INPP5D and PECAM1

Number of citations of the paper that reports this interaction (PMID 10350061)
17

Data Source:
BioGRID (far western blotting)
HPRD (in vitro)

		INPP5D	PECAM1
Gene Name		inositol polyphosphate-5-phosphatase, 145kDa	platelet/endothelial cell adhesion molecule 1
Image
Gene Ontology Annotations	Cellular Component	Cytosol Membrane	Extracellular Space Plasma Membrane Integral Component Of Membrane Cell Junction Platelet Alpha Granule Membrane Extracellular Vesicular Exosome
	Molecular Function	Inositol-polyphosphate 5-phosphatase Activity Protein Binding SH3 Domain Binding	Protein Binding
	Biological Process	Phospholipid Metabolic Process Phosphatidylinositol Biosynthetic Process Phosphate-containing Compound Metabolic Process Apoptotic Process Signal Transduction Blood Coagulation Inositol Phosphate Metabolic Process Small Molecule Metabolic Process Phosphatidylinositol Dephosphorylation T Cell Receptor Signaling Pathway Leukocyte Migration	Platelet Degranulation Phagocytosis Cell Adhesion Signal Transduction Blood Coagulation Cell Recognition Platelet Activation Extracellular Matrix Organization Leukocyte Migration Diapedesis Glomerular Endothelium Development
Pathways		Downstream TCR signaling Metabolism of lipids and lipoproteins Cytokine Signaling in Immune system Inositol phosphate metabolism PECAM1 interactions Cell surface interactions at the vascular wall Synthesis of PIPs at the plasma membrane Signaling by Interleukins TCR signaling Interleukin receptor SHC signaling Synthesis of IP3 and IP4 in the cytosol Interleukin receptor SHC signaling Interleukin-2 signaling Phospholipid metabolism Interleukin-3, 5 and GM-CSF signaling PI Metabolism Adaptive Immune System	Platelet homeostasis Platelet sensitization by LDL Response to elevated platelet cytosolic Ca2+ Platelet degranulation Integrin cell surface interactions Platelet activation, signaling and aggregation Cell surface interactions at the vascular wall PECAM1 interactions
Drugs
Diseases
GWAS		Crohn's disease ( 22412388 23128233)
Protein-Protein Interactions		40 interactors: ARAP1 CD22 CD300LF CRKL CSF1R CSF3R DAB1 DAB2 DOK1 DOK2 DOK3 EPOR FCGR2B FGR FLT3 GAB1 GAB2 GRB2 HCK IL4R JAK1 JAK3 KHDRBS3 KIT KRT31 KRT40 KRTAP10-3 KRTAP10-7 KRTAP10-9 LILRB4 LYN MET NOTCH2NL PECAM1 PLCG1 PTPN11 SH3KBP1 SHC1 XIAP ZDHHC17	22 interactors: CD38 CSK CTNNB1 DSP EFNB2 FYN HCK INPP5D ITGA5 ITGB3 JUP LCK LYN PIK3R1 PLCG1 PRKCE PRPF40A PTPN11 PTPN6 SRC XRCC6 YES1
Entrez ID		3635	5175
HPRD ID		09033	01425
Ensembl ID		ENSG00000168918
Uniprot IDs		Q92835	P16284
PDB IDs		2YSX	2KY5
Enriched GO Terms of Interacting Partners?		Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Signal Transduction Signaling Cell Communication Immune System Process Cell Migration Positive Regulation Of Signal Transduction Cell Motility Intracellular Signal Transduction Cell Surface Receptor Signaling Pathway Cellular Response To Stimulus Regulation Of Immune System Process Positive Regulation Of Kinase Activity Regulation Of Signal Transduction Locomotion Regulation Of Immune Response Positive Regulation Of Transferase Activity Leukocyte Migration Cytokine-mediated Signaling Pathway Regulation Of Signaling Cellular Response To Organic Substance Positive Regulation Of Intracellular Signal Transduction Fc Receptor Signaling Pathway Peptidyl-tyrosine Phosphorylation Movement Of Cell Or Subcellular Component Regulation Of Intracellular Signal Transduction Positive Regulation Of Phosphorylation Response To Cytokine Response To Stimulus Positive Regulation Of Protein Phosphorylation Positive Regulation Of Protein Modification Process Protein Autophosphorylation Regulation Of Protein Kinase Activity Cellular Response To Cytokine Stimulus Response To Organic Substance Positive Regulation Of Protein Kinase Activity Regulation Of MAPK Cascade Regulation Of Kinase Activity Innate Immune Response Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Protein Phosphorylation Immune Response Regulation Of Phosphorylation Defense Response Positive Regulation Of Cellular Protein Metabolic Process Cellular Response To Hormone Stimulus Cellular Response To Peptide Hormone Stimulus Positive Regulation Of MAPK Cascade Cellular Response To Peptide	Cell Migration Cell Motility Leukocyte Migration Immune Response-regulating Cell Surface Receptor Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Locomotion Blood Coagulation Hemostasis Wound Healing Immune Response-regulating Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Movement Of Cell Or Subcellular Component Response To Wounding Regulation Of Body Fluid Levels T Cell Costimulation Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Lymphocyte Activation Cellular Response To Peptide Hormone Stimulus Innate Immune Response Positive Regulation Of Cell Activation Immune System Process Cellular Response To Peptide Cellular Response To Organonitrogen Compound Positive Regulation Of Immune Response Regulation Of Cell Activation Regulation Of Immune Response Antigen Receptor-mediated Signaling Pathway Positive Regulation Of Immune System Process Peptidyl-tyrosine Autophosphorylation Positive Regulation Of Cell Adhesion Regulation Of Immune System Process Immune Response Fc Receptor Signaling Pathway Cell Surface Receptor Signaling Pathway Response To Organonitrogen Compound Regulation Of T Cell Activation Regulation Of Cell Adhesion Response To Peptide Hormone Platelet Activation Response To Peptide Positive Regulation Of T Cell Activation Response To Stress Positive Regulation Of Homotypic Cell-cell Adhesion Positive Regulation Of Signal Transduction Regulation Of Cell-cell Adhesion Positive Regulation Of Cell-cell Adhesion Viral Process Defense Response Cellular Response To Hormone Stimulus Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis
Tagcloud ?		cytoskeleton dataset deposited dysregulation exerts expand heterodimeric http identifier inositol mapkapk2 nad nadk nonreceptor org pertaining phosphatases phosphoproteome phosphoproteomic polyphosphate proteomecentral proteomexchange ptpn12 pxd000984 reorganization ripk1 silac threonine tnfrsf	alox15 ccl5 chd consisted cx37 cyp1a1 fcgr2a gpx1 harvested indian meta odd ppard rest retrieved rs1042522 rs1050450 rs1131012 rs12953 rs1764391 rs1801274 rs2016520 rs2107538 rs2228315 rs34210653 rs4646903 rs668 selplg variants
Tagcloud (Difference) ?		cytoskeleton dataset deposited dysregulation exerts expand heterodimeric http identifier inositol mapkapk2 nad nadk nonreceptor org pertaining phosphatases phosphoproteome phosphoproteomic polyphosphate proteomecentral proteomexchange ptpn12 pxd000984 reorganization ripk1 silac threonine tnfrsf	alox15 ccl5 chd consisted cx37 cyp1a1 fcgr2a gpx1 harvested indian meta odd ppard rest retrieved rs1042522 rs1050450 rs1131012 rs12953 rs1764391 rs1801274 rs2016520 rs2107538 rs2228315 rs34210653 rs4646903 rs668 selplg variants
Tagcloud (Intersection) ?