SH3GL2 and ITSN1

Number of citations of the paper that reports this interaction (PubMedID 21900206)
0

Data Source:
BioGRID (two hybrid)

		SH3GL2	ITSN1
Description		SH3 domain containing GRB2 like 2, endophilin A1	intersectin 1
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GO Annotations	Cellular Component	Golgi Membrane Cytoplasm Endosome Early Endosome Cytosol Plasma Membrane Membrane Clathrin-coated Endocytic Vesicle Membrane Cell Projection Synapse Perinuclear Region Of Cytoplasm Photoreceptor Ribbon Synapse Presynapse Postsynapse Glutamatergic Synapse Presynaptic Cytosol	Nucleus Nuclear Envelope Cytoplasm Endosome Cytosol Plasma Membrane Clathrin-coated Pit Endomembrane System Membrane Lamellipodium Cytoplasmic Vesicle Presynaptic Membrane Cell Projection Neuron Projection Neuronal Cell Body Dendritic Spine Synapse Recycling Endosome Apical Dendrite Intracellular Vesicle Postsynaptic Endocytic Zone Postsynaptic Actin Cytoskeleton Glutamatergic Synapse
	Molecular Function	Protein Binding Lipid Binding Identical Protein Binding	Guanyl-nucleotide Exchange Factor Activity Calcium Ion Binding Protein Binding Protein-macromolecule Adaptor Activity Metal Ion Binding Molecular Adaptor Activity Proline-rich Region Binding
	Biological Process	Regulation Of Receptor Internalization Endocytosis Signal Transduction Central Nervous System Development Negative Regulation Of Gene Expression Neuron Projection Development Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of MAPK Cascade Synaptic Vesicle Endocytosis Dendrite Extension Postsynaptic Actin Cytoskeleton Organization Negative Regulation Of Blood-brain Barrier Permeability Cellular Response To Brain-derived Neurotrophic Factor Stimulus	Exocytosis Endocytosis Intracellular Protein Localization Regulation Of Cell Communication Protein Transport Endosomal Transport Regulation Of Signaling Intracellular Signal Transduction Regulation Of Small GTPase Mediated Signal Transduction Positive Regulation Of Growth Hormone Secretion Positive Regulation Of Dendritic Spine Development Regulation Of Postsynapse Organization Clathrin-dependent Synaptic Vesicle Endocytosis Regulation Of Modification Of Postsynaptic Actin Cytoskeleton Positive Regulation Of Caveolin-mediated Endocytosis
Pathways		Retrograde neurotrophin signalling Retrograde neurotrophin signalling EGFR downregulation MHC class II antigen presentation Lysosome Vesicle Biogenesis Golgi Associated Vesicle Biogenesis Recycling pathway of L1 Recycling pathway of L1 Negative regulation of MET activity Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis InlB-mediated entry of Listeria monocytogenes into host cell	NRAGE signals death through JNK EPHB-mediated forward signaling EPHB-mediated forward signaling G alpha (12/13) signalling events Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis CDC42 GTPase cycle RHOQ GTPase cycle RHOG GTPase cycle
Drugs
Diseases
GWAS		Cerebral cortical growth ( 29682794) Cognitive performance ( 19734545) FEV1 ( 30804560) HDL cholesterol levels in HIV infection ( 33109212) Heart failure ( 20445134) Lung function (FVC) ( 30804560) Midgestational circulating levels of PBDEs ( 28235828) Multiple sclerosis ( 19010793) Myopia ( 27182965) Nontraumatic osteonecrosis of the femoral head ( 32701715) Obesity-related traits ( 23251661) Obsessive-compulsive traits ( 33531474) Parkinson's disease ( 22451204 32201043 28892059 27182965) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892) Pursuit maintenance gain ( 29064472) Small cell lung carcinoma ( 28604730) Spherical equivalent or myopia (age of diagnosis) ( 29808027) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993) Vertical cup-disc ratio (multi-trait analysis) ( 31959993)	Bitter non-alcoholic beverage consumption ( 31046077) Educational attainment ( 25201988) Height ( 31562340) Mean corpuscular hemoglobin ( 27863252 32888494) Mean corpuscular hemoglobin concentration ( 32888494) Mean corpuscular volume ( 27863252 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) QT interval ( 29213071) Red blood cell count ( 32888494) Red cell distribution width ( 27863252 32888494) Tonsillectomy ( 27182965 28928442)
