SH3GL2 and PPP6R1

Number of citations of the paper that reports this interaction (PubMedID 21900206)
0

Data Source:
BioGRID (two hybrid)

		SH3GL2	PPP6R1
Description		SH3 domain containing GRB2 like 2, endophilin A1	protein phosphatase 6 regulatory subunit 1
Image			No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Cytoplasm Endosome Early Endosome Cytosol Plasma Membrane Membrane Clathrin-coated Endocytic Vesicle Membrane Cell Projection Synapse Perinuclear Region Of Cytoplasm Photoreceptor Ribbon Synapse Presynapse Postsynapse Glutamatergic Synapse Presynaptic Cytosol	Nucleus Cytoplasm Cytosol Lamellipodium
	Molecular Function	Protein Binding Lipid Binding Identical Protein Binding	Protein Binding Protein Phosphatase Regulator Activity Protein Phosphatase Binding Small GTPase Binding
	Biological Process	Regulation Of Receptor Internalization Endocytosis Signal Transduction Central Nervous System Development Negative Regulation Of Gene Expression Neuron Projection Development Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of MAPK Cascade Synaptic Vesicle Endocytosis Dendrite Extension Postsynaptic Actin Cytoskeleton Organization Negative Regulation Of Blood-brain Barrier Permeability Cellular Response To Brain-derived Neurotrophic Factor Stimulus	Regulation Of Signal Transduction
Pathways		Retrograde neurotrophin signalling Retrograde neurotrophin signalling EGFR downregulation MHC class II antigen presentation Lysosome Vesicle Biogenesis Golgi Associated Vesicle Biogenesis Recycling pathway of L1 Recycling pathway of L1 Negative regulation of MET activity Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis InlB-mediated entry of Listeria monocytogenes into host cell	COPII-mediated vesicle transport
Drugs
Diseases
GWAS		Cerebral cortical growth ( 29682794) Cognitive performance ( 19734545) FEV1 ( 30804560) HDL cholesterol levels in HIV infection ( 33109212) Heart failure ( 20445134) Lung function (FVC) ( 30804560) Midgestational circulating levels of PBDEs ( 28235828) Multiple sclerosis ( 19010793) Myopia ( 27182965) Nontraumatic osteonecrosis of the femoral head ( 32701715) Obesity-related traits ( 23251661) Obsessive-compulsive traits ( 33531474) Parkinson's disease ( 22451204 32201043 28892059 27182965) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892) Pursuit maintenance gain ( 29064472) Small cell lung carcinoma ( 28604730) Spherical equivalent or myopia (age of diagnosis) ( 29808027) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993) Vertical cup-disc ratio (multi-trait analysis) ( 31959993)	Cutaneous leishmaniasis ( 32830257) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Thyroid stimulating hormone levels ( 32769997)
Interacting Genes		53 interacting genes: ACTG1 ADAM15 ADAM19 ADRB1 AMPH APP ARNT2 ATXN2 BIN1 CD2AP CLEC3B DACT1 DLGAP4 DNM1 DNM2 DPPA4 DPYSL4 EGFL6 EMD ERH F13A1 FBXO32 FXR1 GCH1 GSTM3 HLA-DQA1 IGHM IL6 ITCH ITSN1 LCP2 LRRK2 MAP4K3 MAST2 PAK2 PAXIP1 PDCD6IP PPP1R21 PPP6R1 PRR14 SH3GL3 SH3KBP1 SHANK3 SLC17A7 SYNJ1 TCEA2 TERF1 TIAM2 TMEM108 TYMS ZNF219 ZNF580 ZXDC	3 interacting genes: MTNR1B PRKDC SH3GL2
Entrez ID		6456	22870
HPRD ID		05125	17207
Ensembl ID		ENSG00000107295	ENSG00000105063
Uniprot IDs		Q99962	Q9UPN7
PDB IDs		1X03 1X04 2D4C 2DBM
Enriched GO Terms of Interacting Partners?		Endocytosis Synapse Neuron Projection Import Into Cell SH3 Domain Binding Endosome Regulation Of Endocytosis Regulation Of Cellular Component Organization Synaptic Vesicle Endocytosis Vesicle Scission Presynaptic Endocytosis Modulation Of Excitatory Postsynaptic Potential Regulation Of Vesicle-mediated Transport Cytoplasmic Vesicle Glutamatergic Synapse Positive Regulation Of Immune System Process Regulation Of Synaptic Vesicle Endocytosis Regulation Of Long-term Neuronal Synaptic Plasticity Growth Cone Clathrin-coated Pit Cell Junction Organization Presynapse Synaptic Vesicle Budding From Presynaptic Endocytic Zone Membrane Regulation Of Synaptic Vesicle Recycling Positive Regulation Of Multicellular Organismal Process Regulation Of Synapse Structure Or Activity Maintenance Of Blood-brain Barrier Vesicle-mediated Transport Vesicle-mediated Transport In Synapse Clathrin Binding Receptor-mediated Endocytosis Axon Cerebellar Mossy Fiber Developmental Process Regulation Of Long-term Synaptic Potentiation Cellular Response To Manganese Ion Positive Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of Membrane Potential Cell-cell Junction Early Endosome Regulation Of Nervous System Process Nuclear Envelope Lumen Cytoplasm Tight Junction Assembly Regulation Of Protein Metabolic Process Negative Regulation Of Long-term Synaptic Potentiation Tight Junction Organization Positive Regulation Of Neurogenesis Regulation Of Developmental Process Synaptic Vesicle	Dendrite Extension Negative Regulation Of Intracellular Signal Transduction Peptidyl-threonine Phosphorylation Negative Regulation Of Signal Transduction Negative Regulation Of Cell Communication Negative Regulation Of Signaling Neuron Projection Extension Regulation Of Intracellular Signal Transduction Regulation Of Circadian Rhythm Developmental Cell Growth Developmental Growth Involved In Morphogenesis Response To Ionizing Radiation Positive Regulation Of Platelet Formation Carbohydrate Homeostasis Melatonin Receptor Activity Glucose Homeostasis Positive Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep DNA-dependent Protein Kinase Activity Intrinsic Apoptotic Signaling Pathway Pro-B Cell Differentiation Small-subunit Processome Assembly Histone H2AXS139 Kinase Activity T Cell Receptor V(D)J Recombination Negative Regulation Of Blood-brain Barrier Permeability Intracellular Protein-containing Complex Positive Regulation Of Vesicle Transport Along Microtubule Regulation Of Signal Transduction Positive Regulation Of Transmission Of Nerve Impulse Positive Regulation Of Circadian Sleep/wake Cycle, Sleep Regulation Of Cell Communication Negative Regulation Of CGMP-mediated Signaling Vascular Process In Circulatory System Regulation Of Neuronal Action Potential Negative Regulation Of Transmission Of Nerve Impulse Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep Regulation Of Signaling DNA-dependent Protein Kinase-DNA Ligase 4 Complex B Cell Lineage Commitment DNA-dependent Protein Kinase Complex Photoreceptor Ribbon Synapse LRR Domain Binding Negative Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development Circulatory System Process Immunoglobulin V(D)J Recombination Double-strand Break Repair Via Alternative Nonhomologous End Joining Nonhomologous End Joining Complex Apoptotic Signaling Pathway Regulation Of Blood-brain Barrier Permeability Cellular Response To Brain-derived Neurotrophic Factor Stimulus Regulation Of Organelle Transport Along Microtubule
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