduction Locomotion Regulation Of Immune Response Positive Regulation Of Transferase Activity Leukocyte Migration Cytokine-mediated Signaling Pathway Regulation Of Signaling Cellular Response To Organic Substance Positive Regulation Of Intracellular Signal Transduction Fc Receptor Signaling Pathway Peptidyl-tyrosine Phosphorylation Movement Of Cell Or Subcellular Component Regulation Of Intracellular Signal Transduction Positive Regulation Of Phosphorylation Response To Cytokine Response To Stimulus Positive Regulation Of Protein Phosphorylation Positive Regulation Of Protein Modification Process Protein Autophosphorylation Regulation Of Protein Kinase Activity Cellular Response To Cytokine Stimulus Response To Organic Substance Positive Regulation Of Protein Kinase Activity Regulation Of MAPK Cascade Regulation Of Kinase Activity Innate Immune Response Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Protein Phosphorylation Immune Response Regulation Of Phosphorylation Defense Response Positive Regulation Of Cellular Protein Metabolic Process Cellular Response To Hormone Stimulus Cellular Response To Peptide Hormone Stimulus Positive Regulation Of MAPK Cascade Cellular Response To Peptide	Cellular Response To Peptide Hormone Stimulus Cellular Response To Peptide Immune Response Leukocyte Migration Regulation Of Immune Response Response To Peptide Hormone Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cellular Response To Organonitrogen Compound Response To Peptide Regulation Of Immune System Process Intracellular Signal Transduction Cellular Response To Hormone Stimulus Cell Migration Enzyme Linked Receptor Protein Signaling Pathway Peptidyl-tyrosine Autophosphorylation Cell Motility Immune System Process Defense Response Innate Immune Response Regulation Of Cell Proliferation Movement Of Cell Or Subcellular Component JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway Response To Organonitrogen Compound Response To Organic Substance Growth Hormone Receptor Signaling Pathway Cellular Response To Growth Hormone Stimulus Locomotion Response To Hormone Regulation Of Signal Transduction Regulation Of Phosphorylation Regulation Of Protein Phosphorylation Cellular Response To Organic Substance Regulation Of Phosphorus Metabolic Process Response To Growth Hormone Regulation Of Signaling Immune Response-regulating Cell Surface Receptor Signaling Pathway Positive Regulation Of Immune System Process Positive Regulation Of Signal Transduction JAK-STAT Cascade Blood Coagulation Hemostasis Regulation Of Intracellular Signal Transduction Signal Transduction Cytokine-mediated Signaling Pathway Fc Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Peptidyl-tyrosine Phosphorylation Positive Regulation Of Protein Phosphorylation Regulation Of Protein Kinase Activity Response To Stimulus
Tagcloud ?		cytoskeleton dataset deposited dysregulation exerts expand heterodimeric http identifier inositol mapkapk2 nad nadk nonreceptor org pertaining phosphatases phosphoproteome phosphoproteomic polyphosphate proteomecentral proteomexchange ptpn12 pxd000984 reorganization ripk1 silac threonine tnfrsf	1155insttgtc accuracy allele asxl1 calr carried cml cnl criteria diagnostic differential gammopathy jak2 leukocytosis mgus monoclonal mutations neutrophilic observe protocol retrospectively reviewed sequenced setbp1 significance suspected twelve uncertain v617f
Tagcloud (Difference) ?		cytoskeleton dataset deposited dysregulation exerts expand heterodimeric http identifier inositol mapkapk2 nad nadk nonreceptor org pertaining phosphatases phosphoproteome phosphoproteomic polyphosphate proteomecentral proteomexchange ptpn12 pxd000984 reorganization ripk1 silac threonine tnfrsf	1155insttgtc accuracy allele asxl1 calr carried cml cnl criteria diagnostic differential gammopathy jak2 leukocytosis mgus monoclonal mutations neutrophilic observe protocol retrospectively reviewed sequenced setbp1 significance suspected twelve uncertain v617f
Tagcloud (Intersection) ?