Interacting Genes		53 interacting genes: ACTG1 ADAM15 ADAM19 ADRB1 AMPH APP ARNT2 ATXN2 BIN1 CD2AP CLEC3B DACT1 DLGAP4 DNM1 DNM2 DPPA4 DPYSL4 EGFL6 EMD ERH F13A1 FBXO32 FXR1 GCH1 GSTM3 HLA-DQA1 IGHM IL6 ITCH ITSN1 LCP2 LRRK2 MAP4K3 MAST2 PAK2 PAXIP1 PDCD6IP PPP1R21 PPP6R1 PRR14 SH3GL3 SH3KBP1 SHANK3 SLC17A7 SYNJ1 TCEA2 TERF1 TIAM2 TMEM108 TYMS ZNF219 ZNF580 ZXDC	140 interacting genes: AGFG1 AGFG2 AJUBA ANKRD36 ANKRD54 ARF6 ARFIP2 ARHGAP31 ASAP2 BECN1 BFSP1 BRCC3 BRWD3 CCDC24 CCNO CDC42 CEP85L CLIP2 CLTC COG4 CSNK2B CYTH1 CYTH3 DAB1 DAB2 DES DISC1 DLGAP1 DNAI7 DNAJA2 DNM1 DNM2 DST DYNC1H1 EEF1A1 EPHB2 EPN2 EPS15 EXOC1 FCHO1 FCHO2 FCHSD2 FNBP1 FNBP4 GAREM2 GCC1 GFAP GNPTG GOLGA5 HIP1 HNRNPK HRAS IFT74 ITSN2 KHDRBS1 KIF16B KIF5A KIF5C KRT222 LMO3 LMO4 MAP3K20 MAPK6 MAPK8IP2 MED4 MRPL20 MTUS2 MYH14 NASP NEFL NEFM NEMF PACSIN3 PDCD6IP PDE2A PDZD8 PFDN5 PICALM PIK3AP1 PIK3C2B PIK3R1 PLK1 PPFIA2 PPL PREX1 PRRG4 RAB11FIP2 RAB5A RABEP1 RAI14 RALBP1 REPS1 REPS2 RIN1 RNF40 RPS6KA5 RRBP1 SCAI SCAMP1 SCOC SF3B4 SH3GL2 SHANK3 SIAH1 SMARCC2 SMC1A SNAP23 SNAP25 SNRNP70 SNX5 SNX6 SOS1 SOS2 SPDL1 SPECC1 SPRY2 SPTAN1 SPTBN1 STON2 SYNC SYNE1 SYNJ1 SYNJ2 TK1 TRAF3IP1 TRIM5 TRIM8 TRPM7 TSG101 TTC27 UBC UBE2K UNC119 VLDLR WASL WBP11 WHAMM ZFC3H1 ZFPM2 ZMYM5
Entrez ID		6456	6453
HPRD ID		05125	03898
Ensembl ID		ENSG00000107295	ENSG00000205726
Uniprot IDs		Q99962	A7XZY7 F8W7U0 Q15811 Q6PD56
PDB IDs		1X03 1X04 2D4C 2DBM	1KI1 2KGR 2KHN 3FIA 3QBV 4IIM 5HZI 5HZJ 5HZK 6GBU 6H5T
Enriched GO Terms of Interacting Partners?		Endocytosis Synapse Neuron Projection Import Into Cell SH3 Domain Binding Endosome Regulation Of Endocytosis Regulation Of Cellular Component Organization Synaptic Vesicle Endocytosis Vesicle Scission Presynaptic Endocytosis Modulation Of Excitatory Postsynaptic Potential Regulation Of Vesicle-mediated Transport Cytoplasmic Vesicle Glutamatergic Synapse Positive Regulation Of Immune System Process Regulation Of Synaptic Vesicle Endocytosis Regulation Of Long-term Neuronal Synaptic Plasticity Growth Cone Clathrin-coated Pit Cell Junction Organization Presynapse Synaptic Vesicle Budding From Presynaptic Endocytic Zone Membrane Regulation Of Synaptic Vesicle Recycling Positive Regulation Of Multicellular Organismal Process Regulation Of Synapse Structure Or Activity Maintenance Of Blood-brain Barrier Vesicle-mediated Transport Vesicle-mediated Transport In Synapse Clathrin Binding Receptor-mediated Endocytosis Axon Cerebellar Mossy Fiber Developmental Process Regulation Of Long-term Synaptic Potentiation Cellular Response To Manganese Ion Positive Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of Membrane Potential Cell-cell Junction Early Endosome Regulation Of Nervous System Process Nuclear Envelope Lumen Cytoplasm Tight Junction Assembly Regulation Of Protein Metabolic Process Negative Regulation Of Long-term Synaptic Potentiation Tight Junction Organization Positive Regulation Of Neurogenesis Regulation Of Developmental Process Synaptic Vesicle	Endocytosis Vesicle-mediated Transport Import Into Cell Cytoplasm Cytosol Establishment Of Localization In Cell Clathrin-coated Pit Clathrin Coat Assembly Cytoskeleton Organization Organelle Organization Cytoskeleton Regulation Of Cellular Component Organization Receptor-mediated Endocytosis Organelle Localization Membrane Organization Cellular Component Assembly Clathrin-coated Vesicle Protein Transport Clathrin-dependent Endocytosis Intermediate Filament-based Process Cellular Localization Establishment Of Organelle Localization Intracellular Transport Negative Regulation Of Cellular Component Organization Synaptic Vesicle Endocytosis Establishment Of Protein Localization Regulation Of Protein Localization To Cell Periphery Presynaptic Endocytosis Vesicle-mediated Transport In Synapse Intermediate Filament Cytoskeleton Organization Intracellular Protein Localization Protein-containing Complex Assembly Clathrin Coat Of Coated Pit Intermediate Filament Cytoskeleton Protein-containing Complex Organization Structural Constituent Of Cytoskeleton Post-Golgi Vesicle-mediated Transport Glutamatergic Synapse Microtubule Binding Establishment Of Vesicle Localization Endosomal Transport Cell Cortex Cytoplasmic Vesicle Golgi Vesicle Transport Regulation Of Protein Localization To Plasma Membrane Vesicle Localization Cytoskeleton-dependent Intracellular Transport Cell Projection Organization Mitotic Cytokinesis Regulation Of Epidermal Growth Factor Receptor Signaling Pathway
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